Latest & greatest articles for hypertension

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Top results for hypertension

1201. Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics.

Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. 2871333 1986 06 06 1986 06 06 2015 06 16 0140-6736 1 8488 1986 May 03 Lancet (London, England) Lancet Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. 997-1001 The effect of sulindac on renal function and blood pressure was compared with those of placebo, piroxicam, and naproxen in 20 patients with primary hypertension being treated (...) effects Clinical Trials as Topic Diuretics therapeutic use Double-Blind Method Drug Synergism Drug Therapy, Combination Female Humans Hydrochlorothiazide administration & dosage Hypertension drug therapy Indenes pharmacology Male Middle Aged Naproxen pharmacology Piroxicam Random Allocation Sulindac metabolism pharmacology Thiazines pharmacology Thromboxane A2 urine Timolol therapeutic use 1986 5 3 1986 5 3 0 1 1986 5 3 0 0 ppublish 2871333 S0140-6736(86)91271-7

Lancet1986

1202. The effects of aerobic exercise on plasma catecholamines and blood pressure in patients with mild essential hypertension.

The effects of aerobic exercise on plasma catecholamines and blood pressure in patients with mild essential hypertension. 4057469 1985 11 27 1985 11 27 2016 10 17 0098-7484 254 18 1985 Nov 08 JAMA JAMA The effects of aerobic exercise on plasma catecholamines and blood pressure in patients with mild essential hypertension. 2609-13 The effects of a 16-week aerobic exercise program on blood pressure and plasma catecholamine levels were evaluated in 56 patients with baseline diastolic blood (...) 0098-7484 L628TT009W Isoproterenol X4W3ENH1CV Norepinephrine YKH834O4BH Epinephrine AIM IM Adult Blood Pressure Epinephrine blood Exercise Therapy Heart Rate Humans Hypertension blood physiopathology therapy Isoproterenol Male Norepinephrine blood Sympathetic Nervous System physiopathology 1985 11 8 1985 11 8 0 1 1985 11 8 0 0 ppublish 4057469

JAMA1985

1203. Dietary therapy slows the return of hypertension after stopping prolonged medication.

Dietary therapy slows the return of hypertension after stopping prolonged medication. 3881608 1985 03 18 1985 03 18 2016 10 17 0098-7484 253 5 1985 Feb 01 JAMA JAMA Dietary therapy slows the return of hypertension after stopping prolonged medication. 657-64 This study asks whether prolonged antihypertensive therapy will "cure" a substantial percent of rigorously treated hypertensive patients and whether nutritional change will add an antihypertensive effect and reduce the relapse rate. Of 584 (...) for the sodium group and 3.43 for the weight group. Highest success rates were in the nonoverweight mild hypertensives with sodium restriction (78%) and the overweight mild hypertensives who were reducing their weight (72%). These data demonstrate that weight loss or sodium restriction, in hypertensives controlled for five years, more than doubles success in withdrawal of drug therapy. Langford H G HG Blaufox M D MD Oberman A A Hawkins C M CM Curb J D JD Cutter G R GR Wassertheil-Smoller S S Pressel S S

JAMA1985

1204. Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia.

Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia. 3883170 1985 04 02 1985 04 02 2013 11 21 0028-4793 312 12 1985 Mar 21 The New England journal of medicine N. Engl. J. Med. Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia. 746-9 Changes in potassium balance have been found to have variable effects on the blood pressure of animals, and the administration of potassium supplements has been reported to lower the blood (...) pressure of normokalemic hypertensive patients. To assess the effect of potassium repletion in hypokalemic hypertension, we administered either potassium chloride, 60 mmol per day, or placebo tablets, each for six weeks, in a randomized, double-blind, crossover trial to 16 hypertensive patients who had diuretic-induced hypokalemia and who continued to take a constant amount of diuretic. We selected patients whose control serum potassium levels were below 3.5 mmol per liter. In association with an average rise

NEJM1985

1205. Therapeutic effect of propranolol on paradoxical hypertension after repair of coarctation of the aorta.

Therapeutic effect of propranolol on paradoxical hypertension after repair of coarctation of the aorta. 3887159 1985 05 30 1985 05 30 2013 11 21 0028-4793 312 19 1985 May 09 The New England journal of medicine N. Engl. J. Med. Therapeutic effect of propranolol on paradoxical hypertension after repair of coarctation of the aorta. 1224-8 Patients undergoing repair of coarctation of the aorta often have self-limited but severe hypertension in the first week after surgery (paradoxical hypertension (...) ). We conducted a controlled trial of treatment with propranolol before repair of coarctation of the aorta in 14 children to determine whether the drug would prevent paradoxical hypertension. Seven patients were randomly assigned to receive propranolol for two weeks before surgery and throughout the first postoperative week, and seven patients were assigned to receive standard postoperative care. Both groups had a similar significant (P less than 0.05) increase in the plasma norepinephrine level

NEJM1985

1206. Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients.

Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients. 2860441 1985 07 22 1985 07 22 2015 06 16 0140-6736 1 8440 1985 Jun 01 Lancet (London, England) Lancet Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients. 1233-6 Weight reduction was compared with metoprolol (200 mg daily) in a randomised placebo-controlled trial of first-line treatment of mild hypertension (diastolic blood pressure 90 (...) lipids commonly associated with antihypertensive drug therapy. MacMahon S W SW Macdonald G J GJ Bernstein L L Andrews G G Blacket R B RB eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Lancet 2985213R 0140-6736 0 Lipids GEB06NHM23 Metoprolol AIM IM Adult Blood Pressure drug effects Body Weight Clinical Trials as Topic Diet, Reducing Double-Blind Method Female Humans Hypertension complications diet therapy drug therapy therapy

Lancet1985

1207. Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.

Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide. 2861527 1985 08 19 1985 08 19 2015 06 16 0140-6736 2 8446 1985 Jul 13 Lancet (London, England) Lancet Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide. 73-5 In a crossover study of 26 hypertensive patients, the effects of triamterene (50 mg/day) and amiloride (5 mg/day) on urinary sediment were compared. Each drug was given (...) for one month and all patients also received hydrochlorothiazide (50 mg/day). An abnormal urinary sediment--evident grossly as a reddish-brown precipitate after routine staining procedures and microscopically as characteristic reddish-brown crystals and casts, as previously described--was identified in 14 of 26 (54%) triamterene urine samples but in none of the amiloride samples. Results of renal function tests were similar for both drugs. In a clinic population of more than 1000 hypertensive patients

Lancet1985

1208. Treatment of mild hypertension with diuretics. The importance of ECG abnormalities in the Oslo Study and in MRFIT.

Treatment of mild hypertension with diuretics. The importance of ECG abnormalities in the Oslo Study and in MRFIT. 6366258 1984 03 30 1984 03 30 2016 10 17 0098-7484 251 10 1984 Mar 09 JAMA JAMA Treatment of mild hypertension with diuretics. The importance of ECG abnormalities in the Oslo Study and in MRFIT. 1298-9 The Multiple Risk Factor Intervention Trial (MRFIT) showed that diuretic treatment of hypertensive men with certain ECG abnormalities at entry was associated with an increased (...) coronary heart disease mortality in the special-intervention group as compared with the usual-care group. Following the same criteria for resting ECG abnormalities as in MRFIT, The Oslo Study trial of mild hypertension has been reanalyzed for similar effects. Although numbers of first coronary events are low in this study (20 cases in the treated group and 13 in the control group), similar trends are present in The Oslo Study. The excess of seven cases of coronary events in the Oslo treatment group can

JAMA1984

1209. Blood-pressure response to moderate sodium restriction and to potassium supplementation in mild essential hypertension.

Blood-pressure response to moderate sodium restriction and to potassium supplementation in mild essential hypertension. 6143083 1984 05 14 1984 05 14 2015 06 16 0140-6736 1 8380 1984 Apr 07 Lancet (London, England) Lancet Blood-pressure response to moderate sodium restriction and to potassium supplementation in mild essential hypertension. 757-61 To determine whether moderate restriction of dietary sodium content or supplementation of potassium intake reduces blood-pressure in patients (...) with mild essential hypertension, twelve patients were put on three different diets--a control diet (180 mmol sodium/day), a sodium restricted diet (80 mmol/day). Each diet was taken for at least 4 weeks and the sequence of the regimens was randomised. At the completion of each regimen intra-arterial pressure was recorded continuously, and vasoactive hormones were measured hourly, for 24 h, under standardised conditions, in hospital. Compared with the control diet, sodium restriction was associated

Lancet1984

1210. Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension.

Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. 6131164 1983 04 21 1983 04 21 2015 06 16 0140-6736 1 8322 1983 Feb 26 Lancet (London, England) Lancet Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. 431-4 Atenolol was compared with placebo in a randomised and double-blind prospective study of 120 women with mild to moderate pregnancy-associated hypertension who were also initially managed conventionally by bed rest (...) common after atenolol but the systolic blood-pressure of the babies was the same in both groups. There was no difference between the groups in maternal symptoms which could have been attributed to beta-blocker therapy. Thus atenolol is more effective than conventional obstetric management in this form of hypertension and does not adversely affect mother or baby. Rubin P C PC Butters L L Clark D M DM Reynolds B B Sumner D J DJ Steedman D D Low R A RA Reid J L JL eng Clinical Trial Comparative Study

Lancet1983

1211. Evaluation of the effectiveness of a low sodium diet in the treatment of mild to moderate hypertension.

Evaluation of the effectiveness of a low sodium diet in the treatment of mild to moderate hypertension. 6133987 1983 07 08 1983 07 08 2015 06 16 0140-6736 1 8335 1983 May 28 Lancet (London, England) Lancet Evaluation of the effectiveness of a low sodium diet in the treatment of mild to moderate hypertension. 1179-82 28 patients who had a sustained diastolic blood pressure of 95 to 104 mm Hg and who had no treatment for it for at least 13 months before the trial, but who were otherwise (...) thus seem that the antihypertensive effect of a restricted sodium diet may be related to the increased consultation and monitoring activity of such intervention rather than to the dietary manipulation itself. Silman A J AJ Locke C C Mitchell P P Humpherson P P eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Lancet 2985213R 0140-6736 AIM IM Clinical Trials as Topic Diastole Diet, Sodium-Restricted Follow-Up Studies Humans Hypertension diet therapy Middle Aged

Lancet1983

1212. Final report of study on hypertension during pregnancy: the effects of specific treatment on the growth and development of the children.

Final report of study on hypertension during pregnancy: the effects of specific treatment on the growth and development of the children. 6121965 1982 06 21 1982 06 21 2015 06 16 0140-6736 1 8273 1982 Mar 20 Lancet (London, England) Lancet Final report of study on hypertension during pregnancy: the effects of specific treatment on the growth and development of the children. 647-9 195 (97.5%) children born to hypertensive women participating in a trial of methyldopa treatment during pregnancy (...) Lancet 2985213R 0140-6736 0 Antihypertensive Agents 56LH93261Y Methyldopa AIM IM Antihypertensive Agents adverse effects Blood Pressure drug effects Child Child, Preschool Clinical Trials as Topic Female Follow-Up Studies Gestational Age Humans Hypertension drug therapy Infant Infant, Newborn Intelligence drug effects Male Maternal-Fetal Exchange Methyldopa adverse effects therapeutic use Pregnancy Pregnancy Complications, Cardiovascular drug therapy Prenatal Exposure Delayed Effects Random

Lancet1982

1213. Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension.

Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension. 6120346 1982 04 20 1982 04 20 2015 06 16 0140-6736 1 8268 1982 Feb 13 Lancet (London, England) Lancet Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension. 351-5 Nineteen unselected patients with mild to moderate essential hypertension, whose average supine blood pressure after two months' observation on no treatment was 156/98 mm Hg, were advised (...) +/- 9 mmol/24 h (p less than 0.001). There was no difference in potassium excretion. These results suggest that moderate sodium restriction achieved by not adding salt and avoiding sodium-laden foods should, if not already, become part of the management of essential hypertension. MacGregor G A GA Markandu N D ND Best F E FE Elder D M DM Cam J M JM Sagnella G A GA Squires M M eng Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Lancet 2985213R 0140

Lancet1982

1214. Moderate potassium supplementation in essential hypertension.

Moderate potassium supplementation in essential hypertension. 6125727 1982 10 21 1982 10 21 2015 06 16 0140-6736 2 8298 1982 Sep 11 Lancet (London, England) Lancet Moderate potassium supplementation in essential hypertension. 567-70 23 unselected patients with mild to moderate essential hypertension, whose average supine blood pressure after two months' observation on no treatment was 154/99 mm Hg, were entered into an eight week double blind randomised crossover study of one month's treatment (...) caused a small but significant fall in blood pressure in patients with mild to moderate essential hypertension and could be additive to the effects of moderate sodium restriction. This increase in potassium intake could be achieved with a potassium-based salt substitute and a moderate increase in vegetable and fruit consumption. Moderate dietary sodium restriction with dietary potassium supplementation may obviate or reduce the need for drug treatment in some patients with mild to moderate

Lancet1982

1215. Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. Veterans Administration Cooperative Study Group on Antihypertensive agents.

Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. Veterans Administration Cooperative Study Group on Antihypertensive agents. 6750166 1982 12 03 1982 12 03 2016 10 17 0098-7484 248 16 1982 Oct 22 JAMA JAMA Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences (...) in response. Veterans Administration Cooperative Study Group on Antihypertensive agents. 1996-2003 We compared hydrochlorothiazide and propranolol hydrochloride for monotherapy of hypertension by a double-blind study of 683 men who were titrated to less than 90 mm Hg diastolic BP or to 640 mg of propranolol or 200 mg of hydrochlorothiazide. Propranolol reduced systolic BP from 146.0 +/- 14.4 (SD) to 134.8 +/- 16.3 mm Hg and diastolic BP from 101.6 +/- 4.6 to 90.5 +/- 7.5 mm Hg. Hydrochlorothiazide lowered

JAMA1982

1216. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents.

Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. 6750167 1982 12 03 1982 12 03 2016 10 17 0098-7484 248 16 1982 Oct 22 JAMA JAMA Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. 2004-11 (...) 0J48LPH2TH Hydrochlorothiazide 9Y8NXQ24VQ Propranolol AIM IM Adult Aged Blood Pressure drug effects Body Weight drug effects Clinical Trials as Topic Double-Blind Method Heart Rate drug effects Humans Hydrochlorothiazide therapeutic use Hypertension drug therapy Male Middle Aged Propranolol administration & dosage therapeutic use Random Allocation Time Factors 1982 10 22 1982 10 22 0 1 1982 10 22 0 0 ppublish 6750167

JAMA1982

1217. The effect of treatment on mortality in "mild" hypertension: results of the hypertension detection and follow-up program.

The effect of treatment on mortality in "mild" hypertension: results of the hypertension detection and follow-up program. 7110301 1982 10 29 1982 10 29 2017 04 03 0028-4793 307 16 1982 10 14 The New England journal of medicine N. Engl. J. Med. The effect of treatment on mortality in "mild" hypertension: results of the hypertension detection and follow-up program. 976-80 In the Hypertension Detection and Follow-up Program, 7825 (71.5 per cent) of the 10,940 participants had diastolic blood (...) with diastolic pressures of 90 to 104 mm Hg who had no evidence of end-organ damage and were not receiving antihypertensive medication when they entered the study. This subgroup had 28.6 per cent fewer deaths at five years among those treated with stepped care than among those treated with referred care (P less than 0.01). These findings support a recommendation that in patients with mild hypertension, treatment should be considered early, before damage to end organs occurs. Hypertension Detection and Follow

NEJM1982

1218. Untreated mild hypertension. A report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension.

Untreated mild hypertension. A report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension. 6119558 1982 03 22 1982 03 22 2015 06 16 0140-6736 1 8265 1982 Jan 23 Lancet (London, England) Lancet Untreated mild hypertension. A report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension. 185-91 In all subjects of the Australian therapeutic trial in mild hypertension, mean pressures for the two screening visits were within the range 95 (...) -109 mm Hg for diastolic blood-pressure phase V(DBP) and less than 200 mm Hg for systolic blood-pressure (SBP). In the 1943 control (placebo) subjects mean blood-pressures fell from 158/102 mm Hg at the first screening visit to 144/91 mm Hg 3 years later. At that time pressures remained within the mild hypertension range in 32%, ahd risen above it in 12%, and had fallen below in 48%. Trial end-points (ischaemic heart disease or cerebrovascular accident) occurred in 8%. The outcome was related

Lancet1982

1219. Usefulness of home BP determination in treating borderline hypertension.

Usefulness of home BP determination in treating borderline hypertension. 7047770 1982 09 10 1982 09 10 2016 10 17 0098-7484 248 5 1982 Aug 06 JAMA JAMA Usefulness of home BP determination in treating borderline hypertension. 555-8 This study explores whether home BP self-determination can be used to assess the effect of treatment in patients with borderline hypertension. Sixteen untreated patients underwent a double-blind trial of propranolol hydrochloride (average dose, 105 mg), clonidine (...) hydrochloride (0.24 mg), and placebo. Home BP readings decreased with both active compounds (-8/-5 with propranolol and -11/-7 with clonidine). During placebo, the readings increased to levels identical to untreated values. This study demonstrates that patients with borderline hypertension are consistently capable of detecting small average changes in home BP. It is also shown that sympatholytic monotherapy can be effectively used to lower the BP in such patients. Cottier C C Julius S S Gajendragadkar S V

JAMA1982

1220. Randomised controlled trial of a no-added-sodium diet for mild hypertension.

Randomised controlled trial of a no-added-sodium diet for mild hypertension. 6125636 1982 10 12 1982 10 12 2015 06 16 0140-6736 2 8296 1982 Aug 28 Lancet (London, England) Lancet Randomised controlled trial of a no-added-sodium diet for mild hypertension. 455-8 90 patients on medication for mild hypertension were randomly allocated to diet and control groups and kept under surveillance by their own doctors every 2 weeks for 12 weeks to test the short-term effectiveness of a diet free from (...) of blood-pressure control. Beard T C TC Cooke H M HM Gray W R WR Barge R R eng Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Lancet 2985213R 0140-6736 AIM IM Adult Aged Blood Pressure Body Weight Clinical Trials as Topic Diet, Sodium-Restricted Double-Blind Method Female Humans Hypertension diet therapy prevention & control Male Middle Aged Quality of Life Random Allocation 1982 8 28 1982 8 28 0 1 1982 8 28 0 0 ppublish 6125636 S0140-6736(82)90491-3

Lancet1982