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Latest & greatest articles for gestational diabetes
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microRNA-503 contribute to pancreatic beta cell dysfunction by targeting the mTOR pathway in gestationaldiabetes mellitus Loss of pancreatic β cells is involved in pathogenesis of gestationaldiabetes mellitus (GDM). Recently, several studies have elucidated the connection between microRNAs (miRNAs) and diabetes mellitus (DM), but the role of miRNAs in GDM remains unclear. The aim of this study was to evaluate the potential functions of miRNAs in GDM and to investigate the underlying
Gestationaldiabetes mellitus: The prevalence, associated factors and foeto-maternal outcome of women attending antenatal care The aim of the study is to determine the prevalence of gestationaldiabetes mellitus (GDM), its associated risk factors, foeto-maternal outcomes and prevalence of postnatal diabetes mellitus (DM).This is a cross-sectional study using retrospective data from existing antenatal records of new antenatal women who registered at 72 public health clinics in Selangor (...) in January 2014.A total of 745 antenatal records were reviewed. The prevalence of GDM women was 27.9% (n = 184). GDM risks were higher in women aged 35 years old and above and in those with maternal obesity. GDM women had a higher risk of having a non-spontaneous vaginal delivery compared to non-GDM women. The prevalence of postnatal DM among GDM mother was 12.1%. Working GDM mothers were at higher risk of developing postnatal DM.The prevalence of GDM among newly registered women attending antenatal
Interconception care for women with a history of gestationaldiabetes for improving maternal and infant outcomes. Gestationaldiabetes mellitus (GDM) is associated with adverse health outcomes for mothers and their infants both perinatally and long term. Women with a history of GDM are at risk of recurrence in subsequent pregnancies and may benefit from intervention in the interconception period to improve maternal and infant health outcomes.To assess the effects of interconception care
GestationalDiabetes Mellitus and Frequency of Blood Glucose Monitoring: A Randomized Controlled Trial To assess whether testing blood glucose four times daily compared with four times every other day would lead to similar birth weights among patients with gestationaldiabetes mellitus (GDM).This noninferiority randomized controlled trial was conducted at five centers. After receiving a diagnosis of GDM, women tested their blood glucose every day for 7 days. After that period, compliant women (...) were randomized, 149 (51%) were tested four times a day and 144 (49%) were tested every other day. Between the two groups, there were no significant differences with regard to need for medical treatment, induction, gestational age at delivery, mode of delivery, rate of preeclampsia, or shoulder dystocia. Birth weight was similar between both groups and the upper bound of the 90% confidence interval (CI) was less than 165 g, establishing noninferiority with a mean difference of -41 g (90% CI -137
Association Between A Functional Polymorphism rs10830963 In Melatonin Receptor 1B And Risk Of GestationalDiabetes Mellitus: An Updated Meta-Analysis Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestationaldiabetes mellitus: an updated meta-analysis | bioRxiv Search for this keyword New Results Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestationaldiabetes mellitus: an updated meta-analysis Yu (...) ,541199, P.R. China Shi Qingfeng 2 Department of Obstetrics, The First Affiliated Hospital of Guilin Medical University , Guilin, 541001, P.R. China Yu Hongping 5 Affiliated Tumor Hospital of Guangxi Medical University , Nanning,530021, P.R. China For correspondence: Abstract The melatonin receptor 1B ( MTNR1B ) as a candidate gene for gestationaldiabetes mellitus (GDM) on the basis of its association with T2DM, β-cells function and fasting plasma glucose (FPG) level. Many studies have investigated
Sensitivity of postnatal fasting plasma glucose in identifying impaired glucose tolerance in women with gestationaldiabetes â€“ 25 Yearsâ€™ data To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance.Retrospective study of 1961 women diagnosed with gestationaldiabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery.Of 1961 women, 1090 (56
Childhood maltreatment and inflammation among pregnant women with gestationaldiabetes mellitus: A pilot study Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes.This pilot study was a secondary data analysis of 24 women with gestationaldiabetes mellitus; 17% of the sample also reported (...) in pregnant women diagnosed with gestationaldiabetes mellitus.
Periodontal Disease is a Risk Factor for the Development of GestationalDiabetes Mellitus UTCAT3223, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Periodontal Disease is a Risk Factor for the Development of GestationalDiabetes Mellitus Clinical Question In pregnant women, does having periodontal disease increase the risk of gestationaldiabetes mellitus (GDM)? Clinical Bottom Line Studies have shown that periodontal (...) disease and its inflammatory mediators are associated with an increased risk for the development of gestationaldiabetes. This is based on a meta-analysis of 5,724 pregnant patients including 624 cases of GDM. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Abariga/2016 Females with periodontal disease Meta-Analysis Key results Forty-four articles were reviewed, and 10 studies met the eligibility criteria
High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With GestationalDiabetes Mellitus Gestationaldiabetes mellitus (GDM), defined as any degree of glucose intolerance with first recognition during pregnancy, is a heterogeneous form of diabetes characterized by various degrees of β-cell dysfunction.We aimed to estimate the prevalence of possibly pathogenic variants in the maturity-onset diabetes of the young genes GCK, HNF1A, HNF4A, HNF1B, and INS among women (...) in anthropometric traits, high-sensitivity C-Reactive Protein (CRP), and glucose metabolism were measured.At baseline, 17 possibly disease-causing variants were found in 21 women, revealing a combined GCK, HNF1A, HNF4A, HNF1B, and INS variant prevalence of 5.9% (95% confidence interval: 3.5% to 8.4%). At follow-up, 15 out of 135 women with diabetes (11%) were carriers of variants in GCK, HNF1A, HNF4A, HNF1B, or INS.Almost 6% of Danish women with diet-treated GDM have possibly pathogenic variants in GCK, HNF1A
Correlation of the plasma sphingoid base profile with results from oral glucose tolerance tests in gestationaldiabetes mellitus Oral glucose tolerance test (OGTT) is usually insufficient to accurately predict the risk for type 2 diabetes mellitus (T2DM), it is therefore necessary to identify an additional biomarker that would most likely improve the accuracy of OGTT. The current OGTT was performed in 53 volunteers after ingestion of 75 g glucose in 250 ml water to each volunteer. Similarly (...) with gestationaldiabetes in comparison with normal subjects. These findings underlined that 1-deoxysphingolipids (1-deoxySLs) and their ratios with C18SAdiene could be significantly correlated with the glucose load of OGTT and might be used as predictive biomarkers along with OGTT for the risk assessment of diabetes.
The Prevention of GestationalDiabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial This study investigated if inositol in a combination of myo-inositol and D-chiro-inositol would prevent gestationaldiabetes mellitus (GDM) in women with a family history of diabetes.This was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents GDM. The trial was carried out in a single-center tertiary referral center. Women (...) with a family history of diabetes were enrolled at the first antenatal visit. They were randomized to the intervention group, which received a combination of 1,100 mg myo-inositol, 27.6 mg D-chiro-inositol, and 400 μg folic acid, or to the control group, which received 400 μg folic acid only. All women had an oral glucose tolerance test between 24 and 28 weeks' gestation. The primary end point was the incidence of GDM. Statistical analysis was carried out using SPSS Statistical Package version 20.Two
The Risk Factors of GestationalDiabetes Mellitus: A Systematic Review and Meta-Analysis Study International Journal of Women's Health and Reproduction Sciences Oct 2017, Vol 5, Issue 4 Advanced Search Title Authors Keyword For Author's & Reviewer's Poll How do you find the scientific quality of the published articles on our web site? Very good Good Fair Bad Very bad ] [ ] [ ] [ ] --> The Risk Factors of GestationalDiabetes Mellitus: A Systematic Review and Meta-Analysis Study , , , , 1 (...) , School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran IJWHR 2017; 5: 253-263 DOI: 10.15296/ijwhr.2017.44 Viewed : 3124 times Downloaded : 5293 times. Keywords : Gestationaldiabetes, risk factors, meta-analysis, Iran | Abstract --> Cite By, Google Scholar Articles by Articles by Articles by Articles by Articles by PubMed Articles by Articles by Articles by Articles by Articles by Publication Information Publisher Editors in Chief Deputy Editor
Pregnancy Health: Lifestyle Interventions to Reduce the Risk of GestationalDiabetes Pregnancy Health: GestationalDiabetes | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Recommended (strong evidence) December 2017 Audience Adults Parents/Caregivers Setting Clinical/Health Systems Community Strategy Counseling Health (...) Education Pregnancy Health: Lifestyle Interventions to Reduce the Risk of GestationalDiabetes Tabs Snapshot Summary of CPSTF Finding The lifestyle interventions delivered during the first two trimesters of pregnancy to reduce the risk of gestationaldiabetes. The CPSTF finds Strong evidence of effectiveness for lifestyle interventions that provide supervised exercise classes, either alone or in combination with other components Sufficient evidence of effectiveness for lifestyle interventions
Perceived needs in women with gestationaldiabetes: A qualitative study Diabetes is the most common medical complication of pregnancy. It can be associated with many complications for mother and fetus. Gestationaldiabetes is also one of the main health issues in Iran. Therefore, the present study is aimed at a deeper understanding of women's experiences of gestationaldiabetes and their perceived needs to inform future lifestyle interventions.This qualitative content analysis study was carried (...) out in 2015. Participants were pregnant women diagnosed with gestationaldiabetes in the 24th to 36th week of pregnancy, who were referred to the clinics affiliated with Shahid Beheshti Medical Science University in Tehran, Iran. In-depth interviews were conducted with participants, using semi-structured questions. Interviews were audio taped and transcribed verbatim. Conventional content analysis was carried out for data analysis. Interviews continued until data saturation was obtained. Data were
Exercise and its role in gestationaldiabetes mellitus Gestationaldiabetes mellitus (GDM) refers to diabetes diagnosed in the second or third trimester of pregnancy that is not clearly either type 1 or type 2 diabetes. GDM is a common medical complication in pregnancy that has been rapidly increasing worldwide. GDM is associated with both short- and long-term health issues for both mothers and offspring. Consistent with type 2 diabetes, peripheral insulin resistance contributes
Diagnosis, prevention and management of gestationaldiabetes mellitus 29063042 2019 01 16 2095-882X 2 4 2016 Dec Chronic diseases and translational medicine Chronic Dis Transl Med Diagnosis, prevention and management of gestationaldiabetes mellitus. 199-203 10.1016/j.cdtm.2016.11.004 Wang Chen C Department of Obstetrics and Gynecology of Peking University First Hospital, Beijing 100034, China. Yang Hui-Xia HX Department of Obstetrics and Gynecology of Peking University First Hospital, Beijing (...) 100034, China. eng Editorial 2016 12 04 China Chronic Dis Transl Med 101679934 2095-882X Diagnosis Gestationaldiabetes mellitus Management Postpartum follow-up Prevention 2016 08 10 2017 10 25 6 0 2017 10 25 6 0 2017 10 25 6 1 epublish 29063042 10.1016/j.cdtm.2016.11.004 S2095-882X(16)30062-7 PMC5643832 Int J Gynaecol Obstet. 2010 Oct;111(1):37-40 20542272 Diabetes Care. 2003 Aug;26(8):2261-7 12882846 BMC Pregnancy Childbirth. 2014 Jan 22;14:41 24450389 Obstet Gynecol Clin North Am. 2007 Jun;34(2
Regular Exercise to Prevent the Recurrence of GestationalDiabetes Mellitus: A Randomized Controlled Trial To investigate the effect of a supervised home-based exercise program on the recurrence and severity of gestationaldiabetes mellitus (GDM) together with other aspects of maternal health and obstetric and neonatal outcomes.This randomized controlled trial allocated women with a history of GDM to an exercise intervention (14-week supervised home-based stationary cycling program (...) ) or to a control group (standard care) at 13±1 weeks of gestation. The primary outcome was a diagnosis of GDM. Secondary outcomes included maternal fitness, psychological well-being, and obstetric and neonatal outcomes. A sample size of 180 (90 in each group) was required to attain 80% power to detect a 40% reduction in the incidence of GDM.Between June 2011 and July 2014, 205 women provided written consent and completed baseline assessments. Of these, 33 (16%) were subsequently excluded as a result
Dietary supplementation with myo-inositol in women during pregnancy for treating gestationaldiabetes. Gestationaldiabetes mellitus (GDM) is any degree of glucose intolerance that first presents and is recognised during pregnancy and usually resolves after the birth of the baby. GDM is associated with increased short- and long-term morbidity for the mother and her baby. Treatment usually includes lifestyle modification and/or pharmacological therapy (oral antidiabetic agents or insulin (...) of myo-inositol for the treatment of gestationaldiabetes, with no data to examine the majority of outcomes in this review. There do not appear to be any benefits for the infant associated with exposure to myo-inositol such as reduced risk of being born large-for-gestational age. Although the risk of neonatal hypoglycaemia is reduced for the myo-inositol group, there is evidence of imprecision. Evidence from two studies suggested that myo-inositol was associated with a reduced change in maternal BMI
2016CochraneControlled trial quality: predicted high
Risk perception and unrecognized type 2 diabetes in women with previous gestationaldiabetes mellitus. Women with a history of gestationaldiabetes mellitus (GDM) have a high chance of developing type 2 diabetes mellitus (T2DM) following the index pregnancy, however, little is known of women's perception of this risk. The objectives were to (1) determine women's perception of risk of future development of T2DM following a GDM pregnancy and (2) describe the prevalence of undetected dysglycaemia (...) in a Canadian population. The study was designed as a 9-11 year follow-up study of women previously enrolled in a randomized controlled trial of tight versus minimal intervention for GDM. Women's perception of future risk of diabetes was determined by questionnaire. Fasting lipid profile, height and weight were performed on all participants. Oral glucose tolerance tests were performed on all women without prior history of diabetes mellitus type 2 (DM2). The study was conducted at Ottawa Hospital General