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Latest & greatest articles for hypertension
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on hypertension or other clinical topics then use Trip today.
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Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats 28462145 2018 11 13 2213-4220 6 1 2017 Mar Integrative medicine research Integr Med Res Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats. 60-65 10.1016/j.imr.2016.12.002 Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80-90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays (...) as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats. The animals were randomly divided into four groups comprising of six rats per group. Hypertension was induced by subcutaneous injection of dexamethasone (10 μg/rat/day) in hypertensive rats. Two hypertensive group animals were treated with nicorandil (6 mg/kg/day, po) and allicin (8 mg
The Use of the Ambulatory Arterial Stiffness Index in Patients Suspected of Secondary Hypertension 28018907 2018 11 13 2297-055X 3 2016 Frontiers in cardiovascular medicine Front Cardiovasc Med The Use of the Ambulatory Arterial Stiffness Index in Patients Suspected of Secondary Hypertension. 50 10.3389/fcvm.2016.00050 The ambulatory arterial stiffness index (AASI) is a marker of arterial stiffness and is derived from ambulatory 24-h blood pressure registration. We studied whether the AASI (...) could be used as a predictive factor for the presence of renal artery stenosis (RAS) in patients with a suspicion of secondary hypertension and as such as a diagnostic tool for RAS. We included 169 patients with difficult-to-treat hypertension. They all underwent 24-h ambulatory blood pressure monitoring registration, imaging of the renal arteries, and cardiovascular risk measurement, including smoking, history, biometrics, blood pressure, renal function, lipids, and glucose metabolism. Performing
Subacute right heart failure revealing three simultaneous causes of postâ€embolic pulmonary hypertension in metastatic dissemination of breast cancer 28217316 2018 11 13 2055-5822 4 1 2017 Feb ESC heart failure ESC Heart Fail Subacute right heart failure revealing three simultaneous causes of post-embolic pulmonary hypertension in metastatic dissemination of breast cancer. 75-77 10.1002/ehf2.12106 A 72-year-old woman with history of breast cancer only treated surgically was referred to our (...) department for pulmonary hypertension (PH) suspicion. Echocardiogram revealed elevated right ventricular systolic pressure. Computed tomography (CT) angiogram showed no pulmonary embolism (PE), but lung scan revealed two ventilation-perfusion mismatch areas. Right cardiac catheterization established precapillary PH. Despite treatment with PH specific therapy (sildenafil, ambrisentan, and epoprostenol), her condition worsened rapidly with acute right heart failure (RHF). She died 22 days after admission
Pulmonary Arterial Hypertension Diagnosis, Treatment, and Clinical Management in the Contemporary Era 27851839 2018 11 13 2380-6591 1 9 2016 Dec 01 JAMA cardiology JAMA Cardiol Diagnosis, Treatment, and Clinical Management of Pulmonary Arterial Hypertension in the Contemporary Era: A Review. 1056-1065 10.1001/jamacardio.2016.4471 Pulmonary arterial hypertension (PAH) is characterized by severe remodeling of the distal pulmonary arteries, increased pulmonary vascular resistance, and right
Trends and level of control of hypertension among adults attending an ambulatory HIV clinic in Kampala, Uganda: a retrospective study 28588953 2018 11 13 2059-7908 1 3 2016 BMJ global health BMJ Glob Health Trends and level of control of hypertension among adults attending an ambulatory HIV clinic in Kampala, Uganda: a retrospective study. e000055 10.1136/bmjgh-2016-000055 With an ageing HIV-positive population, sub-Saharan Africa is now facing a dual epidemic of communicable and non (...) -communicable diseases (NCDs). This study aimed to assess trends in the prevalence of hypertension and factors associated with hypertension, among adults attending an ambulatory HIV clinic in Kampala, Uganda. We conducted a retrospective chart review to identify patients with hypertension. We used a random number generator to select 400 patient charts from each year from 2009 to 2014. Blood pressure, age, body mass index (BMI), WHO disease stage and Karnofsky scores were extracted. Logistic regression
Management of mild hypertension in adults. Elevated blood pressure is a common risk factor for cardiovascular disease and affects one in three adults. Blood pressure lowering drugs substantially reduce the risk of stroke, coronary heart disease, heart failure, and premature death, but most clinical trials showing benefits have primarily included patients with moderate to severe hypertension, known cardiovascular disease, or elevated risk of cardiovascular disease. The benefits of treating mild (...) hypertension in patients without cardiovascular disease are less clear, but recent meta-analyses offer some insights. Pooled data from trials that include a large percentage of participants with mild hypertension show significant reductions in stroke, death from cardiovascular disease, and total mortality. Meta-analyses comparing lower blood pressure targets also suggest a benefit of treating patients with mild hypertension, although net benefits are greater for patients at higher absolute levels
Reply to comment on coronary artery disease and hypertension in a non-selected spinal cord injury patient population (letter to the Editor) 28053770 2018 11 13 2058-6124 2 2016 Spinal cord series and cases Spinal Cord Ser Cases Reply to comment on coronary artery disease and hypertension in a non-selected spinal cord injury patient population (letter to the Editor). 16029 10.1038/scsandc.2016.29 Aidinoff Elena E Faculty of Medicine, Department of Rehabilitation, and School of Mathematics
Portal hypertension: an uncommon clinical manifestation of Takayasu arteritis in a 9-year-old child 27895519 2018 11 13 1179-156X 8 2016 Open access rheumatology : research and reviews Open Access Rheumatol Portal hypertension: an uncommon clinical manifestation of Takayasu arteritis in a 9-year-old child. 115-118 Takayasu arteritis (TA) is the third most common childhood vasculitis and its clinical manifestations depend on the arteries involved. We report a case of a 9-year-old boy (...) hemorrhage. Angiography revealed enlargement of aneurysms enlargement and new aneurysms. He also developed portal hypertension. Treatment with intravenous corticosteroids, azathioprine, and monthly intravenous cyclophosphamide was begun. After 6 months of no improvement, infliximab was begun. The aim of this article was to report the concurrence of coronary involvement and portal vein hypertension in pediatric TA because there were scarce reports on this matter. Herrera Cristina N CN Department
Building on a Legacy of Hypertension Research: Charting Our Future Together 27849567 2018 01 29 2018 11 13 1524-4563 69 1 2017 01 Hypertension (Dallas, Tex. : 1979) Hypertension Building on a Legacy of Hypertension Research: Charting Our Future Together. 5-10 Mensah George A GA From the National Heart, Lung, and Blood Institute, Bethesda, MD. Galis Zorina S ZS From the National Heart, Lung, and Blood Institute, Bethesda, MD. Fine Lawrence J LJ From the National Heart, Lung, and Blood Institute (...) , Bethesda, MD. Garcia Melissa E ME From the National Heart, Lung, and Blood Institute, Bethesda, MD. Levy Daniel F DF From the National Heart, Lung, and Blood Institute, Bethesda, MD. Gibbons Gary H GH From the National Heart, Lung, and Blood Institute, Bethesda, MD. Gary.Gibbons@nih.gov. eng Z99 HL999999 NULL Intramural NIH HHS United States Journal Article Review 2016 11 14 United States Hypertension 7906255 0194-911X IM PLoS Genet. 2015 Mar 18;11(3):e1005035 25785607 Circ Res. 2013 Apr 26;112(9):1212
Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? | Clinical Correlations Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? November 9, 2016 By Amar Parikh, MD Peer Reviewed Welcome to Gamechangers, a series that takes a critical look at the latest in medical literature to answer one important question: would the results of this article change my practice? Featuring (...) thorough evidence-based review as well as expert commentary, our aim is for this series to help you decide if the results of a given study are, in fact, a gamechanger. A 65 year-old Hispanic male with type 2 diabetes, hypertension, hyperlipidemia, and erectile dysfunction presents to clinic for follow-up and is found to be hypertensive to a systolic blood pressure (SBP) in the 160s on a regimen of amlodipine 10 mg daily, lisinopril 40 mg daily, and hydrochlorothiazide 25 mg daily. The patient
Hypertension Control, Apparent Treatment Resistance, and Outcomes in the Elderly Population With Chronic Kidney Disease 29142956 2018 11 13 2468-0249 2 2 2017 Mar Kidney international reports Kidney Int Rep Hypertension Control, Apparent Treatment Resistance, and Outcomes in the Elderly Population With Chronic Kidney Disease. 180-191 10.1016/j.ekir.2016.10.006 Chronic kidney disease (CKD) is often associated with poor hypertension control and treatment resistance, but whether CKD modifies (...) the effect of hypertension control on outcomes is unknown. We studied 10-year mortality and cardiovascular events according to hypertension control status and CKD (glomerular filtration rate <60 ml/min/1.73m 2 ) in 4262 community-dwelling individuals (40% men) more than 65 years of age. At baseline, 19% had CKD, and 31.2% had controlled hypertension on ≤3 antihypertensive drugs, 62.3% uncontrolled hypertension ≥140/90 mm Hg on ≤2 drugs, and 6.5% apparent treatment-resistant hypertension (aTRH) ≥140/90 mm
Sex Differences in Hypertension: Recent Advances 27777357 2018 01 26 2018 11 13 1524-4563 68 6 2016 12 Hypertension (Dallas, Tex. : 1979) Hypertension Sex Differences in Hypertension: Recent Advances. 1322-1327 Gillis Ellen E EE From the Department of Physiology, Augusta University, GA. Sullivan Jennifer C JC From the Department of Physiology, Augusta University, GA. firstname.lastname@example.org. eng R01 HL127091 HL NHLBI NIH HHS United States Journal Article Research Support, N.I.H., Extramural (...) Review 2016 10 24 United States Hypertension 7906255 0194-911X IM Hypertension. 2015 May;65(5):1073-81 25776077 Hypertension. 2011 Mar;57(3):397-405 21263119 Hypertension. 2011 Feb;57(2):275-82 21189402 Cell Immunol. 2015 Apr;294(2):95-101 25498375 Hypertension. 2015 Aug;66(2):396-402 26056343 Nat Rev Cardiol. 2016 Mar;13(3):167-79 26525543 Hypertension. 2012 Jan;59(1):129-35 22124434 Am J Med. 2016 Oct;129(10):1030-6 27427323 J Cell Mol Med. 2015 Aug;19(8):1975-85 25991381 Hypertension. 2014 Sep;64
A rare cause of hypertension in pregnancy: Phaeochromocytoma 28680468 2018 11 13 1753-495X 10 2 2017 Jun Obstetric medicine Obstet Med A rare cause of hypertension in pregnancy: Phaeochromocytoma. 83-84 10.1177/1753495X16669995 A 26-year-old primigravida at 35 weeks' gestation was transferred to our institution from a regional hospital for management of presumed preeclampsia. Due to the labile nature of her hypertension, further investigation was undertaken which revealed a right-sided (...) phaeochromocytoma. Alpha blockade was commenced, and an uncomplicated elective caesarean delivery was performed at 38 weeks' gestation under spinal anaesthetic. The patient underwent an elective right laparoscopic adrenalectomy six weeks post-partum. This case highlights the importance of investigating young women for secondary causes of hypertension to avoid mislabelling as essential or gestational hypertension. Shah Sonali S Department of Endocrinology, Austin and Mercy Health, Melbourne, Australia. Edwards