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Latest & greatest articles for fatigue
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Guided self-instructions for people with chronic fatigue syndrome: randomised controlled trial 18827302 2008 10 01 2009 07 27 2008 10 01 1472-1465 193 4 2008 Oct The British journal of psychiatry : the journal of mental science Br J Psychiatry Guided self-instructions for people with chronic fatigue syndrome: randomised controlled trial. 340-1 10.1192/bjp.bp.108.051292 A minimal intervention, based on cognitive-behavioural therapy for chronic fatigue syndrome and consisting of self-instructions (...) combined with email contact, was tested in a randomised controlled trial (ISRCTN27293439). A total of 171 patients participated in the trial: 85 were allocated to the intervention condition and 86 to the waiting-list condition. All patients met the Centers for Disease Control and Prevention criteria for chronic fatigue syndrome. An intention-to-treat analysis showed a significant decrease in fatigue and disability after self-instruction. The level of disability was negatively correlated with treatment
Cognitive behaviour therapy for chronic fatigue syndrome in adults. BACKGROUND: Chronic fatigue syndrome (CFS) is a common, debilitating and serious health problem. Cognitive behaviour therapy (CBT) may help to alleviate the symptoms of CFS. OBJECTIVES: To examine the effectiveness and acceptability of CBT for CFS, alone and in combination with other interventions, compared with usual care and other interventions. SEARCH STRATEGY: CCDANCTR-Studies and CCDANCTR-References were searched on 28/3 (...) /2008. We conducted supplementary searches of other bibliographic databases. We searched reference lists of retrieved articles and contacted trial authors and experts in the field for information on ongoing/completed trials. SELECTION CRITERIA: Randomised controlled trials involving adults with a primary diagnosis of CFS, assigned to a CBT condition compared with usual care or another intervention, alone or in combination. DATA COLLECTION AND ANALYSIS: Data on patients, interventions and outcomes
Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue 18263672 2008 05 07 2008 06 24 2016 07 19 0012-3692 133 5 2008 May Chest Chest Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue. 1189-95 10.1378/chest.07-2952 Fatigue is a common complaint in patients with sarcoidosis. We studied the effectiveness of dexmethylphenidate hydrochloride (d-MPH) in treating (...) sarcoidosis-associated fatigue. This was a double-blind, randomized, placebo-controlled, crossover trial of d-MPH. Patients were seen weekly and completed Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Fatigue Assessment Score (FAS) instruments. After a 1-week wash-in period, patients received either d-MPH or placebo. After 8 weeks, the medications were stopped. Following a 2-week wash-out period, patients were crossed over to 8 weeks of the other treatment. FVC and 6-min walk
A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue 18256342 2008 02 15 2008 04 29 2008 11 21 1534-7796 70 2 2008 Feb Psychosomatic medicine Psychosom Med A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue. 205-13 10.1097/PSY.0b013e3181643065 The purpose of this study was to assess the efficacy of cognitive behavior therapy (CBT) as a treatment for multiple sclerosis (MS) fatigue. A randomized controlled design (...) was used where 72 patients with MS fatigue were randomly assigned to eight weekly sessions of CBT or relaxation training (RT). RT was designed to control for therapist time and attention. Participants were assessed before and after treatment, and at 3 and 6 months posttreatment. The primary outcome was the Fatigue Scale. Secondary outcomes included measures of stress, mood, and fatigue-related impairment. Analysis was by intention-to-treat. A group by time interaction showed that the CBT group reported
Exercise for the management of cancer-related fatigue in adults. BACKGROUND: Cancer-related fatigue is now recognised as an important symptom associated with cancer and its treatment. A number of studies have investigated the effects of physical activity in reducing cancer-related fatigue with no definitive conclusions regarding its effectiveness. OBJECTIVES: To evaluate the effect of exercise on cancer-related fatigue both during and after cancer treatment. SEARCH STRATEGY: The Cochrane (...) of cancer-related fatigue were contacted. SELECTION CRITERIA: Randomised controlled trials (RCTs) that investigated the effect of exercise on cancer-related fatigue in adults were included. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed the methodological quality of studies and extracted data based upon predefined criteria. Where data were available meta-analyses were performed for fatigue using a random-effects model. MAIN RESULTS: Twenty-eight studies were identified
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial 17545193 2007 12 13 2008 01 14 2013 11 21 1468-2060 67 1 2008 Jan Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. 91-7 Dehydroepiandrosterone (DHEA) administration has been (...) reported to improve fatigue, psychological distress, and physical disability. These are common features of primary Sjögren syndrome (pSS). We investigated the effects of DHEA administration on fatigue, well-being, and functioning in women with pSS. In a double-blind, randomised placebo-controlled clinical trial, 60 female patients with pSS received 200 mg oral DHEA or placebo. Primary outcome measures were general fatigue, depressive mood, mental well-being, and physical functioning. In addition, pain
Drug therapy for the management of cancer related fatigue. BACKGROUND: Cancer related fatigue (CRF) is common, under-recognised and difficult to treat. There have been trials looking at drug interventions to improve CRF but results have been conflicting depending on the population studied and outcome measures used. No previous reviews of this topic have been exhaustive or have synthesised all available data. OBJECTIVES: To assess the efficacy of drugs for the management of CRF. SEARCH STRATEGY (...) with a clinical diagnosis of cancer. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Meta-analyses were performed on different drug classes using continuous variable data. MAIN RESULTS: Forty-five trials met the inclusion criteria. Only 27 of these trials involving 6746 participants were judged to have used a sufficiently robust measure of fatigue and thus were deemed suitable for detailed analysis. The drugs were analysed by class (psychostimulants
Drug therapy effective for cancer related fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared as an educational resource and do not replace clinician judgement in the management of individual cases. View PEARLS online (...) at: www.cochraneprimarycare.org Drug therapy effective for cancer related fatigue Clinical question How effective and safe are drugs for the management of cancer related fatigue (CRF)? Bottom line Compared to placebo, haemopoietic growth factors such as erythropoietin and darbopoietin (for anaemic patients on chemotherapy), and psychostimulants such as methylphenidate, showed small but significant improvements in CRF. Antidepressants such as paroxetine and progestational steroids demonstrated no superiority over placebo
Exercise can help reduce cancer-related fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared as an educational resource and do not replace clinician judgement in the management of individual cases. View PEARLS online at: www.cochraneprimarycare.org (...) Exercise can help reduce cancer-related fatigue Clinical Question Is exercise effective for the management of cancer- related fatigue in adults? Bottom Line In adults, physical exercise can help to reduce fatigue both during and after treatment for cancer. However, the evidence is not sufficient to demonstrate the best type or intensity of exercise for reducing the symptoms of fatigue. Therefore, exercise should be considered as one component of the management strategy for fatigue that may include
Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Kangas M, Bovbjerg D H, Montgomery G H CRD summary The authors concluded that both psychosocial and exercise interventions are of clinically significant (...) benefit for cancer-related fatigue, but that it was unclear which was most effective. In view of methodological problems in the review, especially the failure to adequately address statistical heterogeneity between the studies, these conclusions should be interpreted with caution. Authors' objectives To assess the effectiveness of psychosocial and physical exercise interventions for reducing fatigue and improving vigour and vitality in adult cancer patients. Searching The following databases were
Nursing intervention for fatigue during the treatment for cancer Nursing intervention for fatigue during the treatment for cancer Nursing intervention for fatigue during the treatment for cancer de Nijs EJ, Ros W, Grijpdonck MH CRD summary This review concluded that exercise interventions delivered by nurses seem to be effective for preventing the worsening of cancer related fatigue during treatment. Evidence for other interventions was unclear. The review had methodological and reporting (...) weaknesses and many included studies had a weak design and/or small sample size. These limitations suggest that the conclusions should be treated with caution. Authors' objectives To identify interventions that can be used by nurses to prevent or reduce fatigue during cancer treatment. Searching The authors searched PubMed and CINAHL from 1995 to February 2005. Search terms were reported. Study selection Studies of non-pharmacological interventions that could be applied by nurses to prevent or reduce
Treatment of fatigue in multiple sclerosis: a systematic review of the literature Treatment of fatigue in multiple sclerosis: a systematic review of the literature Treatment of fatigue in multiple sclerosis: a systematic review of the literature Lee D, Newell R, Ziegler L, Topping A CRD summary The review concluded there was limited evidence of the effectiveness of pharmacological or psychosocial/psychological approaches in the management of fatigue for people with Multiple Sclerosis (...) . The authors’ cautious conclusion appeared reasonable, but it should be borne in mind that it was based on a number of small and quite variable poor-quality studies. Authors' objectives To evaluate pharmacological and psychosocial or psychological interventions for fatigue in multiple sclerosis (MS). Searching MEDLINE, LILACS, PsycINFO, Web of Knowledge, Cochrane Database of Systematic Reviews, DARE, Ingenta, Zetoc, ADOLEC, National Research Register, HMIC, NeLH and GALE databases were searched for studies
Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Chester A C, Sindwani R, Smith T L, Bhattacharyya N CRD summary This study assessed whether endoscopic sinus surgery improved fatigue levels associated with chronic rhinosinusitis. The authors concluded (...) that there was a notable improvement in patients with chronic rhinosinusitis-related fatigue following surgery. However, given some methodological shortcomings the findings may be compromised. Authors' objectives To assess whether endoscopic sinus surgery improved fatigue levels associated with chronic rhinosinusitis. Searching MEDLINE, EMBASE, Web of Science, Cochrane databases and web-based sources such as Google Scholar and open-access journal sites were searched from January 1980 to the end of July 2007
Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis Malouff J M, Thorsteinsson E B, Rooke S E, Bhullar N, Schutte N S CRD summary This review evaluated the efficacy of cognitive behavioural therapy (CBT) in chronic fatigue syndrome. The authors concluded that CBT had a moderate positive (...) effect. Inadequate information about participants and interventions, lack of reporting of study quality and differences between studies meant that it was difficult to assess the reliability of the authors’ conclusions. Authors' objectives To evaluate the efficacy of cognitive behavioural therapy (CBT) in patients with chronic fatigue syndrome (CFS). Searching PubMed and PsycINFO were searched from inception to June 2007 using reported search terms. In addition, reference lists of relevant articles
Amantadine for fatigue in multiple sclerosis. BACKGROUND: Fatigue is one of the most common and disabling symptoms of people with Multiple Sclerosis (MS). The effective management of fatigue has an important impact on the patient's functioning, abilities, and quality of life. Although a number of strategies have been devised for reducing fatigue, treatment recommendations are based on a limited amount of scientific evidence. Many textbooks report amantadine as a first-choice drug for MS-related (...) fatigue because of published randomised controlled trials (RCTs) showing some benefit. OBJECTIVES: To determine the effectiveness and safety of amantadine in treating fatigue in people with MS. SEARCH STRATEGY: We searched The Cochrane MS Group Trials Register (July 2006), The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2006), MEDLINE (January 1966 to July 2006), EMBASE (January 1974 to July 2006), bibliographies of relevant articles and handsearched
Palliative management of fatigue at the close of life: "it feels like my body is just worn out". Fatigue is the most common chronic symptom associated with cancer and other chronic progressive diseases. The assessment and treatment of fatigue at or near the end of life can be complex. Some of the challenges include its subjective nature, with great variability in its source, how it is expressed, and how it is perceived, requiring treatment to be based on patient report of frequency and severity (...) ; its multidimensional character; and the limited understanding of its pathophysiology. Using the case of an 82-year-old retired nurse with fatigue that could be explained by a number of concurrent conditions, including anemia, weight loss, depression and isolation, dyspnea, deconditioning, and medications, the authors illustrate the clinical approach to assess and treat fatigue at the end of life.
Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue Jacobsen P B, Donovan K A, Vadaparampil S T, Small B J CRD summary There was limited support for the use of psychological and activity based interventions (...) to manage cancer related fatigue. The lack of research with heightened fatigue as an eligibility criterion was a weakness of the evidence base. The reliability of the authors' cautious conclusions are uncertain due to lack of reporting of review methods and differences between studies. Authors' objectives To evaluate the effectiveness of psychological and activity-based interventions for the management of cancer-related fatigue in adult cancer patients. Searching MEDLINE (from 1966), PsycINFO (from 1967
A critical review of complementary therapies for cancer-related fatigue A critical review of complementary therapies for cancer-related fatigue A critical review of complementary therapies for cancer-related fatigue Sood A, Barton D L, Bauer B A, Loprinzi C L CRD summary This review evaluated the effectiveness of complementary and alternative medicine for cancer-related fatigue. The authors concluded that there was insufficient evidence to recommend any specific intervention and that large (...) randomised clinical trials are needed. Given some substantial methodological limitations in the review process and apparent discrepancies in the research recommendations, the reliability of the authors’ conclusions is unclear. Authors' objectives To evaluate the use of complementary and alternative medicine (CAM) for cancer-related fatigue (CRF) and to determine the direction of future research. Searching PubMed (1966 to 2006), EMBASE (1988 to 2006), CINAHL (1982 to 2006), PsycINFO (1985 to 2006) and SPORTDiscus (1985
The treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis in adults and children The treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis in adults and children The treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis in adults and children Centre for Reviews and Dissemination CRD summary The authors concluded that there was evidence supporting the effectiveness of cognitive-behavioural therapy and graded exercise (...) therapy in reducing symptoms and improving physical functioning, but further research is required. This was a well-conducted and clearly reported review and the authors' conclusions are likely to be reliable. Authors' objectives To evaluate the interventions (or combinations of interventions) for the treatment, management and rehabilitation of adults and children with chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME), and to update a previous systematic review (see Other Publications of Related
Management of medically unexplained symptoms (chronic pain and fatigue) Management of medically unexplained symptoms (chronic pain and fatigue) Management of medically unexplained symptoms (chronic pain and fatigue) Flynn K Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Flynn K. Management of medically unexplained symptoms (chronic pain (...) and fatigue) Boston: VA Technology Assessment Program (VATAP). 2007 Authors' conclusions The amount of literature, complexity of interventions, and apparent dependence of results on setting are such as to defy sweeping conclusions. However, restricting labels to the chronic fatigue and fibromyalgia specified in the VA/DoD guideline leads to a conclusion that the guideline is still in alignment with more recent research, hence requires no updating. NICE (2007) summarizes a general approach that agrees well