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Latest & greatest articles for gestational diabetes
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Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestationaldiabetes planning pregnancy, or pregnant women with pre-existing diabetes. While most guidance recommends the use of insulin in women whose pregnancies are affected by pre-existing diabetes, oral anti-diabetic agents may be more acceptable to women. The effects of these oral anti-diabetic agents on maternal and infant health outcomes need to be established in pregnant women with pre (...) -existing diabetes or impaired glucose tolerance, as well as in women with previous gestationaldiabetes mellitus preconceptionally or during a subsequent pregnancy. This review is an update of a review that was first published in 2010.To investigate the effects of oral anti-diabetic agents in women with established diabetes, impaired glucose tolerance or previous gestationaldiabetes who are planning a pregnancy, or pregnant women with pre-existing diabetes, on maternal and infant health. The use
Gestationaldiabetes mellitus: The prevalence, associated factors and foeto-maternal outcome of women attending antenatal care The aim of the study is to determine the prevalence of gestationaldiabetes mellitus (GDM), its associated risk factors, foeto-maternal outcomes and prevalence of postnatal diabetes mellitus (DM).This is a cross-sectional study using retrospective data from existing antenatal records of new antenatal women who registered at 72 public health clinics in Selangor
Interconception care for women with a history of gestationaldiabetes for improving maternal and infant outcomes. Gestationaldiabetes mellitus (GDM) is associated with adverse health outcomes for mothers and their infants both perinatally and long term. Women with a history of GDM are at risk of recurrence in subsequent pregnancies and may benefit from intervention in the interconception period to improve maternal and infant health outcomes.To assess the effects of interconception care
Screening for gestationaldiabetes mellitus based on different risk profiles and settings for improving maternal and infant health. Gestationaldiabetes mellitus (GDM) is a form of diabetes that occurs in pregnancy. Although GDM usually resolves following birth, it is associated with significant morbidities for mothers and their infants in the short and long term. There is strong evidence to support treatment for GDM. However, there is uncertainty as to whether or not screening all pregnant (...) women for GDM will improve maternal and infant health and if so, the most appropriate setting for screening. This review updates a Cochrane Review, first published in 2010, and subsequently updated in 2014.To assess the effects of screening for gestationaldiabetes mellitus based on different risk profiles and settings on maternal and infant outcomes.We searched Cochrane Pregnancy and Childbirth's Trials Register (31 January 2017), ClinicalTrials.gov, the WHO International Clinical Trials Registry
GestationalDiabetes Mellitus and Frequency of Blood Glucose Monitoring: A Randomized Controlled Trial To assess whether testing blood glucose four times daily compared with four times every other day would lead to similar birth weights among patients with gestationaldiabetes mellitus (GDM).This noninferiority randomized controlled trial was conducted at five centers. After receiving a diagnosis of GDM, women tested their blood glucose every day for 7 days. After that period, compliant women (...) were randomized, 149 (51%) were tested four times a day and 144 (49%) were tested every other day. Between the two groups, there were no significant differences with regard to need for medical treatment, induction, gestational age at delivery, mode of delivery, rate of preeclampsia, or shoulder dystocia. Birth weight was similar between both groups and the upper bound of the 90% confidence interval (CI) was less than 165 g, establishing noninferiority with a mean difference of -41 g (90% CI -137
Exercise for pregnant women with gestationaldiabetes for improving maternal and fetal outcomes. Gestationaldiabetes mellitus (GDM) is associated with both short- and long-term complications for the mother and her baby. Exercise interventions may be useful in helping with glycaemic control and improve maternal and infant outcomes.The original review on Exercise for diabetic pregnant women has been split into two new review titles reflecting the role of exercise for pregnant women (...) with gestationaldiabetes and for pregnant women with pre-existing diabetes. Exercise for pregnant women with gestationaldiabetes for improving maternal and fetal outcomes (this review) Exercise for pregnant women with pre-existing diabetes for improving maternal and fetal outcomes OBJECTIVES: To evaluate the effects of exercise interventions for improving maternal and fetal outcomes in women with GDM.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (27 August 2016
Sensitivity of postnatal fasting plasma glucose in identifying impaired glucose tolerance in women with gestationaldiabetes â€“ 25 Yearsâ€™ data To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance.Retrospective study of 1961 women diagnosed with gestationaldiabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery.Of 1961 women, 1090 (56
Childhood maltreatment and inflammation among pregnant women with gestationaldiabetes mellitus: A pilot study Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes.This pilot study was a secondary data analysis of 24 women with gestationaldiabetes mellitus; 17% of the sample also reported (...) in pregnant women diagnosed with gestationaldiabetes mellitus.
Lifestyle interventions for the treatment of women with gestationaldiabetes. Gestationaldiabetes (GDM) is glucose intolerance, first recognised in pregnancy and usually resolving after birth. GDM is associated with both short- and long-term adverse effects for the mother and her infant. Lifestyle interventions are the primary therapeutic strategy for many women with GDM.To evaluate the effects of combined lifestyle interventions with or without pharmacotherapy in treating women (...) with gestational diabetes.We searched the Pregnancy and Childbirth Group's Trials Register (14 May 2016), ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP) (14th May 2016) and reference lists of retrieved studies.We included only randomised controlled trials comparing a lifestyle intervention with usual care or another intervention for the treatment of pregnant women with GDM. Quasi-randomised trials were excluded. Cross-over trials were not eligible for inclusion. Women with pre
Periodontal Disease is a Risk Factor for the Development of GestationalDiabetes Mellitus UTCAT3223, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Periodontal Disease is a Risk Factor for the Development of GestationalDiabetes Mellitus Clinical Question In pregnant women, does having periodontal disease increase the risk of gestationaldiabetes mellitus (GDM)? Clinical Bottom Line Studies have shown that periodontal (...) disease and its inflammatory mediators are associated with an increased risk for the development of gestationaldiabetes. This is based on a meta-analysis of 5,724 pregnant patients including 624 cases of GDM. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Abariga/2016 Females with periodontal disease Meta-Analysis Key results Forty-four articles were reviewed, and 10 studies met the eligibility criteria
High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With GestationalDiabetes Mellitus Gestationaldiabetes mellitus (GDM), defined as any degree of glucose intolerance with first recognition during pregnancy, is a heterogeneous form of diabetes characterized by various degrees of β-cell dysfunction.We aimed to estimate the prevalence of possibly pathogenic variants in the maturity-onset diabetes of the young genes GCK, HNF1A, HNF4A, HNF1B, and INS among women (...) in anthropometric traits, high-sensitivity C-Reactive Protein (CRP), and glucose metabolism were measured.At baseline, 17 possibly disease-causing variants were found in 21 women, revealing a combined GCK, HNF1A, HNF4A, HNF1B, and INS variant prevalence of 5.9% (95% confidence interval: 3.5% to 8.4%). At follow-up, 15 out of 135 women with diabetes (11%) were carriers of variants in GCK, HNF1A, HNF4A, HNF1B, or INS.Almost 6% of Danish women with diet-treated GDM have possibly pathogenic variants in GCK, HNF1A
Correlation of the plasma sphingoid base profile with results from oral glucose tolerance tests in gestationaldiabetes mellitus Oral glucose tolerance test (OGTT) is usually insufficient to accurately predict the risk for type 2 diabetes mellitus (T2DM), it is therefore necessary to identify an additional biomarker that would most likely improve the accuracy of OGTT. The current OGTT was performed in 53 volunteers after ingestion of 75 g glucose in 250 ml water to each volunteer. Similarly (...) with gestationaldiabetes in comparison with normal subjects. These findings underlined that 1-deoxysphingolipids (1-deoxySLs) and their ratios with C18SAdiene could be significantly correlated with the glucose load of OGTT and might be used as predictive biomarkers along with OGTT for the risk assessment of diabetes.
The Prevention of GestationalDiabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial This study investigated if inositol in a combination of myo-inositol and D-chiro-inositol would prevent gestationaldiabetes mellitus (GDM) in women with a family history of diabetes.This was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents GDM. The trial was carried out in a single-center tertiary referral center. Women (...) with a family history of diabetes were enrolled at the first antenatal visit. They were randomized to the intervention group, which received a combination of 1,100 mg myo-inositol, 27.6 mg D-chiro-inositol, and 400 μg folic acid, or to the control group, which received 400 μg folic acid only. All women had an oral glucose tolerance test between 24 and 28 weeks' gestation. The primary end point was the incidence of GDM. Statistical analysis was carried out using SPSS Statistical Package version 20.Two
Different types of dietary advice for women with gestationaldiabetes mellitus. Dietary advice is the main strategy for managing gestationaldiabetes mellitus (GDM). It remains unclear what type of advice is best.To assess the effects of different types of dietary advice for women with GDM for improving health outcomes for women and babies.We searched Cochrane Pregnancy and Childbirth's Trials Register (8 March 2016), PSANZ's Trials Registry (22 March 2016) and reference lists of retrieved (...) studies.Randomised controlled trials comparing the effects of different types of dietary advice for women with GDM.Two authors independently assessed study eligibility, risk of bias, and extracted data. Evidence quality for two comparisons was assessed using GRADE, for primary outcomes for the mother: hypertensive disorders of pregnancy; caesarean section; type 2 diabetes mellitus; and child: large-for-gestational age; perinatal mortality; neonatal mortality or morbidity composite; neurosensory disability
Prevention of gestationaldiabetes in pregnant women with risk factors for gestationaldiabetes: a systematic review and meta-analysis of randomised trials. Gestationaldiabetes mellitus can be defined as 'glucose intolerance or hyperglycaemia with onset or first recognition during pregnancy.'The objective of our systematic review was to see if there was any intervention that could be used for primary prevention of gestationaldiabetes mellitus in women with risk factors for gestational (...) diabetes mellitus.Major databases were searched from 1966 to Aug 2012 without language restriction.Randomised trials comparing intervention with standard care in women with risk factors for gestationaldiabetes were included. Meta-analysis was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. The primary outcome assessed was the incidence of gestational diabetes.Data from included trials were extracted independently by two authors and analysed
Oral anti-diabetic pharmacological therapies for the treatment of women with gestationaldiabetes. Gestationaldiabetes mellitus (GDM) is a major public health issue with rates increasing globally. Gestationaldiabetes, glucose intolerance first recognised during pregnancy, usually resolves after birth and is associated with short- and long-term complications for the mother and her infant. Treatment options can include oral anti-diabetic pharmacological therapies.To evaluate the effects of oral (...) women, very low-quality evidence), perineal trauma (RR 0.98, 95% CI 0.06 to 15.62; one study, 375 women, very low-quality evidence) or induction of labour (RR 1.18, 95% CI 0.79 to 1.76; one study, 375 women; very low-quality evidence). No data were reported for development of type 2 diabetes or other pre-specified GRADE maternal outcomes (return to pre-pregnancy weight, postnatal depression). For the infant, there was no evidence of a difference in the risk of being born large-for-gestational age
Dietary advice interventions in pregnancy for preventing gestationaldiabetes mellitus. Gestationaldiabetes mellitus (GDM) is a form of diabetes occurring during pregnancy which can result in short- and long-term adverse outcomes for women and babies. With an increasing prevalence worldwide, there is a need to assess strategies, including dietary advice interventions, that might prevent GDM.To assess the effects of dietary advice interventions for preventing GDM and associated adverse health (...) , 201 women; GRADE: very low-quality evidence) and gestational weight gain (MD -1.23 kg, 95% CI -4.08 to 1.61; four trials, 787 women; Tau² = 7.31; I² = 90%; GRADE: very low-quality evidence), or for other reported secondary outcomes.The trials did not report the majority of secondary outcomes including those related to long-term health and health service use and costs. We were not able to assess the following outcomes using GRADE: perineal trauma; postnatal depression; maternal type 2 diabetes
Perceived needs in women with gestationaldiabetes: A qualitative study Diabetes is the most common medical complication of pregnancy. It can be associated with many complications for mother and fetus. Gestationaldiabetes is also one of the main health issues in Iran. Therefore, the present study is aimed at a deeper understanding of women's experiences of gestationaldiabetes and their perceived needs to inform future lifestyle interventions.This qualitative content analysis study was carried (...) out in 2015. Participants were pregnant women diagnosed with gestationaldiabetes in the 24th to 36th week of pregnancy, who were referred to the clinics affiliated with Shahid Beheshti Medical Science University in Tehran, Iran. In-depth interviews were conducted with participants, using semi-structured questions. Interviews were audio taped and transcribed verbatim. Conventional content analysis was carried out for data analysis. Interviews continued until data saturation was obtained. Data were
Exercise and its role in gestationaldiabetes mellitus Gestationaldiabetes mellitus (GDM) refers to diabetes diagnosed in the second or third trimester of pregnancy that is not clearly either type 1 or type 2 diabetes. GDM is a common medical complication in pregnancy that has been rapidly increasing worldwide. GDM is associated with both short- and long-term health issues for both mothers and offspring. Consistent with type 2 diabetes, peripheral insulin resistance contributes