Latest & greatest articles for heparin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on heparin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on heparin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for heparin

1. Occlusion between heparin saline and 0.9% sodium chloride in adults: A Snapshot

Occlusion between heparin saline and 0.9% sodium chloride in adults: A Snapshot Heparin versus saline and occlusion in adults: A Snapshot 1 Occlusion between heparin saline and 0.9% sodium chloride in adults: A Snapshot Citation Corey Joseph & Angela Melder. August 2018. Occlusion between heparin saline and 0.9% sodium chloride in adults: A Snapshot. Centre for Clinical Effectiveness, Monash Health, Melbourne, Australia. Executive Summary Background The Centre for Clinical Effectiveness have (...) patency between heparinised saline and 0.9% Sodium Chloride solution in Adults. Specifically, the review will focus on central lines only. Findings ? Given the very low-quality of the evidence, it is uncertain whether heparin saline results in fewer occlusions than normal saline. 3,4 ? Low quality evidence suggests there is no difference in occlusion of line access, lumen and patient between heparin saline and normal saline. 4 ? In the short term ( 30 days) there was not difference in occlusion

2019 Monash Health Evidence Reviews

2. Heparin Flushing of IV Lines

Heparin Flushing of IV Lines Rapid Review 1 Heparin flushing of IV lines Citation Centre for Clinical Effectiveness. 2017. Heparin flushing of IV lines: Rapid Review. Centre for Clinical Effectiveness, Monash Health, Melbourne, Australia. Executive Summary Background Monash Health are working on improving procedural and maintenance documentation as a result of the dramatic increase in the size of the lines service with the opening of the new Children’s Hospital. As part of this, they are re (...) - considering the use of heparin for flushing paediatric lines which is common practice around the world. Changing practice from heparin to saline at Monash Health would be a significant change in practice. Anaesthetics have engaged the Centre for Clinical Effectiveness to undertake a rapid review of current literature about the use of heparin for flushing paediatric lines. Objective The purpose of this Rapid Review was to synthesise recent evidence pertaining to the use of heparin versus saline flushing

2017 Monash Health Evidence Reviews

3. Heparin

Heparin Top results for heparin - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for heparin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

4. Economic Evaluation of Unfractionated Heparin Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in General Medical and Non Orthopedic Surgical Patients

Economic Evaluation of Unfractionated Heparin Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in General Medical and Non Orthopedic Surgical Patients Economic Evaluation of Unfractionated Heparin Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in General Medical and Non Orthopedic Surgical Patients | CADTH.ca CADTH Document Viewer Economic Evaluation of Unfractionated Heparin Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism (...) in General Medical and Non Orthopedic Surgical Patients Table of Contents Search this document Economic Evaluation of Unfractionated Heparin Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in General Medical and Non Orthopedic Surgical Patients April 2017 Key Finding: Economic Evaluation The price of low-molecular-weight heparin (LMWH) has decreased since it was marketed in the mid‑1990s in Canada, while unfractionated heparin (UFH) has recently become more costly because of changes

2017 CADTH - Plasma Products

5. A randomized controlled clinical trial of 4% sodium citrate versus heparin as locking solution for temporary dialysis catheters among hemodialysis patients
. (Abstract)

A randomized controlled clinical trial of 4% sodium citrate versus heparin as locking solution for temporary dialysis catheters among hemodialysis patients
. Limited reports are available on the role of 4% citrate as a locking solution for temporary dialysis catheters. Hence, the aim of this study is to investigate the role of 4% citrate vs. heparin 5,000 µ/mL as a catheter-locking solution in a randomized controlled trial.The trial was conducted in Egypt where the use of non-tunneled (...) %) in the heparin group (p < 0.025). The number of patients who developed catheter dysfunction in the citrate group was similar to those in the heparin group. The incidence of catheter-site infection, thrombosis, and local bleeding in the citrate group was similar to that in the heparin group.Citrate 4% lock solution is equally effective as heparin in maintaining catheter patency in dialysis patients. It may have a favorable effect on prevention of catheter-related infection due to its additional antiseptic

2018 Clinical nephrology Controlled trial quality: uncertain

6. Heparin versus normal saline for patency of arterial lines. Full Text available with Trip Pro

Heparin versus normal saline for patency of arterial lines. For most patients who require intensive care, the success of clinical decision making and interventions is dependent on the accuracy of different physiological variables measured or obtained from samples using an arterial catheter. Maintaining the patency of these catheters is therefore essential for obtaining accurate measures, minimizing patient discomfort and reducing expenses incurred when an occluded catheter requires replacement (...) . Uncertainty exists amongst clinicians as to best practice surrounding the contents of the arterial catheter flush solution (heparin or saline). The use of heparin is more expensive and is accompanied by significant risks such as haemorrhage, hypersensitivity and heparin-induced thrombocytopenia (HIT).The objective of this review was to evaluate whether normal saline is as efficacious and safe as heparin in maintaining the patency of arterial intravascular catheters in adult patients without

2014 Cochrane

7. Heparin Lock Solutions for Open-Ended Vascular Access Devices: An Update Regarding the Clinical Effectiveness, Safety, and Guidelines

Heparin Lock Solutions for Open-Ended Vascular Access Devices: An Update Regarding the Clinical Effectiveness, Safety, and Guidelines Heparin Lock Solutions for Open-Ended Vascular Access Devices: An Update Regarding the Clinical Effectiveness, Safety, and Guidelines | CADTH.ca Find the information you need Heparin Lock Solutions for Open-Ended Vascular Access Devices: An Update Regarding the Clinical Effectiveness, Safety, and Guidelines Heparin Lock Solutions for Open-Ended Vascular Access (...) Devices: An Update Regarding the Clinical Effectiveness, Safety, and Guidelines Published on: September 13, 2017 Project Number: RA0929-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness of heparin lock solutions to maintain the patency of open-ended central vascular access devices? What are the evidence-based guidelines associated with the use of heparin lock solutions to maintain the patency of open-ended central vascular

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Unfractionated Heparin and Low-Molecular-Weight Heparin

Unfractionated Heparin and Low-Molecular-Weight Heparin © 2013 Thrombosis Canada. Page 1 of 5 UNFRACTIONATED HEPARIN AND LOW-MOLECULAR-WEIGHT HEPARIN TARGET AUDIENCE: All Canadian health care professionals. OBJECTIVE: To aid practitioners in prescribing unfractionated heparin and low-molecular-weight heparins to patients. ABBREVIATIONS: ALT alanine aminotransferase aPTT activated partial thromboplastin time AST aspartate aminotransferase AT antithrombin CBC complete blood count HIT heparin (...) -induced thrombocytopenia INR international normalized ratio IV intravenous LMWH low-molecular-weight heparin MI myocardial infarction PT prothrombin time TNK tenecteplase tPA tissue plasminogen activator UFH unfractionated heparin U units VTE venous thromboembolism MECHANISM OF ACTION: Unfractionated heparin (UFH) acts as an anticoagulant by forming a complex with antithrombin (AT) catalysing the inhibition of several activated blood coagulation factors: thrombin (factor IIa), factor IXa, Xa, XIa

2015 Thrombosis Interest Group of Canada

9. Heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia Heparin-induced thrombocytopenia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Heparin-induced thrombocytopenia Last reviewed: February 2019 Last updated: May 2018 Summary A severe drug reaction to heparin that can lead to life- and limb-threatening venous and/or arterial thromboembolism. Diagnosis requires the combination of a compatible clinical picture and laboratory confirmation (...) of the presence of heparin-dependent platelet-activating HIT antibodies. Neither discontinuation of heparin alone nor initiation of a vitamin K antagonist alone (e.g., warfarin) is sufficient to stop the development of thrombosis in a patient with acute HIT. If clinical suspicion for HIT is at least moderate, all sources of heparin (including low molecular weight heparin) must be discontinued and initiation of treatment with a non-heparin anticoagulant considered. Definition Heparin-induced thrombocytopenia

2018 BMJ Best Practice

10. Low-molecular weight heparins versus warfarin for the long-term prevention or treatment of deep vein thrombosis or pulmonary embolism: a review of the clinical and cost-effectiveness

Low-molecular weight heparins versus warfarin for the long-term prevention or treatment of deep vein thrombosis or pulmonary embolism: a review of the clinical and cost-effectiveness Low-molecular weight heparins versus warfarin for the long-term prevention or treatment of deep vein thrombosis or pulmonary embolism: a review of the clinical and cost-effectiveness Low-molecular weight heparins versus warfarin for the long-term prevention or treatment of deep vein thrombosis or pulmonary embolism (...) : a review of the clinical and cost-effectiveness CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Low-molecular weight heparins versus warfarin for the long-term prevention or treatment of deep vein thrombosis or pulmonary embolism: a review of the clinical and cost-effectiveness. Ottawa: Canadian Agency for Drugs and Technologies

2014 Health Technology Assessment (HTA) Database.

12. The maintenance of totally implanted venous access devices: When the difference is made by the nursing practice: Correspondence about the paper "Normal saline versus heparin solution to lock totally implanted venous access devices: Results from a multicen (Abstract)

The maintenance of totally implanted venous access devices: When the difference is made by the nursing practice: Correspondence about the paper "Normal saline versus heparin solution to lock totally implanted venous access devices: Results from a multicen 26912415 2016 08 24 2018 12 02 1532-2122 21 2016 Apr European journal of oncology nursing : the official journal of European Oncology Nursing Society Eur J Oncol Nurs The maintenance of totally implanted venous access devices: When (...) the difference is made by the nursing practice: Correspondence about the paper "Normal saline versus heparin solution to lock totally implanted venous access devices: Results from a multicenter randomized trial" by Dal Molin et al. (EJON 19;2015:638-643). 272-3 10.1016/j.ejon.2016.02.005 S1462-3889(16)30012-6 Milani Alessandra A European Institute of Oncology (IEO), Milan, Italy; University of Milan, Italy. Electronic address: alessandra.milani@ieo.it. eng Letter Comment 2016 02 21 Scotland Eur J Oncol Nurs

2016 European journal of oncology nursing : the official journal of European Oncology Nursing Society Controlled trial quality: uncertain

13. Rapid immunoassays for diagnosis of heparin-induced thrombocytopenia: Comparison of diagnostic accuracy, reproducibility, and costs in clinical practice. Full Text available with Trip Pro

Rapid immunoassays for diagnosis of heparin-induced thrombocytopenia: Comparison of diagnostic accuracy, reproducibility, and costs in clinical practice. Immunoassays are crucial in the work-up of patients with suspected heparin-induced thrombocytopenia (HIT) and rapid tests have been recently developed. However, comparative data on diagnostic accuracy, reproducibility, and analytical costs of different immunoassays in clinical practice are limited.Samples of 179 consecutive patients evaluated (...) for suspected HIT in clinical practice using a polyspecific enzyme-linked immunoabsorbent assay (GTI diagnostics; ELISA) and a rapid particle gel immunoassay (PaGIA), were additionally analysed with a IgG-specific chemiluminescent immunoassay (AcuStar HIT-IgG). Presence of HIT was defined as a positive functional heparin-induced platelet aggregation test. Diagnostic accuracy was determined for low, intermediate and high thresholds as previously established (ELISA: optical density 0.4, 1.3, and 2.0

2017 PLoS ONE

14. Efficacy of normal saline solution versus heparin solution for maintaining patency of peripheral intravenous catheters in children

Efficacy of normal saline solution versus heparin solution for maintaining patency of peripheral intravenous catheters in children Efficacy of normal saline solution versus heparin solution for maintaining patency of peripheral intravenous catheters in children Efficacy of normal saline solution versus heparin solution for maintaining patency of peripheral intravenous catheters in children LeDuc K Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Using saline solution flush in maintaining patency of peripheral intermittent intravenous infusion devices (PIID) in paediatric emergency department (ED) patients requiring IV heparin lock placement. Type of intervention Treatment. Economic study type Cost-effectiveness analysis

1997 NHS Economic Evaluation Database.

15. Evaluating the safety and efficacy of regional citrate compared to systemic heparin as anticoagulation for continuous renal replacement therapy in critically ill patients: A service evaluation following a change in practice Full Text available with Trip Pro

Evaluating the safety and efficacy of regional citrate compared to systemic heparin as anticoagulation for continuous renal replacement therapy in critically ill patients: A service evaluation following a change in practice Following the implementation of citrate anticoagulation for continuous renal replacement therapy, we evaluate its first year of use and compare it to the previously used heparin, to assess whether our patients benefit from the recently reported advantages of citrate. We (...) retrospectively analysed 2 years of data to compare the safety and efficacy of citrate versus heparin. The results have shown that 43 patients received continuous renal replacement therapy with heparin, 37 patients with citrate. We found no significant difference in metabolic control of pH, urea and creatinine after 72 h. Filters anticoagulated with citrate had significantly longer median lifespan (33 h vs 17 h; p = 0.001), shorter downtime (0 h vs 5 h; p = 0.015) and less filter sets per patient day (0.37 vs

2017 Journal of the Intensive Care Society

16. Comparing normal saline versus diluted heparin to lock non-valved totally implantable venous access devices in cancer patients: a randomised, non-inferiority, open trial. Full Text available with Trip Pro

Comparing normal saline versus diluted heparin to lock non-valved totally implantable venous access devices in cancer patients: a randomised, non-inferiority, open trial. Heparin has been used for years as a locking solution in totally implantable venous access devices. Normal saline (NS) might be a safe alternative for heparin. However, evidence of non-inferiority of NS versus heparin is lacking.We randomly allocated 802 cancer patients with a newly inserted port either to heparin lock (300 U (...) /3 ml) or to NS lock groups in a 1:1 assignment ratio. The primary outcome was the number of functional complications, which was defined as 'easy injection, impossible aspiration' at port access. Secondary outcomes included all functional problems and catheter-related bacteraemia. We hypothesised that NS locks do not cause more functional problems and catheter-related bacteraemia than heparin locks. Non-inferiority is established if the upper limit of the confidence interval (CI) for the relative

2013 Annals of Oncology Controlled trial quality: predicted high

17. Heparin-induced thrombocytopenia: An international assessment of the quality of laboratory testing. (Abstract)

Heparin-induced thrombocytopenia: An international assessment of the quality of laboratory testing. Accurate diagnosis of heparin-induced thrombocytopenia (HIT) is essential to ensure timely treatment and prevent complications. Current diagnostic assays include enzyme-linked immunosorbent assays (ELISAs) and rapid immunoassays (RIs). RIs offer fast turnaround times but were not significantly represented in previous external proficiency testing challenges.To use external proficiency testing (...) to assess qualitative concordance for heparin/PF4 antibody detection.From 2013 to 2017, the External Quality Control for Assays and Tests (ECAT) Foundation distributed 10 samples internationally.In total, 437 laboratories submitted 3149 results. ELISAs accounted for 1484 (47%) responses with RIs accounting for 1665 (53%) responses. RI use increased over the 5-year period. ELISAs classified 96% of both consensus positive and consensus negative samples concordantly. The coefficient of variation (CV

2019 Journal of Thrombosis and Haemostasis

18. Clinical Effect of Low Molecular Weight Heparin Sodium Combined with Magnesium Sulfate in the Treatment of Patients with Severe Preeclampsia. Full Text available with Trip Pro

Clinical Effect of Low Molecular Weight Heparin Sodium Combined with Magnesium Sulfate in the Treatment of Patients with Severe Preeclampsia. To investigate the effect of low molecular weight heparin sodium combined with magnesium sulfate in the treatment of patients with severe preeclampsia.An experimental study.The Department of Obstetrics and Gynecology, The Affiliated Hospital, North China University of Science and Technology, from April 2016 to July 2017.Patients with severe preeclampsia (...) were randomly divided into observation group (52 cases) and control group (51 cases). In the control group, magnesium sulfate were used, but in observation group low molecular weight heparin sodium were added. After treatment of 7 days, serum TGF-β1, VCAM-1, ES levels and endothelial function markers of NO and ET-1 changes were compared between the two groups.The delivery status after treatment was observed in both groups.After treatment of 7 days, serum TGF-β1 and NO levels in the observation

2019 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Controlled trial quality: uncertain

19. Regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill patients with acute kidney injury (RICH) trial: study protocol for a multicentre, randomised controlled trial. Full Text available with Trip Pro

Regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill patients with acute kidney injury (RICH) trial: study protocol for a multicentre, randomised controlled trial. Acute kidney injury (AKI) is a well-recognised complication of critical illness which is of crucial importance for morbidity, mortality and health resource utilisation. Renal replacement therapy (RRT) inevitably entails an escalation of treatment complexity and increases (...) costs for those patients with severe AKI. However, it is still not clear whether regional citrate anticoagulation or systemic heparin anticoagulation for continuous RRT (CRRT) is most appropriate. We hypothesise that, in contrast to systemic heparin anticoagulation, regional citrate anticoagulation for CRRT prolongs filter life span and improves overall survival in a 90-day follow-up period (coprimary endpoints).We will conduct a prospective, randomised, multicentre, clinical trial including up

2019 BMJ open Controlled trial quality: uncertain

20. Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO

Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study (...) Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03318393 Recruitment Status : Recruiting First Posted : October 23, 2017 Last Update Posted : August 16, 2018

2017 Clinical Trials