Latest & greatest articles for headache

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on headache or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on headache and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for headache

1. Migraine and Tension Headache

with sumatriptan 85/naproxen sodium 500 in (truly) episodic migraine: what's neck pain got to do with it? Postgrad Med. 2014 Mar;126(2):86-90. Créac'h C, Frappe P, Cancade M, et al. In-patient versus out-patient withdrawal programmes for medication overuse headache: a 2- year randomized trial. Cephalalgia. 2011 Aug;31(11):1189-1198. Cull RE. Investigation of late-onset migraine. Scott Med J. 1995 Apr;40(2):50-52. Deitch K, Kuhfahl K, Kinzler D, et al. A Randomized, Double-blind Comparison of Single Dose (...) , Freitag FG. Ibuprofen plus caffeine in the treatment of tension-type headache. Cephalalgia. 2000 Jul;20(6):597-602. Facco E, Liguori A, Petti F, Fauci AJ, Cavallin F, Zanette G. Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study. Minerva Anestesiol. 2013 Jun;79(6):634-642. Fan W, Lv Y, Ying G, Li W, Zhou J. Pilot study of amitriptyline in the prophylactic treatment of medication-overuse headache: a 1-year follow-up. Pain Med. 2014 Oct;15(10

2018 Kaiser Permanente Clinical Guidelines

2. Acupuncture for migraine headaches

Acupuncture for migraine headaches Acupuncture for migraine headaches Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Acupuncture for migraine headaches View/ Open Date 2010-04 Format Metadata Abstract Acupuncture reduces the frequency of migraine headaches when used as an adjunct to, or in place of, medical management

2019 Clinical Inquiries

3. Headache

are relatively similar with 83%–99% sensitivity and specificity [62]. MRA of the neck is most commonly performed with gadolinium contrast, whereas MRA of the head is most commonly performed without contrast. MRA of the brain with contrast is generally indicated if embolization coils or intracranial stents have been placed [63]. Headache of Trigeminal Autonomic Origin Trigeminal autonomic cephalgia is a group of primary headache disorders characterized by pain in unilateral trigeminal distribution (...) , but head MRI may be appropriate since secondary causes need to be excluded. Head MRA and CTA are not usually indicated initially. The ophthalmic form of trigeminal neuralgia may be confused with these entities [64-66]. Clusters of severe, strictly unilateral pain lasting a few hours at most characterize a cluster headache. It is often accompanied by ipsilateral Horner syndrome, tearing, and nasal congestion. The pain stays on the same side from attack to attack. The clusters typically last several

2019 American College of Radiology

4. Pathophysiology and Treatment of Migraine and Related Headache (Treatment)

the Cerena Transcranial Magnetic Stimulator (Cerena TMS), the first device to relieve pain caused by migraine headache with aura for use in patients aged 18 years and older. Users hold the device with both hands to the back of the head and press a button to release a pulse of magnetic energy that stimulates the occipital cortex. The recommended daily usage of the device is not to exceed one treatment in 24 hours. [ , ] Approval for the Cerena TMS was based on a randomized study of 201 patients (...) with moderate to strong migraine headaches, in which 39% of the patients using the device were pain-free 2 hours following its use, relative to 22% of control patients (therapeutic gain: 17%). [ , ] At 24 hours, nearly 34% of patients treated with the device were pain-free, compared with 10% of the control group. Contraindications and precautions regarding the use of the Cerena TMS include the following [ , ] : Do not use for patients with any metal in the head, neck, or upper body that is attracted

2014 eMedicine.com

5. Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache

the following clinical questions: (1) In the adult emergency department patient presenting with acute headache, are 60 there risk-stratification strategies that reliably identify the need for emergent neuroimaging? (2) In the adult 61 emergency department patient treated for acute primary headache, are nonopioids preferred to opioid medications? 62 (3) In the adult emergency department patient presenting with acute headache, does a normal noncontrast head 63 computed tomography scan performed within 6 hours (...) of headache onset preclude the need for further diagnostic 64 workup for subarachnoid hemorrhage? (4) In the adult emergency department patient who is still considered to be 65 at risk for subarachnoid hemorrhage after a negative noncontrast head computed tomography, is computed 66 tomography angiography of the head as effective as lumbar puncture to safely rule out subarachnoid hemorrhage? 67 Evidence was graded and recommendations were made based on the strength of the available data. 68 69 INTRODUCTION

2019 American College of Emergency Physicians

6. A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain

A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain Watson CP, Gilron I, Sawynok J CRD summary The review concluded that at least three classes of oral analgesics were effective for neuropathic pain (...) : antidepressants, opioids and gabapentinoids. Multimodal treatment and combining drugs with different action modes may provide more effective treatment for neuropathic pain and required further research. The reliability of the authors’ conclusions is unclear due to potential limitations in the review process and limited evidence. Authors' objectives To evaluate the safety and efficacy of oral analgesics in neuropathic pain in head-to-head randomised controlled trials. Searching MEDLINE and The Cochrane Library

2010 DARE.

7. Headache

Headache Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Evidence Maps

8. Pathophysiology and Treatment of Migraine and Related Headache (Overview)

== processing > Migraine Headache Updated: Jan 31, 2019 Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD Share Email Print Feedback Close Sections Sections Migraine Headache Overview Practice Essentials Migraine is a complex disorder characterized by recurrent episodes of headache, most often unilateral and in some cases associated with visual or sensory symptoms—collectively known as an aura—that arise most often before the head pain but that may occur during or afterward (see the image (...) and ocular area, but the pain may be felt anywhere around the head or neck Pain builds up over a period of 1–2 hours, progressing posteriorly and becoming diffuse Headache lasts 4–72 hours Nausea (80%) and vomiting (50%), including anorexia and food intolerance, and light-headedness Sensitivity to light and sound Features of migraine aura are as follows: May precede or accompany the headache phase or may occur in isolation Usually develops over 5–20 minutes and lasts less than 60 minutes Most commonly

2014 eMedicine.com

9. Guideline for primary care management of headache in adults

presenting with headache for the first time or those with a change in headache pattern Explore the following important elements of the headache history: Headache onset (thunderclap, head or neck trauma), previous attacks (progression of symptoms), duration of attacks (< 3 hours, > 4 hours, continuous), days per month with headache Pain location (unilateral, bilateral, associated neck pain, etc) Headache-associated symptoms (nausea, vomiting, photophobia, conjunctival injection, rhinorrhea, etc (...) and nearly 1 million men experience migraine. About 90% of migraine sufferers report moderate to severe pain, with 75% reporting impaired function and 33% requiring bed rest during an attack. The economic effects of headache are also substantial. It is estimated that headache accounts for 20% of work absences. Vast quantities of over-the-counter medications are taken for headache disorders, and treatment is often suboptimal. , Although most migraine sufferers use acute treatment to relieve

2015 Institute of Health Economics

10. Injection of Botulinum Toxin (Botox) for Prophylaxis of Headaches in Adults with Chronic Migraine

related to botulinum toxin type A (BOTOX ® ), lyophilised powder 100 units, for prophylaxis of headaches in adults with chronic migraine. The recommended dose is 155 units to 195 units, with injections divided across seven specific head and neck areas, and including fixed-site, fixed-dose injections at 31 sites, totalling 155 units and up to an additional 40 units to eight ‘follow the pain’ sites. The drug is administered using a 30-gauge, 0.5 inch needle as 0.1 mL (5 units) injections per site. BOTOX (...) Injection of Botulinum Toxin (Botox) for Prophylaxis of Headaches in Adults with Chronic Migraine 1/5 Public Summary Document Application No. 1168 – Botulinum toxin type A for the prophylaxis of headaches in patients with chronic migraine Sponsor/Applicant/s: Allergan Australia Pty Ltd Date of MSAC consideration: 1 August 2013 1. Purpose of application In February 2011, an application to the Medical Services Advisory Committee (MSAC) was received from Allergan Australia Pty Ltd for injection

2013 Medical Services Advisory Committee

11. Tension-type headache

Tension-type headache Tension-type headache - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Tension-type headache Last reviewed: February 2019 Last updated: July 2018 Summary Tension-type headaches can be either episodic or chronic. Stress and mental tension are common triggers. Symptoms include dull, non-pulsatile, bilateral, constricting pain (not severe); pericranial tenderness is common. Unlike migraine (...) care and usually successfully self-treat. The attacks are generalised throughout the head with a predilection for involving the frontal and occipital regions. The pain is typically expressed as being a 'tight band' around the head. It does not worsen with routine physical activity. History and exam presence of risk factors generalised head pain frontal or occipital head pain non-pulsatile head pain constricting pain normal neurological examination pericranial tenderness sternocleidomastoid muscle

2018 BMJ Best Practice

12. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort Full Text available with Trip Pro

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthritis and chronic pain, and to analyze preferred cannabis strains, biochemical profiles, and prescription medication (...) substitutions with cannabis.Via electronic survey in medicinal cannabis patients with headache, arthritis, and chronic pain, demographics and patterns of cannabis use including methods, frequency, quantity, preferred strains, cannabinoid and terpene profiles, and prescription substitutions were recorded. Cannabis use for migraine among headache patients was assessed via the ID Migraine™ questionnaire, a validated screen used to predict the probability of migraine.Of 2032 patients, 21 illnesses were treated

2018 The journal of headache and pain

13. The efficacy of acupuncture in the treatment of cephalalgia/ migraine and different conditions

of this assessment has been made for the HTA database. Citation Martinez Pecino F, Sola Arnau I, Betina Nishishinya Aquino M. The efficacy of acupuncture in the treatment of cephalalgia/ migraine and different conditions. Seville: Andalusian Agency for Health Technology Assessment (AETSA). AETSA 2006/04. 2007 Authors' objectives To evaluate the efficacy of acupuncture in the treatment of cephalalgia/ migraine and any pathology or health issue in which pain is not the main symptom. In addition to cephalalgia (...) by CRD MeSH Acupuncture Therapy; Headaches; Migraine Disorders; Pain /prevention & control /therapy Language Published Spanish Country of organisation Spain English Summary English summary available Address for correspondence Avda. de la Innovacion, s/n. Edificio Arena-1, ES-41020 Sevilla, SPAIN, Tel: +34 95 500 6638, Fax: +34 95 500 6677 Email: josea.navarro.sspa@juntadeandalucia.es AccessionNumber 32008100057 Date abstract record published 30/09/2008 Health Technology Assessment (HTA) database

2007 Health Technology Assessment (HTA) Database.

14. Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency

Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency UTCAT3159, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Melatonin Is Superior to Amitriptyline for Headache Prevention Based on the Proportion of Patients Who Improved >50% in Headache Frequency Clinical Question In adults with migraine headaches, is melatonin superior than (...) amitriptyline in preventing the frequency and intensity of migraine headaches? Clinical Bottom Line For patients with migraine headaches, melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline, and as effective as amitriptyline 25 mg. Tolerability measures included the incidences of adverse events, including those that led to the premature withdrawal from the study as well as those that were life threatening. Best Evidence (you may view more info by clicking

2017 UTHSCSA Dental School CAT Library

15. Acupuncture for migraine headaches

Acupuncture for migraine headaches Acupuncture for migraine headaches Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Acupuncture for migraine headaches View/ Open Date 2010-04 Format Metadata Abstract Acupuncture reduces the frequency of migraine headaches when used as an adjunct to, or in place of, medical management

2019 Clinical Inquiries

16. Headache, Migraine (Overview)

31, 2019 Author: Jasvinder Chawla, MD, MBA; Chief Editor: Helmi L Lutsep, MD Share Email Print Feedback Close Sections Sections Migraine Headache Overview Practice Essentials Migraine is a complex disorder characterized by recurrent episodes of headache, most often unilateral and in some cases associated with visual or sensory symptoms—collectively known as an aura—that arise most often before the head pain but that may occur during or afterward (see the image below). Migraine is most common (...) be felt anywhere around the head or neck Pain builds up over a period of 1–2 hours, progressing posteriorly and becoming diffuse Headache lasts 4–72 hours Nausea (80%) and vomiting (50%), including anorexia and food intolerance, and light-headedness Sensitivity to light and sound Features of migraine aura are as follows: May precede or accompany the headache phase or may occur in isolation Usually develops over 5–20 minutes and lasts less than 60 minutes Most commonly visual but can be sensory, motor

2014 eMedicine.com

17. Pathophysiology and Treatment of Migraine and Related Headache (Follow-up)

the Cerena Transcranial Magnetic Stimulator (Cerena TMS), the first device to relieve pain caused by migraine headache with aura for use in patients aged 18 years and older. Users hold the device with both hands to the back of the head and press a button to release a pulse of magnetic energy that stimulates the occipital cortex. The recommended daily usage of the device is not to exceed one treatment in 24 hours. [ , ] Approval for the Cerena TMS was based on a randomized study of 201 patients (...) with moderate to strong migraine headaches, in which 39% of the patients using the device were pain-free 2 hours following its use, relative to 22% of control patients (therapeutic gain: 17%). [ , ] At 24 hours, nearly 34% of patients treated with the device were pain-free, compared with 10% of the control group. Contraindications and precautions regarding the use of the Cerena TMS include the following [ , ] : Do not use for patients with any metal in the head, neck, or upper body that is attracted

2014 eMedicine.com

18. Headache, Migraine (Treatment)

the Cerena Transcranial Magnetic Stimulator (Cerena TMS), the first device to relieve pain caused by migraine headache with aura for use in patients aged 18 years and older. Users hold the device with both hands to the back of the head and press a button to release a pulse of magnetic energy that stimulates the occipital cortex. The recommended daily usage of the device is not to exceed one treatment in 24 hours. [ , ] Approval for the Cerena TMS was based on a randomized study of 201 patients (...) with moderate to strong migraine headaches, in which 39% of the patients using the device were pain-free 2 hours following its use, relative to 22% of control patients (therapeutic gain: 17%). [ , ] At 24 hours, nearly 34% of patients treated with the device were pain-free, compared with 10% of the control group. Contraindications and precautions regarding the use of the Cerena TMS include the following [ , ] : Do not use for patients with any metal in the head, neck, or upper body that is attracted

2014 eMedicine.com

19. Headache

hours prior to headache Aura (25%) - onset one hour before headache begins; visual, auditory and motor issues Headache phase Postdrome - feeling of exhaustion, and sudden head movement can cause transient pain Cluster headache Rarest form of headache Onset age 25-50 years old Will have several attacks over a period of time, and then goes into remission for months or years Severe unilateral, orbital or temporal pain Each attack lasts 15 minutes to three hours May also cause tearing, nasal congestion (...) , birth control, corticosteroids, hormone replacement therapy, decongestants, SSRIs) Withdrawal from medications (e.g. opioids, caffeine, benzodiazepines, SSRIs, psychotropics) Uncontrolled hypertension Shingles and post-herpetic neuralgia – head and facial pain near area of herpetic eruption Sinusitis, otitis media or a dental abscess may cause headache symptoms; suspect if pain is localized to structures in the head and neck (e.g. eyes, ears, sinuses, temporomandibular joint, teeth or neck) : Can

2018 medSask

20. Migraine headache in adults

to light sensitivity to noise aura vomiting unilateral throbbing sensation family history of migraine high caffeine intake exposure to change in barometric pressure female sex obesity habitual snoring stressful life events overuse of headache medications lack of sleep low socio-economic status allergies or asthma hypertension hypothyroidism diet Diagnostic investigations clinical diagnosis erythrocyte sedimentation rate (ESR) lumbar puncture (LP) cerebrospinal fluid (CSF) culture CT head MRI brain (...) Migraine headache in adults Migraine headache in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Migraine headache in adults Last reviewed: February 2019 Last updated: October 2018 Summary Migraine is a chronic, genetically determined, episodic, neurological disorder that usually presents in early-to-mid life. Patients complain of intermittent headache and associated symptoms, such as visual disturbance

2018 BMJ Best Practice