Latest & greatest articles for hypothermia

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Top results for hypothermia

1. Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction

Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction.Patients (n=40) with cardiogenic shock undergoing primary percutaneous coronary intervention without classic (...) indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control. The primary end point was cardiac power index at 24 hours; secondary end points included other hemodynamic parameters and serial measurements of arterial lactate.No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36

2019 EvidenceUpdates

2. Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis To examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE).MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using 'hypoxic ischaemic encephalopathy', 'newborn' and 'hypothermia', and 'clinical trials' as medical subject headings and terms. Manual search of the reference (...) lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles.Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care.Safety and efficacy data extracted independently by two reviewers and analysed.We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta

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2019 EvidenceUpdates

3. Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. (PubMed)

Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated

2019 Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis

4. Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials

Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials Separate trials to evaluate therapeutic hypothermia after paediatric cardiac arrest for out-of-hospital and in-hospital settings reported no statistically significant differences in survival with favourable neurobehavioral outcome or safety compared to therapeutic normothermia. However, larger sample sizes might detect smaller clinical effects. Our aim was to pool data from identically conducted trials (...) to approximately double the sample size of the individual trials yielding greater statistical power to compare outcomes.Combine individual patient data from two clinical trials set in forty-one paediatric intensive care units in USA, Canada and UK. Children aged at least 48 h up to 18 years old, who remained comatose after resuscitation, were randomized within 6 h of return of circulation to hypothermia or normothermia (target 33.0 °C or 36.8 °C). The primary outcome, survival 12 months post-arrest

2018 EvidenceUpdates

5. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. (PubMed)

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury.The Prophylactic Hypothermia (...) Trial to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT) was a multicenter randomized trial in 6 countries that recruited 511 patients both out-of-hospital and in emergency departments after severe traumatic brain injury. The first patient was enrolled on December 5, 2010, and the last on November 10, 2017. The final date of follow-up was May 15, 2018.There were 266 patients randomized to the prophylactic hypothermia group and 245 to normothermic management. Prophylactic

2018 JAMA

6. Unexpected results from a trial of therapeutic hypothermia for severe head injury

Unexpected results from a trial of therapeutic hypothermia for severe head injury Unexpected results from a trial of therapeutic hypothermia for severe head injury Discover Portal Discover Portal Unexpected results from a trial of therapeutic hypothermia for severe head injury Published on 1 December 2015 doi: This NIHR-funded trial of cooling the body temperature (therapeutic hypothermia) to treat traumatic head injury was stopped early by the researchers because it appeared that the treatment (...) might be harmful. People who have severe head injuries from trauma can suffer from injury to the brain, which can be very harmful, even fatal. Survivors of traumatic brain injury can be left with highly variable long-term effects, such as difficulty in communicating, understanding and emotional problems. This trial was testing therapeutic hypothermia compared to standard care alone to see if it produced benefits six months later. The trial was stopped early because of ethical concerns that outcomes

2018 NIHR Dissemination Centre

7. Hypothermia for Neuroprotection in Convulsive Status Epilepticus

Hypothermia for Neuroprotection in Convulsive Status Epilepticus PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

8. Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. (PubMed)

Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication affecting term and late preterm newborns. Although therapeutic hypothermia (cooling) has been shown to be an effective therapy for neonatal HIE, many cooled infants have poor long-term neurodevelopmental outcomes. In animal models of neonatal encephalopathy, inhaled xenon combined with cooling has been shown (...) to offer better neuroprotection than cooling alone.To determine the effects of xenon as an adjuvant to therapeutic hypothermia on mortality and neurodevelopmental morbidity, and to ascertain clinically important side effects of xenon plus therapeutic hypothermia in newborn infants with HIE. To assess early predictors of adverse outcomes and potential side effects of xenon.We used the standard strategy of the Cochrane Neonatal Review Group to search the Cochrane Library (2017, Issue 8), MEDLINE (from

2018 Cochrane

9. Hypothermia

Hypothermia Top results for hypothermia - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for hypothermia The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

10. Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial

Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial The purpose of this study was to evaluate the effects of preoperative forced-air warming on intraoperative hypothermia.In this randomized-controlled trial, adult patients scheduled for elective, non-cardiac surgery under general anesthesia were stratified by scheduled surgical duration (< 2.5 hr or ≥ 2.5 hr) and then randomized to a pre-warming group using a BairPaws™ forced-air warming system (...) for at least 30 min preoperatively or to a control group with warmed blankets on request. All patients were warmed intraoperatively via convective forced-air warming blankets. Perioperative temperature was measured using the SpotOn™ temperature system consisting of a single-use disposable sensor applied to the participant's forehead. The primary outcome was the magnitude of intraoperative hypothermia calculated as the area under the time-temperature curve for core temperatures < 36°C between induction

2018 EvidenceUpdates

11. Hypothermia for newborns with hypoxic-ischemic encephalopathy

Hypothermia for newborns with hypoxic-ischemic encephalopathy Therapeutic hypothermia is a standard of care for infants ≥36 weeks gestational age (GA) with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria. Cooling for infants <35 weeks GA is not recommended. Passive cooling should be started promptly in community centres, in consultation with a tertiary care centre (...) image (MRI) is advised shortly after rewarming and, in cases where earlier findings do not match the clinical picture, a repeat MRI after 10 days of life is suggested. Multidisciplinary neurodevelopmental follow-up is recommended. Keywords: Hypoxic-ischemic encephalopathy; Therapeutic hypothermia

2018 Canadian Paediatric Society

12. Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis

Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis Extra-corporeal life support (ECLS) is a life-saving intervention for patients with hypothermia induced cardiac arrest or severe cardiovascular instability. However, its application is highly variable due to a paucity of data in the literature to guide practice. Current guidelines and recommendations are based on expert opinion, single case (...) reports, and small case series. Combining all of the published data in a patient-level analysis can provide a robust assessment of the influence of patient characteristics on survival with ECLS.To develop a prediction model of survival with good neurologic outcome for accidental hypothermia treated with ECLS.Electronic searches of PubMed, EMBASE, CINAHL were conducted with a hand search of reference lists and major surgical and critical care conference abstracts. Studies had to report the use of ECLS

2018 EvidenceUpdates

13. Flowchart: Hypoxic-ischaemic encephalopathy, Criteria for therapeutic hypothermia (cooling)

Flowchart: Hypoxic-ischaemic encephalopathy, Criteria for therapeutic hypothermia (cooling) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Criteria for therapeutic hypothermia (cooling) Queensland Clinical Guideline: Hypoxic-ischaemic encephalopathy (HIE) F16.11-2-V8-R21 Does therapeutic hypothermia need (...) heart rate, periodic/irregular breathing, apnoea Reassess and document hourly for the first 6 hours following birth [refer to Checklist: Criteria for therapeutic hypothermia (cooling)] The baby presents with evidence of acute perinatal/ intrapartum hypoxia-ischaemia as suggested by at least one of the following: ? Apgar score = 5 at 10 minutes ? The blood gas (cord/arterial/venous/capillary) within 60 minutes of birth includes either a: ? pH < 7.00, or ? Base excess equal to or worse than minus 12

2018 Queensland Health

14. Flowchart: Hypoxic-ischaemic encephalopathy, Checklist for therapeutic hypothermia (cooling)

Flowchart: Hypoxic-ischaemic encephalopathy, Checklist for therapeutic hypothermia (cooling) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Checklist for therapeutic hypothermia If baby has a perinatal event and/or acidosis and meets the criteria below, therapeutic hypothermia may be indicated. Call (...) Retrieval Services Queensland immediately on 1300 799 127 to discuss the need for transfer and therapeutic hypothermia with a neonatologist. Therapeutic hypothermia criteria ? Evidence of acidosis or depression at birth, as indicated by at least one of the following: ? Apgar score = 5 at 10 minutes ? pH < 7.00 or a base excess equal to or worse than minus 12 mmol/L on a cord/arterial/venous/capillary blood gas obtained within 60 minutes of birth ? Mechanical ventilation or ongoing resuscitation for = 10

2018 Queensland Health

15. Revisited: A Systematic Review of Therapeutic Hypothermia for Adult Patients Following Traumatic Brain Injury

Revisited: A Systematic Review of Therapeutic Hypothermia for Adult Patients Following Traumatic Brain Injury Therapeutic hypothermia has been of topical interest for many years and with the publication of two international, multicenter randomized controlled trials, the evidence base now needs updating. The aim of this systematic review of randomized controlled trials is to assess the efficacy of therapeutic hypothermia in adult traumatic brain injury focusing on mortality, poor outcomes (...) significantly more mortality in the therapeutic hypothermia group (risk ratio, 1.37; 95% CI, 1.04-1.79; p = 0.02), whereas randomized controlled trials with a high risk of bias show the opposite with a higher mortality in the control group (risk ratio, 0.70; 95% CI, 0.60-0.82; p < 0.00001).Overall, this review is in-keeping with the conclusions published by the most recent randomized controlled trials. High-quality studies show no significant difference in mortality, poor outcomes, or new pneumonia

2018 EvidenceUpdates

16. Unexpected results from a trial of therapeutic hypothermia for severe head injury

Unexpected results from a trial of therapeutic hypothermia for severe head injury Unexpected results from a trial of therapeutic hypothermia for severe head injury Discover Portal Discover Portal Unexpected results from a trial of therapeutic hypothermia for severe head injury Published on 1 December 2015 doi: This NIHR-funded trial of cooling the body temperature (therapeutic hypothermia) to treat traumatic head injury was stopped early by the researchers because it appeared that the treatment (...) might be harmful. People who have severe head injuries from trauma can suffer from injury to the brain, which can be very harmful, even fatal. Survivors of traumatic brain injury can be left with highly variable long-term effects, such as difficulty in communicating, understanding and emotional problems. This trial was testing therapeutic hypothermia compared to standard care alone to see if it produced benefits six months later. The trial was stopped early because of ethical concerns that outcomes

2018 NIHR Dissemination Centre

17. Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants. (PubMed)

Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants. Newborn admission temperature is a strong predictor of outcomes across all gestations. Hypothermia immediately after birth remains a worldwide issue and, if prolonged, is associated with harm. Keeping preterm infants warm is difficult even when recommended routine thermal care guidelines are followed in the delivery room.To assess the efficacy and safety of interventions designed for prevention (...) of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room, compared with routine thermal care or any other single/combination of intervention(s) also designed for prevention of hypothermia in preterm and/or low birth weight infants applied within 10 minutes after birth in the delivery room.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 5), MEDLINE via PubMed

2018 Cochrane

18. Warming of Irrigation Fluids for Prevention of Perioperative Hypothermia During Arthroscopy: A Systematic Review and Meta-analysis

Warming of Irrigation Fluids for Prevention of Perioperative Hypothermia During Arthroscopy: A Systematic Review and Meta-analysis To determine whether warming of irrigation fluids (32°C-40°C) compared with using room-temperature irrigation fluids (20°C-22°C) decreases the risk of perioperative hypothermia (<36°C) for patients undergoing shoulder, hip, or knee arthroscopy.One reviewer, with the assistance of a medical librarian, searched the following databases: PubMed, Embase, Cochrane Central (...) , SPORTDiscus, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature). Level I and II studies involving shoulder, hip, or knee arthroscopy were included. Two reviewers screened the abstracts and titles. Two reviewers assessed the risk of bias of selected studies using The Cochrane Collaboration tool. Meta-analyses were conducted on the following outcomes: hypothermia, lowest temperature, maximum temperature drop, and shivering.Seven studies of patients undergoing arthroscopy

2018 EvidenceUpdates

19. Therapeutic hypothermia for intacranial hypertension following traumatic brain injury

Therapeutic hypothermia for intacranial hypertension following traumatic brain injury Health Policy Advisory Committee on Technology Technology Brief Therapeutic hypothermia for intracranial hypertension following traumatic brain injury December 2016 © State of Queensland (Queensland Department of Health) 2016 This work is licensed under a Creative Commons Attribution Non-Commercial No Derivatives 3.0 Australia licence. In essence, you are free to copy and communicate the work in its current (...) Committee (HPC). AHMAC supports HealthPACT through funding. This Brief was prepared by Benjamin Ellery and Jacqueline Parsons from Adelaide Health Technology Assessment, University of Adelaide.Hypothermia for intracranial hypertension: December 2016 i Summary of findings A body of high-level but inconsistent evidence was identified on the topic of therapeutic hypothermia for patients with traumatic brain injury (TBI) compared to standard normothermic care. Older evidence (pre-2009) in a relatively

2018 COAG Health Council - Horizon Scanning Technology Briefs

20. CRACKCast E140 – Accidental Hypothermia

CRACKCast E140 – Accidental Hypothermia CRACKCast E140 – Accidental Hypothermia - CanadiEM CRACKCast E140 – Accidental Hypothermia In , , by Dillan Radomske January 2, 2018 This episode of CRACKCast covers Rosen’s Chapter 132, Accidental Hypothermia. Hypothermic patients will appear in the ED at any time and in any season. After listening to this podcast, you will be able to systematically approach these patients with ease. Shownotes: Rosen’s in Perspective Accidental hypothermia has been (...) something that has plagued the human race for time immemorial. It is something that will bring patients to your ED in any season. Don’t forget that today we are talking about accidental hypothermia (or primary hypothermia) – there are a myriad of other conditions causing secondary hypothermia (impaired heat production, impaired heat regulation) Infections – sepsis, meningitis, encephalitis Neurological – strokes, spinal cord injuries Toxic – EtOH intoxication, hypoglycemia Metabolic / endocrine

2018 CandiEM