Latest & greatest articles for hypothermia

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Top results for hypothermia

1. A Randomized Controlled Study of Low-Dose Hydrocortisone Versus Placebo in Dopamine-Treated Hypotensive Neonates Undergoing Hypothermia Treatment for Hypoxic-Ischemic Encephalopathy

A Randomized Controlled Study of Low-Dose Hydrocortisone Versus Placebo in Dopamine-Treated Hypotensive Neonates Undergoing Hypothermia Treatment for Hypoxic-Ischemic Encephalopathy To investigate whether hydrocortisone supplementation increases blood pressure and decreases inotrope requirements compared with placebo in cooled, asphyxiated neonates with volume-resistant hypotension.A double-blind, randomized, placebo-controlled clinical trial was conducted in a Level III neonatal intensive care (...) and 3.3 μg/dL, P = .87; respectively), suggesting inappropriate adrenal function. Short-term clinical outcomes were similar in the 2 groups.Hydrocortisone administration was effective in raising the blood pressure and decreasing inotrope requirement in asphyxiated neonates with volume-resistant hypotension during hypothermia treatment.ClinicalTrials.gov: NCT02700828.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 EvidenceUpdates

2. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score

Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score The HOPE score, based on covariates available at hospital admission, predicts the probability of in-hospital survival after extracorporeal life support (ECLS) rewarming of a given hypothermic cardiac arrest patient with accidental hypothermia. Our goal was to externally validate the HOPE score.We included consecutive hypothermic arrested patients who (...) underwent rewarming with ECLS. The sample comprised 122 patients. The six independent predictors of survival included in the HOPE score were collected for each patient: age, sex, mechanism of hypothermia, core temperature at admission, serum potassium level at admission and duration of CPR. The primary outcome parameter was survival to hospital discharge.Overall, 51 of the 122 included patients survived, resulting in an empirical (global) probability of survival of 42% (95% CI = [33-51

2019 EvidenceUpdates

3. Therapeutic hypothermia for acute ischaemic stroke

Therapeutic hypothermia for acute ischaemic stroke Ther Therapeutic h apeutic hypothermia for acute ischaemic ypothermia for acute ischaemic strok stroke e Interventional procedures guidance Published: 29 May 2019 www.nice.org.uk/guidance/ipg647 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take this guidance fully (...) . Nothing in this guidance should be interpreted in a way that would be inconsistent with compliance with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. 1 1 Recommendations Recommendations 1.1 Current evidence on the safety of therapeutic hypothermia for acute ischaemic stroke shows that there are serious

2019 National Institute for Health and Clinical Excellence - Interventional Procedures

4. Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis To examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE).MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using 'hypoxic ischaemic encephalopathy', 'newborn' and 'hypothermia', and 'clinical trials' as medical subject headings and terms. Manual search of the reference (...) lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles.Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care.Safety and efficacy data extracted independently by two reviewers and analysed.We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta

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2019 EvidenceUpdates

5. Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction

Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction.Patients (n=40) with cardiogenic shock undergoing primary percutaneous coronary intervention without classic (...) indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control. The primary end point was cardiac power index at 24 hours; secondary end points included other hemodynamic parameters and serial measurements of arterial lactate.No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36

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2019 EvidenceUpdates

6. Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. (PubMed)

Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated

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2019 Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis Controlled trial quality: uncertain

7. Neonatal hypothermia and its associated factors in East Africa: a planned systematic review and meta-analysis

Neonatal hypothermia and its associated factors in East Africa: a planned systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

8. Therapeutic hypothermia in patients with acute myocardial infarction: a systematic review and meta-analysis of randomized trials

Therapeutic hypothermia in patients with acute myocardial infarction: a systematic review and meta-analysis of randomized trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

9. Therapeutic hypothermia and mortality in the intensive care unit: systematic review and meta-analysis

Therapeutic hypothermia and mortality in the intensive care unit: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

10. Thermal Suit or Forced Air Warming in Prevention of Perioperative Hypothermia: A Randomized Controlled Trial. (PubMed)

Thermal Suit or Forced Air Warming in Prevention of Perioperative Hypothermia: A Randomized Controlled Trial. To prevent perioperative hypothermia, forced air warming blanket was compared with a passive insulation suit.Prospective, open, randomized controlled trial.Thirty patients were scheduled for orthopedic spinal surgery. The intervention group (group TS) received the thermal suit T-Balance before premedication and throughout the perioperative period, whereas the control group (group C (...) ) received forced air warming (FAW) during surgery.No statistically significant difference (ns) was found between the groups for core temperature 30 minutes after induction of general anesthesia. Perioperative hypothermia occurred in 10 (66.7%) patients in group TS and 6 (40%) in group C (ns). For hypothermic patients, re-establishment of normothermia took significantly longer in group TS, mean 108 ± 111 minutes, than in group C, 33 ± 59.5 minutes (P = .03).The thermal suit did not prevent hypothermia

2019 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses Controlled trial quality: uncertain

11. Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials

Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials Separate trials to evaluate therapeutic hypothermia after paediatric cardiac arrest for out-of-hospital and in-hospital settings reported no statistically significant differences in survival with favourable neurobehavioral outcome or safety compared to therapeutic normothermia. However, larger sample sizes might detect smaller clinical effects. Our aim was to pool data from identically conducted trials (...) to approximately double the sample size of the individual trials yielding greater statistical power to compare outcomes.Combine individual patient data from two clinical trials set in forty-one paediatric intensive care units in USA, Canada and UK. Children aged at least 48 h up to 18 years old, who remained comatose after resuscitation, were randomized within 6 h of return of circulation to hypothermia or normothermia (target 33.0 °C or 36.8 °C). The primary outcome, survival 12 months post-arrest

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2018 EvidenceUpdates

12. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. (PubMed)

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury.The Prophylactic Hypothermia (...) Trial to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT) was a multicenter randomized trial in 6 countries that recruited 511 patients both out-of-hospital and in emergency departments after severe traumatic brain injury. The first patient was enrolled on December 5, 2010, and the last on November 10, 2017. The final date of follow-up was May 15, 2018.There were 266 patients randomized to the prophylactic hypothermia group and 245 to normothermic management. Prophylactic

2018 JAMA Controlled trial quality: predicted high

13. Unexpected results from a trial of therapeutic hypothermia for severe head injury

Unexpected results from a trial of therapeutic hypothermia for severe head injury Unexpected results from a trial of therapeutic hypothermia for severe head injury Discover Portal Discover Portal Unexpected results from a trial of therapeutic hypothermia for severe head injury Published on 1 December 2015 doi: This NIHR-funded trial of cooling the body temperature (therapeutic hypothermia) to treat traumatic head injury was stopped early by the researchers because it appeared that the treatment (...) might be harmful. People who have severe head injuries from trauma can suffer from injury to the brain, which can be very harmful, even fatal. Survivors of traumatic brain injury can be left with highly variable long-term effects, such as difficulty in communicating, understanding and emotional problems. This trial was testing therapeutic hypothermia compared to standard care alone to see if it produced benefits six months later. The trial was stopped early because of ethical concerns that outcomes

2018 NIHR Dissemination Centre

14. Hypothermia for Neuroprotection in Convulsive Status Epilepticus

Hypothermia for Neuroprotection in Convulsive Status Epilepticus PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

15. Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT

Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need (...) . >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Therapeutic hypothermia after traumatic brain injury resulted in poorer functional recovery and higher mortality than standard care alone. {{author}} {{($index , , , , , & . Peter JD Andrews 1, * , H Louise Sinclair 1 , Aryelly Rodríguez 2 , Bridget Harris 1 , Jonathan Rhodes 3 , Hannah Watson 3 , Gordon Murray 2 1 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK 2 Centre

2018 NIHR HTA programme

16. Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. (PubMed)

Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication affecting term and late preterm newborns. Although therapeutic hypothermia (cooling) has been shown to be an effective therapy for neonatal HIE, many cooled infants have poor long-term neurodevelopmental outcomes. In animal models of neonatal encephalopathy, inhaled xenon combined with cooling has been shown (...) to offer better neuroprotection than cooling alone.To determine the effects of xenon as an adjuvant to therapeutic hypothermia on mortality and neurodevelopmental morbidity, and to ascertain clinically important side effects of xenon plus therapeutic hypothermia in newborn infants with HIE. To assess early predictors of adverse outcomes and potential side effects of xenon.We used the standard strategy of the Cochrane Neonatal Review Group to search the Cochrane Library (2017, Issue 8), MEDLINE (from

2018 Cochrane

17. Hypothermia

Hypothermia Top results for hypothermia - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for hypothermia The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

18. Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial

Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial The purpose of this study was to evaluate the effects of preoperative forced-air warming on intraoperative hypothermia.In this randomized-controlled trial, adult patients scheduled for elective, non-cardiac surgery under general anesthesia were stratified by scheduled surgical duration (< 2.5 hr or ≥ 2.5 hr) and then randomized to a pre-warming group using a BairPaws™ forced-air warming system (...) for at least 30 min preoperatively or to a control group with warmed blankets on request. All patients were warmed intraoperatively via convective forced-air warming blankets. Perioperative temperature was measured using the SpotOn™ temperature system consisting of a single-use disposable sensor applied to the participant's forehead. The primary outcome was the magnitude of intraoperative hypothermia calculated as the area under the time-temperature curve for core temperatures < 36°C between induction

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2018 EvidenceUpdates

19. Hypothermia for newborns with hypoxic-ischemic encephalopathy

Hypothermia for newborns with hypoxic-ischemic encephalopathy Therapeutic hypothermia is a standard of care for infants ≥36 weeks gestational age (GA) with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria. Cooling for infants <35 weeks GA is not recommended. Passive cooling should be started promptly in community centres, in consultation with a tertiary care centre (...) image (MRI) is advised shortly after rewarming and, in cases where earlier findings do not match the clinical picture, a repeat MRI after 10 days of life is suggested. Multidisciplinary neurodevelopmental follow-up is recommended. Keywords: Hypoxic-ischemic encephalopathy; Therapeutic hypothermia

2018 Canadian Paediatric Society

20. Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis

Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis Extra-corporeal life support (ECLS) is a life-saving intervention for patients with hypothermia induced cardiac arrest or severe cardiovascular instability. However, its application is highly variable due to a paucity of data in the literature to guide practice. Current guidelines and recommendations are based on expert opinion, single case (...) reports, and small case series. Combining all of the published data in a patient-level analysis can provide a robust assessment of the influence of patient characteristics on survival with ECLS.To develop a prediction model of survival with good neurologic outcome for accidental hypothermia treated with ECLS.Electronic searches of PubMed, EMBASE, CINAHL were conducted with a hand search of reference lists and major surgical and critical care conference abstracts. Studies had to report the use of ECLS

2018 EvidenceUpdates