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Latest & greatest articles for folic acid
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Lowering blood homocysteine with folicacid-based supplements: meta-analysis of randomised trials Lowering blood homocysteine with folicacid-based supplements: meta-analysis of randomised trials Lowering blood homocysteine with folicacid-based supplements: meta-analysis of randomised trials Homocysteine Lowering Trialists' Collaboration Authors' objectives To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folicacid and with vitamins (...) B12 or B6. Searching English and non-English language studies were sought in MEDLINE. The reference lists were scanned and personal contact was made with relevant investigators. Study selection Study designs of evaluations included in the review Published and unpublished randomised controlled trials (RCTs) were included if they had assessed the effects on blood homocysteine concentrations of folicacid supplements with or without the addition of vitamins B6 or B12. Excluded were studies which did
Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folicacid in patients with coronary heart disease. The Food and Drug Administration (FDA) has recommended that cereal-grain products be fortified with folicacid to prevent congenital neural-tube defects. Since folicacid supplementation reduces levels of plasma homocyst(e)ine, or plasma total homocysteine, which are frequently elevated in arterial occlusive disease, we hypothesized that folicacid fortification might (...) reduce plasma homocyst(e)ine levels.To test this hypothesis, we assessed the effects of breakfast cereals fortified with three levels of folicacid, and also containing the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blind, placebo-controlled, crossover trial in 75 men and women with coronary artery disease.Plasma folicacid increased and plasma homocyst(e)ine decreased proportionately with the folicacid content of the breakfast cereal. Cereal providing 127 microg
Lowering blood homocysteine with folicacid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folicacid and with vitamins B-12 or B-6.Meta-analysis of randomised controlled trials that assessed the effects of folicacid based supplements on blood homocysteine concentrations. Multivariate regression analysis was used to determine (...) the effects on homocysteine concentrations of different doses of folicacid and of the addition of vitamin B-12 or B-6.Individual data on 1114 people included in 12 trials.The proportional and absolute reductions in blood homocysteine produced by folicacid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 mumol/l
Minimum effective dose of folicacid for food fortification to prevent neural-tube defects. Although a daily supplement of 400 micrograms folicacid has been shown to prevent neural-tube defects (NTD), most women do not take the recommended supplement. Thus, food fortification is to be introduced in the USA and is being considered in the UK. Because of safety concerns, the USA has chosen a level of fortification that will increase the average woman's intake by only 100 micrograms (...) . Such an increase, although safe, may be ineffective; but a trial to assess its efficacy would be unethical. Because women with red-cell folate concentrations above 400 micrograms/L have a very low risk of NTD, we undertook a randomised trial of several folicacid doses to find out how much is needed to reach this protective concentration.We screened 323 women. 172 with red-cell folate between 150 micrograms/L and 400 micrograms/L were invited to take part in the trial. 121 women were randomly assigned placebo
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folicacid intakes. To determine the risk of elevated total homocysteine (tHcy) levels for arteriosclerotic vascular disease, estimate the reduction of tHcy by folicacid, and calculate the potential reduction of coronary artery disease (CAD) mortality by increasing folicacid intake.MEDLINE search for meta-analysis of 27 studies relating homocysteine to arteriosclerotic (...) vascular disease and 11 studies of folicacid effects on tHcy levels.Studies dealing with CAD, cerebrovascular disease, and peripheral arterial vascular disease were selected. Three prospective and six population-based case-control studies were considered of high quality. Five cross-sectional and 13 other case-control studies were also included. Causality of tHcy's role in the pathogenesis of vascular disease was inferred because of consistency across studies by different investigators using different
Folicacid fortification of grain: an economic analysis Folicacid fortification of grain: an economic analysis Folicacid fortification of grain: an economic analysis Romano P S, Waitzman N J, Scheffler R M, Pi R D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study (...) and the conclusions drawn. Health technology Fortification of grain with folicacid to prevent neural tube defects (spina bifida and anencephaly). Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population Women of child-bearing age (11 to 50 years). Setting Community. The economic study was carried out in California, USA. Dates to which data relate Data on the effectiveness of folicacid fortification was taken from two studies published in 1989 and 1991. The data