Latest & greatest articles for gabapentin

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Top results for gabapentin

61. Gabapentin for drug-resistant partial epilepsy.

Gabapentin for drug-resistant partial epilepsy. BACKGROUND: The majority of epileptic patients have a good prognosis and their seizures can be well controlled with the use of a single antiepileptic agent, but up to 30% develop refractory epilepsy, especially those with partial seizures. In this review we summarise the current evidence regarding a new antiepileptic drug, gabapentin, when used as an add-on treatment for drug-resistant partial epilepsy OBJECTIVES: To evaluate the efficacy (...) and tolerability of gabapentin when used as an add-on treatment for patients with drug-resistant partial epilepsy. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group trial register, the Cochrane Controlled Trials Register of The Cochrane Library Issue 4, 1998. In addition, we contacted Parke Davis (manufacturers of gabapentin) and experts in the field to seek any ongoing studies or unpublished studies. SELECTION CRITERIA: Randomized placebo controlled double blind add-on trials of gabapentin in patients

Cochrane2000

62. Gabapentin add-on for drug-resistant partial epilepsy.

Gabapentin add-on for drug-resistant partial epilepsy. BACKGROUND: The majority of patients with epilepsy have a good prognosis and their seizures are well controlled by a single antiepileptic drug, but up to 30% develop refractory epilepsy, especially those with partial seizures. In this review we summarise the current evidence regarding a new antiepileptic drug, gabapentin, when used as an add-on treatment for drug-resistant partial epilepsy. OBJECTIVES: To evaluate the efficacy (...) and tolerability of gabapentin when used as an add-on treatment for patients with drug-resistant partial epilepsy. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group's trial register, the Cochrane Controlled Trials Register (The Cochrane Library Issue 1, 2000). In addition, we contacted Parke Davis (manufacturers of gabapentin) and experts in the field to seek any ongoing studies or unpublished studies. SELECTION CRITERIA: Randomized placebo controlled double blind add-on trials of gabapentin in patients

Cochrane2000

63. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial.

Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. 9846777 1998 12 17 1998 12 17 2016 10 17 0098-7484 280 21 1998 Dec 02 JAMA JAMA Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. 1831-6 Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies (...) . To evaluate the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy. Randomized, double-blind, placebo-controlled, 8-week trial conducted between July 1996 and March 1997. Outpatient clinics at 20 sites. The 165 patients enrolled had a 1- to 5-year history of pain attributed to diabetic neuropathy and a minimum 40-mm pain score on the Short-Form McGill Pain Questionnaire visual analogue scale. Gabapentin (titrated from 900 to 3600 mg/d or maximum tolerated dosage

JAMA1998

64. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.

Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. 9846778 1998 12 17 1998 12 17 2016 10 17 0098-7484 280 21 1998 Dec 02 JAMA JAMA Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. 1837-42 Postherpetic neuralgia (PHN) is a syndrome of often intractable neuropathic pain following herpes zoster (shingles) that eludes effective treatment in many patients. To determine the efficacy and safety of the anticonvulsant drug (...) gabapentin in reducing PHN pain. Multicenter, randomized, double-blind, placebo-controlled, parallel design, 8-week trial conducted from August 1996 through July 1997. Sixteen US outpatient clinical centers. A total of 229 subjects were randomized. A 4-week titration period to a maximum dosage of 3600 mg/d of gabapentin or matching placebo. Treatment was maintained for another 4 weeks at the maximum tolerated dose. Concomitant tricyclic antidepressants and/or narcotics were continued if therapy

JAMA1998

65. A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy

A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy A cost minimization study comparing vigabatrin, lamotrigine and gabapentin for the treatment of intractable partial epilepsy Hughes D, Cockerell O C Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) . Results of the review In the absence of head to head trials, there was no evidence that the efficacy of the three drugs differed significantly. On this basis, the authors decided to conduct a cost minimization study. The side effects of the three drugs are reported in terms of incidence, the aim being to estimate the resulting level of health service utilisation. For example, 9-15% of patients on lamotrigine, 6-15% of patients on vigabatrin and 3-7% of patients on gabapentin suffer from major side

NHS Economic Evaluation Database.1996

66. Gabapentin in partial epilepsy. UK Gabapentin Study Group.

Gabapentin in partial epilepsy. UK Gabapentin Study Group. 1971862 1990 07 09 1990 07 09 2015 06 16 0140-6736 335 8698 1990 May 12 Lancet (London, England) Lancet Gabapentin in partial epilepsy. UK Gabapentin Study Group. 1114-7 Gabapentin is an analogue of gamma aminobutyric acid (GABA) which has anticonvulsant properties in animals. In a multicentre, double-blind, placebo-controlled, parallel-group study of 1200 mg/day gabapentin as additional therapy in 127 patients with drug-resistant (...) partial epilepsy, 25% of patients who received gabapentin had the number of partial seizures at least halved, compared with 9.8% of patients given placebo. The median reduction in partial seizure frequency during 12 weeks' treatment was 29.2% with gabapentin compared with 12.5% with placebo. The mean adjusted response ratio for gabapentin (-0.192) was significantly better than the ratio of -0.060 for placebo by analysis of variance. 62% of patients who received gabapentin reported mostly mild

Lancet1990