Latest & greatest articles for gemfibrozil

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Top results for gemfibrozil

1. Gemfibrozil

Gemfibrozil Top results for gemfibrozil - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for gemfibrozil The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

2018 Trip Latest and Greatest

2. Are fish oil supplements as effective as gemfibrozil for decreasing elevated triglycerides?

Are fish oil supplements as effective as gemfibrozil for decreasing elevated triglycerides? Are fish oil supplements as effective as gemfibrozil for decreasing elevated triglycerides? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Are fish oil supplements as effective as gemfibrozil for decreasing elevated (...) triglycerides? View/ Open Date 2015-08 Format Metadata Abstract Are fish oil supplements as effective as gemfibrozil for decreasing elevated triglycerides? Evidence-Based Answer: The answer is unclear. In patients with hypertriglyceridemia, omega-3 fatty acid and fibric acid derivatives reduce triglyceride levels compared with baseline, but evidence is conflicting whether omega-3 fatty acid supplementation is as effective as gemfibrozil (SOR: C, inconsistent RCTs with disease-oriented outcomes). URI Part

2015 Evidence Based Practice

3. Cost-effectiveness of gemfibrozil for coronary heart disease patients with low levels of high-density lipoprotein cholesterol

Cost-effectiveness of gemfibrozil for coronary heart disease patients with low levels of high-density lipoprotein cholesterol Cost-effectiveness of gemfibrozil for coronary heart disease patients with low levels of high-density lipoprotein cholesterol Cost-effectiveness of gemfibrozil for coronary heart disease patients with low levels of high-density lipoprotein cholesterol Nyman J A, Martinson M S, Nelson D, Nugent S, Collins D, Wittes J, Fye C L, Wilt T J, Robins S J, Bloomfield Rubins H (...) , for the VA-HIT Study Group Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of gemfibrozil (GEM) (1,200 or 600 mg/day) for the prevention of coronary heart disease (CHD) in men with low levels of both high-density lipoprotein

2002 NHS Economic Evaluation Database.

4. Effects of fenofibrate and gemfibrozil on plasma homocysteine. (PubMed)

Effects of fenofibrate and gemfibrozil on plasma homocysteine. 11454380 2001 07 16 2001 07 26 2015 06 16 0140-6736 358 9275 2001 Jul 07 Lancet (London, England) Lancet Effects of fenofibrate and gemfibrozil on plasma homocysteine. 39-40 Fenofibrate increases plasma homocysteine. Because the concentration of plasma homocysteine depends on renal function, we postulate that increases in plasma homocysteine are a result of the known impairment of renal function caused by fenofibrate. Gemfibrozil (...) , another fibrate, does not affect renal function. In a crossover study we tested whether gemfibrozil would raise homocysteine. 22 patients who had hypertriglyceridaemia were given 900 mg gemfibrozil or 200 mg fenofibrate daily for 6 weeks. Lipids were altered similarly, but homocysteine, creatinine, and cystatin C were raised by fenofibrate but not by gemfibrozil (p for differences between treatment effects: 0.007, 0.006, and 0.040, respectively). We propose gemfibrozil should be the fibrate of choice

2001 Lancet

5. Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. (PubMed)

Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. 11268266 2001 03 27 2001 04 19 2016 10 17 0098-7484 285 12 2001 Mar 28 JAMA JAMA Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. 1585-91 A low plasma level of high-density lipoprotein cholesterol (HDL-C) is a major risk factor for coronary heart disease (CHD). A secondary prevention study, the Veterans Affairs (...) High-Density Lipoprotein Intervention Trial (VA-HIT), demonstrated that CHD events were significantly reduced during a median follow-up of 5.1 years by treating patients with the fibric acid derivative gemfibrozil when the predominant lipid abnormality was low HDL-C. To determine if the reduction in major CHD events with gemfibrozil in VA-HIT could be attributed to changes in major plasma lipid levels. Multicenter, randomized, double-blind, placebo-controlled trial conducted from September 1991 to August 1998

2001 JAMA

6. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. (PubMed)

Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. 10438259 1999 08 05 1999 08 05 2013 11 21 0028-4793 341 6 1999 Aug 05 The New England journal of medicine N. Engl. J. Med. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs (...) High-Density Lipoprotein Cholesterol Intervention Trial Study Group. 410-8 Although it is generally accepted that lowering elevated serum levels of low-density lipoprotein (LDL) cholesterol in patients with coronary heart disease is beneficial, there are few data to guide decisions about therapy for patients whose primary lipid abnormality is a low level of high-density lipoprotein (HDL) cholesterol. We conducted a double-blind trial comparing gemfibrozil (1200 mg per day) with placebo in 2531 men with coronary

1999 NEJM

7. Primary hypertriglyceridemia with borderline high cholesterol and elevated apolipoprotein B concentrations. Comparison of gemfibrozil vs lovastatin therapy. (PubMed)

Primary hypertriglyceridemia with borderline high cholesterol and elevated apolipoprotein B concentrations. Comparison of gemfibrozil vs lovastatin therapy. 2232062 1990 12 26 1990 12 26 2016 10 17 0098-7484 264 21 1990 Dec 05 JAMA JAMA Primary hypertriglyceridemia with borderline high cholesterol and elevated apolipoprotein B concentrations. Comparison of gemfibrozil vs lovastatin therapy. 2759-63 A common pattern of dyslipidemia is elevated levels of plasma triglyceride, borderline high total (...) cholesterol, reduced high-density lipoprotein, and increased apolipoprotein B. This pattern of dyslipidemia frequently is associated with premature coronary heart disease. Nicotinic acid is the drug of first choice for this pattern. In this study, gemfibrozil and lovastatin were compared for their effects on the overall lipoprotein profile in 13 men with this type of dyslipidemia. Both drugs significantly reduced very-low-density lipoprotein and intermediate-density lipoprotein cholesterol levels

1990 JAMA

8. Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. (PubMed)

Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. 2810673 1989 12 21 1989 12 21 2016 10 17 0098-7484 262 22 1989 Dec 08 JAMA JAMA Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia. 3148-53 This study compared lovastatin and gemfibrozil therapy for effects on lipid and lipoprotein levels in 22 normolipidemic patients with reduced high-density lipoprotein cholesterol levels. Most patients had coronary (...) heart disease. A randomized, crossover design consisted of two drug phases (lovastatin and gemfibrozil) alternating with placebo. Lovastatin reduced total and low-density lipoprotein cholesterol and apolipoprotein B levels by 28%, 34%, and 24%, respectively. These were unaffected by gemfibrozil. Both drugs reduced very low-density lipoprotein and intermediate-density lipoprotein cholesterol levels by 30% to 40%. Both caused small but significant increases in high-density lipoprotein cholesterol

1989 JAMA

9. The hypolipidemic effects of gemfibrozil in type V hyperlipidemia. A double-blind, crossover study. (PubMed)

The hypolipidemic effects of gemfibrozil in type V hyperlipidemia. A double-blind, crossover study. 2681858 1989 12 21 1989 12 21 2016 10 17 0098-7484 262 22 1989 Dec 08 JAMA JAMA The hypolipidemic effects of gemfibrozil in type V hyperlipidemia. A double-blind, crossover study. 3154-60 Thirteen patients with phenotypic type V hyperlipidemia were treated with either gemfibrozil (Lopid) or a placebo in a randomized, double-blind, crossover study for two 8-week periods. A 4-week baseline period (...) of a low-fat diet preceded the study and served as a dietary control period. A 4-week washout period followed the two 8-week periods. Compared with the placebo phase, gemfibrozil produced a significant reduction in the concentrations of total plasma triglycerides (21.03 vs 5.50 mmol/L) and very low-density lipoprotein triglycerides (14.40 vs 4.59 mmol/L) as well as in total plasma cholesterol levels (10.88 vs 5.62 mmol/L) and very low-density lipoprotein cholesterol (6.66 vs 2.15 mmol/L

1989 JAMA

10. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. (PubMed)

Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. 3313041 1987 12 01 1987 12 01 2013 11 21 0028-4793 317 20 1987 Nov 12 The New England journal of medicine N. Engl. J. Med. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary (...) heart disease. 1237-45 In a randomized, double-blind five-year trial, we tested the efficacy of simultaneously elevating serum levels of high-density lipoprotein (HDL) cholesterol and lowering levels of non-HDL cholesterol with gemfibrozil in reducing the risk of coronary heart disease in 4081 asymptomatic middle-aged men (40 to 55 years of age) with primary dyslipidemia (non-HDL cholesterol greater than or equal to 200 mg per deciliter [5.2 mmol per liter] in two consecutive pretreatment measurements). One group

1987 NEJM