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Latest & greatest articles for folic acid
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Adherence to prenatal iron-folicacid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis. Daily iron-folicacid supplementation reduces anemia and various adverse obstetric outcomes such as preterm delivery, low birthweight, hemorrhage, and perinatal and maternal morbidity and mortality. However, its supplementation has not been successful that attributed to several determinants including poor adherence. Therefore, we aimed to conduct (...) a systematic review and meta-analysis on the prevalence and determinants of adherence to prenatal iron-folicacid supplementation in low- and middle-income countries. In addition, we will develop a conceptual framework in the context of low- and middle-income countries (LMIC).We will search PubMed, MEDLINE, EMBASE, EBSCO, Web of Science, SCOPUS, WHO Global Index Medicus, and African Journals Online (AJOL) databases to retrieve relevant literatures. Observational (i.e., case-control, cohort, cross-sectional
Supplementation of folicacid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis We aimed to systematically assess the relationship between folicacid supplementation in pregnancy and risk of preeclampsia and gestational hypertension.The relevant studies were included by retrieving the Embase, PubMed and Cochrane library databases. Data extraction was conducted by two investigators independently. The risk ratio (RR) and 95% confidence interval (CI) were used (...) as effect indexes to evaluate the relationship between folicacid supplementation and risk of gestational hypertension or preeclampsia. A subgroup analysis was performed according to the supplementation patterns of folicacid. The homogeneity of the effect size was tested across the studies, and publication biases were examined.In total, 13 cohort studies and 1 randomized controlled trial study was included, containing 160,562 and 149,320 women with and without folicacid supplementation during
Maternal folicacid supplementation for the prevention of preeclampsia: A systematic review and meta-analysis. Preeclampsia is a significant contributor to maternal and neonatal morbidity and mortality. Folicacid supplementation is recommended periconceptionally for the prevention of neural tube defects. Epidemiological evidence suggests that maternal folicacid supplementation may play a role in preventing other adverse birth outcomes. This systematic review aimed to investigate the effect (...) of maternal folicacid supplementation during pregnancy on risk of preeclampsia and gestational hypertension.Multiple scientific databases and grey literature were searched for relevant studies. Studies were reviewed according to pre-specified inclusion and exclusion criteria. Study characteristics were summarised and study quality was assessed. A meta-analysis of observational studies was conducted to examine the effect of maternal folicacid supplementation on preeclampsia risk.Meta-analysis of eight
Folicacid supplementation during the preconception period: A systematic review and meta-analysis. Guidelines recommend that women take folicacid supplements in the preconception period to prevent neural tube defects (NTDs) in their offspring. Estimates of adherence to this recommendation across different countries worldwide have not been synthesized. Medline, CINAHL, and EMBASE were systematically searched to identify studies reporting the prevalence of preconception folicacid (...) supplementation. Pooled prevalence estimates for each country (where data were available) were calculated; and differences based on demographic, methodological, and study quality characteristics were examined. Of 3372 titles and abstracts screened, 722 full-texts were reviewed and 105 articles that reported 106 estimates of preconception folicacid supplementation in 34 countries were included. Pooled prevalence estimates were 32-51% in North America, 9-78% in Europe, 21-46% in Asia, 4-34% in the Middle East
The effect of vitamin B12 and folicacid supplementation on routine haematological parameters in older people: an individual participant data meta-analysis. Low vitamin B12 and folate levels in community-dwelling older people are usually corrected with supplements. However, the effect of this supplementation on haematological parameters in older persons is not known. Therefore, we executed a systematic review and individual participant data meta-analysis of randomised placebo-controlled trials (...) (RCTs).We performed a systematic search in PubMed, EMBASE, Web of Science, Cochrane and CENTRAL for RCTs published between January 1950 and April 2016, where community-dwelling elderly (60+ years) who were treated with vitamin B12 or folicacid or placebo. The presence of anaemia was not required. We analysed the data on haematological parameters with a two-stage IPD meta-analysis.We found 494 full papers covering 14 studies. Data were shared by the authors of four RCTs comparing vitamin B12
FolicAcid in Stroke Prevention in Countries without Mandatory FolicAcid Food Fortification: A Meta-Analysis of Randomized Controlled Trials. Additional folicacid (FA) treatment appears to have a neutral effect on reducing vascular risk in countries that mandate FA fortification of food (e.g., USA and Canada). However, it is uncertain whether FA therapy reduces stroke risk in countries without FA food fortification. The purpose of this study was to comprehensively evaluate the efficacy of FA
Effect of folicacid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. The evidences illustrating the effects of folicacid supplementation (FAS) in individuals with type 2 diabetes on plasma total homocysteine (tHcy) levels and glycemic control have been contradictory. The aim of the study was to systematically search and quantitatively analyze the effect of FAS on tHcy levels and HbA1c compared (...) with placebo.We searched PubMed, Scopus, and Embase up to March 2012 without language restriction. Key words "folicacid" and "diabetes mellitus" with slight modifications based on the sources for search strategy were used. References of initially identified articles were examined to identify any other relevant studies. A random-effects model was used for estimation the pooled effect estimates (weighted mean different, WMD).Of 6185 studies identified, 4 studies with 183 patients were included. FAS had
Folicacid intake and folate status and colorectal cancer risk: AÂ systematic review and meta-analysis. To evaluate the controversies among the studies assessing the association between folicacid intake or folate status and colorectal cancer risk.PubMed, Cochrane library and references of related articles were searched from January 2000 to September 2016. Studies on folicacid intake or folate status and colorectal cancer or adenoma risk were included. Full text review was conducted (...) reduced colorectal cancer risk in total folate intake in cohort studies; 0.71 (95% CI: 0.59-0.86). Odds Ratio was also significantly reduced in case control studies; 0.77 (95% CI: 0.62-0.95). Nevertheless once folate status was measured as Red Blood Cell folate content, no significant effect on colorectal cancer risk was observed; 1.05 (95% CI: 0.85-1.30).The differences in bioavailability and metabolism of synthetic folicacid and natural dietary folate as well as variation in the baseline
FolicAcid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Controversy remains regarding the efficacy of folicacid supplementation in reducing the risk of stroke. This study aimed to evaluate the effect of folicacid supplementation on stroke prevention in patients with cardiovascular disease (CVD).We searched the PubMed, EMBASE and Cochrane Library databases through October 2016 to identify randomized clinical trials of folicacid supplementation to prevent (...) stroke in patients with CVD. Relative risks (RRs) with 95% CIs were used to examine the association between folicacid supplementation and the risk of stroke with a fixed-effect model. Stratified analyses were performed according to modifiers that may affect the efficacy of folicacid supplementation.Eleven studies with a total of 65,790 participants were included. Folicacid supplementation was associated with a significant benefit in reducing the risk of stroke in patients with CVD (RR = 0.90; 95
The association between maternal use of folicacid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis. Previous reviews have been conducted to evaluate the association between maternal use of folicacid supplements during pregnancy and risk of autism spectrum disorders (ASD) in children, with no definitive conclusion. We therefore conducted a more comprehensive meta-analysis to reassess the relationship between folicacid and the risk of ASD (...) . The electronic databases PubMed, Web of Knowledge, and Wanfang Data were carefully searched to find eligible studies as recent as March 2017. A random effects model was used to combine the relative risk (RR) with 95% confidence intervals (CI). Sensitivity analysis and publication bias were conducted. A total of 12 articles with 16 studies comprising 4514 ASD cases were included in this report. It was found that supplementation with folicacid during pregnancy could reduce the risk of ASD [RR = 0.771, 95% CI
A Meta-Analysis of FolicAcid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia. Folicacid is generally used to lower homocysteine concentrations and prevent stroke and cardiovascular disease (CVD) at present. However, the efficacy of therapies that lower homocysteine concentrations in reducing the risk of CVD and stroke remains controversial. Our objective was to do a meta-analysis of relevant randomized controlled trials (RCTs) to evaluate (...) the efficacy of folicacid supplementation among patients with hypertension and Hyperhomocysteinemia (HT/HHcy). We included RCTs examining the effects of folicacid plus antihypertensive therapy compared to antihypertensive alone. Weighted Mean Difference (WMD) and Relative risk (RR) were used as a measure of the effect of folicacid on the outcome measures with a random effect model. Sixty-five studies including 7887 patients met all inclusion criteria. Among them, 49 trials reported significant effect
Is folicacid supplementation useful for chronic kidney disease? Patients with chronic kidney disease have higher cardiovascular risk than general population, a fact that has been linked to high homocysteine levels. Folicacid supplementation can reduce homocysteine levels, which would reduce cardiovascular events. However, there is controversy about the clinical effects of this measure. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six (...) systematic reviews comprising 13 trials addressing the question of this article. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded folicacid supplementation does not reduce the risk of myocardial infarction or stroke in patients with chronic kidney disease, and might have no effect on mortality.
Effects of folicacid fortification on orofacial clefts prevalence: a meta-analysis. Orofacial clefts (OFC) are the most prevalent craniofacial birth defect. Folicacid (FA) supplementation has been demonstrated as an effective intervention to reduce risk of OFC occurrence. However, the effect of mandatory FA fortification of wheat and/or maize flour on OFC prevalence has shown controversial results among countries adopting this policy. Thus, we performed a meta-analysis to synthesize
Meta-analysis of folicacid efficacy trials in stroke prevention: Insight into effect modifiers. To examine the efficacy and effect modifiers of folicacid supplementation in the prevention of stroke in regions without folicacid fortification based on relevant, up-to-date published randomized trials.Relative risk (RR) was used to measure the effect of folicacid supplementation on risk of stroke using a fixed effects model.Overall, folicacid supplementation significantly reduced the stroke (...) risk by 11% (22 trials, n = 82,723; RR 0.89, 95% confidence interval [CI] 0.84-0.96). The effect was greater in low folate regions (2 trials, n = 24,020; Asia, 0.78, 0.67-0.90) compared to high folate regions (7 trials, n = 14,655; America, 1.05, 0.90-1.23), and among patients without folicacid fortification (11 trials, n = 49,957; 0.85; 0.77-0.94) compared with those with folicacid fortification (7 trials, n = 14,655; 1.05, 0.90-1.23). In further stratified analyses among trials without folic
Folicacid alone or multivitamin containing folicacid intake during pregnancy and the risk of gestational hypertension and preeclampsia through meta-analyses. The objective of this study was to assess the effect of folicacid and multivitamin use during pregnancy on the risk of developing of hypertensive disorder of pregnancy.Two reviewers independently determined all prospective cohort study, retrospective cohort study, large population based cohort study, retrospective secondary analysis (...) , and double blinded, placebo-controlled, randomized clinical trial published using PubMed Medline database, KERIS (Korea Education and Research Information Service), Scopus, and the Cochrane Central Register of controlled trials comparing before conception throughout pregnancy intake oral multivitamin containing folicacid or folicacid alone. Meta-analyses were estimated with odds ratios and 95% confidence intervals (CIs) using random effect analysis according to heterogeneity of studies.Data from six
FolicAcid Supplementation for the Prevention of Neural Tube Defects: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. Neural tube defects are among the most common congenital anomalies in the United States. Periconceptional folicacid supplementation is a primary care-relevant preventive intervention.To review the evidence on folicacid supplementation for preventing neural tube defects to inform the US Preventive Services Task Force for an updated (...) Recommendation Statement.MEDLINE, Cochrane Library, EMBASE, and trial registries through January 28, 2016, with ongoing surveillance through November 11, 2016; references; experts.English-language studies of folicacid supplementation in women. Excluded were poor-quality studies; studies of prepubertal girls, men, women without the potential for childbearing, and neural tube defect recurrence; and studies conducted in developing countries.Two investigators independently reviewed abstracts, full-text articles
FolicAcid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folicacid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone.To update the 2009 US Preventive (...) Services Task Force (USPSTF) recommendation on folicacid supplementation in women of childbearing age.In 2009, the USPSTF reviewed the effectiveness of folicacid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folicacid supplementation.The USPSTF assessed the balance of the benefits and harms of folicacid supplementation in women of childbearing age and determined that the net
How does smoking, alcohol use, folicacid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother? Knowledge & Library Services (KLS) Evidence Briefing How does smoking, alcohol use, folicacid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother? Nicola Pearce-Smith November 29 th 2017 How does smoking, alcohol use, folicacid, maternal obesity and timing of antenatal care in pregnancy vary (...) by socioeconomic status or age of mother? KLS Evidence Briefing November 29 th 2017 Question This briefing summarises the evidence on five risk factors in pregnancy (use of alcohol, smoking, maternal obesity, folicacid supplementation and timing of antenatal care) for women of different ages and socioeconomic status (SES), from Jan 2008 to Nov 2017. Key messages ? advanced maternal age (AMA) of 35yrs or older was often associated with an increased risk of stillbirth, low birthweight, preterm birth, Caesarean
FolicAcid for the Prevention of Neural Tube Defects: Preventive Medication Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation Women who are planning or capable of pregnancy The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folicacid. A Population Women who are planning or capable of pregnancy Recommendation Take a daily (...) supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folicacid. Grade: A Risk Assessment All women of childbearing age are at risk of having a pregnancy affected by neural tube defects. Some factors increase this risk, including a personal or family history of neural tube defects, use of particular antiseizure medications, maternal diabetes, obesity, and mutations in folate-related enzymes. Preventive Medication Folicacid is the synthetic form of folate, a water-soluble B vitamin. Folicacid