Latest & greatest articles for folic acid

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Top results for folic acid

21. Bias toward the null hypothesis in pregnancy drug studies that do not include data on medical terminations of pregnancy: the folic acid antagonists

Bias toward the null hypothesis in pregnancy drug studies that do not include data on medical terminations of pregnancy: the folic acid antagonists 21343345 2012 01 06 2012 04 26 2012 01 06 1552-4604 52 1 2012 Jan Journal of clinical pharmacology J Clin Pharmacol Bias toward the null hypothesis in pregnancy drug studies that do not include data on medical terminations of pregnancy: the folic acid antagonists. 78-83 10.1177/0091270010390806 Most studies on safety/risk of drugs in pregnancy (...) consider the proportion of births (but not pregnancy terminations) affected by the drug from all exposed infants. Lack of data on pregnancy terminations could bias results. A computerized database for medications dispensed to pregnant women in southern Israel was linked with records from the district hospital; 84 823 deliveries and 998 medical pregnancy terminations took place; 571 of the women were exposed to folic acid antagonists in the first trimester. When only births were examined

EvidenceUpdates2012

22. Intermittent iron and folic acid supplementation in non-anaemic pregnant women

Intermittent iron and folic acid supplementation in non-anaemic pregnant women WHO | Archived: Intermittent iron and folic acid supplementation in non-anaemic pregnant women Archived This publication and its contents has been superseded by a more recent version. It is here for reference purposes. Please follow Access Search Search the Navigation Language Nutrition Menu Archived: Intermittent iron and folic acid supplementation in non-anaemic pregnant women Guideline Authors : World Health (...) Organization Publication details Number of pages : 26 Publication date : 2012 Languages : English, Portuguese, Spanish ISBN : 978 92 4 150201 6 Downloads pdf, 1.20Mb pdf, 661.67kb pdf, 807kb Overview This guideline provides global, evidence-informed recommendations on intermittent iron and folic acid supplementation as a public health intervention for the purpose of improving pregnancy outcomes and reducing maternal anaemia in pregnancy. The guideline will help Member States and their partners

World Health Organisation Guidelines2012

23. Daily iron and folic acid supplementation in pregnant women

Daily iron and folic acid supplementation in pregnant women WHO | Archived: Daily iron and folic acid supplementation in pregnant women Archived This publication and its contents has been superseded by a more recent version. It is here for reference purposes. Please follow Access Search Search the Navigation Language Nutrition Menu Archived: Daily iron and folic acid supplementation in pregnant women Guideline Authors : World Health Organization Publication details Editors : World Health (...) Organization Number of pages : 27 Publication date : 2012 Languages : English, Portuguese, Spanish ISBN : 978 92 4 150199 6 Downloads pdf, 862kb Overview This guideline provides global, evidence-informed recommendations on daily iron and folic acid supplementation in pregnant women as a public health intervention for the purpose of improving pregnancy outcomes and reducing maternal anaemia in pregnancy. The guideline will help Members States and their partners in their efforts to make informed decisions

World Health Organisation Guidelines2012

24. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis

Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis Huo Y, Qin X, Wang J, Sun N, Zeng Q, Liu L, Xu X, Wang X CRD summary This review found that folic acid supplementation was effective for stroke prevention in populations with partial or no folic acid fortification (...) of flour. In addition, larger effects were observed in trials with lower percentage use of statins. The review was well conducted and the authors' conclusions are likely to be reliable. Authors' objectives To evaluate the efficacy of folic acid supplementation in stroke prevention. Searching MEDLINE was searched to January 2012 for relevant studies; search terms were reported. The references from review articles and relevant trials were checked to identify additional studies. There were no language

DARE.2012

25. Folic acid supplements in pregnancy and severe language delay in children.

Folic acid supplements in pregnancy and severe language delay in children. CONTEXT: Prenatal folic acid supplements reduce the risk of neural tube defects and may have beneficial effects on other aspects of neurodevelopment. OBJECTIVE: To examine associations between mothers' use of prenatal folic acid supplements and risk of severe language delay in their children at age 3 years. DESIGN, SETTING, AND PATIENTS: The prospective observational Norwegian Mother and Child Cohort Study recruited (...) pregnant women between 1999 and December 2008. Data on children born before 2008 whose mothers returned the 3-year follow-up questionnaire by June 16, 2010, were used. Maternal use of folic acid supplements within the interval from 4 weeks before to 8 weeks after conception was the exposure. Relative risks were approximated by estimating odds ratios (ORs) with 95% CIs in a logistic regression analysis. MAIN OUTCOME MEASURE: Children's language competency at age 3 years measured by maternal report

JAMA2011 Full Text: Link to full Text with Trip Pro

26. Homocysteine-Lowering and Cardiovascular Disease Outcomes in Kidney Transplant Recipients: Primary Results From the Folic Acid for Vascular Outcome Reduction in Transplantation Trial

Homocysteine-Lowering and Cardiovascular Disease Outcomes in Kidney Transplant Recipients: Primary Results From the Folic Acid for Vascular Outcome Reduction in Transplantation Trial 21482964 2011 04 26 2011 06 30 2017 02 20 1524-4539 123 16 2011 Apr 26 Circulation Circulation Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. 1763-70 10.1161/CIRCULATIONAHA (...) to a multivitamin that included either a high dose (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocysteine concentrations reduced the rate of the primary composite arteriosclerotic cardiovascular disease outcome (myocardial infarction, stroke, cardiovascular disease death, resuscitated sudden death, coronary artery or renal artery revascularization, lower-extremity arterial disease, carotid endarterectomy or angioplasty, or abdominal

EvidenceUpdates2011

27. Folic acid for fragile X syndrome.

Folic acid for fragile X syndrome. BACKGROUND: It has been argued that individuals with fragile X syndrome could have low folate levels in their bodies and that supplementing their dietary intake might remediate the adverse developmental and behavioural effects of the condition. OBJECTIVES: To review the efficacy and safety of folic acid in the treatment of people with fragile X syndrome. SEARCH STRATEGY: We searched four databases in November 2010: CENTRAL, PubMed, EMBASE and PsycINFO (...) of autism or autistic behaviour. Four of the studies were placebo-controlled cross-over trials and one study was a parallel design. The duration of follow-up ranged from two months to 12 months and the period on folic acid or placebo ranged from two to eight months. Doses of folic acid ranged from 10 mg to 250 mg per day, 10 mg per day being the most common. Most of the younger patients involved were also taking part in special education programmes (usually involving language and occupational therapy

Cochrane2011

28. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children

Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children 21482950 2011 04 12 2011 06 07 2016 12 15 1526-632X 76 15 2011 Apr 12 Neurology Neurology Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. 1338-43 10.1212/WNL.0b013e3182152844 Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half of the patients. This study aimed to evaluate the effect of oral folic acid supplementation (0.5 (...) mg/day) for the prevention of PHT-induced gingival overgrowth (PIGO) in children with epilepsy aged 6-15 years on PHT monotherapy for 6 months. This was a randomized, double-blind, placebo-controlled trial conducted at a tertiary level hospital from May 2008 to June 2009. Children aged 6-15 years started on PHT monotherapy within last 1 month were eligible for inclusion. Preexisting gingival overgrowth, use of other folic acid antagonists, and macrocytic anemia were exclusion criteria. Trial

EvidenceUpdates2011 Full Text: Link to full Text with Trip Pro

29. Intermittent iron and folic acid supplementation in menstruating women

Intermittent iron and folic acid supplementation in menstruating women WHO | Intermittent iron and folic acid supplementation in menstruating women Access Search Search the Navigation Language Nutrition Menu Intermittent iron and folic acid supplementation in menstruating women Guideline Authors : World Health Organization Publication details Number of pages : 30 Publication date : 2011 Languages : Chinese, English, Farsi, French, Portuguese, Russian, Spanish ISBN : 978 92 4 150202 3 Downloads (...) pdf, 1.24Mb pdf, 661.67kb pdf, 762.61kb Overview This guideline provides global, evidence-informed, recommendations on the intermittent use of iron and folic acid supplements as a public health measure for the purpose of reducing anaemia and improving iron status among menstruating women. The guideline will help Members States and their partners in their efforts to make informed decisions on the appropriate nutrition actions to achieve the Millennium Development Goals, in particular, promotion

World Health Organisation Guidelines2011

30. Systematic review and meta-analysis: No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced

Systematic review and meta-analysis: No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you (...) are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years

Evidence-Based Medicine (Requires free registration)2011

31. Vitamins B(12), B(6), and folic acid for cognition in older men

Vitamins B(12), B(6), and folic acid for cognition in older men 20861451 2010 10 26 2010 11 12 2013 11 21 1526-632X 75 17 2010 Oct 26 Neurology Neurology Vitamins B(12), B(6), and folic acid for cognition in older men. 1540-7 10.1212/WNL.0b013e3181f962c4 To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function. The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind (...) controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was the change in the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog). A secondary aim of the study was to determine if supplementation with vitamins decreased the risk of cognitive impairment and dementia over 8 years. The groups were well-balanced for demographic and biochemical parameters. There was no difference in the ADAS-cog change from

EvidenceUpdates2010

32. Mental health literacy, folic acid and vitamin B12, and physical activity for the prevention of depression in older adults: randomised controlled trial

Mental health literacy, folic acid and vitamin B12, and physical activity for the prevention of depression in older adults: randomised controlled trial 20592433 2010 07 01 2010 11 16 2013 11 21 1472-1465 197 1 2010 Jul The British journal of psychiatry : the journal of mental science Br J Psychiatry Mental health literacy, folic acid and vitamin B12, and physical activity for the prevention of depression in older adults: randomised controlled trial. 45-54 10.1192/bjp.bp.109.075291 Few (...) randomised controlled trials (RCTs) have examined potential preventive agents in high-risk community populations. To determine whether a mental health literacy intervention, the promotion of physical activity, or folic acid plus vitamin B(12) reduce depression symptoms in community-dwelling older adults with elevated psychological distress. An RCT with a completely crossed 2 x 2 x 2 factorial design: (400 mcg/d folic acid + 100 mcg/d vitamin B(12) v. placebo)x(physical activity v. nutrition promotion

EvidenceUpdates2010

33. Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels

Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels Miller ER, Juraschek S, Pastor-Barriuso R, Bazzano LA, Appel LJ, Guallar E CRD (...) summary This review concluded that folic acid supplementation had no effect on cardiovascular disease, mortality and stroke. Stratified analysis showed higher risk of cardiovascular disease with folic acid with high baseline homocysteine level and lower risk with lower homocysteine. The authors’ conclusions on the overall outcomes appeared reasonable, but those for stratified analyses should be treated with caution. Authors' objectives To assess the effects of folic acid supplementation

DARE.2010

34. Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis

Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis Lee M, Hong KS, Chang SC, Saver JL CRD summary The authors concluded that folic acid supplementation was not associated with a major effect in averting stroke. This conclusion reflects the evidence presented (...) and is likely to be reliable, although incomplete reporting of review processes suggests a need for some caution. Authors' objectives To assess the efficacy of folic acid supplementation in the prevention of stroke. Searching MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov were searched from January 1966 to May 2009. Search terms were reported. No language restrictions were applied. Abstracts of American Heart Association-sponsored meetings were searched from January

DARE.2010

35. Folic acid to reduce neonatal mortality from neural tube disorders

Folic acid to reduce neonatal mortality from neural tube disorders Folic acid to reduce neonatal mortality from neural tube disorders Folic acid to reduce neonatal mortality from neural tube disorders Blencowe H, Cousens S, Modell B, Lawn J CRD summary This review provided further evidence of the effectiveness of folic acid for reducing the incidence of neural tube defects in neonates. The authors' conclusions warrant a cautious interpretation given the quality of the evidence and limitations (...) in the review methods. Authors' objectives To evaluate the effectiveness of folic acid fortification or supplementation on neonatal mortality from neural tube defects in low-income countries. Searching PubMed, EMBASE, the Cochrane Library and all World Health Organisation (WHO) regional databases were searched, up to September 2009, for studies published in any language. Search terms were reported. A snowball search method was used. Study selection Randomised controlled trials and observational studies

DARE.2010

36. Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer

Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer Carroll C, Cooper K, Papaioannou D, Hind D, Tappenden P, Pilgrim H, Booth A CRD summary This well-conducted review concluded that there was no evidence that folic acid was effective in the chemo-prevention (...) of colorectal adenomas or colorectal cancer for any population. The authors' conclusions reflected the results and are likely to be reliable, but the authors also noted that there were concerns with the small number of trials and the short duration of follow-up. Authors' objectives To assess the effectiveness of folic acid in reducing the recurrence of colorectal adenomas in increased-risk populations and reducing the occurrence of colorectal cancer in the average-risk (general) population. Searching

DARE.2010

37. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.

Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. 20571015 2010 06 23 2010 06 28 2016 12 03 1538-3598 303 24 2010 Jun 23 JAMA JAMA Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. 2486-94 10.1001/jama.2010.840 Blood homocysteine levels are positively associated (...) with cardiovascular disease, but it is uncertain whether the association is causal. To assess the effects of reducing homocysteine levels with folic acid and vitamin B(12) on vascular and nonvascular outcomes. Double-blind randomized controlled trial of 12,064 survivors of myocardial infarction in secondary care hospitals in the United Kingdom between 1998 and 2008. 2 mg folic acid plus 1 mg vitamin B(12) daily vs matching placebo. First major vascular event, defined as major coronary event (coronary death

JAMA2010

38. Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding 19507305 2009 06 08 2009 06 22 2013 11 21 1528-1167 50 5 2009 May Epilepsia Epilepsia Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee (...) of the American Academy of Neurology and the American Epilepsy Society. 1247-55 A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implications of placental and breast-milk transfer of antiepileptic drugs (AEDs). The committee evaluated the available evidence based on a structured literature review and classification

EvidenceUpdates2009

39. Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force.

Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force. Folic acid supplementation for th... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 2009 ) Volume: 150 , Issue: 9 , Pages: 632-639 PubMed: Available from or Find this paper at: Abstract BACKGROUND: Neural tube defects (NTDs) are among the most (...) common birth defects in the United States. In 1996, the U.S. Preventive Services Task Force (USPSTF) recommended that all women planning a pregnancy or capable of conception take a supplement containing folic acid to reduce the risk for NTDs. PURPOSE: To search for new evidence published since 1996 on the benefits and harms of folic acid supplementation for women of childbearing age to prevent neural tube defects in offspring, to inform an updated USPSTF recommendation. DATA SOURCES: MEDLINE

Annals of Internal Medicine2009

40. Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada.

Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada. OBJECTIVE: To investigate whether the 1998 government policy for mandatory fortification of flour and pasta products with folate was followed by a reduction in the prevalence of severe congenital heart defects. DESIGN: Time trend analysis. SETTING: Province of Quebec, Canada. PARTICIPANTS: Infants born in 1990-2005 identified with severe congenital heart defects (...) measures to increase folic acid intake were followed by a decrease in the birth prevalence of severe congenital heart defects. These findings support the hypothesis that folic acid has a preventive effect on heart defects.

BMJ2009 Full Text: Link to full Text with Trip Pro