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Latest & greatest articles for heart failure
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Quality of life and longâ€term mortality in patients with advanced chronic heart failuretreated with intermittent lowâ€dose intravenous inotropes in an outpatient setting 28451448 2018 11 13 2055-5822 4 2 2017 May ESC heart failureESCHeart Fail Quality of life and long-term mortality in patients with advanced chronic heart failuretreated with intermittent low-dose intravenous inotropes in an outpatient setting. 122-129 10.1002/ehf2.12114 There are limited data on the effect of low-dose (...) , intermittent inotropic therapy in an outpatient setting on the quality of life (QOL) in patients with advanced refractory heart failure (HF) symptoms. We aimed to analyse the effect of this treatment modality on QOL and subsequent survival. The study population comprised 287 consecutive patients with advanced refractory HFsymptomswho were treated with low-dose, intravenous intermittent inotropic therapy in the HFDayCare Service at Sheba Medical Centre between September 2000 and September 2012. All
Antiplatelet versus anticoagulation treatment for patients with heart failurein sinus rhythm. BACKGROUND: Morbidity in patients with chronic heart failureis high, and this predisposes them to thrombotic complications, including stroke and thromboembolism, which in turn contribute to high mortality. Oral anticoagulants (e.g. warfarin) and antiplatelet agents (e.g. aspirin) are the principle oral antithrombotic agents. Many heart failurepatients with sinus rhythm take aspirin because coronary artery (...) disease is the leading cause of heart failure. Oral anticoagulants have become a standard in the management of heart failurewith atrial fibrillation. However, a question remains regarding the appropriateness of oral anticoagulants in heart failurewith sinus rhythm. This update of a review previously published in 2012 aims to address this question. OBJECTIVES: To assess the effects of oral anticoagulant therapy versus antiplatelet agents for all-cause mortality, non-fatal cardiovascular events and risk of major
Sexual function of patients with heart failure: facts and numbers 28217306 2018 11 13 2055-5822 4 1 2017 Feb ESC heart failureESCHeart Fail Sexual function of patients with heart failure: facts and numbers. 3-7 10.1002/ehf2.12108 Approximately 60% to 87% of patients with heart failure (HF) reportsexual problems, and numbers as low as 31% of HFpatientsyounger than 70 have normal sexual function. When compared with healthy elders, the amount of perceived sexual dysfunction might be similar (...) (around 56%), but patients with HFarereporting more erectile dysfunction (ED) and also perceive that their HFsymptoms (20%) or HFmedication (10%) is the cause for their problems. The prevalence of ED is highly prevalent in men with cardiac disease and reported in up to 81% of cardiac patients, compared with 50% in the general older population. In total 25-76% of women with HFreportsexual problems or concerns. The physical effort related to sexual activity in cardiac patients can be compared
Cocoa flavanols reduce N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure. 27588209 2016 09 02 2017 02 20 2055-5822 3 2 2016 Jun ESC heart failureESCHeart Fail Cocoa flavanols reduce N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure. 97-106 Poor prognosis in chronic heart failure (HF) islinked to endothelial dysfunction for which there is no specific treatment currently available. Previous studies have shown reproducible (...) improvements in endothelial function with cocoa flavanols, but the clinical benefit of this effect in chronic HFhasyet to be determined. Therefore, the aim of this study was to assess the potential therapeutic value of a high dose of cocoa flavanols in patients with chronic HF, byusing reductions in N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an index of improved cardiac function. Thirty-two patients with chronic HF, stableon guideline-directed medical therapy, were randomized to consume
Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failurewith Mild Symptoms in Alberta, Canada 27300508 2016 07 27 2017 01 17 2017 01 17 1179-187X 16 5 2016 Oct American journal of cardiovascular drugs : drugs, devices, and other interventions Am J Cardiovasc Drugs Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failurewith Mild Symptoms in Alberta, Canada. 365-76 10.1007/s40256-016-0177-0 Eplerenone has been demonstrated as being cost effective (...) for the treatment of patients with systolic heart failure (HF) andmild symptoms in several jurisdictions; however, its cost effectiveness is unknown in the context of Alberta, Canada. We used a discrete-event simulation model to compare costs and outcomes between standard care and standard care plus eplerenone for the treatment of HFwithmild symptoms. We used Alberta data (whenever possible) together with a healthcare perspective, a lifetime horizon, and 3 % annual discount rate for analyses. Clinically
Age- and sex-related differences in use of guideline-recommended care and mortality among patients with incident heart failurein Denmark 27496924 2016 09 20 2016 09 20 1468-2834 45 5 2016 Sep Age and ageing Age Ageing Age- and sex-related differences in use of guideline-recommended care and mortality among patients with incident heart failurein Denmark. 635-42 10.1093/ageing/afw119 data are sparse on age- and sex-related differences in use of guideline-recommended care and subsequent (...) mortality among patients with heart failure (HF). weidentified 24,308 incident patients with a verified primary diagnosis of HFrecordedduring 2003-2010 in the Danish Heart FailureRegistry. The registry monitors guideline-recommended processes of care: echocardiography, New York Heart Association Classification, treatment with angiotensin converting enzyme inhibitors/angiotensin II receptor blockers, betablockers, physical training and patient education. older age was associated with lower use
Cost-Effectiveness of Sacubitril-Valsartan in Patients With Heart FailureWith Reduced Ejection Fraction. Background: Sacubitril-valsartan therapy reduces cardiovascular mortality compared with enalapril therapy in patients with heart failurewith reduced ejection fraction. Objective: To evaluate the cost-effectiveness of sacubitril-valsartan versus angiotensin-converting enzyme inhibitor therapy in patients with chronic heart failure. Design: Markov decision model. Data Sources: Clinical (...) trials, observational analyses, reimbursement data from the Centers for Medicare & Medicaid Services, drug pricing databases, and Centers for Disease Control and Prevention life tables. Target Population: Patients at an average age of 64 years, New York Heart Association (NYHA) class II to IV heart failure, and left ventricular ejection fraction of 0.40 or less. Time Horizon: Lifetime. Perspective: Societal. Intervention: Treatment with sacubitril-valsartan or lisinopril. Outcome Measures: Life
Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure. BACKGROUND: The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failurecaused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failurethat is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failurehas improved (...) since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). METHODS: In a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause
Correlation between inner strength and health-promoting behaviors in women with heart failure27757194 2018 11 13 2008-5842 8 8 2016 Aug Electronic physician Electron Physician Correlation between inner strength and health-promoting behaviors in women with heart failure. 2810-2817 Inner strength is a factor for mental health and well-being and, consequently, a dynamic component of holistic healing. Health-promoting behaviors are appropriate activities to improve health status and prevent (...) the progression of the functional defect resulting from heart failure. The present study aimed to determine the correlation between inner strength and health-promoting behaviors in women with heart failurereferred to hospitals affiliated with Shahid Beheshti University of Medical Sciences (SBMU) in 2013. In this cross-sectional study, 145 women with hearth failure were selected through convenient sampling from the clients referred to hospitals affiliated with SBMU. The data collection tool included a three
Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failureand Reduced Ejection Fraction: A Randomized Clinical Trial. IMPORTANCE: Abnormal cardiac metabolism contributes to the pathophysiology of advanced heart failurewith reduced left ventricular ejection fraction (LVEF). Glucagon-like peptide 1 (GLP-1) agonists have shown cardioprotective effects in early clinical studies of patients with advanced heart failure, irrespective of type 2 diabetes status. OBJECTIVE (...) : To test whether therapy with a GLP-1 agonist improves clinical stability following hospitalization for acute heart failure. DESIGN, SETTING, AND PARTICIPANTS: Phase 2, double-blind, placebo-controlled randomized clinical trial of patients with established heart failureand reduced LVEF who were recently hospitalized. Patients were enrolled between August 2013 and March 2015 at 24 US sites. INTERVENTIONS: The GLP-1 agonist liraglutide (n = 154) or placebo (n = 146) via a daily subcutaneous injection
Heart failureepidemiology and novel treatments in Japan: facts and numbers Heart failureepidemiology and novel treatments in Japan: facts and numbers Masaaki Konishi 1 * , Junichi Ishida 1 , Jochen Springer 1 , Stephan von Haehling 1 , Yoshihiro J. Akashi 2 , Hiroaki Shimokawa 3 and Stefan D. Anker 1 1 Innovative Clinical Trials, Department of Cardiology and Pneumology, University of Göttingen Medical School, Göttingen, Germany; 2 Division of Cardiology, Department of Internal Medicine, St (...) . Marianna University School of Medicine, Kawasaki, Japan; 3 Department of Cardiovascular Medicine,Tohoku University Graduate School of Medicine, Sendai, Japan Abstract Japan has the highest proportion of older people in the world, 25.9% of the population were aged 65 or above in 2014. Although there have been no population-based studies that precisely examined the prevalence of heart failurein Japan, one report estimated the number of Japanese outpatients with left ventricular dysfunction was 979, 000
Multimorbidity in Heart Failure: Effect on Outcomes 27348135 2016 07 12 2017 02 20 1532-5415 64 7 2016 Jul Journal of the American Geriatrics Society J Am Geriatr Soc Multimorbidity in Heart Failure: Effect on Outcomes. 1469-74 10.1111/jgs.14206 To investigate the effect of the number and type of comorbid conditions on death and hospitalizations in individuals with incident heart failure (HF). Population-based cohort study. Olmsted County, Minnesota. Olmsted County, Minnesota, residents (...) with incident HFfrom2000 to 2010 (mean age 76 ± 14, 56% female) (N = 1,714). The prevalence of 16 chronic conditions obtained at HFdiagnosisclassified into three groups: cardiovascular (CV) related, other physical, and mental. The mean number of conditions per participant was 2.6 ± 1.5 for CV-related conditions, 1.3 ± 1.1 for other physical conditions, and 0.30 ± 0.61 for mental conditions. After a mean follow-up of 4.2 years, 1,073 deaths and 6,306 hospitalizations had occurred. After adjustment
Heart FailureAfterMyocardial Infarction Is Associated With Increased Risk of Cancer 27417004 2016 07 15 2017 02 20 1558-3597 68 3 2016 Jul 19 Journal of the American College of Cardiology J. Am. Coll. Cardiol. Heart FailureAfterMyocardial Infarction Is Associated With Increased Risk of Cancer. 265-71 10.1016/j.jacc.2016.04.053 S0735-1097(16)33130-8 Heart failure (HF) isassociated with excess morbidity and mortality for which noncardiac causes are increasingly recognized. The authors (...) previously described an increased risk of cancer among HFpatientscompared with community controls. This study examined whether HFwasassociated with an increased risk of subsequent cancer among a homogenous population of first myocardial infarction (MI) survivors. A prospective cohort study was conducted among Olmsted County, Minnesota, residents with incident MI from 2002 to 2010. Patients with prior cancer or HFdiagnoseswere excluded. A total of 1,081 participants (mean age 64 ± 15 years; 60% male
6-Year Change in High Sensitivity Cardiac Troponin-T and Risk for Subsequent Coronary Heart Disease, Heart Failureand Death 27439107 2018 10 01 2018 11 13 2380-6591 1 5 2016 08 01 JAMA cardiology JAMA Cardiol Six-Year Change in High-Sensitivity Cardiac Troponin T and Risk of Subsequent Coronary Heart Disease, Heart Failure, and Death. 519-28 10.1001/jamacardio.2016.0765 High-sensitivity cardiac troponin T (hs-cTnT) is a biomarker of cardiovascular risk and could be approved in the United (...) States for clinical use soon. However, data linking long-term temporal change in hs-cTnT to outcomes are limited, particularly in primary prevention settings. To examine the association of 6-year change in hs-cTnT with incident coronary heart disease (CHD), heart failure (HF), andall-cause mortality. This prospective observational cohort study, performed from January 1, 1990, to December 31, 2011, included 8838 participants with biracial representation from the Atherosclerosis Risk in Communities
Popeye’s new spinach: IV iron for heart
Accuracy of Point-of-Care B-Line Lung Ultrasound in Comparison to NT-ProBNP for Screening Acute Heart Failure27689182 2016 10 05 2018 11 13 2509-596X 2 3 2016 Sep Ultrasound international open Ultrasound Int Open Accuracy of Point-of-Care B-Line Lung Ultrasound in Comparison to NT-ProBNP for Screening Acute Heart Failure. E90-2 10.1055/s-0042-108343 The objective of this pilot study was to determine the accuracy of point-of-care B-line lung ultrasound in comparison to NT Pro-BNP for screening (...) acute heart failure. An 8-zone lung ultrasound was performed by experienced sonographers in patients presenting with acute dyspnea in the ED. AHF was determined as the final diagnosis by 2 independent reviewers. Contrary to prior studies, B-line ultrasound in our study was highly specific, but moderately sensitive for identifying patients with AHF. There was a strong association between elevated NT-proBNP levels and an increased number of B-lines. In conclusion, point-of-care lung ultrasound