Latest & greatest articles for gabapentin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on gabapentin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on gabapentin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for gabapentin

41. Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis

Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis Gabapentin for the treatment of hot flashes in women with natural or tamoxifen-induced menopause: a systematic review and meta-analysis Toulis K A, Tzellos T, Kouvelas D, Goulis D G CRD summary This review investigated (...) the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. Authors' objectives To investigate the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Searching

DARE.2009

42. Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials

Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct (...) and indirect meta-analyses of randomized controlled trials Chou R, Carson S, Chan B K CRD summary This review concluded that there was no difference in pain relief between gabapentin and tricyclic antidepressants in patients with diabetic neuropathy or post-herpetic neuralgia, although direct evidence was limited. The review was well conducted and these findings are likely to be reliable. Authors' objectives To compare gabapentin with tricyclic antidepressants for the treatment of diabetic neuropathy

DARE.2009

43. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial.

Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. 19796802 2009 10 12 2009 10 29 2015 06 16 1474-547X 374 9697 2009 Oct 10 Lancet (London, England) Lancet Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. 1252-61 10.1016/S0140-6736(09)61081-3 Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when (...) given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. In this double-blind, double-dummy, crossover trial, patients with diabetic polyneuropathy or postherpetic neuralgia, and who had a daily pain score of at least 4 (scale 0-10), were enrolled and treated at one study site in Canada between Nov 5, 2004, and Dec 13, 2007. 56 patients were randomised in a 1:1:1 ratio with a balanced Latin square design to receive

Lancet2009

44. Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study

Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study 18566196 2008 06 20 2008 09 09 2013 06 11 0832-610X 55 6 2008 Jun Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study. 337-43 10.1007/BF03021488 Despite adequate epidural analgesia, up to 97% of patients undergoing thoracotomy experience ipsilateral (...) shoulder pain. In this setting, this study evaluated the safety and the efficacy of pre-emptive gabapentin. A double-blind, placebo-controlled study was undertaken in 51 patients randomized into two groups. Two hours before surgery, 23 patients received gabapentin 1200 mg po (Group G), and 28 patients received placebo (Group P). Shoulder pain and postoperative pain, at the surgical site, were monitored every four hours for 24 hr, using a numerical rating scale. Subcutaneous hydromorphone

EvidenceUpdates2008

45. Cost-effectiveness analysis of a lidocaine 5% medicated plaster compared with gabapentin and pregabalin for treating postherpetic neuralgia: a German perspective

Cost-effectiveness analysis of a lidocaine 5% medicated plaster compared with gabapentin and pregabalin for treating postherpetic neuralgia: a German perspective Cost-effectiveness analysis of a lidocaine 5% medicated plaster compared with gabapentin and pregabalin for treating postherpetic neuralgia: a German perspective Cost-effectiveness analysis of a lidocaine 5% medicated plaster compared with gabapentin and pregabalin for treating postherpetic neuralgia: a German perspective Liedgens H (...) , Hertel N, Gabriel A, Nuijten M, Dakin H, Mitchell S, Poulsen Nautrup B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to examine the cost-effectiveness of the lidocaine 5% medicated plaster versus gabapentin

NHS Economic Evaluation Database.2008

46. Use of gabapentin for perioperative pain control: a meta-analysis

Use of gabapentin for perioperative pain control: a meta-analysis Use of gabapentin for perioperative pain control: a meta-analysis Use of gabapentin for perioperative pain control: a meta-analysis Peng P W, Wijeysundera D N, Li C C CRD summary This generally well-conducted review assessed the use of gabapentin for peri-operative pain control in adults. The authors concluded that gabapentin is associated with a reduction in pain, analgesic consumption and opioid-related side-effects (...) , but there is an increased risk of dizziness and sedation. These conclusions appear to be supported by the data presented, although there may be some risk of publication bias. Authors' objectives To assess the analgesic effectiveness, opioid-sparing effects and side-effects of gabapentin used peri-operatively. Searching MEDLINE (1966 to February 2006), EMBASE (1980 to February 2006), the Cochrane Controlled Trials Register (Issue 1, 2006), Science Citation Index, Current Controlled Trials Register, TextMed, Science

DARE.2007

47. Cost-effectiveness of a lidocaine 5% medicated plaster relative to gabapentin for postherpetic neuralgia in the United Kingdom

Cost-effectiveness of a lidocaine 5% medicated plaster relative to gabapentin for postherpetic neuralgia in the United Kingdom Cost-effectiveness of a lidocaine 5% medicated plaster relative to gabapentin for postherpetic neuralgia in the United Kingdom Cost-effectiveness of a lidocaine 5% medicated plaster relative to gabapentin for postherpetic neuralgia in the United Kingdom Dakin H, Nuijten M, Liedgens H, Poulsen Nautrup B Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to assess the cost-effectiveness of lidocaine 5% medicated plasters in place of gabapentin in the treatment of postherpetic neuralgia, in patients who had insufficient pain relief with standard analgesics and who could not tolerate, or had

NHS Economic Evaluation Database.2007

48. Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia

Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia Rodriguez M J, Diaz S, Vera (...) -Llonch M, Dukes E, Rejas E A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to assess the cost-effectiveness of branded pregabalin (PGB) in comparison with generic gabapentin (GBP) in patients with neuropathic pain due

NHS Economic Evaluation Database.2007

49. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The authors assessed five antiepileptic drugs. These were carbamazepine, gabapentin, lamotrigine, oxcarbazepine and topiramate. The drug dosages and preparations were used as they would be by a clinician in everyday practice. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population

NHS Economic Evaluation Database.2007

50. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial.

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. 17382827 2007 03 26 2007 04 05 2017 02 19 1474-547X 369 9566 2007 Mar 24 Lancet (London, England) Lancet The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. 1000-15 Carbamazepine (...) carbamazepine was deemed to be standard treatment, and they were randomly assigned to receive carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate. Primary outcomes were time to treatment failure, and time to 12-months remission, and assessment was by both intention to treat and per protocol. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN38354748. For time to treatment failure, lamotrigine was significantly better than carbamazepine (hazard

Lancet2007 Full Text: Link to full Text with Trip Pro

51. Narrative review: the promotion of gabapentin: an analysis of internal industry documents.

Narrative review: the promotion of gabapentin: an analysis of internal industry documents. BACKGROUND: Internal documents from the pharmaceutical industry provide a unique window for understanding the structure and methods of pharmaceutical promotion. Such documents have become available through litigation concerning the promotion of gabapentin (Neurontin, Pfizer, Inc., New York, New York) for off-label uses. PURPOSE: To describe how gabapentin was promoted, focusing on the use of medical (...) education, research, and publication. DATA SOURCES: Court documents available to the public from United States ex. rel David Franklin vs. Pfizer, Inc., and Parke-Davis, Division of Warner-Lambert Company, mostly from 1994-1998. DATA EXTRACTION: All documents were reviewed by 1 author, with selected review by coauthors. Marketing strategies and tactics were identified by using an iterative process of review, discussion, and re-review of selected documents. DATA SYNTHESIS: The promotion of gabapentin

Annals of Internal Medicine2006

52. Gabapentin and postoperative pain: a systematic review of randomized controlled trials

Gabapentin and postoperative pain: a systematic review of randomized controlled trials Gabapentin and postoperative pain: a systematic review of randomized controlled trials Gabapentin and postoperative pain: a systematic review of randomized controlled trials Ho K Y, Gan T J, Habib A S CRD summary This review evaluated the efficacy and tolerability of peri-operative gabapentin administration to control acute post-operative pain. Peri-operative gabapentin administration was found (...) to be effective in reducing pain scores, opioid requirements and opioid-related adverse effects in the first 24 hours after surgery. Given the significant differences between the studies and the possibility of bias, the authors' conclusions should be interpreted with caution. Authors' objectives To evaluate the efficacy and tolerability of peri-operative gabapentin administration to control acute post-operative pain. Searching MEDLINE (1966 to 2006), the Cochrane CENTRAL Register (2006), Scopus and CINAHL

DARE.2006

53. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis

The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis Hurley R W, Cohen S P, Williams K A, Rowlingson A J, Wu C L CRD summary The authors concluded that peri-operative oral gabapentin is a useful addition to post-operative pain management. The evidence appears to support the authors (...) ’ conclusions, but the lack of reporting of concomitant analgesic regimens and control treatments makes it difficult assess the settings in which these findings might apply. Authors' objectives To evaluate the analgesic effects of peri-operative gabapentin in surgical patients. Searching PubMed (1966 to November 2005) and abstracts from the Society of Neuroscience (1998 to 2004) and the American Society of Anesthesiologists were searched; some details of the search terms were reported. No language

DARE.2006

54. The Use of Gabapentin and Tricyclic Antidepressants in the Treatment of Neuropathic Pain in Cancer Patients

The Use of Gabapentin and Tricyclic Antidepressants in the Treatment of Neuropathic Pain in Cancer Patients

Cancer Care Ontario2006

55. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial.

Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. 16139656 2005 09 05 2005 10 18 2016 10 25 1474-547X 366 9488 2005 Sep 3-9 Lancet (London, England) Lancet Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. 818-24 Most women receiving systemic therapy for breast cancer experience hot flashes. We undertook a randomised, double-blind, placebo-controlled, multi-institutional (...) trial to assess the efficacy of gabapentin in controlling hot flashes in women with breast cancer. 420 women with breast cancer who were having two or more hot flashes per day were randomly assigned placebo, gabapentin 300 mg/day, or gabapentin 900 mg/day by mouth in three divided doses for 8 weeks. Each patient kept a 1-week, self-report diary on the frequency, severity, and duration of hot flashes before the start of the study and during weeks 4 and 8 of treatment. Analyses were by intention

Lancet2005 Full Text: Link to full Text with Trip Pro

56. Morphine, gabapentin, or their combination for neuropathic pain.

Morphine, gabapentin, or their combination for neuropathic pain. 15800228 2005 03 31 2005 04 05 2013 11 21 1533-4406 352 13 2005 Mar 31 The New England journal of medicine N. Engl. J. Med. Morphine, gabapentin, or their combination for neuropathic pain. 1324-34 The available drugs to treat neuropathic pain have incomplete efficacy and dose-limiting adverse effects. We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful (...) diabetic neuropathy or postherpetic neuralgia. In this randomized, double-blind, active placebo-controlled, four-period crossover trial, patients received daily active placebo (lorazepam), sustained-release morphine, gabapentin, and a combination of gabapentin and morphine--each given orally for five weeks. The primary outcome measure was mean daily pain intensity in patients receiving a maximal tolerated dose; secondary outcomes included pain (rated according to the Short-Form McGill Pain

NEJM2005

57. Gabapentin improved sensory and motor symptoms in the restless legs syndrome

Gabapentin improved sensory and motor symptoms in the restless legs syndrome Gabapentin improved sensory and motor symptoms in the restless legs syndrome | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Gabapentin improved sensory and motor symptoms in the restless legs syndrome Article Text Therapeutics Gabapentin improved sensory and motor symptoms in the restless legs syndrome Free Alberto Albanese , MD , Graziella Filippini , MD Statistics from Altmetric.com No Altmetric data available for this article. ( 2002 ) Neurology 59 , 1573 . Garcia

Evidence-Based Medicine (Requires free registration)2004

58. Gabapentin for non-malignant chronic pain

Gabapentin for non-malignant chronic pain Gabapentin for non-malignant chronic pain Gabapentin for non-malignant chronic pain Alberta Heritage Foundation for Medical Research Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Alberta Heritage Foundation for Medical Research. Gabapentin for non-malignant chronic pain. Edmonton: Alberta (...) Heritage Foundation for Medical Research (AHFMR). Technote TN 47. 2004 Authors' objectives

The aim of this report is to describe the background and the current evidence on the safety and efficacy/effectiveness of gabapentin when used in the management of non-malignant chronic pain.

Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetic Acids /therapeutic use; Analgesics /therapeutic use; Chronic Disease; Pain Language Published English Country of organisation Canada

Health Technology Assessment (HTA) Database.2004

59. Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer.

Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin. On this basis, we did an open-label study in which oral gabapentin 300 mg thrice daily was given for every other chemotherapy treatment in nine patients with breast cancer. Six of the nine reported at least a three-point improvement in peak (...) delayed nausea (on an eight-point nausea scale), and three patients had complete resolution of nausea when taking gabapentin. This preliminary evidence shows that gabapentin might have a role in treatment of chemotherapy-induced nausea.

Lancet2003

60. Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature

Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature Mellegers M A, Furlan A D, Mailis A Authors' objectives To assess the efficacy, effectiveness and side-effects of gabapentin for the treatment of neuropathic pain. Searching MEDLINE (from 1966 to March 2001), EMBASE (...) (from 1980 to March 2001), the Science Citation Index (from 1993 to September 1999), and the Cochrane Controlled Trials Register (Issue 1, 2001) were searched. The authors also searched the reference lists in retrieved articles, reviews and book chapters, and contacted content experts for other relevant studies. The terms used in the search were 'pain', 'nociceptors', 'analgesia', 'neuropathy', 'neuropathic', 'allodynia', 'hyperalgesia', 'gabapentin', 'Neurontin' and registry number '60142-96-3

DARE.2001