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Latest & greatest articles for fatigue
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Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial. To evaluate the effectiveness of home delivered pragmatic rehabilitation-a programme of gradually increasing activity designed collaboratively by the patient and the therapist-and supportive listening-an approach based on non-directive counselling-for patients in primary care with chronic fatigue syndrome/myalgic encephalomyelitis or encephalitis (CFS/ME).Single (...) four months' training, including supervised practice, in each of the interventions. GP treatment as usual was unconstrained except that patients were not to be referred for systematic psychological therapies during the treatment period. Main outcome measures The primary clinical outcomes were fatigue and physical functioning at the end of treatment (20 weeks) and 70 weeks from recruitment compared with GP treatment as usual. Lower fatigue scores and higher physical functioning scores denote better
Effect of epoetin alfa on survival and cancer treatment-related anemia and fatigue in patients receiving radical radiotherapy with curative intent for head and neck cancer To evaluate the effect of epoetin alfa on local disease-free survival (DFS), overall survival (OS), and cancer treatment-related anemia and fatigue in patients with head and neck cancer receiving radical radiotherapy with curative intent.Patients (N = 301) with hemoglobin (Hb) less than 15 g/dL were randomly assigned (...) weeks postradiotherapy and annually for 5 years. Cancer treatment-related anemia and fatigue were evaluated with the Functional Assessment of Cancer Therapy-Anemia and Functional Assessment of Cancer Therapy-Head and Neck. Adverse events were recorded up to 12 weeks postradiotherapy.Hb levels increased from baseline with epoetin alfa. The median duration of local DFS was not statistically different between groups (observation, 35.42 months; epoetin alfa, 31.47 months; hazard ratio, 1.04; 95% CI
[Chronic fatigue syndrome: state of the evidence and assessment of intervention modalities in Quebec] Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec [Chronic fatigue syndrome: state of the evidence and assessment of intervention modalities in Quebec] Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec [Chronic fatigue syndrome: state of the evidence and assessment of intervention (...) modalities in Quebec] Rouleau G, Ceppi U, Hjelholt Pedersen V, Dagenais P Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Rouleau G, Ceppi U, Hjelholt Pedersen V, Dagenais P. Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec. [Chronic fatigue syndrome: state
Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome. Chronic fatigue is increasingly common. Conventional medical care is limited in treating chronic fatigue, leading some patients to use traditional Chinese medicine therapies, including herbal medicine.To assess the effectiveness of traditional Chinese medicine herbal products in treating idiopathic chronic fatigue and chronic fatigue syndrome.The following databases were searched (...) for terms related to traditional Chinese medicine, chronic fatigue, and clinical trials: CCDAN Controlled Trials Register (July 2009), MEDLINE (1966-2008), EMBASE (1980-2008), AMED (1985-2008), CINAHL (1982-2008), PSYCHINFO (1985-2008), CENTRAL (Issue 2 2008), the Chalmers Research Group PedCAM Database (2004), VIP Information (1989-2008), CNKI (1976-2008), OCLC Proceedings First (1992-2008), Conference Papers Index (1982-2008), and Dissertation Abstracts (1980-2008). Reference lists of included studies
(odds ratio [OR], 1.10 per unit increase; 95% confidence interval [CI], 1.03-1.16; P = .002) and fatigue score (OR, 1.14 per unit increase; 95% CI, 1.08-1.21; P < .001). Subsequent error was also associated with burnout (ORs per 1-unit change: depersonalization OR, 1.09; 95% CI, 1.05-1.12; P < .001; emotional exhaustion OR, 1.06; 95% CI, 1.04-1.08; P < .001; lower personal accomplishment OR, 0.94; 95% CI, 0.92-0.97; P < .001), a positive depression screen (OR, 2.56; 95% CI, 1.76-3.72; P < .001 (...) Association of resident fatigue and distress with perceived medical errors. Fatigue and distress have been separately shown to be associated with medical errors. The contribution of each factor when assessed simultaneously is unknown.To determine the association of fatigue and distress with self-perceived major medical errors among resident physicians using validated metrics.Prospective longitudinal cohort study of categorical and preliminary internal medicine residents at Mayo Clinic
Interventions for post-stroke fatigue. Fatigue after stroke is common and distressing to patients. The best way to treat this fatigue is uncertain. Theoretically, several different interventions may be of benefit.To determine whether any treatment for fatigue after stroke reduces the proportion of patients with fatigue, or fatigue severity, or both, and to determine the effect of treatment on health-related quality of life, disability, dependency and death, and whether such treatments are cost (...) with stroke where fatigue was a primary or secondary endpoint.The two review authors who scrutinised references independently extracted data. We performed a narrative review; we had intended to perform a meta-analysis but this was not possible as the interventions were too diverse for data to be combined.We identified three trials. One randomised 83 patients with emotional disturbance after stroke to fluoxetine or placebo. After correcting for differences in fatigue severity at baseline
Fatigue during breast cancer radiotherapy: An initial randomized study of cognitive-behavioral therapy plus hypnosis The study purpose was to test the effectiveness of a psychological intervention combining cognitive-behavioral therapy and hypnosis (CBTH) to treat radiotherapy-related fatigue.Women (n = 42) scheduled for breast cancer radiotherapy were randomly assigned to receive standard medical care (SMC) (n = 20) or a CBTH intervention (n = 22) in addition to SMC. Participants assigned (...) to receive CBTH met individually with a clinical psychologist. CBTH participants received training in hypnosis and CBT. Participants assigned to the SMC control condition did not meet with a study psychologist.Fatigue was measured on a weekly basis by using the fatigue subscale of the Functional Assessment of Chronic Illness Therapy (FACIT) and daily using visual analogue scales.Multilevel modeling indicated that for weekly FACIT fatigue data, there was a significant effect of the CBTH intervention
Effects of pulmonary rehabilitation on fatigue, functional status and health perceptions in patients with chronic obstructive pulmonary disease: a randomized controlled trial To test the effects of pulmonary rehabilitation on fatigue, functional status and health perceptions in patients with chronic obstructive pulmonary disease.Randomized controlled trial.Pulmonary outpatient department.Thirty patients randomly assigned to a rehabilitation (3 men, 9 women, mean age 66 (+/-2) years (...) ) or a control group (10 men, 4 women, mean age 64 (+/-2) years).The patients in the rehabilitation group participated in a multidisciplinary rehabilitation programme comprising exercise training twice weekly, for a 12-week period, nutritional and self-care advice, and education about disease and energy conservation strategies.Fatigue, functional limitations due to fatigue, functional performance and satisfaction, six-minute walking distance, hand grip strength and health perception were assessed at baseline
Short-term effects of aerobic exercise on functional capacity, fatigue, and quality of life in patients with post-polio syndrome To investigate and compare the impact of hospital and home exercise programmes on aerobic capacity, fatigue, and quality of life in patients with post-polio syndrome.A prospective, randomized controlled trial.Department of Physical Medicine and Rehabilitation, University Hospital.Thirty-two patients were divided into two groups for either hospital- or home-based (...) aerobic exercise programme.Patients were assessed before and after the rehabilitation programme, with respect to functional capacity (pVo2), fatigue (Fatigue Severity Scale, Fatigue Impact Scale) and quality of life (Nottingham Heath Profile).After the exercise programme, improvement was observed in the hospital exercise group compared to a pre-exercise period in all Nottingham Heath Profile scores (except sleep scores), pVo2, Fatigue Severity Scale and Fatigue Impact Scale (cognitive, physical
when participants were tired, but only for some variables in some studies, or only for certain individuals. One study indicated that there was a learning effect for both sleep-deprived and non-sleep deprived states. Psychomotor skill performance Simulated performance There were 11 studies that assessed performance using simulation-based methods when a participant was rested and/or fatigued (Deaconson et al 1988; DeMaria et al 2005; Eastridge et al 2003; Grantcharov et al 2001; Jakubowicz et al 2005 (...) The effect of fatigue on surgeon performance and surgical outcomes: a systematic review Systematic Review The Effect of Fatigue on Surgeon Performance and Surgical Outcomes ASERNIP-S REPORT NO. 68 August 2009 Australian Safety & Efficacy Register of New Interventional Procedures – Surgical The Royal Australasian College of Surgeons ASERNIP S Australian Safety and Efficacy Register of New Interventional Procedures - Surgical - ASERNIP-S REVIEW OF THE EFFECT OF FATIGUE ON SURGERY & SURGICAL
when participants were tired, but only for some variables in some studies, or only for certain individuals. One study indicated that there was a learning effect for both sleep-deprived and non-sleep deprived states. Psychomotor skill performance Simulated performance There were 11 studies that assessed performance using simulation-based methods when a participant was rested and/or fatigued (Deaconson et al 1988; DeMaria et al 2005; Eastridge et al 2003; Grantcharov et al 2001; Jakubowicz et al 2005 (...) The effect of fatigue on surgeon performance and surgical outcomes: A systematic review Systematic Review The Effect of Fatigue on Surgeon Performance and Surgical Outcomes ASERNIP-S REPORT NO. 68 August 2009 Australian Safety & Efficacy Register of New Interventional Procedures – Surgical The Royal Australasian College of Surgeons ASERNIP S Australian Safety and Efficacy Register of New Interventional Procedures - Surgical - ASERNIP-S REVIEW OF THE EFFECT OF FATIGUE ON SURGERY & SURGICAL
Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Hardy SE CRD summary The review did not find definitive evidence (...) of effectiveness of methylphenidate in medically ill older adults with depression, fatigue or apathy, although it appeared to be tolerated in the short term. Due to variation in outcomes, methodological flaws in the included studies and shortcomings in the review process, the reliability of the author's conclusions is not clear. Authors' objectives To assess the efficacy and tolerability of methylphenidate for the treatment of depressive symptoms, fatigue and apathy in medically ill older adults and adults
The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance Sturm L Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Sturm L. The effect of fatigue on surgeon performance . Stepney: Australian Safety and Efficacy Register of New (...) Interventional Procedures -Surgical (ASERNIP-S). ASERNIP-S Report No 68. 2009 Authors' conclusions There is a paucity of evidence investigating the effects of sleep loss and fatigue on the performance of surgeons and subsequent clinical outcomes. The overall weight of (poor) evidence shows that clinical, academic, and cognitive performance are not proven to be affected by sleep deprivation or fatigue and that psychomotor performance may or may not be. Variations in results were in some cases attributable
Fatigue Predicts Mortality in Older Adults To determine the association between fatigue and survival over 10 years in a population of older community-dwelling primary care patients.Prospective cohort study.Medicare health maintenance organization and Veterans Affairs primary care programs.Older primary care patients (N=492).Fatigue, operationalized as feeling tired most of the time, was assessed at baseline. Mortality was ascertained from the National Death Index. Covariates included (...) demographics, comorbidity, cognitive function, depressive symptoms, body mass index, self-rated health, functional status, and gait speed.Mortality rates at 10 years were 59% (123/210) for older adults with fatigue, versus 38% (106/282) for those without fatigue (P<.001). After adjustment for multiple potential confounders, participants who were tired at baseline had a greater risk of death than those who were not (hazard ratio=1.44, 95% confidence interval=1.08-1.93).A single simple question "Do you feel
Guided self-instructions for people with chronic fatigue syndrome: randomised controlled trial A minimal intervention, based on cognitive-behavioural therapy for chronic fatigue syndrome and consisting of self-instructions combined with email contact, was tested in a randomised controlled trial (ISRCTN27293439). A total of 171 patients participated in the trial: 85 were allocated to the intervention condition and 86 to the waiting-list condition. All patients met the Centers for Disease Control (...) and Prevention criteria for chronic fatigue syndrome. An intention-to-treat analysis showed a significant decrease in fatigue and disability after self-instruction. The level of disability was negatively correlated with treatment outcome. Guided self-instructions are an effective treatment for patients with relatively less severe chronic fatigue syndrome.
Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigueFatigue is a common complaint in patients with sarcoidosis. We studied the effectiveness of dexmethylphenidate hydrochloride (d-MPH) in treating sarcoidosis-associated fatigue.This was a double-blind, randomized, placebo-controlled, crossover trial of d-MPH. Patients were seen weekly and completed Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Fatigue (...) Assessment Score (FAS) instruments. After a 1-week wash-in period, patients received either d-MPH or placebo. After 8 weeks, the medications were stopped. Following a 2-week wash-out period, patients were crossed over to 8 weeks of the other treatment. FVC and 6-min walk distance (6MWD) were determined initially and after each treatment arm.Ten patients with sarcoidosis were enrolled: 8 women and 5 African Americans. All were receiving systemic sarcoidosis therapy. Significant improvement in fatigue
A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue The purpose of this study was to assess the efficacy of cognitive behavior therapy (CBT) as a treatment for multiple sclerosis (MS) fatigue.A randomized controlled design was used where 72 patients with MS fatigue were randomly assigned to eight weekly sessions of CBT or relaxation training (RT). RT was designed to control for therapist time and attention. Participants were assessed before and after (...) treatment, and at 3 and 6 months posttreatment. The primary outcome was the Fatigue Scale. Secondary outcomes included measures of stress, mood, and fatigue-related impairment.Analysis was by intention-to-treat. A group by time interaction showed that the CBT group reported significantly greater reductions in fatigue across the 8 months compared with the RT group (p < .02). Calculated effect sizes for fatigue from baseline to the end of treatment were 3.03 [95% confidence interval, 2.22-3.68
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial Dehydroepiandrosterone (DHEA) administration has been reported to improve fatigue, psychological distress, and physical disability. These are common features of primary Sjögren syndrome (pSS). We investigated the effects of DHEA administration on fatigue, well-being, and functioning in women with pSS.In a double-blind, randomised placebo (...) -controlled clinical trial, 60 female patients with pSS received 200 mg oral DHEA or placebo. Primary outcome measures were general fatigue, depressive mood, mental well-being, and physical functioning. In addition, pain, sicca complaints and disease activity parameters were measured. Patients were assessed before treatment, after 3, 6, and 12 months on study medication, and 6 months after cessation of treatment.Patients from both the DHEA- and placebo-treated group improved on general fatigue (p<0.001