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Latest & greatest articles for folic acid
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Maternal folicacid supplementation and infant birthweight in low- and middle-income countries: A systematic review. The relationship between maternal folicacid supplementation in pregnancy and infant birthweight has not been well described in low- and middle-income countries. We conducted a systematic review and meta-analysis of the current evidence of the association between folicacid supplementation in pregnancy on three primary outcomes: the incidence of low birthweight, small (...) for gestational age, and mean birthweight. Seventeen studies were identified, which satisfied the inclusion criteria, covering a total of 275,421 women from 13 cohort studies and four randomized controlled trials. For the primary outcome of mean birthweight (n = 9), the pooled mean difference between folicacid and control groups was 0.37 kg (95% confidence interval [CI]: 0.24 to 0.50), and this effect was larger in the randomized controlled trials (0.56, 95% CI: 0.15 to 0.97, n = 3). The pooled odds ratio
Association of maternal prenatal folicacid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis. A number of studies have explored the link of antenatal folicacid (FA) intake with autism spectrum disorder (ASD) in children, with inconsistent findings. Therefore, we conducted a systematic review and meta-analysis of relevant studies to elucidate the actual association between maternal FA intake during the prenatal period and the risk of ASD
Adherence to iron-folicacid supplementation among pregnant women in Ethiopia: a systematic review and meta-analysis. Despite the supplementation of iron-folicacid is the recommended strategy during the antenatal period; iron deficiency anemia is the commonest hematologic complication during pregnancy. Therefore, this systematic review and meta-analysis aimed to assess the level of adherence to iron-folicacid supplementation and its associated factors among pregnant women (...) pregnant women. The overall pooled prevalence of adherence to iron-folicacid supplementation among pregnant women in Ethiopia was 41.38% (95% CI: 33.09, 49.67). Having secondary and above educational status of the women (AOR:2.68,95%CI:1.25, 5.74), having an early registration of antenatal care follow-up (≤16 weeks) (AOR:2.54,95%CI:1.99, 3.24), having anemia complication during current pregnancy (AOR:3.01,95%CI:1.88, 4.81), having good knowledge of iron-folicacid supplementation (AOR: 2.96, 95%CI
The Protective Effect of Maternal FolicAcid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies. Maternal folicacid supplementation is considered mandatory in almost every country in the world to prevent congenital malformations. However, little is known about the association of maternal folicacid intake with the occurrence of childhood cancer. Hence, this study aimed to determine the effects of maternal folicacid consumption on the risk (...) of childhood cancer.A total of 158 related articles were obtained from PubMed, Google Scholar, Scopus, and ProQuest using standardized keywords, of which 17 were included in the final review.Eleven of the 17 articles showed a significant protective association between maternal folicacid supplementation and childhood cancer. Using a random-effects model, pooled odds ratios (ORs) showed a protective association between maternal folicacid supplementation and childhood acute lymphoblastic leukaemia (OR, 0.75
Compliance to Iron-FolicAcid Supplementation and Its Association with the Number of ANC Visits in Ethiopia: Systematic Review and Meta-Analysis. The World Health Organization recommended that 80% of communities in all countries should receive the standard dose of iron folicacid. But, in Ethiopia, this target was not yet achieved. The compliance of iron folicacid was also variable across each district. Therefore, the aim of this study was to assess women compliance with iron-folicacid (...) supplementation and its association with a number of antenatal care visits in Ethiopia using systematic review and meta-analysis, 2018.In the current meta-analysis, the target variables were searched from different electronic database system like PubMed, Google Scholar, Science Direct, and Cochrane Library. To predict the pooled prevalence of compliance with iron-folicacid supplementation in Ethiopia, all original studies were considered. All necessary data were extracted by using a standardized data
Review and meta-analysis found that prenatal folicacid was associated with a 58% reduction in autism but had no effect on mental and motor development. The impact of prenatal folicacid on children's neurodevelopment and the risk of autism spectrum disorder (ASD) remain unclear and this review and meta-analysis aimed to quantify any associations.We systematically searched PubMed, Scopus and The Cochrane Library until June 2018 with no language restrictions. Standardised mean differences (...) and odds ratio with 95% confidence intervals are used to describe any associations between folicacid and mental development, motor development and ASD.The search strategy identified 647 papers and 16 were finally included in the meta-analysis after the application of the exclusion criteria. These provided a total cohort size of 756 365 children aged 11 months to 15 years from 10 countries. The main finding was that prenatal use of folicacid was associated with a 58% reduction in the risk of ASD
Systematic Review and Bayesian Meta-analysis of the Dose-response Relationship between FolicAcid Intake and Changes in Blood Folate Concentrations. The threshold for population-level optimal red blood cell (RBC) folate concentration among women of reproductive age for the prevention of neural tube defects has been estimated at 906 nmol/L; however, the dose-response relationship between folicacid intake and blood folate concentrations is uncharacterized. To estimate the magnitude of blood (...) folate concentration increase in response to specific dosages of folicacid under steady-state conditions (as could be achieved with food fortification), a systematic review of the literature and meta-analysis was conducted. Of the 14,002 records we identified, 533 were selected for full-text review, and data were extracted from 108 articles. The steady-state concentrations (homeostasis) of both serum/plasma and RBC folate concentrations were estimated using a Bayesian meta-analytic approach and one
Homocysteine, folicacid, and vitamin B12 levels in patients on isotretinoin therapy for acne vulgaris: A meta-analysis. Oral isotretinoin (Iso) is one of the most commonly used drugs for patients with moderate-to-severe acne; however, its use has been associated with several adverse effects. Some studies have suggested an association between Iso therapy and homocysteine (Hcy), folicacid, and vitamin B12 plasma levels.To evaluate the changes in plasma Hcy, folicacid, and vitamin B12 levels (...) during Iso therapy for acne using meta-analytic methods.Five scientific databases (MEDLINE, EMBASE, Cochrane Library, SCOPUS, and Web of Science) were searched according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines up to December 2018. A review of 734 publications identified 10 studies that assessed plasma levels of Hcy, folicacid, and vitamin B12 during Iso therapy in acne patients.A total of 10 studies consisting of 592 patients were included
Adherence of iron and folicacid supplementation and determinants among pregnant women in Ethiopia: a systematic review and meta-analysis. Iron and folicacid deficiency anaemia are one of the global public health challenges that pose 1.45% of all disability-adjusted life-years. It is recognized as a cause for an unacceptably high proportion of maternal and perinatal morbidity and mortality. Adherence to iron and folicacid supplementation during the antenatal period is paramount to reduce (...) anaemia and its associated morbidities. Although several studies have been conducted across the country, their reports were inconsistent and inconclusive for intervention. Therefore, this systematic review and meta-analysis were aimed to estimate the pooled national level adherence to iron and folicacid supplementation and its determinants among pregnant women in Ethiopia.This systematic review and meta-analysis were pursued the Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Effect of FolicAcid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial. Dietary supplements marketed for male fertility commonly contain folicacid and zinc based on limited prior evidence for improving semen quality. However, no large-scale trial has examined the efficacy of this therapy for improving semen quality or live birth.To determine the effect of daily folicacid and zinc supplementation on semen (...) quality and live birth.The FolicAcid and Zinc Supplementation Trial was a multicenter randomized clinical trial. Couples (n = 2370; men aged ≥18 years and women aged 18-45 years) planning infertility treatment were enrolled at 4 US reproductive endocrinology and infertility care study centers between June 2013 and December 2017. The last 6-month study visit for semen collection occurred during August 2018, with chart abstraction of live birth and pregnancy information completed during April 2019.Men
FolicAcid and Risk of Preterm Birth: A Meta-Analysis. The results from epidemiologic studies linking blood folate concentrations, folicacid supplementation, or dietary folate to the risk of preterm birth are inconsistent. In this study, we aimed to summarize the available evidence on these associations. A systematic search of the PubMed/MEDLINE, Google Scholar, Web of Science, and Cochrane Library databases up to October 20, 2018 was performed and reference lists of retrieved articles were (...) screened. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the highest vs. the lowest levels of folate concentrations, folicacid supplementation, and dietary folate were calculated using random-effects models. Subgroup analyses and univariate meta-regression were performed to explore the sources of heterogeneity. Ten studies (six prospective cohort studies and four case-control studies) were included on folate concentrations, 13 cohort studies were included about folicacid
Efficacy of Periconceptional High-Dose FolicAcid in Isolated Orofacial Cleft Prevention: A Systematic Review. Background The effectiveness of folicacid in prevention of neural tube defects has been well established. Periconceptional supplementation of folicacid in low doses has been shown to be effective in some studies on its efficacy in prevention of occurrence of clefts. There are few studies on high-dose folicacid for prevention of occurrence and recurrence of clefts in high risk cases (...) and the overall consensus based on these is not available. Objectives The aim of this review is to assess whether high-dose folicacid supplementation during the periconceptional period reduces the risk of occurrence of nonsyndromic clefts and recurrence in high-risk cases. Search Methods Search was conducted in the various databases and trial registers. There were no restrictions in the search with regards to language, study setting, or date of publication. Results The search yielded four studies-one
The effect of folicacid in patients with cardiovascular disease: A systematic review and meta-analysis. The effectiveness of folicacid supplementation in stroke risk has been investigated, however, the available results are inconclusive and conflicting. The purpose of this systemic review and meta-analysis was to assess the effect of folicacid in patients with cardiovascular disease (CVD).By searching the PubMed, EMBASE, and Cochrane library databases, we conducted a meta-analysis (...) to evaluate effect of folicacid supplementation in patients with CVD. All-cause mortality, cardiovascular mortality, the risk of coronary heart disease (CHD) and stroke were summarized; hazard ratios (HR), the relative risk (RR) and its 95% confidence interval (CI) were also calculated. Fixed effects models were used to combine the data. A total of 12 randomized controlled trials, which involved 47,523 participants, met the inclusion criteria in this systematic review and meta-analysis.Our meta-analysis
Fortification of wheat and maize flour with folicacid for population health outcomes. Folate is a B-vitamin required for DNA synthesis, methylation, and cellular division. Wheat and maize (corn) flour are staple crops consumed widely throughout the world and have been fortified with folicacid in over 80 countries to prevent neural tube defects. Folicacid fortification may be an effective strategy to improve folate status and other health outcomes in the overall population.To evaluate (...) the health benefits and safety of folicacid fortification of wheat and maize flour (i.e. alone or in combination with other micronutrients) on folate status and health outcomes in the overall population, compared to wheat or maize flour without folicacid (or no intervention).We searched the following databases in March and May 2018: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and MEDLINE In Process, Embase, CINAHL, Web of Science (SSCI, SCI), BIOSIS, Popline, Bibliomap, TRoPHI
Folicacid/methylfolate for the treatment of psychopathology in schizophrenia: a systematic review and meta-analysis. This study aims to examine whether folate/folicacid/methylfolate/folinic acid supplemented to antipsychotics (FA + AP) is beneficial in schizophrenia treatment.We conducted a comprehensive systematic review and meta-analysis of double-blind, placebo-controlled, randomized clinical trials (RCTs) of FA + AP for schizophrenia.The primary outcome was an improvement in total (...) symptoms. Other outcomes were psychopathology subscales (positive, negative, general, and depressive symptoms), discontinuation due to all-cause and adverse events, and individual adverse events. The meta-analysis evaluated the effect size based on a random-effects model.Although we included ten RCTs with 925 patients in total (seven folicacid RCTs (n = 789), two methylfolate RCTs (n = 96), and one folinic acid RCT (n = 40)) in the systematic review, only seven RCTs were included in the meta-analysis
Effect of high dose folicacid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial. To determine the efficacy of high dose folicacid supplementation for prevention of pre-eclampsia in women with at least one risk factor: pre-existing hypertension, prepregnancy diabetes (type 1 or 2), twin pregnancy, pre-eclampsia in a previous pregnancy, or body mass index ≥35.Randomised, phase III, double blinded international (...) , multicentre clinical trial.70 obstetrical centres in five countries (Argentina, Australia, Canada, Jamaica, and UK).2464 pregnant women with at least one high risk factor for pre-eclampsia were randomised between 2011 and 2015 (1144 to the folicacid group and 1157 to the placebo group); 2301 were included in the intention to treat analyses.Eligible women were randomised to receive either daily high dose folicacid (four 1.0 mg oral tablets) or placebo from eight weeks of gestation to the end of week 16
Folicacid Top results for folicacid - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for folicacid The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms