Latest & greatest articles for hydrochlorothiazide

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Top results for hydrochlorothiazide

41. Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study.

Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study. 3511308 1986 03 26 1986 03 26 2016 10 17 0098-7484 255 10 1986 Mar 14 JAMA JAMA Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study. 1304-10 In a randomized double-blind study (N = 562), a traditional treatment schedule, starting (...) antihypertensive treatment in elderly hypertensive patients (60 to 75 years old) with 25 mg of hydrochlorothiazide once daily and doubling the dose if a satisfactory response was not achieved, was compared with antihypertensive treatment of 100 mg of metoprolol once daily, adding 12.5 mg of hydrochlorothiazide for patients whose response was not satisfactorialy achieved with metoprolol alone. Systolic and diastolic blood pressure was significantly reduced with both regimens. The frequency rates of responders

JAMA1986

42. Enalapril, atenolol, and hydrochlorothiazide in mild to moderate hypertension. A comparative multicentre study in general practice in Norway.

Enalapril, atenolol, and hydrochlorothiazide in mild to moderate hypertension. A comparative multicentre study in general practice in Norway. 2870352 1986 05 16 1986 05 16 2015 06 16 0140-6736 1 8486 1986 Apr 19 Lancet (London, England) Lancet Enalapril, atenolol, and hydrochlorothiazide in mild to moderate hypertension. A comparative multicentre study in general practice in Norway. 872-5 Enalapril, atenolol, and hydrochlorothiazide were compared in a double-blind randomised parallel study (...) in general practice. 436 patients with mild to moderate hypertension were included at 76 centres. A two-week placebo run-in period was followed by 16 weeks of monotherapy. The initial doses were: enalapril 20 mg; atenolol 50 mg; and hydrochlorothiazide 25 mg. These were doubled if treatment was not effective after 4 weeks. Adverse reactions were the main reason for withdrawal from the study (9 on enalapril, 19 on atenolol, and 8 on hydrochlorothiazide). Systolic and diastolic blood pressures were

Lancet1986

43. Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion.

Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion. 2857210 1985 03 06 1985 03 06 2015 06 16 0140-6736 1 8421 1985 Jan 19 Lancet (London, England) Lancet Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion. 123-6 14 hypertensive men with type II diabetes sequentially received, in random order, hydrochlorothiazide 50 mg twice (...) a day, propranolol 80 mg twice a day, and both drugs in combination. The 3-week treatment periods were separated by a 1-week washout period. Hydrochlorothiazide significantly increased fasting glucose by 31% (p less than 0.05) and glycosylated haemoglobin (HbA1c) by 6.0% (p less than 0.10). A similar treatment period of propranolol 80 mg twice a day caused no significant increases. However, when both drugs were taken in combination, fasting glucose rose by 56% and HbA1c by 14.7% (p less than 0.01

Lancet1985

44. Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.

Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide. 2861527 1985 08 19 1985 08 19 2015 06 16 0140-6736 2 8446 1985 Jul 13 Lancet (London, England) Lancet Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide. 73-5 In a crossover study of 26 hypertensive patients, the effects of triamterene (50 mg/day) and amiloride (5 mg/day) on urinary sediment were compared. Each drug was given (...) for one month and all patients also received hydrochlorothiazide (50 mg/day). An abnormal urinary sediment--evident grossly as a reddish-brown precipitate after routine staining procedures and microscopically as characteristic reddish-brown crystals and casts, as previously described--was identified in 14 of 26 (54%) triamterene urine samples but in none of the amiloride samples. Results of renal function tests were similar for both drugs. In a clinic population of more than 1000 hypertensive patients

Lancet1985

45. Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. Veterans Administration Cooperative Study Group on Antihypertensive agents.

Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. Veterans Administration Cooperative Study Group on Antihypertensive agents. 6750166 1982 12 03 1982 12 03 2016 10 17 0098-7484 248 16 1982 Oct 22 JAMA JAMA Comparison of propranolol and hydrochlorothiazide for thr initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences (...) in response. Veterans Administration Cooperative Study Group on Antihypertensive agents. 1996-2003 We compared hydrochlorothiazide and propranolol hydrochloride for monotherapy of hypertension by a double-blind study of 683 men who were titrated to less than 90 mm Hg diastolic BP or to 640 mg of propranolol or 200 mg of hydrochlorothiazide. Propranolol reduced systolic BP from 146.0 +/- 14.4 (SD) to 134.8 +/- 16.3 mm Hg and diastolic BP from 101.6 +/- 4.6 to 90.5 +/- 7.5 mm Hg. Hydrochlorothiazide lowered

JAMA1982

46. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents.

Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. 6750167 1982 12 03 1982 12 03 2016 10 17 0098-7484 248 16 1982 Oct 22 JAMA JAMA Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. 2004-11 (...) As described in the preceding communication, either propranolol hydrochloride or hydrochlorothiazide were randomly allocated in a double-blind manner to 683 patients with initial diastolic BP in the range of 95 to 114 mm Hg. Of this number, 394 entered the long-term treatment phase. During the subsequent 12 months of long-term treatment, hydrochlorothiazide was more effective than propranolol in controlling BP (mean reductions, -17.5/-13.1 mm Hg with hydrochlorothiazide compared with -8.3/-11.3

JAMA1982

47. Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover.

Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover. 372609 1979 06 29 1979 06 29 2016 10 17 0098-7484 241 20 1979 May 18 JAMA JAMA Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover. 2174-6 Twenty-eight patients completed a double-blind study of the antihypertensive effects of ticrynafen compared with those of hydrochlorothiazide. The results of blood pressure reduction were (...) comparable in the two groups. After six months, 12 patients were crossed over to ticrynafen therapy from hydrochlorothiazide. They maintained their blood pressure reduction. The most striking difference between the two groups was in the uric acid response. The uric acid level in the patients receiving hydrochlorothiazide therapy rose from a baseline of 5.9 to 7.5 mg/dL (normal range, 3.0 to 8.0 mg/dL). The uric acid level of those patients receiving ticrynafen therapy decreased from a baseline of 6.4 mg

JAMA1979

48. Comparative effects of ticrynafen and hydrochlorothiazide in the treatment of hypertension.

Comparative effects of ticrynafen and hydrochlorothiazide in the treatment of hypertension. 377081 1979 09 01 1979 09 01 2013 11 21 0028-4793 301 6 1979 Aug 09 The New England journal of medicine N. Engl. J. Med. Comparative effects of ticrynafen and hydrochlorothiazide in the treatment of hypertension. 293-7 Two dose levels of ticrynafen, a new uricosuric diuretic, and of hydrochlorothiazide were randomly assigned, double-blind to 240 men with initial diastolic blood pressures in the range (...) of 95 to 114 mm Hg. A dose of 500 mg of ticrynafen once daily exerted an antihypertensive effect comparable to that of 50 or 100 mg of hydrochlorothiazide. Whereas serum uric acid levels rose in patients treated with hydrochlorothiazide, they fell markedly in those receiving ticrynafen. Otherwise, both diuretics produced similar chemical changes in serum. Patients tolerated ticrynafen as well as they did hydrochlorothiazide over a period of six months of observation, and there was no evidence

NEJM1979

49. Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension.

Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension. 357764 1978 12 02 1978 12 02 2016 10 17 0098-7484 240 17 1978 Oct 20 JAMA JAMA Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension. 1863-6 In a double-blind crossover study, the effectiveness of furosemide, 40 mg twice daily, was compared with hydrochlorothiazide, 50 mg twice daily, in hypertensive patients. Both hydrochlorothiazide and furosemide significantly reduced blood (...) pressure (BP) during three months of therapy. However, the fall in BP was consistently greater with hydrochlorothiazide than with furosemide, although the difference was significant only with respect to systolic BP. The somewhat greater antihypertensive effectiveness of hydrochlorothiazide may be related to its longer action permitting a more continuous diuretic effect and, hence, maintenance of reduced extracellular fluid volume throughout the 24-hour period. Araoye M A MA Chang M Y MY Khatri I M IM Freis

JAMA1978

50. Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial.

Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial. 60566 1976 10 20 1976 10 20 2015 06 16 0140-6736 2 7981 1976 Aug 14 Lancet (London, England) Lancet Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity. Double-blind factorial trial. 328-31 The effects of timolol (10 mg thrice daily) and hydrochlorothiazide (50 mg/day) have been compared in a double-blind factorial trial in 20 patients (...) with essential hypertension. There were four randomised test phases of 8 weeks each during which patients received timolol alone, hydrochlorothiazide alone, timolol plus hydrochlorothiazide, and no treatment (placebo). Blood-pressure was measured weekly, alternately at the outpatient clinic and at the patient's home. Supine mean arterial pressure fell from 119 mm Hg in the placebo phase to 110 mm Hg in the hydrochlorothiazide phase, 106 mm Hg in the timolol phase, and 101 mm Hg in the combined timolol plus

Lancet1976

51. Efficacy of an antihypertensive agent. Comparison of methyldopa and hydrochlorothiazide in combination and singly.

Efficacy of an antihypertensive agent. Comparison of methyldopa and hydrochlorothiazide in combination and singly. 1088916 1975 02 18 1975 02 18 2016 10 17 0098-7484 231 2 1975 Jan 13 JAMA JAMA Efficacy of an antihypertensive agent. Comparison of methyldopa and hydrochlorothiazide in combination and singly. 155-8 In a double-blind evaluation, the efficacy of a combination of methyldopa with hydrochlorothiazide was compared with that of its components, methyldopa and hydrochlorothiazide (...) . The combination was found to be more efficacious than either of its components. It reduced the arithmetic mean of the pressures of all patients from 170/116 to 133/95 mm Hg in four weeks. Despite the greater effect of the combination, side effects were mild. McMahon F G FG eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Placebos 0J48LPH2TH Hydrochlorothiazide 56LH93261Y Methyldopa AIM IM Adult Aged Blood Pressure drug effects Clinical

JAMA1975