Latest & greatest articles for hypertension

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Top results for hypertension

1141. Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group.

Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group. 8446137 1993 04 05 1993 04 05 2013 11 21 0028-4793 328 13 1993 Apr 01 The New England journal of medicine N. Engl. J. Med. Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group. 907-13 We conducted a multicenter trial comparing two angiotensin-converting-enzyme inhibitors (...) to determine whether effects on quality of life during antihypertensive therapy are uniform within this pharmacologic class of agents, and to relate the effects of the drugs on quality of life to objective adverse events, such as the loss of a job or the death of a spouse. After a four-week washout period when they received placebo, 379 men with mild-to-moderately-severe hypertension were randomly assigned to receive captopril (25 to 50 mg twice daily, with or without hydrochlorothiazide) or enalapril (5

NEJM1993

1142. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.

Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. 8446138 1993 04 05 1993 04 05 2013 11 21 0028-4793 328 13 1993 Apr 01 The New England journal of medicine N. Engl. J. Med. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive (...) therapy for hypertension. In addition to cost and quality of life, these factors should be considered in the initial choice of a drug. Materson B J BJ Medical Research Service, Department of Veterans Affairs, Miami, FL. Reda D J DJ Cushman W C WC Massie B M BM Freis E D ED Kochar M S MS Hamburger R J RJ Fye C C Lakshman R R Gottdiener J J eng Clinical Trial Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non

NEJM1993

1143. Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Italian study of aspirin in pregnancy.

Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Italian study of aspirin in pregnancy. 8094168 1993 03 11 1993 03 11 2015 06 16 0140-6736 341 8842 1993 Feb 13 Lancet (London, England) Lancet Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Italian study of aspirin in pregnancy. 396-400 Meta-analysis of data from several controlled trials has shown that low-dose (...) aspirin reduces the risk of pregnancy-induced hypertension (PIH) and intrauterine growth retardation (IUGR) in women at high risk of these disorders. We have assessed the efficacy of low-dose aspirin in women judged to be at moderate risk. Women were included on prophylactic criteria--age under 18 or over 40 years, mild or moderate chronic hypertension (diastolic pressure between 90 and 110 mm Hg), nephropathy with normal renal function and blood pressure, history of PIH or IUGR, and twin pregnancy

Lancet1993

1144. Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group.

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. 8336373 1993 08 23 1993 08 23 2016 10 17 0098-7484 270 6 1993 Aug 11 JAMA JAMA Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. 713-24 To compare six antihypertensive interventions for the treatment of mild hypertension. Randomized, double-blind, placebo-controlled clinical trial. Four hypertension screening and treatment centers (...) in the United States. Hypertensive men and women, aged 45 to 69 years, with diastolic blood pressure less than 100 mm Hg. Sustained nutritional-hygienic advice to all participants to reduce weight, dietary sodium intake, and alcohol intake, and increase physical activity. Participants were randomly allocated to take (1) placebo (n = 234); (2) chlorthalidone (n = 136); (3) acebutolol (n = 132); (4) doxazosin mesylate (n = 134); (5) amlodipine maleate (n = 131); or (6) enalapril maleate (n = 135). Blood

JAMA1993

1145. Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis.

Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis. 1458144 1993 01 13 1993 01 13 2013 11 21 0959-8138 305 6860 1992 Oct 24 BMJ (Clinical research ed.) BMJ Comparison of enalapril and nifedipine in treating non-insulin dependent diabetes associated with hypertension: one year analysis. 981-5 To compare the efficacy, safety, and tolerance of enalapril and nifedipine in hypertensive patients with (...) Humans Hypertension complications drug therapy physiopathology Kidney physiopathology Male Nifedipine therapeutic use PMC1883996 1992 10 24 1992 10 24 0 1 1992 10 24 0 0 ppublish 1458144 PMC1883996

BMJ1992 Full Text: Link to full Text with Trip Pro

1146. Renal function change in hypertensive members of the Multiple Risk Factor Intervention Trial. Racial and treatment effects. The MRFIT Research Group.

Renal function change in hypertensive members of the Multiple Risk Factor Intervention Trial. Racial and treatment effects. The MRFIT Research Group. 1433739 1992 12 14 1992 12 14 2016 10 17 0098-7484 268 21 1992 Dec 02 JAMA JAMA Renal function change in hypertensive members of the Multiple Risk Factor Intervention Trial. Racial and treatment effects. The MRFIT Research Group. 3085-91 To evaluate the contribution of mild to moderate hypertension to progressive loss of renal function by analysis (...) of renal function data from the Multiple Risk Factor Intervention Trial. The cohort of men with mild to moderate hypertension (baseline diastolic blood pressure > or = 90 mm Hg), randomized to a special intervention (SI) group or usual care (UC) group, were examined for change in renal function based on individual reciprocal creatinine slopes over an average of 7 years' follow-up as the outcome measure. Contribution of blood pressure control during follow-up, age, race, and blood pressure at entry were

JAMA1992

1147. Randomised controlled trial of day care for hypertension in pregnancy.

Randomised controlled trial of day care for hypertension in pregnancy. 1346182 1992 02 20 1992 02 20 2015 06 16 0140-6736 339 8787 1992 Jan 25 Lancet (London, England) Lancet Randomised controlled trial of day care for hypertension in pregnancy. 224-7 Our aim was to assess the effect of the introduction of a day-care unit on the care of women with non-proteinuric hypertension in pregnancy. A randomised controlled trial was carried out on 54 women who presented at 26 weeks of pregnancy or later (...) with non-proteinuric hypertension (systolic blood pressure 150-170 mm Hg and/or diastolic pressure 90-105 mm Hg on two occasions at least 15 min apart). 30 women were allocated to care by the day unit and 24 were managed according to the established practice of their clinicians without access to the day unit (control group). Women in the control group spent on average 4.6 times longer as inpatients (difference in mean stay 4.0 days [95% confidence interval 2.1-5.9 days]) than the day-unit group

Lancet1992

1148. The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels. Results of the Trials of Hypertension Prevention, Phase I.

The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels. Results of the Trials of Hypertension Prevention, Phase I. 1586398 1992 03 30 1992 03 30 2016 10 17 0098-7484 267 9 1992 Mar 04 JAMA JAMA The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels. Results of the Trials of Hypertension Prevention, Phase I. 1213-20 To test the short-term feasibility and efficacy of seven nonpharmacologic interventions (...) States JAMA 7501160 0098-7484 0 Sodium, Dietary AIM IM JAMA. 1992 Mar 4;267(9):1256-7 1538565 JAMA. 1992 Jul 8;268(2):198; author reply 198-9 1608133 JAMA. 1992 Jul 8;268(2):198; author reply 198-9 1608135 JAMA. 1992 Jul 8;268(2):198; author reply 198-9 1608134 JAMA 1992 May 6;267(17):2330 Adult Behavior Therapy Blood Pressure Female Follow-Up Studies Humans Hypertension physiopathology therapy Life Style Male Middle Aged Sodium, Dietary administration & dosage Stress, Physiological therapy Weight

JAMA1992

1149. Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men.

Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. 1735925 1992 03 12 1992 03 12 2016 10 17 0098-7484 267 8 1992 Feb 26 JAMA JAMA Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. 1083-9 To investigate the patterns of electrolyte abnormalities resulting from thiazide administration and whether they cause ventricular arrhythmias, and to help resolve the controversy over whether clinicians (...) should routinely prescribe potassium-conserving therapy to all patients treated with thiazides. Double-blind, randomized controlled trial. A total of 233 hypertensive men aged 35 to 70 years. Participants were withdrawn from prior diuretic treatment and were replenished with oral potassium chloride and magnesium oxide. They were then randomized to 2 months of treatment with (1) hydrochlorothiazide; (2) hydrochlorothiazide with oral potassium; (3) hydrochlorothiazide with oral potassium and magnesium

JAMA1992

1150. Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.

Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party. 1445513 1992 04 23 1992 04 23 2013 11 21 0959-8138 304 6824 1992 Feb 15 BMJ (Clinical research ed.) BMJ Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party. 405-12 To establish whether treatment with diuretic or beta blocker in hypertensive older adults reduces risk of stroke, coronary heart disease, and death (...) reduce the risk of stroke, coronary events, and all cardiovascular events in older hypertensive adults. eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England BMJ 8900488 0959-535X 0 Diuretics 0J48LPH2TH Hydrochlorothiazide 50VV3VW0TI Atenolol 7DZO8EB0Z3 Amiloride AIM IM Lancet. 1991 Nov 23;338(8778):1281-5 1682683 JAMA. 1981 Mar 27;245(12):1225-9 7206111 Jpn Heart J. 1981 Jan;22(1):75-85 7012398 Br Med J (Clin Res Ed). 1981 Oct 31;283(6300):1151-3 6794796 Br Heart J

BMJ1992 Full Text: Link to full Text with Trip Pro

1151. Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans.

Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans. 1937660 1991 12 26 1991 12 26 2016 07 26 0194-911X 18 5 1991 Nov Hypertension (Dallas, Tex. : 1979) Hypertension Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans. 583-92 The experimental goals were to determine if regular low-intensity aerobic exercise reduces 24-hour arterial blood pressure in middle-aged and older (aged 50 years or older) humans with mild diastolic (90-105 (...) mm Hg) essential hypertension and, if so, whether this is accurately reflected by changes in casual recordings made at rest. Fourteen subjects walked 3-4 days/wk for 6 months, with 10 exercising an additional 6 months; 12 other subjects served as nonexercising controls. In the exercising subjects, maximal oxygen consumption increased 7-14% (p less than 0.05) with little or no change in body weight or fat. Conventional casual readings of systolic, mean, and diastolic arterial pressure at rest were

Hypertension (Dallas, Tex. : 1979)1991

1152. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension.

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. 1682593 1991 12 09 1991 12 09 2015 06 16 0140-6736 338 8776 1991 Nov 09 Lancet (London, England) Lancet Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. 1173-4 The acute effects of inhaled nitric oxide (NO) (40 ppm in air) on pulmonary (PVR) and systemic (SVR) vascular resistance were compared with those of an intravenous infusion of prostacyclin (24 (...) micrograms/h) in 8 patients with severe pulmonary hypertension and 10 cardiac patients with normal values of PVR. 10 healthy volunteers were studied non-invasively. In the patients with pulmonary hypertension, PVR fell significantly after inhaled NO and after prostacyclin. PVR also fell significantly in the cardiac patients after inhaled NO. Although SVR fell substantially after prostacyclin in patients with pulmonary hypertension, inhaled NO had no effect on SVR in any patient or volunteer. Inhaled

Lancet1991

1153. Calcium supplementation to prevent hypertensive disorders of pregnancy.

Calcium supplementation to prevent hypertensive disorders of pregnancy. 1922250 1991 11 20 1991 11 20 2013 11 21 0028-4793 325 20 1991 Nov 14 The New England journal of medicine N. Engl. J. Med. Calcium supplementation to prevent hypertensive disorders of pregnancy. 1399-405 Calcium supplementation has been reported to reduce blood pressure in pregnant and nonpregnant women. We undertook this prospective study to determine the effect of calcium supplementation on the incidence of hypertensive (...) disorders of pregnancy (gestational hypertension and preeclampsia) and to determine the value of urinary calcium levels as a predictor of the response. We studied 1194 nulliparous women who were in the 20th week of gestation at the beginning of the study. The women were randomly assigned to receive 2 g per day of elemental calcium in the form of calcium carbonate (593 women) or placebo (601 women). Urinary excretion of calcium and creatinine was measured before calcium supplementation was begun

NEJM1991

1154. Caffeine restriction: effect on mild hypertension.

Caffeine restriction: effect on mild hypertension. 1747643 1992 01 22 1992 01 22 2016 10 19 0959-8138 303 6812 1991 Nov 16 BMJ (Clinical research ed.) BMJ Caffeine restriction: effect on mild hypertension. 1235-8 To determine the effects on blood pressure of modifying dietary caffeine intake in patients with mild and borderline hypertension by monitoring ambulatory and clinic blood pressure. Four way, randomised, crossover trial of four consecutive two week dietary regimens: normal diet (...) , caffeine free diet alone, caffeine free diet with decaffeinated instant coffee, caffeine free diet with caffeinated instant coffee (instant coffee phases conducted double blind). Hospital hypertension clinic, Scotland. 52 patients (23 men; aged 26-67 years) with untreated borderline or mild hypertension (diastolic blood pressure 90-105 mm Hg) who normally drank a minimum of three cups of coffee daily. Mean ambulatory blood pressure over 24 hours; mean morning, daytime, and night time ambulatory blood

BMJ1991 Full Text: Link to full Text with Trip Pro

1155. Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)

Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) 1682683 1991 12 19 1991 12 19 2015 06 16 0140-6736 338 8778 1991 Nov 23 Lancet (London, England) Lancet Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) 1281-5 Although the benefits of antihypertensive treatment in "young" elderly (under 70 years) hypertensive patients are well established, the value of treatment in older patients (70-84 years (...) ) is less clear. The Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) was a prospective, randomised, double-blind, intervention study set up to compare the effects of active antihypertensive therapy (three beta-blockers and one diuretic) and placebo on the frequency of fatal and non-fatal stroke and myocardial infarction and other cardiovascular death in hypertensive Swedish men and women aged 70-84 years. We recruited 1627 patients at 116 health centres throughout Sweden, who were

Lancet1991

1156. Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis.

Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. 1675316 1991 07 17 1991 07 17 2015 06 16 0140-6736 337 8755 1991 Jun 15 Lancet (London, England) Lancet Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. 1431-4 The two main causes of gastrointestinal bleeding in cirrhosis are oesophageal varices and portal hypertensive gastropathy (PHG). Rebleeding from varices can be prevented (...) Heart Rate drug effects Humans Hypertension, Portal complications Liver Cirrhosis complications Male Middle Aged Multivariate Analysis Propranolol administration & dosage therapeutic use Recurrence Stomach Diseases complications etiology 1991 6 15 1991 6 15 0 1 1991 6 15 0 0 ppublish 1675316

Lancet1991

1157. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. 2046107 1991 07 15 1991 07 15 2016 10 17 0098-7484 265 24 1991 Jun 26 JAMA JAMA Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative (...) Research Group. 3255-64 To assess the ability of antihypertensive drug treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated systolic hypertension. Multicenter, randomized, double-blind, placebo-controlled. Community-based ambulatory population in tertiary care centers. 4736 persons (1.06%) from 447,921 screenees aged 60 years and above were randomized (2365 to active treatment, 2371 to placebo). Systolic blood pressure ranged from 160 to 219 mm Hg and diastolic blood

JAMA1991

1158. Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial.

Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial. 1920698 1991 10 29 1991 10 29 2016 10 17 0098-7484 266 15 1991 Oct 16 JAMA JAMA Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial. 2098-104 --To assess the effects of physical exercise training on blood pressure in patients with mild hypertension. --Randomized controlled trial. --Hospital-based cardiac (...) rehabilitation program. --Ninety-nine men and women with untreated mild hypertension (systolic blood pressure, 140 to 180 mm Hg; diastolic blood pressure, 90 to 105 mm Hg) were included in the volunteer sample. --Subjects were randomly assigned to a 4-month program of aerobic exercise training, strength and flexibility training, or to a waiting list control group. --The main outcome measures were systolic and diastolic blood pressures measured four times with a random zero sphygmomanometer on 3 separate days

JAMA1991

1159. Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. Melbourne Diabetic Nephropathy Study Group.

Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. Melbourne Diabetic Nephropathy Study Group. 1998761 1991 04 05 1991 04 05 2013 11 21 0959-8138 302 6770 1991 Jan 26 BMJ (Clinical research ed.) BMJ Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. Melbourne Diabetic Nephropathy Study Group. 210-6 To compare the efficacy of angiotensin converting enzyme (...) inhibition with calcium antagonism in diabetic patients with microalbuminuria. Randomised study of diabetic patients with microalbuminuria treated with perindopril or nifedipine for 12 months and monitored for one or three months after stopping treatment depending on whether they were hypertensive or normotensive. Patients were randomised separately according to whether they were hypertensive or normotensive. Diabetic clinics in three university teaching hospitals. 50 diabetic patients with persistent

BMJ1991 Full Text: Link to full Text with Trip Pro

1160. Long-term cost-effectiveness of various initial monotherapies for mild to moderate hypertension

Long-term cost-effectiveness of various initial monotherapies for mild to moderate hypertension Long-term cost-effectiveness of various initial monotherapies for mild to moderate hypertension Long-term cost-effectiveness of various initial monotherapies for mild to moderate hypertension Edelson J T, Weinstein M C, Tosteson A N, Williams L, Lee T H, Goldman L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Monotherapies to reduce hypertension. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Persons with mild to moderate essential hypertension, aged 35-64 years. Setting The study was carried out in the USA. Dates to which data relate Price related to 1987. Source

NHS Economic Evaluation Database.1990