Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for folic acid
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on folic acid or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on folic acid and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
Reduction in neural-tube defects after folic acid fortification in Canada. BACKGROUND: In 1998, folic acid fortification of a large variety of cereal products became mandatory in Canada, a country where the prevalence of neural-tube defects was historically higher in the eastern provinces than in the western provinces. We assessed changes in the prevalence of neural-tube defects in Canada before and after food fortification with folic acid was implemented. METHODS: The study population included (...) live births, stillbirths, and terminations of pregnancies because of fetal anomalies among women residing in seven Canadian provinces from 1993 to 2002. On the basis of published results of testing of red-cell folatelevels, the study period was divided into prefortification, partial-fortification, and full-fortification periods. We evaluated the relationship between baseline rates of neural-tube defects in each province and the magnitude of the decrease after fortification was implemented. RESULTS
Folic acid supplements and risk of facial clefts: national population based case-control study. OBJECTIVE: To explore the role of folic acid supplements, dietary folates, and multivitamins in the prevention of facial clefts. DESIGN: National population based case-control study. SETTING: Infants born 1996-2001 in Norway. PARTICIPANTS: 377 infants with cleft lip with or without cleft palate; 196 infants with cleft palate alone; 763 controls. MAIN OUTCOME MEASURES: Association of facial clefts (...) with maternal intake of folic acid supplements, multivitamins, and folates in diet. RESULTS: Folic acid supplementation during early pregnancy (> or =400 microg/day) was associated with a reduced risk of isolated cleft lip with or without cleft palate after adjustment for multivitamins, smoking, and other potential confounding factors (adjusted odds ratio 0.61, 95% confidence interval 0.39 to 0.96). Independent of supplements, diets rich in fruits, vegetables, and other high folatecontaining foods
Folic acid and risk of twinning: a systematic review of the recent literature, July 1994 to July 2006 Folic acid and risk of twinning: a systematic review of the recent literature, July 1994 to July 2006 Folic acid and risk of twinning: a systematic review of the recent literature, July 1994 to July 2006 Muggli E E, Halliday J L CRD summary The authors concluded that there is evidence of a possible association between periconceptional folic acid and the risk of twinning, but further research (...) is required. The authors' cautious conclusions appear to reflect the limited data, but the poorly defined review question, inadequate reporting of the review methods and inadequate quality assessment make it difficult to assess the reliability of these conclusions. Authors' objectives To examine the association between periconceptional folic acid (FA) supplementation and fortification of foods with FA and the risk of twinning. Searching The Cochrane Library (Issue 4, 2005), MEDLINE via PubMed, MEDLINE
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis Efficacy of folic acid supplementation in stroke prevention: a meta-analysis Efficacy of folic acid supplementation in stroke prevention: a meta-analysis Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, Sun N, Liu L, Xu X CRD summary This review evaluated the efficacy of folic acid supplementation in the prevention of stroke. Folic acid administration was associated with a significant reduction in the risk of stroke (...) which had greater statistical significance when folic acid was given for primary stroke prevention. Whilst the conclusions are supported by the evidence presented, it is not possible to determine fully their reliability. Authors' objectives To review the efficacy of folic acid supplementation in the primary and secondary prevention of stroke. Searching The authors evaluated relevant articles from another meta-analysis on a similar topic (see Other Publications of Related Interest) in which a MEDLINE
Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials de Bree A, van Mierlo LA, Draijer R CRD summary The review aimed to quantify the effect of folic acid on endothelial function and concluded that high doses improved function after four weeks (...) of supplementation. The presence of review methodology and reporting issues, coupled with the small sample sizes of included studies, means the authors' conclusions should be interpreted with caution. Authors' objectives To quantify the effect of folic acid on endothelial function, as measured with the use of flow-mediated dilatation. Searching MEDLINE was searched from 1966 to September 2005 for studies published in English; search terms were reported. Conference abstract books and reference lists of obtained
Cost-effectiveness of a folic acid fortification program in Chile Cost-effectiveness of a folic acid fortification program in Chile Cost-effectiveness of a folic acid fortification program in Chile Llanos A, Hertrampf E, Cortes F, Pardo A, Grosse S D, Uauy R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical (...) assessment on the reliability of the study and the conclusions drawn. CRD summary This study determined the cost-effectiveness of wheat flour fortified with folic acid, compared with standard wheat flour, in the periconceptional period to reduce neural tube defects (NTDs) in all births weighing more than 499 g in Chile. The authors concluded that the programme was a cost-effective intervention for the prevention of NTDs in Chile. The quality of the study methodology was satisfactory, with good reporting
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. 17551129 2007 06 06 2007 06 11 2016 10 25 1538-3598 297 21 2007 Jun 06 JAMA JAMA Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. 2351-9 Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine. To assess the safety and efficacy of folic acid supplementation for preventing colorectal adenomas. A double-blind, placebo (...) -controlled, 2-factor, phase 3, randomized clinical trial conducted at 9 clinical centers between July 6, 1994, and October 1, 2004. Participants included 1021 men and women with a recent history of colorectal adenomas and no previous invasive large intestine carcinoma. Participants were randomly assigned in a 1:1 ratio to receive 1 mg/d of folic acid (n = 516) or placebo (n = 505), and were separately randomized to receive aspirin (81 or 325 mg/d) or placebo. Follow-up consisted of 2 colonoscopic
Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. 17240287 2007 01 22 2007 02 01 2015 06 16 1474-547X 369 9557 2007 Jan 20 Lancet (London, England) Lancet Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. 208-16 Low folateand raised homocysteine concentrations in blood are associated with poor (...) cognitive performance in the general population. As part of the FACIT trial to assess the effect of folic acid on markers of atherosclerosis in men and women aged 50-70 years with raised plasma total homocysteine and normal serum vitamin B12 at screening, we report here the findings for the secondary endpoint: the effect of folic acid supplementation on cognitive performance. Our randomised, double blind, placebo controlled study took place between November, 1999, and December, 2004, in the Netherlands
Folic acid: a public-health challenge. Despite worldwide public-health campaigns recommending periconceptional daily supplementation of synthetic folic acid to reduce the risk of neural tube defects, many women are not following these recommendations. At the same time, in most European countries no decline in defects has been recorded in recent years. Vulnerable groups are those with a low standard of education, young people, and women with unplanned pregnancies. Furthermore, in most countries (...) without mandatory fortification, the general population is not consuming the recommended 0.4 mg of food folateper day. Voluntary fortification improves the situation, but does not reach all parts of the population. In the USA, Canada, and Chile, mandatory fortification of flour substantially improved folateand homocysteine status, and neural tube defects rates fell by between 31% and 78%. Nevertheless, many countries do not choose mandatory folic acid fortification, in part because expected
Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials Bazzano L A, Reynolds K, Holder K N, He J CRD summary This review showed that, for people with cardiovascular or renal disease (...) , folic acid supplementation had no effect on the risk of further cardiovascular disease (CVD), coronary heart disease, stroke or all-cause mortality. The authors concluded that folic acid is ineffective in the secondary prevention of CVD. The review was generally well conducted and the conclusions are likely to be reliable. Authors' objectives To assess the effects of folic acid supplements in people with pre-existing vascular disease. Searching MEDLINE was searched from January 1966 to July 2006
Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. 16413877 2006 01 17 2006 01 24 2015 06 16 1474-547X 367 9505 2006 Jan 14 Lancet (London, England) Lancet Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission (...) setting: community-based, randomised, placebo-controlled trial. 133-43 Anaemia caused by iron deficiency is common in children younger than age 5 years in eastern Africa. However, there is concern that universal supplementation of children with iron and folic acid in areas of high malaria transmission might be harmful. We did a randomised, placebo-controlled trial, of children aged 1-35 months and living in Pemba, Zanzibar. We assigned children to daily oral supplementation with: iron (12.5 mg
Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. 16413878 2006 01 17 2006 01 24 2016 12 15 1474-547X 367 9505 2006 Jan 14 Lancet (London, England) Lancet Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. 144-52 Iron deficiency (...) is widespread in the developing world and is especially common in young children who live on the Indian subcontinent. Supplementation with iron and folic acid alleviates severe anaemia and enhances neurodevelopment in deficient populations, but little is known about the risks of mortality and morbidity associated with supplementation. We did a community-based, cluster-randomised, double-masked, placebo-controlled, 2x2 factorial trial in children aged 1-36 months and residing in southern Nepal. We randomly
Homocysteine lowering with folic acid and B vitamins in vascular disease. 16531613 2006 04 13 2006 04 18 2013 11 21 1533-4406 354 15 2006 Apr 13 The New England journal of medicine N. Engl. J. Med. Homocysteine lowering with folic acid and B vitamins in vascular disease. 1567-77 In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation (...) reduced the risk of major cardiovascular events in patients with vascular disease. We randomly assigned 5522 patients 55 years of age or older who had vascular disease or diabetes to daily treatment either with the combination of 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 or with placebo for an average of five years. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, and stroke. Mean plasma homocysteine levels decreased by 2.4
Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records. OBJECTIVE: To determine whether failure to adequately adjust for a reported 40% misclassification of use of in vitro fertilisation (IVF) as reported in a Swedish study could have led to a false finding that folic acid increases dizygotic twinning. DESIGN: Modelling with population based data. SETTING: Swedish vital records for 1995-9. MAIN OUTCOME (...) MEASURES: Rates of twinning calculated according to whether women used IVF to become pregnant. Estimated unadjusted and adjusted odds ratios of the association between use of folic acid and twinning by use of IVF. RESULTS: In 1995-9, Swedish women who used IVF had an almost 20 times the chance of having twins than women who did not use IVF (rate ratio 19.7, 95% confidence interval 18.7 to 20.6). In the absence of a true effect of folic acid, the use of a 40% misclassified surrogate variable to adjust
International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? OBJECTIVES: To evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing the occurrence of neural tube defects. DESIGN: Retrospective cohort study of births monitored by birth defect registries. SETTING: 13 birth defects registries monitoring rates of neural tube defects from 1988 to 1998 in Norway, Finland, Northern (...) ) and before and after the year of local recommendations (when applicable). RESULTS: The issuing of recommendations on folic acid was followed by no detectable improvement in the trends of incidence of neural tube defects. CONCLUSIONS: Recommendations alone did not seem to influence trends in neural tube defects up to six years after the confirmation of the effectiveness of folic acid in clinical trials. New cases of neural tube defects preventable by folic acid continue to accumulate. A reasonable
Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study. BACKGROUND: Folic acid supplements are recommended for women of childbearing age to prevent neural tube defects in their offspring. Results of some studies, however, suggest an increase in multiple births associated with use of vitamin supplements that contain folic acid during pregnancy. Our aim was to assess this association. METHODS: We used data from a population-based cohort (...) study from which we assessed the occurrence of multiple births in women (n=242015) who had participated in a campaign to prevent neural tube defects with folic acid supplements (400 microg per day) in China. Folic acid use was ascertained before pregnancy outcome was known. We studied the relation between multiple births and any use of folic acid pills before or during early pregnancy; additionally, we investigated mechanisms by which folic acid could potentially affect the occurrence of multiple
Folic acid with or without vitamin B12 for cognition and dementia. BACKGROUND: Folates are vitamins essential to the development of the central nervous system. Insufficient folateactivity at the time of conception and early pregnancy can result in congenital neural tube defects. In adult life folatedeficiency has been known for decades to produce a characteristic form of anaemia ("megaloblastic"). More recently degrees of folateinadequacy, not severe enough to produce anaemia, have been (...) found to be associated with high blood levels of the amino acid homocysteine. Such degrees of folateinadequacy can arise because of insufficient folates in the diet or because of inefficient absorption or metabolic utilisation of folates due to genetic variations. Conventional criteria for diagnosing folatedeficiency may be inadequate for identifying people capable of benefiting from dietary supplementation. High blood levels of homocysteine have been linked with the risk of arterial disease
Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Fortification of food with folic acid to prevent neural-tube defects in babies also lowers plasma total homocysteine, which is a risk factor for vascular disease. We investigated the effect of folateand vitamin B12 on homocysteine concentrations. 30 men and 23 women received sequential supplementation with increasing doses of folic acid. After supplementation, the usual dependency of homocysteine on folate (...) diminished, and vitamin B12 became the main determinant of plasma homocysteine concentration. This finding suggests that a fortification policy based on folic acid and vitamin B12, rather than folic acid alone, is likely to be much more effective at lowering of homocysteine concentrations, with potential benefits for reduction of risk of vascular disease.