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Latest & greatest articles for heparin
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Effect of low-dose heparin prophylaxis on arterial oxygen tension after high laparotomy. The effect of low doses of heparin (5000 units of sodium heparin every 12 hours for 5 days) on arterial oxygenation was studied in 24 patients in the postoperative period after upper abdominal surgery. Another 24 patients served as a control group. The arterial oxygen tension was the same in both groups preoperatively and was equally significantly reduced during the 1st postoperative day. During the 2nd day (...) , oxygen tension rose in the heparin-treated group to values which no longer differed significantly from the peroperative level. In the control group the significant reduction persisted until the 4th postoperative day. The arterial carbon-dioxide tension did not differ between the groups, neither did it vary significantly between days. There were no clinical signs of large pulmonary embolism during the postoperative period, chest X-ray was normal in all patients examined and a photoscan was normal
[Prevention of postoperative deep vein thrombosis with small doses of heparin]. 4426267 1975 01 22 2013 11 21 0012-7183 90 11 1974 Duodecim; laaketieteellinen aikakauskirja Duodecim [Prevention of postoperative deep vein thrombosis with small doses of heparin]. 834-8 Kettunen K K Poikolainen E E Karjalainen P P Oksala I I Alhava E E Rehnberg V V Huttunen H H Mattila M M fin Clinical Trial English Abstract Journal Article Randomized Controlled Trial Pienet hepariiniannokset postoperatiivisen (...) syvän laskimontukoksen profylaksina Finland Duodecim 0373207 0012-7183 9005-49-6 Heparin SY7Q814VUP Calcium IM Adult Aged Calcium administration & dosage therapeutic use Female Heparin administration & dosage adverse effects therapeutic use Humans Injections, Subcutaneous Male Middle Aged Postoperative Complications prevention & control Premedication Thrombophlebitis drug therapy prevention & control 1974 1 1 1974 1 1 0 1 1974 1 1 0 0 ppublish 4426267
Management of heparin therapy: Controlled prospective trial. Among 100 consecutive patients receiving heparin in therapeutic dosage, major bleeding occurred in 21, and minor bleeding in 16. Two patients died from bleeding, and two had recurrent pulmonary embolism. Major bleeding occurred in 21% when therapy was regulated with whole-blood clotting time and in 20% when heparin was given without clotting tests. In a subsequent prospective trial patients received heparin by intermittent intravenous (...) injection with or without laboratory control according to the partial thromboplastin time or continuously by intravenous infusion. Recurrent thromboembolism occurred once in each group. Major bleeding was seven times more frequent with intermittent injection than with continuous infusion. Control with the partial thromboplastin time did not prevent major bleeding in patients receiving intermittent injections. With continuous infusion, one-fourth less heparin was required than with intermittent
Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An international multicentre trial. The efficacy of low-dose heparin in preventing fatal postoperative pulmonary embolism has been investigated in a multicentre prospective randomised trial. 4121 patients over the age of forty years undergoing a variety of elective major surgical procedures were included in the trial; 2076 of these were in the control group and 2045 patients received heparin. The two groups were well (...) matched for age, sex, weight, blood-group, and other factors which could predispose to the development of venous thromboembolism. 180 (4-4 %) patients died during the postoperative period, 100 in the control and 80 in the heparin group: 72% of deaths in the control and 66% in the heparin group had necropsy examination. 16 patients in the control group and 2 in the heparin group were found at necropsy to have died due to acute massive pulmonary embolism (P smaller than 0-005). In addition, emboli found