Latest & greatest articles for hypertension

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Top results for hypertension

1221. Relaxation therapy and continuous ambulatory blood pressure in mild hypertension: a controlled study.

Relaxation therapy and continuous ambulatory blood pressure in mild hypertension: a controlled study. 2196946 1990 08 24 1990 08 24 2013 10 02 0959-8138 300 6736 1990 May 26 BMJ (Clinical research ed.) BMJ Relaxation therapy and continuous ambulatory blood pressure in mild hypertension: a controlled study. 1368-72 To determine the long term effects of relaxation therapy on 24 hour ambulatory intra-arterial blood pressure in patients with mild untreated and uncomplicated hypertension. Four week (...) screening period followed by randomisation to receive either relaxation therapy or non-specific counselling for one year. Ambulatory intra-arterial blood pressure was measured before and after treatment. Outpatient clinic in Amsterdam's university hospital. 35 Subjects aged 20-60 who were being treated by general practitioners for hypertension but were referred to take part in the study. At three consecutive screening visits all subjects had a diastolic blood pressure without treatment of 95-110 mm Hg

BMJ1990 Full Text: Link to full Text with Trip Pro

1222. The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet.

The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet. 2406601 1990 03 20 1990 03 20 2013 11 21 0028-4793 322 9 1990 Mar 01 The New England journal of medicine N. Engl. J. Med. The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet. 569-74 Clinical and epidemiologic studies suggest that the intake of potassium chloride lowers blood pressure. To investigate whether supplemental potassium chloride (96 mmol (...) of microcrystalline potassium chloride a day) reduced the need for antihypertensive medication in hypertensive men on a restricted-sodium diet, we conducted a randomized, placebo-controlled, double-blind clinical trial. A total of 287 men 45 to 68 years of age, 142 given potassium chloride and 145 given placebo, were followed for an average of 2.2 years after the withdrawal of their antihypertensive medication. Men in both groups received instructions on following a low-sodium diet. Overnight urinary sodium

NEJM1990

1223. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study.

Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study. 2137901 1990 04 12 1990 04 12 2015 11 19 0028-4793 322 12 1990 Mar 22 The New England journal of medicine N. Engl. J. Med. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromsø study. 795-801 Studies of whether polyunsaturated fatty acids in fish oil--in (...) particular, eicosapentaenoic and docosahexaenoic acids--lower blood pressure have varied in design and results. We conducted a population-based, randomized, 10-week dietary-supplementation trial in which the effects of 6 g per day of 85 percent eicosapentaenoic and docosahexaenoic acids were compared with those of 6 g per day of corn oil in 156 men and women with previously untreated stable, mild essential hypertension. The mean systolic blood pressure fell by 4.6 mm Hg (P = 0.002), and diastolic

NEJM1990

1224. An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy.

An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy. 2407872 1990 04 03 1990 04 03 2016 10 17 0098-7484 263 11 1990 Mar 16 JAMA JAMA An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy. 1507-12 This multicenter, factorial-design trial assessed the safety and additive (...) antihypertensive efficacy of a slow-release (SR) formulation of diltiazem hydrochloride given alone or in combination with hydrochlorothiazide for treatment of mild to moderate hypertension. After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 possible combinations of diltiazem SR and hydrochlorothiazide for 6 weeks. A dose-related reduction in blood

JAMA1990

1225. Prolonged blood pressure reduction by orally active renin inhibitor RO 42-5892 in essential hypertension.

Prolonged blood pressure reduction by orally active renin inhibitor RO 42-5892 in essential hypertension. 2203486 1990 10 05 1990 10 05 2013 10 02 0959-8138 301 6745 1990 Jul 28 BMJ (Clinical research ed.) BMJ Prolonged blood pressure reduction by orally active renin inhibitor RO 42-5892 in essential hypertension. 205-10 To investigate the effects of a novel specific renin inhibitor, RO 42-5892, with high affinity for human renin (Ki = 0.5 x 10(-9) mol/l), on plasma renin activity (...) and angiotensin II concentration and on 24 hour ambulatory blood pressure in essential hypertension. Exploratory study in which active treatment was preceded by placebo. Inpatient unit of teaching hospital. Nine men with uncomplicated essential hypertension who had a normal sodium intake. Two single intravenous doses of RO 42-5892 (100 and 1,000 micrograms/kg in 10 minutes) given to six patients and one single oral dose (600 mg) given to the three others as well as to three of the patients who also received

BMJ1990 Full Text: Link to full Text with Trip Pro

1226. Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity.

Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. 2724504 1989 07 10 1989 07 10 2016 10 17 0098-7484 261 24 1989 Jun 23-30 JAMA JAMA Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. 3577-81 Twenty-four adults who were undergoing operations on the abdominal aorta were enrolled in a randomized, double-blind, placebo-controlled study in which epidural morphine sulfate (6 mg (...) ) was employed to attenuate the sympathoadrenal response to surgery to evaluate the possible contribution of sympathetic nervous system hyperactivity to postoperative hypertension. Patients who received epidural morphine required less parenteral morphine in the 24 hours following surgery, had lower analogue pain scores, and had markedly lower plasma norepinephrine levels when compared with patients in the control group who received an identical volume of saline in the epidural space. Epidural morphine had

JAMA1989

1227. Fall in blood pressure with modest reduction in dietary salt intake in mild hypertension. Australian National Health and Medical Research Council Dietary Salt Study Management Committee.

Fall in blood pressure with modest reduction in dietary salt intake in mild hypertension. Australian National Health and Medical Research Council Dietary Salt Study Management Committee. 2563786 1989 03 30 1989 03 30 2015 06 16 0140-6736 1 8635 1989 Feb 25 Lancet (London, England) Lancet Fall in blood pressure with modest reduction in dietary salt intake in mild hypertension. Australian National Health and Medical Research Council Dietary Salt Study Management Committee. 399-402 111 untreated (...) as Topic Delayed-Action Preparations Diet, Sodium-Restricted Female Humans Hypertension diet therapy epidemiology urine Male Middle Aged Multicenter Studies as Topic Potassium urine Random Allocation Sodium urine Sodium, Dietary administration & dosage pharmacology Tablets 1989 2 25 1989 2 25 0 1 1989 2 25 0 0 ppublish 2563786 S0140-6736(89)90001-9

Lancet1989

1228. Noradrenergic activity and silent ischaemia in hypertensive patients with stable angina: effect of metoprolol.

Noradrenergic activity and silent ischaemia in hypertensive patients with stable angina: effect of metoprolol. 2563787 1989 03 30 1989 03 30 2015 06 16 0140-6736 1 8635 1989 Feb 25 Lancet (London, England) Lancet Noradrenergic activity and silent ischaemia in hypertensive patients with stable angina: effect of metoprolol. 403-6 30 patients (10 normotensive, 20 hypertensive) with stable angina and positive treadmill exercise tests entered a double-blind, placebo-controlled crossover trial (...) normotensive and hypertensive subjects, and reduced the frequency and duration of silent ischaemic episodes in hypertensive subjects. Plasma noradrenaline measured during silent ischaemia while the patients were resting was significantly higher than the control supine level without ischaemia. These findings suggest that noradrenergic hyperactivity may have a role in coronary vasoconstriction and that treatment which neutralizes sympathetic tone may be especially beneficial in treatment of silent ischaemia

Lancet1989

1229. Sodium restriction and blood pressure in hypertensive type II diabetics: randomised blind controlled and crossover studies of moderate sodium restriction and sodium supplementation.

Sodium restriction and blood pressure in hypertensive type II diabetics: randomised blind controlled and crossover studies of moderate sodium restriction and sodium supplementation. 2493869 1989 05 03 1989 05 03 2013 10 02 0959-8138 298 6668 1989 Jan 28 BMJ (Clinical research ed.) BMJ Sodium restriction and blood pressure in hypertensive type II diabetics: randomised blind controlled and crossover studies of moderate sodium restriction and sodium supplementation. 227-30 To determine the effect (...) of moderate dietary sodium restriction on the hypertension of non-insulin-dependent (type II) diabetes. Randomised parallel controlled study of moderate sodium restriction for three months compared with usual diabetic diet, followed by randomised double blind crossover trial of sustained release preparation of sodium for one month versus placebo for one month in patients continuing with sodium restriction. Patients attending diabetic outpatient clinic of city hospital. Thirty four patients

BMJ1989 Full Text: Link to full Text with Trip Pro

1230. Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients.

Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. 2500169 1989 08 09 1989 08 09 2013 11 21 0959-8138 298 6681 1989 Apr 29 BMJ (Clinical research ed.) BMJ Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. 1152-7 To compare the effects (...) of metoprolol and atenolol on carbohydrate and lipid metabolism and on insulin response to an intravenous glucose load. Randomised, double blind, double dummy, controlled crossover trial. University Hospital, Uppsala, Sweden. 60 Patients with primary hypertension (diastolic blood pressure when resting supine 95-119 mm Hg on at least two occasions during four to six weeks of treatment with placebo) randomised to receive either metoprolol (n = 30) or atenolol (n = 30) during the first treatment period

BMJ1989 Full Text: Link to full Text with Trip Pro

1231. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.

The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. 2648152 1989 05 10 1989 05 10 2013 11 21 0028-4793 320 16 1989 Apr 20 The New England journal of medicine N. Engl. J. Med. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. 1037-43 Both n-3 and n-6 polyunsaturated fats have been suggested to lower blood pressure, an effect ascribed (...) to altered biosynthesis of eicosanoids. To test these hypotheses, we studied blood pressure and eicosanoid production during supplementation of dietary fat for four weeks in 32 men with mild essential hypertension. Supplementation was preceded and followed by four-week run-in and recovery periods. Groups of eight subjects received either 10 ml or 50 ml of fish oil (3 or 15 g of n-3 fatty acids) daily, 50 ml of safflower oil (39 g of n-6 fatty acids), or 50 ml of a mixture of oils that approximated

NEJM1989

1232. Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly.

Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly. 2503114 1989 09 12 1989 09 12 2013 10 02 0959-8138 298 6687 1989 Jun 10 BMJ (Clinical research ed.) BMJ Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly. 1552-6 To investigate the relation between mortality (...) 3236313 J Hum Hypertens. 1988 Jun;2(1):7-10 3236316 J Hum Hypertens. 1988 Aug;2(2):79-88 3244149 Angiology. 1975 Jan;26(1 Pt. 1):1-14 1122043 Lancet. 1978 Nov 25;2(8100):1139-41 82694 Lancet. 1979 Apr 21;1(8121):861-5 86103 Am Heart J. 1982 Apr;103(4 Pt 1):579-82 7064799 Fam Pract. 1986 Mar;3(1):3-8 3956900 Aged Aged, 80 and over Blood Pressure Body Weight Cardiovascular Diseases complications mortality Clinical Trials as Topic Double-Blind Method Europe Female Hemoglobins analysis Humans Hypertension

BMJ1989 Full Text: Link to full Text with Trip Pro

1233. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies.

The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. 2664522 1989 08 22 1989 08 22 2013 11 21 0028-4793 321 6 1989 Aug 10 The New England journal of medicine N. Engl. J. Med. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. 351-6 We carried out a prospective, randomized, double-blind, placebo (...) -controlled study to investigate the capacity of aspirin to prevent pregnancy-induced hypertension and to alter prostaglandin metabolism. A total of 791 pregnant women with various risk factors for pre-eclamptic toxemia were screened with use of the rollover test (a comparison of blood pressure before and after the woman rolls from her left side to her back) during week 28 or 29 of gestation. Of 69 women with abnormal results (an increase in blood pressure during the rollover test), 65 entered the study

NEJM1989

1234. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension.

Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. 2664523 1989 08 22 1989 08 22 2013 11 21 0028-4793 321 6 1989 Aug 10 The New England journal of medicine N. Engl. J. Med. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. 357-62 There is evidence that aspirin in low doses favorably influences the course of pregnancy (...) -induced hypertension, but the mechanism, although assumed to involve suppression of the production of thromboxane by platelets, has not been established. We performed a randomized study of the effect of the long-term daily administration of 60 mg of aspirin (n = 17) or placebo (n = 16) on platelet thromboxane A2 and vascular prostacyclin in women at risk for pregnancy-induced hypertension. Low doses of aspirin were associated with a longer pregnancy and increased weight of newborns. Serum levels

NEJM1989

1235. Antihypertensive effect of diet compared with drug treatment in obese men with mild hypertension.

Antihypertensive effect of diet compared with drug treatment in obese men with mild hypertension. 2507028 1989 11 22 1989 11 22 2013 10 02 0959-8138 299 6697 1989 Aug 19 BMJ (Clinical research ed.) BMJ Antihypertensive effect of diet compared with drug treatment in obese men with mild hypertension. 480-5 To determine whether dietary treatment has a similar antihypertensive effect to conventional drug treatment while being superior to drugs in improving serum lipid concentrations in obese men (...) with mild hypertension. Six week run in period followed by randomisation to either diet or drug treatment groups for one year. Outpatient clinic in city hospital. 61 Men aged 40-69 years, body mass index greater than or equal to 26, diastolic blood pressure 90-104 mm Hg when untreated. Exclusion criteria were signs of organ damage secondary to hypertension and diseases that might have interfered with compliance or with interpretation of results. Dietary treatment was based on weight reduction

BMJ1989 Full Text: Link to full Text with Trip Pro

1236. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension.

A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. 2671740 1989 10 12 1989 10 12 2013 11 21 0028-4793 321 13 1989 Sep 28 The New England journal of medicine N. Engl. J. Med. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. 868-73 It has been suggested that the metabolic side effects of antihypertensive drugs are responsible for their failure (...) to reduce cardiovascular morbidity in patients with hypertension. Therefore, in 50 patients with essential hypertension, we performed a randomized, double-blind, crossover study comparing the effects of carbohydrate and lipid metabolism of captopril (mean [+/- SD] dose, 81 +/- 24 mg per day) and hydrochlorothiazide (40 +/- 12 mg per day) over two four-month treatment periods. Captopril increased the insulin-mediated disposal of glucose, as compared with placebo, from 5.7 +/- 2.4 to 6.3 +/- 2.5 mg per

NEJM1989

1237. Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial.

Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial. 2778913 1989 10 26 1989 10 26 2016 10 17 0098-7484 262 13 1989 Oct 06 JAMA JAMA Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial. 1801-7 A 5-year trial involving 201 men and women with high-normal blood pressure at baseline demonstrated the ability to reduce the incidence of hypertension in participants randomized (...) to nutritional-hygienic intervention compared with a control group. The incidence of hypertension was 8.8% among 102 intervention group participants vs 19.2% among 99 control group members. The odds ratio for the incidence of hypertension in the control group was 2.4. Mean trial blood pressure also was lower in the intervention compared with the control group (-1.2 and -1.9 mm Hg, respectively, for diastolic blood pressure at work-site and office visits and -1.3 and -2.0 mm Hg, respectively, for systolic

JAMA1989

1238. Verapamil versus hydrochlorothiazide in the treatment of hypertension: results of long term double blind comparative trial. Verapamil versus Diuretic (VERDI) Trial Research Group.

Verapamil versus hydrochlorothiazide in the treatment of hypertension: results of long term double blind comparative trial. Verapamil versus Diuretic (VERDI) Trial Research Group. 2510877 1990 01 02 1990 01 02 2013 11 21 0959-8138 299 6704 1989 Oct 07 BMJ (Clinical research ed.) BMJ Verapamil versus hydrochlorothiazide in the treatment of hypertension: results of long term double blind comparative trial. Verapamil versus Diuretic (VERDI) Trial Research Group. 881-6 To compare the efficacy (...) and tolerability of hydrochlorothiazide, sustained release verapamil, and their combination in patients with mild to moderate hypertension. Randomised multicentre trial of 48 weeks' duration with a double blind comparison of hydrochlorothiazide and verapamil followed by an open trial of combined treatment for patients not achieving the target diastolic blood pressure (less than 90 mm Hg) during treatment with a single drug. Outpatient departments in 10 clinics and 10 private practices of general practitioners

BMJ1989 Full Text: Link to full Text with Trip Pro

1239. Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension.

Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. 2573761 1989 12 27 1989 12 27 2015 06 16 0140-6736 2 8674 1989 Nov 25 Lancet (London, England) Lancet Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. 1244-7 20 patients with mild hypertension (average supine blood pressure without treatment, 164/101 mm Hg) reduced their salt intake to 50 mmol (3 g) per day for a month (...) /87 (SE 3/2) mm Hg with a 24 h urinary sodium excretion of 54 (7) mmol. These results show a progressive blood pressure fall as salt intake is reduced and that, in many patients with mild essential hypertension, blood pressure can be controlled without the need for drug therapy. MacGregor G A GA Department of Medicine, St George's Hospital Medical School, London. Markandu N D ND Sagnella G A GA Singer D R DR Cappuccio F P FP eng Clinical Trial Journal Article Randomized Controlled Trial England

Lancet1989

1240. Is the pharmacological treatment of mild to moderate hypertension cost effective in stroke prevention?

Is the pharmacological treatment of mild to moderate hypertension cost effective in stroke prevention? Is the pharmacological treatment of mild to moderate hypertension cost effective in stroke prevention? Is the pharmacological treatment of mild to moderate hypertension cost effective in stroke prevention? Malcolm L A, Kawachi I, Jackson R, Bonita R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment of hypertension. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population Mild to moderate hypertension patients. Setting The study was carried out in New Zealand. Dates to which data relate Price related to 1982. Source of effectiveness data Review of studies

NHS Economic Evaluation Database.1988