Latest & greatest articles for gabapentin

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Top results for gabapentin

1. Gabapentin add-on treatment for drug-resistant focal epilepsy.

Gabapentin add-on treatment for drug-resistant focal epilepsy. BACKGROUND: This is an updated version of the Cochrane Review previously published in 2013.Most people with epilepsy have a good prognosis and their seizures are well controlled by a single antiepileptic drug, but up to 30% develop drug-resistant epilepsy, especially those with focal seizures. In this review, we summarised the evidence from randomised controlled trials (RCTs) of gabapentin, when used as an add-on treatment for drug (...) -resistant focal epilepsy. OBJECTIVES: To evaluate the efficacy and tolerability of gabapentin when used as an add-on treatment for people with drug-resistant focal epilepsy. SEARCH METHODS: For the latest update, we searched the Cochrane Register of Studies (CRS Web, 20 March 2018), which includes the Cochrane Epilepsy Group's Specialized Register and the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid, 1946 to 20 March 2018), ClinicalTrials.gov (20 March 2018) and the World

Cochrane2018

2. Gabapentin

Gabapentin Top results for gabapentin - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for gabapentin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

3. Gabapentin for Chronic Neuropathic Pain.

Gabapentin for Chronic Neuropathic Pain. Clinical Question: Is gabapentin associated with pain relief in people with chronic neuropathic pain? Bottom Line: Oral gabapentin (1200-3600 mg/d for 4-12 weeks) for patients with moderate or severe neuropathic pain from postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN) is associated with pain reduction of at least 50% in 14% to 17% more patients than placebo.

JAMA2018

4. Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial

Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial 29238824 2018 02 07 2168-6262 2017 Dec 13 JAMA surgery JAMA Surg Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: A Randomized Clinical Trial. 10.1001/jamasurg.2017.4915 Guidelines recommend using gabapentin to decrease postoperative pain and opioid use, but significant variation (...) exists in clinical practice. To determine the effect of perioperative gabapentin on remote postoperative time to pain resolution and opioid cessation. A randomized, double-blind, placebo-controlled trial of perioperative gabapentin was conducted at a single-center, tertiary referral teaching hospital. A total of 1805 patients aged 18 to 75 years scheduled for surgery (thoracotomy, video-assisted thoracoscopic surgery, total hip replacement, total knee replacement, mastectomy, breast lumpectomy, hand

EvidenceUpdates2018

5. The Efficacy of Preoperative Gabapentin in Spinal Surgery: A Meta-Analysis of Randomized Controlled Trials

The Efficacy of Preoperative Gabapentin in Spinal Surgery: A Meta-Analysis of Randomized Controlled Trials 29149144 2017 11 17 2150-1149 20 7 2017 Nov Pain physician Pain Physician The Efficacy of Preoperative Gabapentin in Spinal Surgery: A Meta-Analysis of Randomized Controlled Trials. 649-661 Pain management after spinal surgery has been studied for years. Gabapentin is a third-generation antiepileptic drug that selectively affects the nociceptive process and has been used for pain (...) relief after surgery. However, the relationship between gabapentin and postoperative pain in spinal surgery is still controversial. To assess the efficacy of the pre-emptive use of gabapentin in spinal surgery. A meta-analysis of randomized controlled studies. The MEDLINE, EMBASE, ClinicalTrials.gov, and Web of Science databases were systematically searched. This meta-analysis of randomized controlled trials (RCTs) was performed to compare the use of gabapentin with placebo in spinal surgery regarding

EvidenceUpdates2018

6. Gabapentin (Neurontin): risk of severe respiratory depression

Gabapentin (Neurontin): risk of severe respiratory depression Gabapentin (Neurontin): risk of severe respiratory depression - GOV.UK GOV.UK uses cookies to make the site simpler. Search Gabapentin (Neurontin): risk of severe respiratory depression From: Published: 26 October 2017 Therapeutic area: and Gabapentin has been associated with a rare risk of severe respiratory depression even without concomitant opioid medicines. Patients with compromised respiratory function, respiratory (...) or neurological disease, renal impairment, concomitant use of central nervous system (CNS) depressants, and elderly people might be at higher risk of experiencing severe respiratory depression. Dose adjustments might be necessary in these patients. Contents Advice for healthcare professionals: be aware of the risk of CNS depression, including severe respiratory depression, with gabapentin consider whether dose adjustments might be necessary in patients at higher risk of respiratory depression, including

MHRA Drug Safety Update2017

7. Comparison of the effect of topiramate versus gabapentin on neuropathic pain in patients with polyneuropathy: A randomized clinical trial

Comparison of the effect of topiramate versus gabapentin on neuropathic pain in patients with polyneuropathy: A randomized clinical trial 29238506 2018 11 13 2008-5842 9 10 2017 Oct Electronic physician Electron Physician Comparison of the effect of topiramate versus gabapentin on neuropathic pain in patients with polyneuropathy: A randomized clinical trial. 5617-5622 10.19082/5617 Neuropathic pain is one of the most common complaints of neurologic clinics. Neuropathic pain is common (...) and important and has inappropriate complications, and despite their importance, there is no effective treatment for them. Because of the importance of neuropathic pain and safe and effective treatment, in this study, we determined the effect of topiramate versus gabapentin in patients with neuropathic pain. In this randomized clinical trial, 30 patients with pain attributed to neuropathy who had at least one month of neuropathic pain in one area, were randomized to receive either gabapentin, titrated from

Electronic physician2017 Full Text: Link to full Text with Trip Pro

8. Abuse and Misuse of Gabapentin: Clinical Evidence, Safety, and Guidelines

Abuse and Misuse of Gabapentin: Clinical Evidence, Safety, and Guidelines Abuse and Misuse of Gabapentin: Clinical Evidence, Safety, and Guidelines | CADTH.ca Find the information you need Abuse and Misuse of Gabapentin: Clinical Evidence, Safety, and Guidelines Abuse and Misuse of Gabapentin: Clinical Evidence, Safety, and Guidelines Published on: October 19, 2017 Project Number: RB1146-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What (...) is the clinical evidence for the potential misuse or abuse of gabapentin? What are the harms associated with the potential misuse or abuse of gabapentin? What are the evidence-based guidelines regarding managing patients abusing gabapentin? Key Message Three systematic reviews and three non-randomized studies were identified regarding the potential abuse and misuse of gabapentin. Tags street drugs, substance abuse detection, substance abuse treatment centers, addiction, gabapentin Files Rapid Response Summary

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

9. Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial

Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial 28727581 2017 07 20 2017 09 22 1528-1175 127 4 2017 Oct Anesthesiology Anesthesiology Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. 633-644 10.1097/ALN.0000000000001804 Postoperative pain and opioid use are associated with postoperative delirium. We designed a single-center, randomized, placebo (...) -controlled, parallel-arm, double-blinded trial to determine whether perioperative administration of gabapentin reduced postoperative delirium after noncardiac surgery. Patients were randomly assigned to receive placebo (N = 347) or gabapentin 900 mg (N = 350) administered preoperatively and for the first 3 postoperative days. The primary outcome was postoperative delirium as measured by the Confusion Assessment Method. Secondary outcomes were postoperative pain, opioid use, and length of hospital stay

EvidenceUpdates2017

10. Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness

Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness | CADTH.ca Find the information you need Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Published on: July 31, 2017 (...) Project Number: RB1124-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of pre-operative administration of gabapentin to reduce post-operative pain following orthopedic surgery? What is the clinical effectiveness of pre-operative administration of celecoxib to reduce post-operative pain following orthopedic surgery? What is the clinical effectiveness of pre-operative administration of acetaminophen to reduce post

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

11. Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes

Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes 27521437 2016 09 20 2017 05 08 2017 05 08 1526-632X 87 12 2016 Sep 20 Neurology Neurology Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. 1242-9 10.1212/WNL.0000000000003118 To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy (...) modeling showing superior efficacy for pregabalin. The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset seizures was randomized, flexible dose, double blind, and parallel group. The study included a 6-week baseline and a 21-week treatment phase. The primary endpoint was the percentage change from baseline in 28-day seizure rate to the treatment phase. A total of 484 patients were randomized to pregabalin (n

EvidenceUpdates2016 Full Text: Link to full Text with Trip Pro

12. Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness

Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness | CADTH.ca Find the information you need Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness Gabapentin for HIV-associated Neuropathic Pain: A Review of the Clinical Effectiveness Published on: January 22, 2016 Project Number: RC0750-000 Product Line: Research Type: Drug Report Type (...) : Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of gabapentin for the treatment of HIV-associated neuropathic pain? Key Message There is limited evidence for the use of gabapentin for the treatment of HIV-associated neuropathy. One relevant RCT, included in a systematic review, and one non-randomized study were identified. The studies suggest that gabapentin may improve pain and related sleep disturbances caused by HIV-associated sensory neuropathy

Canadian Agency for Drugs and Technologies in Health - Rapid Review2016

13. Gabapentin for HIV-Associated Neuropathic Pain: Clinical Effectiveness

Gabapentin for HIV-Associated Neuropathic Pain: Clinical Effectiveness Gabapentin for HIV-Associated Neuropathic Pain: Clinical Effectiveness | CADTH.ca Find the information you need Gabapentin for HIV-Associated Neuropathic Pain: Clinical Effectiveness Gabapentin for HIV-Associated Neuropathic Pain: Clinical Effectiveness Published on: November 25, 2015 Project Number: RA0817-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical (...) effectiveness of gabapentin for the treatment of HIV-associated neuropathic pain? Key Message One systematic review, one randomized controlled trial, and one non-randomized study were identified regarding the clinical effectiveness of gabapentin for the treatment of HIV-associated neuropathic pain. Tags hiv, human immunodeficiency virus, human immunodeficiency viruses, neuralgia, pain management, hiv/aids, other miscellaneous topics, Neurontin, human immuno-deficiency virus, human immuno-deficiency viruses

Canadian Agency for Drugs and Technologies in Health - Rapid Review2015

14. Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014

Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014 Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014 | CADTH.ca Find the information you need Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014 Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014 (...) , as well as place a significant burden on our health, social services, and public safety systems.” 1 The purpose of this Environmental Scan is to provide an overview of policies, practices, and initiatives which the publicly funded drug programs, colleges of physicians and surgeons, and colleges of pharmacy are implementing across Canada to address the misuse, abuse, and diversion of prescription narcotics (opioids), benzodiazepines, stimulants, and gabapentin. This information may assist drug policy

Canadian Agency for Drugs and Technologies in Health - Environmental Scanning2015

15. Epidural steroid injections compared with gabapentin for lumbosacral radicular pain: multicenter randomized double blind comparative efficacy study.

Epidural steroid injections compared with gabapentin for lumbosacral radicular pain: multicenter randomized double blind comparative efficacy study. 25883095 2015 04 17 2015 06 01 2017 02 20 1756-1833 350 2015 Apr 16 BMJ (Clinical research ed.) BMJ Epidural steroid injections compared with gabapentin for lumbosacral radicular pain: multicenter randomized double blind comparative efficacy study. h1748 10.1136/bmj.h1748 To evaluate whether an epidural steroid injection or gabapentin is a better (...) received either epidural steroid injection plus placebo pills or sham injection plus gabapentin. Average leg pain one and three months after the injection on a 0-10 numerical rating scale. A positive outcome was defined as a ≥ 2 point decrease in leg pain coupled with a positive global perceived effect. All patients had one month follow-up visits; patients whose condition improved remained blinded for their three month visit. There were no significant differences for the primary outcome measure at one

BMJ2015 Full Text: Link to full Text with Trip Pro

17. Randomized controlled trial of gabapentin as an adjunct to perioperative analgesia in total hip arthroplasty patients

Randomized controlled trial of gabapentin as an adjunct to perioperative analgesia in total hip arthroplasty patients 25772701 2015 04 08 2015 12 29 2015 04 08 1496-8975 62 5 2015 May Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Randomized controlled trial of gabapentin as an adjunct to perioperative analgesia in total hip arthroplasty patients. 476-84 10.1007/s12630-014-0310-y Gabapentin was investigated as a single-dose adjunct to morphine for postoperative (...) pain management. The primary objective was to determine if gabapentin given preoperatively and for two days postoperatively as part of multimodal analgesia would decrease postoperative morphine consumption in patients undergoing primary total hip arthroplasty (THA). The study group included 102 patients aged 19-90 years who were undergoing primary THA in a single joint with no contraindications to the study medications, no chronic pain syndrome, and no chronic opioid use. Intervention group

EvidenceUpdates2015

19. Gabapentin and pregabalin: major adverse effects

Gabapentin and pregabalin: major adverse effects Prescrire IN ENGLISH - Spotlight ''Gabapentin and pregabalin: major adverse effects'', 1 November 2014 {1} {1} {1} | | > > > Gabapentin and pregabalin: major adverse effects Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Gabapentin and pregabalin: major adverse effects To reduce the consequences (...) of some severe adverse effects associated with gabapentin or pregabalin, it is advisable not to expose patients to them other than in situations where these drugs have proved to be highly effective. Gabapentin and pregabalin are used in certain epilepsies and for pain in neurological diseases. Pregabalin is also used to treat anxiety disorders. According to a review of French pharmacovigilance data published in 2013, between 1995 and 2009, 2415 adverse effects linked to gabapentin or pregabalin were

Prescrire2014

20. Gabapentin Is as Effective as an Occlusal Appliance in Controlling Nighttime Masticatory EMG Activity

Gabapentin Is as Effective as an Occlusal Appliance in Controlling Nighttime Masticatory EMG Activity UTCAT2762, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Gabapentin Is as Effective as an Occlusal Appliance in Controlling Nighttime Masticatory EMG Activity Clinical Question In a patient with fixed orthodontic bands and nighttime parafunctional habits, is gabapentin as effective and safe as an oral appliance (...) in reducing levels of nighttime masticatory EMG activity? Clinical Bottom Line Gabapentin (200 or 300 mg at bedtime) is a good treatment option for reducing nighttime masticatory EMG activity when an occlusal appliance cannot be used; it also has a good safety profile. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Madani/2012 20 patients (stabilization splint group [n = 10] and gabapentin group [n = 10

UTHSCSA Dental School CAT Library2014