Latest & greatest articles for hepatitis

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Top results for hepatitis

181. Tenofovir reduces mother-to-child hepatitis B transmission

Tenofovir reduces mother-to-child hepatitis B transmission Tenofovir reduces mother-to-child hepatitis B transmission Discover Portal Discover Portal Tenofovir reduces mother-to-child hepatitis B transmission Published on 25 July 2017 doi: Giving pregnant women with hepatitis B the drug tenofovir reduced the likelihood of passing the infection on to their baby by about 80% and did not have any adverse impact on mother or child. Hepatitis B often doesn't cause any obvious symptoms in adults (...) and typically passes in a few months without treatment, but in children it often persists for years and may cause progressive liver damage with cirrhosis and increased risk of liver cancer. Babies can get the infection from their mother during birth. The findings of this systematic review support current NICE recommendations that pregnant women with active hepatitis B infection are treated in the third trimester using the drug tenofovir and at risk babies immunised after birth. Share your views

2018 NIHR Dissemination Centre

182. Two drug treatments for severe alcoholic hepatitis do not improve survival rates

Two drug treatments for severe alcoholic hepatitis do not improve survival rates Two drug treatments for severe alcoholic hepatitis do not improve survival rates Discover Portal Discover Portal Two drug treatments for severe alcoholic hepatitis do not improve survival rates Published on 23 April 2015 doi: This NIHR funded trial found that neither prednisolone nor pentoxifylline improved mortality for people with severe alcoholic hepatitis. No differences were found in mortality at 28 or 90 days (...) , or in the need for liver transplant at one year. Overall mortality was high. Nearly three in ten people died before 90 days and more than half (56%) at one year. This shows that other new treatments are needed and more needs to be done to encourage complete abstinence from alcohol following severe alcoholic hepatitis. Share your views on the research. Why was this study needed? UK estimates from 2009 show a quarter of adults drink in a hazardous or harmful way. People with prolonged and heavy alcohol use can

2018 NIHR Dissemination Centre

183. Elbasvir/grazoprevir in Asia‐Pacific/Russian participants with chronic hepatitis C virus genotype 1, 4, or 6 infection (PubMed)

Elbasvir/grazoprevir in Asia‐Pacific/Russian participants with chronic hepatitis C virus genotype 1, 4, or 6 infection The prevalence of hepatitis C virus (HCV) infection in Asian countries is high. This study assessed the efficacy and safety of elbasvir/grazoprevir (EBR/GZR) in participants with HCV infection from Asia-Pacific countries and Russia. In this phase 3, randomized, placebo-controlled, double-blind study, treatment-naive participants with HCV genotype (GT) 1, 4, or 6 infection

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2018 Hepatology communications Controlled trial quality: predicted high

184. Diagnosis of Minimal Hepatic Encephalopathy: A Systematic Review of Point-of-Care Diagnostic Tests

Diagnosis of Minimal Hepatic Encephalopathy: A Systematic Review of Point-of-Care Diagnostic Tests Minimal hepatic encephalopathy (HE) is common, characterized by deficits in reaction time and executive function, and strongly associated with disability and mortality. Point-of-care diagnostics performed without specialized skills or equipment are now available, albeit with limited data regarding their generalizability.We systematically reviewed MEDLINE, EMBASE, Cochrane Library, and Scopus

2018 EvidenceUpdates

185. Sofosbuvir-velpatasvir-voxilaprevir (Vosevi) - chronic hepatitis C virus (HCV)

Sofosbuvir-velpatasvir-voxilaprevir (Vosevi) - chronic hepatitis C virus (HCV) Published 9 April 2018 1 sofosbuvir 400mg, velpatasvir 100mg, voxilaprevir 100mg film-coated tablet (Vosevi ® ) SMC No 1317/18 Gilead Sciences Ltd 9 March 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following a full (...) submission sofosbuvir-velpatasvir-voxilaprevir (Vosevi®) is accepted for restricted use within NHS Scotland. Indication under review: Treatment of chronic hepatitis C virus (HCV) infection in adults. SMC restriction: for patients who: (1) Have failed to achieve a sustained virologic response (SVR) with a direct-acting anti-viral (DAA) or (2) are DAA-naïve, have genotype 3 (GT3) HCV infection, with or without cirrhosis, and are suitable for treatment with an eight-week course. Sofosbuvir-velpatasvir

2018 Scottish Medicines Consortium

186. Sofosbuvir-velpatasvir (Epclusa) - chronic hepatitis C virus (HCV)

Sofosbuvir-velpatasvir (Epclusa) - chronic hepatitis C virus (HCV) Published 9 April 2018 1 Re-Submission sofosbuvir 400mg, velpatasvir 100mg film-coated tablets (Epclusa ® ) SMC No 1271/17 Gilead Sciences Ltd 9 March 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following a resubmission sofosbuvir (...) -velpatasvir (Epclusa ® ) is accepted for restricted use within NHS Scotland. Indication under review: treatment of chronic hepatitis C virus (HCV) infection in adults. SMC restriction: in patients with genotype 1 or 4 HCV infection. Sofosbuvir-velpatasvir was associated with high rates of sustained virologic suppression in adults with genotype 1 and 4 chronic HCV infection, including those with decompensated cirrhosis. This SMC advice takes account of the benefits of a Patient Access Scheme (PAS

2018 Scottish Medicines Consortium

187. Hepatitis C: sofosbuvir + velpatasvir (Epclusa) represents an advance for some patients

Hepatitis C: sofosbuvir + velpatasvir (Epclusa) represents an advance for some patients Prescrire IN ENGLISH - Spotlight ''Hepatitis C: sofosbuvir + velpatasvir (Epclusa°) represents an advance for some patients'', 1 April 2018 {1} {1} {1} | | > > > Hepatitis C: sofosbuvir + velpatasvir (Epclusa°) represents an advance for some patients Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |    (...) |   |   |  Spotlight Hepatitis C: sofosbuvir + velpatasvir (Epclusa°) represents an advance for some patients The combination sofosbuvir + velpatasvir (Epclusa°) offers a therapeutic advance in the treatment of hepatitis C, especially in patients infected by a genotype 2 virus. But the uncertainty surrounding its adverse effects is unacceptable. Hepatitis C can cause complications such as cirrhosis and liver cancer. Treatment depends on the virus genotype, the severity

2018 Prescrire

188. Practice Advisory: Hepatitis B Prevention

Practice Advisory: Hepatitis B Prevention Practice Advisory: Hepatitis B Prevention - ACOG Menu ▼ Practice Advisory: Hepatitis B Prevention Page Navigation ▼ Share: Practice Advisory: Hepatitis B Prevention The Centers for Disease Control and Prevention (CDC) and the Advisory Committee on Immunization Practices (ACIP) have released updated guidance on preventing the transmission of hepatitis B virus (HBV) infection (1). A critical element of the strategy to eliminate HBV in the United States (...) is the prevention of perinatal transmission. The CDC and ACIP’s updated guidance reflects the best currently available evidence and select new or updated recommendations include the following: Pregnant women positive for hepatitis B surface antigen (HBsAg) should be tested for hepatitis B virus deoxyribonucleic acid (HBV DNA) to guide the use of antiviral medication to prevent perinatal transmission Persons with chronic liver disease* should be vaccinated against HBV The American Association for the Study

2018 American College of Obstetricians and Gynecologists

189. Diagnostic Accuracy of Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis 4 Scores in Predicting Advanced Liver Fibrosis in Patients with End-stage Renal Disease and Chronic Viral Hepatitis: Experience from Pakistan (PubMed)

Diagnostic Accuracy of Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis 4 Scores in Predicting Advanced Liver Fibrosis in Patients with End-stage Renal Disease and Chronic Viral Hepatitis: Experience from Pakistan The aim was to assess the diagnostic accuracy of APRI and FIB-4 in assessing the stage of liver fibrosis in end stage renal disease (ESRD) patients with chronic viral hepatitis and to compare the two tests with standard tru-cut liver biopsy.The study was conducted (...) at Sindh Institute of Urology and Transplantation Karachi (SIUT) from May 2010 to May 2014. All ESRD patients, being considered as candidates for renal transplantation and in whom liver biopsy was performed were included. Fibrosis stage was assessed on liver biopsy using Ishak scoring system. The serum transaminases and platelet counts were used to calculate APRI and FIB-4 scores.Out of 109 patients, hepatitis C and B virus infections were present in 104 (95.4%) and 3(2.8%), respectively, while 2 (1.8

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2018 Journal of translational internal medicine

190. Liver‐enriched transcription factor expression relates to chronic hepatic failure in humans (PubMed)

Liver‐enriched transcription factor expression relates to chronic hepatic failure in humans The mechanisms by which the liver fails in end-stage liver disease remain elusive. Disruption of the transcription factor network in hepatocytes has been suggested to mediate terminal liver failure in animals. However, this hypothesis remains unexplored in human subjects. To study the relevance of transcription factor expression in terminal stages of chronic liver failure in humans, we analyzed (...) the expression of liver-enriched transcription factors (LETFs) hepatocyte nuclear factor (HNF)4α, HNF1α, forkhead box protein A2 (FOXA2), CCAAT/enhancer-binding protein (CEBP)α, and CEBPβ. We then selected downstream genes responsible for some hepatic functions (ornithine transcarbamylase [OTC], cytochrome P450 3A4 [CYP3A4], coagulation factor VII [F7], cadherin 1 [CDH1], phospho-ezrin (Thr567)/radixin (Thr564)/moesin (Thr558) [p-ERM], phospho-myosin light chain [p-MLC], low-density lipoprotein receptor

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2018 Hepatology communications

191. Coding variants in PNPLA3 and TM6SF2 are risk factors for hepatic steatosis and elevated serum alanine aminotransferases caused by a glucagon receptor antagonist (PubMed)

Coding variants in PNPLA3 and TM6SF2 are risk factors for hepatic steatosis and elevated serum alanine aminotransferases caused by a glucagon receptor antagonist LY2409021 is a glucagon receptor antagonist that was associated with hepatic steatosis and elevated aminotransferases in phase 2 diabetes studies. We investigated the relationship between selected genetic variants and hepatic steatosis and elevated alanine aminotransferases (ALTs) associated with LY2409021. Patients participated in a 6 (...) -week placebo-controlled trial (I1R-MC-GLDI [GLDI], n = 246) and a 52-week placebo- and active comparator-controlled trial (I1R-MC-GLDJ [GLDJ], n = 158). GLDJ had endpoints at 6 months, including measures of hepatic fat fraction (HFF) by magnetic resonance imaging. The five genes tested were patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409 and rs738491), transmembrane 6 superfamily member 2 (TM6SF2) (rs58542926), peroxisome proliferative activated receptor gamma coactivator 1 alpha

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2018 Hepatology communications Controlled trial quality: uncertain

192. Consensus on Pegylated Interferon Alpha in Treatment of Chronic Hepatitis B (PubMed)

Consensus on Pegylated Interferon Alpha in Treatment of Chronic Hepatitis B 29577026 2018 11 14 2225-0719 6 1 2018 Mar 28 Journal of clinical and translational hepatology J Clin Transl Hepatol Consensus on Pegylated Interferon Alpha in Treatment of Chronic Hepatitis B. 1-10 10.14218/JCTH.2017.00073 Zhang Wenhong W Huashang Hospital of Fudan University, Shanghai, China. Zhang Dazhi D The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Dou Xiaoguang X Shengjing (...) Consensus Hepatitis B Interferons Therapy The authors have no conflict of interests related to this publication. 2017 11 08 2018 02 05 2018 02 09 2018 3 27 6 0 2018 3 27 6 0 2018 3 27 6 1 ppublish 29577026 10.14218/JCTH.2017.00073 JCTH.2017.00073 PMC5862993 Gut. 2013 Feb;62(2):290-8 22859496 Hepatology. 2009 Apr;49(4):1151-7 19115222 J Infect Dis. 2016 Mar 15;213(6):966-74 26582959 Gastroenterology. 2009 Dec;137(6):2002-9 19737568 Zhonghua Gan Zang Bing Za Zhi. 2010 Jul;18(7):495-7 20678437 J Viral

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2018 Journal of clinical and translational hepatology

193. HBsAg Loss with Peg-interferon Alfa-2a in Hepatitis B Patients with Partial Response to Nucleos(t)ide Analog: New Switch Study (PubMed)

HBsAg Loss with Peg-interferon Alfa-2a in Hepatitis B Patients with Partial Response to Nucleos(t)ide Analog: New Switch Study Background and Aims: Hepatitis B surface antigen (HBsAg) loss is seldom achieved with nucleos(t)ide analog (NA) therapy in chronic hepatitis B patients but may be enhanced by switching to finite pegylated-interferon (Peg-IFN) alfa-2a. We assessed HBsAg loss with 48- and 96-week Peg-IFN alfa-2a in chronic hepatitis B patients with partial response to a previous NA (...) . Methods: Hepatitis B e antigen (HBeAg)-positive patients who achieved HBeAg loss and hepatitis B virus DNA <200 IU/mL with previous adefovir, lamivudine or entecavir treatment were randomized 1:1 to receive Peg-IFN alfa-2a for 48 (n = 153) or 96 weeks (n = 150). The primary endpoint of this study was HBsAg loss at end of treatment. The ClinicalTrials.gov identifier is NCT01464281. Results: At the end of 48 and 96 weeks' treatment, 14.4% (22/153) and 20.7% (31/150) of patients, respectively, who

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2018 Journal of clinical and translational hepatology Controlled trial quality: uncertain

194. Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects (PubMed)

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects Insulin plays a central role in glucose homeostasis, and impairment of insulin action causes glucose intolerance and leads to type 2 diabetes mellitus (T2DM). A decrease in the transient peak and sustained increase of circulating insulin following an infusion of glucose accompany T2DM pathogenesis. However, the mechanism underlying this abnormal temporal (...) pattern of circulating insulin concentration remains unknown. Here we show that changes in opposite direction of hepatic and peripheral insulin clearance characterize this abnormal temporal pattern of circulating insulin concentration observed in T2DM. We developed a mathematical model using a hyperglycemic and hyperinsulinemic-euglycemic clamp in 111 subjects, including healthy normoglycemic and diabetic subjects. The hepatic and peripheral insulin clearance significantly increase and decrease

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2018 NPJ systems biology and applications

195. Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B. (PubMed)

Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B. Pregnant women with an elevated viral load of hepatitis B virus (HBV) have a risk of transmitting infection to their infants, despite the infants' receiving hepatitis B immune globulin.In this multicenter, double-blind clinical trial performed in Thailand, we randomly assigned hepatitis B e antigen (HBeAg)-positive pregnant women with an alanine aminotransferase level of 60 IU or less per liter to receive tenofovir (...) disoproxil fumarate (TDF) or placebo from 28 weeks of gestation to 2 months post partum. Infants received hepatitis B immune globulin at birth and hepatitis B vaccine at birth and at 1, 2, 4, and 6 months. The primary end point was a hepatitis B surface antigen (HBsAg)-positive status in the infant, confirmed by the HBV DNA level at 6 months of age. We calculated that a sample of 328 women would provide the trial with 90% power to detect a difference of at least 9 percentage points in the transmission

2018 NEJM Controlled trial quality: predicted high

196. Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet‐induced mouse model of nonalcoholic steatohepatitis (PubMed)

Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet‐induced mouse model of nonalcoholic steatohepatitis Nonalcoholic steatohepatitis (NASH) is a progressive liver disease projected to become the leading cause of cirrhosis and liver transplantation in the next decade. Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage trafficking and is under clinical investigation for the treatment of human NASH fibrosis. We assessed (...) weeks based on histologic and molecular markers, mirroring observations in human NASH CVC trials. CVC also directly inhibited the profibrotic gene signature of transforming growth factor-β-stimulated primary mouse hepatic stellate cells in vitro. Conclusion: CVC is a novel therapeutic agent that is associated with reduced fibrosis despite ongoing steatohepatitis. Its ability to alter intrahepatic macrophage populations and inhibit profibrogenic genes in hepatic stellate cells in NASH livers may

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2018 Hepatology communications

197. Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus-Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial. (PubMed)

Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus-Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial. Given the high mortality rate for patients with end-stage kidney disease receiving dialysis and the efficacy and safety of hepatitis C virus (HCV) treatments, discarded kidneys from HCV-infected donors may be a neglected public health resource.To determine the tolerability and feasibility of using direct-acting antivirals (DAAs

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2018 Annals of Internal Medicine

198. Risk of hepatocellular carcinoma for patients treated with direct-acting antivirals: steps after hepatitis C virus eradication to achieve elimination (PubMed)

Risk of hepatocellular carcinoma for patients treated with direct-acting antivirals: steps after hepatitis C virus eradication to achieve elimination 29682622 2018 11 14 2415-1289 3 2018 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Risk of hepatocellular carcinoma for patients treated with direct-acting antivirals: steps after hepatitis C virus eradication to achieve elimination. 15 10.21037/tgh.2018.02.03 Lee Mei-Hsuan MH Institute of Clinical Medicine, National (...) Yang-Ming University, Taipei. eng Editorial Comment 2018 03 05 China Transl Gastroenterol Hepatol 101683450 2415-1289 Gastroenterology. 2017 Oct;153(4):996-1005.e1 28642197 Conflicts of Interest: The author has no conflicts of interest to declare. 2018 02 04 2018 02 19 2018 4 24 6 0 2018 4 24 6 0 2018 4 24 6 1 epublish 29682622 10.21037/tgh.2018.02.03 tgh-03-2018.02.03 PMC5897667 JAMA. 2012 Dec 26;308(24):2584-93 23268517 J Viral Hepat. 2018 Mar;25(3):228-235 29053909 Epidemiol Rev. 2015;37:131-43

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2018 Translational gastroenterology and hepatology

199. Sofosbuvir (Sovaldi) - for the treatment of chronic hepatitis C in adolescents

Sofosbuvir (Sovaldi) - for the treatment of chronic hepatitis C in adolescents Published 12 March 2018 Statement of Advice: sofosbuvir 400mg film-coated tablets (Sovaldi ® ) SMC No 1326/18 Gilead Sciences Ltd 9 February 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation sofosbuvir (Sovaldi ® ) is not recommended for use within NHS Scotland. Indication under review: In combination with other medicinal products for the treatment of chronic hepatitis C

2018 Scottish Medicines Consortium

200. Sofosbuvir?velpatasvir?voxilaprevir for treating chronic hepatitis C

Sofosbuvir?velpatasvir?voxilaprevir for treating chronic hepatitis C Sofosbuvir–v Sofosbuvir–velpatasvir–v elpatasvir–vo oxilapre xilaprevir for vir for treating chronic hepatitis C treating chronic hepatitis C T echnology appraisal guidance Published: 21 February 2018 nice.org.uk/guidance/ta507 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations (...) and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C (TA507) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 17Contents Contents 1 Recommendations

2018 National Institute for Health and Clinical Excellence - Technology Appraisals