Latest & greatest articles for geriatrics

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Top results for geriatrics

41. Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial

Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) /jamapediatrics.2020.2271. Online ahead of print. Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial , , , , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Neonatology, Department of Pediatrics, University of Washington, Seattle. 2 Department of Biostatistics, University of Washington, Seattle. 3 now with Center for Clinical and Translational Research, Seattle Children's

2020 EvidenceUpdates

42. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial

people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design: Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010-2017 ('ASPirin in Reducing Events in the Elderly (ASPREE)', n=19 114) in community-dwelling persons aged ≥70 years. Clinical characteristics were collected at baseline and annually. The endpoint was major GI bleeding that resulted in transfusion (...) City, Iowa, USA. 9 Division of Geriatrics, Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, Minnesota, USA. 10 Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare, Minneapolis, Minnesota, USA. PMID: 32747412 DOI: Item in Clipboard Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial Suzanne E Mahady et al. Gut . 2020 . Show details Display

2020 EvidenceUpdates

43. Group-Based vs Individual Pelvic Floor Muscle Training to Treat Urinary Incontinence in Older Women: A Randomized Clinical Trial

-text links Cite Display options Display options Format Abstract Importance: Urinary incontinence is one of the most prevalent health concerns experienced by older women (aged ≥60 years). Individual pelvic floor muscle training (PFMT) is the recommended first-line treatment for stress or mixed urinary incontinence in women, but human and financial resources limit its delivery. Whether group-based PFMT performs as well as individual PFMT in this population remains unclear. Objective: To assess (...) the efficacy of group-based PFMT relative to individual PFMT for urinary incontinence in older women. Design, setting, and participants: The Group Rehabilitation or Individual Physiotherapy (GROUP) study is a single-blind, randomized, noninferiority trial conducted in 2 Canadian research centers, from July 1, 2012, to June 2, 2018. A total of 362 community-dwelling women aged 60 years or older with symptoms of stress or mixed urinary incontinence were enrolled. Interventions: After an individual session

2020 EvidenceUpdates

44. Physical fitness in older women with osteoporosis and vertebral fracture after a resistance and balance exercise programme: 3-month post-intervention follow-up of a randomised controlled trial Full Text available with Trip Pro

of Physiotherapy, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. 3 Department of Kinesiology, University of Waterloo and Schlegel-UW Research Institute for Aging, Waterloo, Canada. 4 School of Health and Life Sciences, Institute of Applied Health Research, Centre for Living, Glasgow Caledonian University, Glasgow, UK. PMID: 32682416 PMCID: DOI: Free PMC article Item in Clipboard Physical fitness in older women with osteoporosis and vertebral fracture after a resistance and balance (...) fractures, but few studies have investigated the effect of exercise on outcomes of importance for this population. Post-intervention effects of exercise are even less studied. The objective of this study was to evaluate habitual walking speed and other health-related outcomes after cessation of a 3-month exercise intervention. Methods: This follow-up study was conducted 3 months post-intervention of a randomised controlled trial. A total of 149 community-dwelling Norwegian women aged 65 years or older

2020 EvidenceUpdates

45. Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial

York, USA. 7 Aging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA. 8 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. PMID: 32710658 DOI: Item in Clipboard Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial Kenneth S Boockvar et al. J Am Geriatr Soc . 2020 . Show details Display options Display options Format J Am Geriatr Soc Actions . 2020 (...) College, New York, New York, USA. 7 Aging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA. 8 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. PMID: 32710658 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Background/objectives: The Hospital Elder Life Program (HELP) has been shown to prevent delirium in hospitalized older adults. The objective

2020 EvidenceUpdates

46. ECG predictors of cardiac arrhythmias in older adults with syncope

ECG predictors of cardiac arrhythmias in older adults with syncope Prognosis Critical Appraisal Form Citation: Nishijima, D. K., Lin, A. L., Weiss, R. E., Yagapen, A. N., Malveau, S. E., Adler, D. H., . . . Sun, B. C. (2018). ECG Predictors of Cardiac Arrhythmias in Older Adults With Syncope. Annals of Emergency Medicine, 71(4)..2017.11.014 Methodology: Prospective convenience sample of 11 academic ED’s in the USA. Authors attempted to assess patients over the age of 60 with a complaint (...) and may overrepresent those with more serious overall outcomes of 9%. Which is higher than generally reported in syncope data of serious adverse events of 3-5% A majority of their patients were admitted to an observation unit and it is unclear what the mean period of observation was or what their observation protocol was. In some ways yes- obviously we see plenty of elderly patients, although the number of white people do seem over- represented. Also given this was largely performed in large cities

2020 Emergency Medicine Journal Club

47. Nifurtimox (Lampit) - To treat Chagas disease in certain pediatric patients younger than age 18

Nifurtimox (Lampit) - To treat Chagas disease in certain pediatric patients younger than age 18 Drug Approval Package: LAMPIT U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: LAMPIT Company: Bayer HealthCare Pharmaceuticals, Inc. Application Number: 213464 Approval Date: 08/6/2020 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application (...) Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: August 31, 2020 Vision impaired people having problems accessing certain pages of a PDF file may call (301) 796-3634 for assistance. Note: Documents in PDF format require the . Note: If you need help accessing information in different file formats, see . Language Assistance Available: | | | | | | | | | | | | | | | FDA Popular Content Product Areas

2020 FDA - Drug Approval Package

48. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Lennox?Gastaut syndrome (LGS) in conjunction with clobazam, for patients 2 years of age and older.

Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Lennox?Gastaut syndrome (LGS) in conjunction with clobazam, for patients 2 years of age and older. 1 Published 7 September 2020 1 SMC2263 cannabidiol 100mg/ml oral solution (Epidyolex®) GW Research Ltd 7 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice (...) is summarised as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Lennox- Gastaut syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced drop seizure frequency in the clobazam-treated subgroup of children and adults (aged 2 to 55 years

2020 Scottish Medicines Consortium

49. Brolucizumab (Beovu) - For the treatment of neovascular (wet) age-related macular degeneration (wAMD).

Brolucizumab (Beovu) - For the treatment of neovascular (wet) age-related macular degeneration (wAMD). 1 Published 7 September 2020 1 SMC2272 brolucizumab 120mg/mL solution for injection in pre- filled syringe (Beovu®) Novartis Pharmaceutical UK Ltd 07 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards and Area Drug and Therapeutics Committees (ADTCs) on its use in NHSScotland (...) . The advice is summarised as follows: ADVICE: following a full submission brolucizumab (Beovu®) is accepted for use within NHSScotland. Indication under review: in adults for the treatment of neovascular (wet) age-related macular degeneration (AMD). Non-inferiority of brolucizumab versus another anti-vascular endothelial growth factor medicine was demonstrated for mean change in best corrected visual acuity from baseline to week 48 in two phase III studies in patients with neovascular AMD. This advice

2020 Scottish Medicines Consortium

50. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with  Dravet syndrome (DS) in conjunction with clobazam, for patients 2 years of age and older.

Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with  Dravet syndrome (DS) in conjunction with clobazam, for patients 2 years of age and older. 1 Published 7 September 2020 1 SMC2262 cannabidiol 100mg/ml oral solution (Epidyolex®) GW Research Ltd 7 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised (...) as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Dravet syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced convulsive seizure frequency in the clobazam-treated subgroup of children (aged 2 to 18 years) with Dravet syndrome

2020 Scottish Medicines Consortium

51. Declining COVID-19 Case Fatality Rates across all ages: analysis of German data

has declined in all age groups, and the older age groups drive the overall reduction. We have that the UK case-fatality rate (CFR) has fallen substantially from its peak in April. One explanation is that, unlike in March and April, new cases are predominantly in younger people who have a better outcome. We, therefore, sought to examine trends in CFR over time to see if the fatality rate was declining across all age groups. Due to the absence of age-stratified case data in the UK (although we’re (...) 10 (week commencing 3rd March) till week 35 (week ending 31st August). In the early phase of the pandemic, deaths in Germany mirrored cases, but the recent trend is for cases to increase whilst deaths continue to decline. Crude estimates of the CFR over time show that for people aged 80 and over the average CFR was 29% up to week 18, fell to 17% in weeks 19 to 27, and for mid-July onwards the CFR was 11% – a decrease of 61%. A larger decrease is seen in the ages 60-79 with average CFR ~ 9

2020 Oxford COVID-19 Evidence Service

52. Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. (Abstract)

Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. Implementation of appropriate oral anticoagulant treatment for the prevention of stroke in very elderly patients with atrial fibrillation is challenging because of concerns regarding bleeding.We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled, event-driven trial to compare a once-daily 15-mg dose of edoxaban with placebo in elderly Japanese patients (≥80 years of age) with nonvalvular atrial (...) , 1.87; 95% CI, 0.90 to 3.89; P = 0.09). There were substantially more events of gastrointestinal bleeding in the edoxaban group than in the placebo group. There was no substantial between-group difference in death from any cause (9.9% in the edoxaban group and 10.2% in the placebo group; hazard ratio, 0.97; 95% CI, 0.69 to 1.36).In very elderly Japanese patients with nonvalvular atrial fibrillation who were not appropriate candidates for standard doses of oral anticoagulants, a once-daily 15-mg dose

2020 NEJM

53. Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data. Full Text available with Trip Pro

Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data. Previous trials suggest lower long-term risk of mortality after invasive rather than non-invasive management of patients with non-ST elevation myocardial infarction (NSTEMI), but the trials excluded very elderly patients. We aimed to estimate the effect of invasive versus non-invasive management within 3 days of peak troponin (...) concentration on the survival of patients aged 80 years or older with NSTEMI.Routine clinical data for this study were obtained from five collaborating hospitals hosting NIHR Biomedical Research Centres in the UK (all tertiary centres with emergency departments). Eligible patients were 80 years old or older when they underwent troponin measurements and were diagnosed with NSTEMI between 2010 (2008 for University College Hospital) and 2017. Propensity scores (patients' estimated probability of receiving

2020 Lancet

54. Radiotherapy for neovascular age-related macular degeneration. Full Text available with Trip Pro

Radiotherapy for neovascular age-related macular degeneration. Radiotherapy has been proposed as a treatment for new vessel growth in people with neovascular age-related macular degeneration (AMD).To examine the effects of radiotherapy on neovascular AMD.We searched CENTRAL, MEDLINE, Embase, LILACS and three trials registers and checked references of included studies. We last searched the databases on 4 May 2020.  SELECTION CRITERIA: We included all randomised controlled trials in which (...) radiotherapy was compared to another treatment, sham treatment, low dosage irradiation or no treatment in people with choroidal neovascularisation (CNV) secondary to AMD.We used standard procedures expected by Cochrane. We graded the certainty of the evidence using GRADE. We considered the following outcomes at 12 months: best-corrected visual acuity (BCVA) (loss of 3 or more lines, change in visual acuity), contrast sensitivity, new vessel growth, quality of life and adverse effects at any time point

2020 Cochrane

55. In older adults, some antidepressants were associated with increased fracture risk. (Abstract)

In older adults, some antidepressants were associated with increased fracture risk. Tamblyn R, Bates DW, Buckeridge DL, et al. Multinational investigation of fracture risk with antidepressant use by class, drug, and indication. J Am Geriatr Soc. 2020;68:1494-503. 32181493.

2020 Annals of Internal Medicine

56. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. Full Text available with Trip Pro

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an efficacy study.This randomised, double-blind, placebo (...) -controlled, phase 2 trial of the Ad5-vectored COVID-19 vaccine was done in a single centre in Wuhan, China. Healthy adults aged 18 years or older, who were HIV-negative and previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-free, were eligible to participate and were randomly assigned to receive the vaccine at a dose of 1 × 1011 viral particles per mL or 5 × 1010 viral particles per mL, or placebo. Investigators allocated participants at a ratio of 2:1:1 to receive a single

2020 Lancet

57. Evidence review on the benefits of physical activity for older people

of developing functional limitations or a decline in Basic Activities of Daily Living (BADL) disability 14 15 was reduced Institute of Public Health 6 by participation in physical activity 15 . Emerging evidence also highlights the positive impact of physical activity on the healthy ageing process, by improving QoL and increasing the odds of maintaining wellbeing in older age 16 . Finally, as the global population ages, the number of people living with cognitive impairment or dementia is expected (...) 18 19 . Growing evidence also reports that physical activity can improve cognitive function and, consequently, delay the progression of cognitive impairment in older adults 14 20 21 . Implications for Research and Policy Physical activity plays a key role in healthy ageing across the life cycle but especially in later years in the management of one’s health and wellbeing. The goal of public health is to decrease the time spent in ill- health as people age and ensure that an increase in life

2020 Institute of Public Health in Ireland

58. The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial

The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features (...) : 10.1016/j.jen.2020.04.011. Online ahead of print. The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial , , , , , PMID: 32690314 DOI: Item in Clipboard The Effect of a Cartoon and an Information Video About Intravenous Insertion on Pain and Fear in Children Aged 6 to 12 Years in the Pediatric Emergency Unit: A Randomized Controlled Trial Duygu Sönmez Düzkaya et al. J

2020 EvidenceUpdates

59. Effects of Whole-Body Vibration Training on the Physical Function of the Frail Elderly: An Open, Randomized Controlled Trial

Cite Abstract Objective: To investigate the feasibility and benefits of whole-body vibration (WBV) exercise as a safe and effective training tool for countering sarcopenia and age-related declines in mobility and function in the frail elderly. Design: An open, randomized controlled trial. Setting: Residential care facilities. Participants: Male and female volunteers (N=117; 82.5±7.9y). Interventions: After prescreening for contraindications, participants were randomly allocated to a control (...) Effects of Whole-Body Vibration Training on the Physical Function of the Frail Elderly: An Open, Randomized Controlled Trial Effects of Whole-Body Vibration Training on the Physical Function of the Frail Elderly: An Open, Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly

2020 EvidenceUpdates

60. Cost-effectiveness of a preventive self-care health management program for community-dwelling older adults: a randomised controlled trial

for community-dwelling older adults: a randomised controlled trial , , Affiliations Expand Affiliations 1 School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. 2 School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. PMID: 32638995 DOI: Item in Clipboard Cost-effectiveness of a preventive self-care health management program for community-dwelling older adults: a randomised controlled trial Arkers Kwan Ching Wong et al. Age Ageing . 2020 (...) provide some evidence to suggest that the addition of a home-based, preventive self-care health management program may have effects on cost outcomes for community-dwelling older adults in Hong Kong. Keywords: community-dwelling older adults; cost-effectiveness; self-care; self-efficacy. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. Similar articles Lewis H

2020 EvidenceUpdates