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Latest & greatest articles for gabapentin
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Gabapentin for non-malignant chronic pain Gabapentin for non-malignant chronic pain Gabapentin for non-malignant chronic pain Alberta Heritage Foundation for Medical Research Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Alberta Heritage Foundation for Medical Research. Gabapentin for non-malignant chronic pain. Edmonton: Alberta (...) Heritage Foundation for Medical Research (AHFMR). Technote TN 47. 2004 Authors' objectives
The aim of this report is to describe the background and the current evidence on the safety and efficacy/effectiveness of gabapentin when used in the management of non-malignant chronic pain.
Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetic Acids /therapeutic use; Analgesics /therapeutic use; Chronic Disease; Pain Language Published English Country of organisation Canada
Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin. On this basis, we did an open-label study in which oral gabapentin 300 mg thrice daily was given for every other chemotherapy treatment in nine patients with breast cancer. Six of the nine reported at least a three-point improvement in peak (...) delayed nausea (on an eight-point nausea scale), and three patients had complete resolution of nausea when taking gabapentin. This preliminary evidence shows that gabapentin might have a role in treatment of chemotherapy-induced nausea.
Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Mellegers M A, Furlan A D, Mailis A Authors' objectives To assess the efficacy, effectiveness and side-effects of gabapentin for the treatment of neuropathic pain. Searching MEDLINE (from 1966 to March 2001), EMBASE (...) (from 1980 to March 2001), the Science Citation Index (from 1993 to September 1999), and the Cochrane Controlled Trials Register (Issue 1, 2001) were searched. The authors also searched the reference lists in retrieved articles, reviews and book chapters, and contacted content experts for other relevant studies. The terms used in the search were 'pain', 'nociceptors', 'analgesia', 'neuropathy', 'neuropathic', 'allodynia', 'hyperalgesia', 'gabapentin', 'Neurontin' and registry number '60142-96-3
Gabapentin for drug-resistant partial epilepsy. The majority of epileptic patients have a good prognosis and their seizures can be well controlled with the use of a single antiepileptic agent, but up to 30% develop refractory epilepsy, especially those with partial seizures. In this review we summarise the current evidence regarding a new antiepileptic drug, gabapentin, when used as an add-on treatment for drug-resistant partial epilepsyTo evaluate the efficacy and tolerability of gabapentin (...) when used as an add-on treatment for patients with drug-resistant partial epilepsy.We searched the Cochrane Epilepsy Group trial register, the Cochrane Controlled Trials Register of The Cochrane Library Issue 4, 1998. In addition, we contacted Parke Davis (manufacturers of gabapentin) and experts in the field to seek any ongoing studies or unpublished studies.Randomized placebo controlled double blind add-on trials of gabapentin in patients with drug-resistant partial epilepsy.Two reviewers
Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies.To evaluate the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy.Randomized, double-blind, placebo-controlled, 8-week trial conducted between July 1996 and March 1997.Outpatient (...) Pain Questionnaire scores, Patient Global Impression of Change and Clinical Global Impression of Change, the Short Form-36 Quality of Life Questionnaire scores, and the Profile of Mood States results.Eighty-four patients received gabapentin and 70 (83%) completed the study; 81 received placebo and 65 (80%) completed the study. By intent-to-treat analysis, gabapentin-treated patients' mean daily pain score at the study end point (baseline, 6.4; end point, 3.9; n = 82) was significantly lower (P<.001
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. Postherpetic neuralgia (PHN) is a syndrome of often intractable neuropathic pain following herpes zoster (shingles) that eludes effective treatment in many patients.To determine the efficacy and safety of the anticonvulsant drug gabapentin in reducing PHN pain.Multicenter, randomized, double-blind, placebo-controlled, parallel design, 8-week trial conducted from August 1996 through July 1997.Sixteen US (...) outpatient clinical centers.A total of 229 subjects were randomized.A 4-week titration period to a maximum dosage of 3600 mg/d of gabapentin or matching placebo. Treatment was maintained for another 4 weeks at the maximum tolerated dose. Concomitant tricyclic antidepressants and/or narcotics were continued if therapy was stabilized prior to study entry and remained constant throughout the study.The primary efficacy measure was change in the average daily pain score based on an 11-point Likert scale (0
A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy Hughes D, Cockerell O C Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) . Results of the review In the absence of head to head trials, there was no evidence that the efficacy of the three drugs differed significantly. On this basis, the authors decided to conduct a cost minimization study. The side effects of the three drugs are reported in terms of incidence, the aim being to estimate the resulting level of health service utilisation. For example, 9-15% of patients on lamotrigine, 6-15% of patients on vigabatrin and 3-7% of patients on gabapentin suffer from major side
Gabapentin in partial epilepsy. UK Gabapentin Study Group. Gabapentin is an analogue of gamma aminobutyric acid (GABA) which has anticonvulsant properties in animals. In a multicentre, double-blind, placebo-controlled, parallel-group study of 1200 mg/day gabapentin as additional therapy in 127 patients with drug-resistant partial epilepsy, 25% of patients who received gabapentin had the number of partial seizures at least halved, compared with 9.8% of patients given placebo. The median (...) reduction in partial seizure frequency during 12 weeks' treatment was 29.2% with gabapentin compared with 12.5% with placebo. The mean adjusted response ratio for gabapentin (-0.192) was significantly better than the ratio of -0.060 for placebo by analysis of variance. 62% of patients who received gabapentin reported mostly mild or moderate adverse effects compared with 41% on placebo; no interactions were observed between gabapentin and other standard anticonvulsants. Gabapentin is an effective