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Latest & greatest articles for fatigue
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Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Hardy SE CRD summary The review did not find definitive evidence (...) of effectiveness of methylphenidate in medically ill older adults with depression, fatigue or apathy, although it appeared to be tolerated in the short term. Due to variation in outcomes, methodological flaws in the included studies and shortcomings in the review process, the reliability of the author's conclusions is not clear. Authors' objectives To assess the efficacy and tolerability of methylphenidate for the treatment of depressive symptoms, fatigue and apathy in medically ill older adults and adults
The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance Sturm L Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Sturm L. The effect of fatigue on surgeon performance . Stepney: Australian Safety and Efficacy Register of New (...) Interventional Procedures -Surgical (ASERNIP-S). ASERNIP-S Report No 68. 2009 Authors' conclusions There is a paucity of evidence investigating the effects of sleep loss and fatigue on the performance of surgeons and subsequent clinical outcomes. The overall weight of (poor) evidence shows that clinical, academic, and cognitive performance are not proven to be affected by sleep deprivation or fatigue and that psychomotor performance may or may not be. Variations in results were in some cases attributable
Fatigue Predicts Mortality in Older Adults 18811604 2008 12 04 2008 12 24 2016 11 22 1532-5415 56 10 2008 Oct Journal of the American Geriatrics Society J Am Geriatr Soc Fatigue predicts mortality in older adults. 1910-4 10.1111/j.1532-5415.2008.01957.x To determine the association between fatigue and survival over 10 years in a population of older community-dwelling primary care patients. Prospective cohort study. Medicare health maintenance organization and Veterans Affairs primary (...) care programs. Older primary care patients (N=492). Fatigue, operationalized as feeling tired most of the time, was assessed at baseline. Mortality was ascertained from the National Death Index. Covariates included demographics, comorbidity, cognitive function, depressive symptoms, body mass index, self-rated health, functional status, and gait speed. Mortality rates at 10 years were 59% (123/210) for older adults with fatigue, versus 38% (106/282) for those without fatigue (P<.001). After adjustment
Guided self-instructions for people with chronic fatigue syndrome: randomised controlled trial 18827302 2008 10 01 2009 07 27 2008 10 01 1472-1465 193 4 2008 Oct The British journal of psychiatry : the journal of mental science Br J Psychiatry Guided self-instructions for people with chronic fatigue syndrome: randomised controlled trial. 340-1 10.1192/bjp.bp.108.051292 A minimal intervention, based on cognitive-behavioural therapy for chronic fatigue syndrome and consisting of self-instructions (...) combined with email contact, was tested in a randomised controlled trial (ISRCTN27293439). A total of 171 patients participated in the trial: 85 were allocated to the intervention condition and 86 to the waiting-list condition. All patients met the Centers for Disease Control and Prevention criteria for chronic fatigue syndrome. An intention-to-treat analysis showed a significant decrease in fatigue and disability after self-instruction. The level of disability was negatively correlated with treatment
Cognitive behaviour therapy for chronic fatigue syndrome in adults. BACKGROUND: Chronic fatigue syndrome (CFS) is a common, debilitating and serious health problem. Cognitive behaviour therapy (CBT) may help to alleviate the symptoms of CFS. OBJECTIVES: To examine the effectiveness and acceptability of CBT for CFS, alone and in combination with other interventions, compared with usual care and other interventions. SEARCH STRATEGY: CCDANCTR-Studies and CCDANCTR-References were searched on 28/3 (...) /2008. We conducted supplementary searches of other bibliographic databases. We searched reference lists of retrieved articles and contacted trial authors and experts in the field for information on ongoing/completed trials. SELECTION CRITERIA: Randomised controlled trials involving adults with a primary diagnosis of CFS, assigned to a CBT condition compared with usual care or another intervention, alone or in combination. DATA COLLECTION AND ANALYSIS: Data on patients, interventions and outcomes
Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue 18263672 2008 05 07 2008 06 24 2016 07 19 0012-3692 133 5 2008 May Chest Chest Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue. 1189-95 10.1378/chest.07-2952 Fatigue is a common complaint in patients with sarcoidosis. We studied the effectiveness of dexmethylphenidate hydrochloride (d-MPH) in treating (...) sarcoidosis-associated fatigue. This was a double-blind, randomized, placebo-controlled, crossover trial of d-MPH. Patients were seen weekly and completed Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Fatigue Assessment Score (FAS) instruments. After a 1-week wash-in period, patients received either d-MPH or placebo. After 8 weeks, the medications were stopped. Following a 2-week wash-out period, patients were crossed over to 8 weeks of the other treatment. FVC and 6-min walk
A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue 18256342 2008 02 15 2008 04 29 2008 11 21 1534-7796 70 2 2008 Feb Psychosomatic medicine Psychosom Med A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue. 205-13 10.1097/PSY.0b013e3181643065 The purpose of this study was to assess the efficacy of cognitive behavior therapy (CBT) as a treatment for multiple sclerosis (MS) fatigue. A randomized controlled design (...) was used where 72 patients with MS fatigue were randomly assigned to eight weekly sessions of CBT or relaxation training (RT). RT was designed to control for therapist time and attention. Participants were assessed before and after treatment, and at 3 and 6 months posttreatment. The primary outcome was the Fatigue Scale. Secondary outcomes included measures of stress, mood, and fatigue-related impairment. Analysis was by intention-to-treat. A group by time interaction showed that the CBT group reported
Exercise for the management of cancer-related fatigue in adults. BACKGROUND: Cancer-related fatigue is now recognised as an important symptom associated with cancer and its treatment. A number of studies have investigated the effects of physical activity in reducing cancer-related fatigue with no definitive conclusions regarding its effectiveness. OBJECTIVES: To evaluate the effect of exercise on cancer-related fatigue both during and after cancer treatment. SEARCH STRATEGY: The Cochrane (...) of cancer-related fatigue were contacted. SELECTION CRITERIA: Randomised controlled trials (RCTs) that investigated the effect of exercise on cancer-related fatigue in adults were included. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed the methodological quality of studies and extracted data based upon predefined criteria. Where data were available meta-analyses were performed for fatigue using a random-effects model. MAIN RESULTS: Twenty-eight studies were identified
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial 17545193 2007 12 13 2008 01 14 2013 11 21 1468-2060 67 1 2008 Jan Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. 91-7 Dehydroepiandrosterone (DHEA) administration has been (...) reported to improve fatigue, psychological distress, and physical disability. These are common features of primary Sjögren syndrome (pSS). We investigated the effects of DHEA administration on fatigue, well-being, and functioning in women with pSS. In a double-blind, randomised placebo-controlled clinical trial, 60 female patients with pSS received 200 mg oral DHEA or placebo. Primary outcome measures were general fatigue, depressive mood, mental well-being, and physical functioning. In addition, pain
Drug therapy for the management of cancer related fatigue. BACKGROUND: Cancer related fatigue (CRF) is common, under-recognised and difficult to treat. There have been trials looking at drug interventions to improve CRF but results have been conflicting depending on the population studied and outcome measures used. No previous reviews of this topic have been exhaustive or have synthesised all available data. OBJECTIVES: To assess the efficacy of drugs for the management of CRF. SEARCH STRATEGY (...) with a clinical diagnosis of cancer. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. Meta-analyses were performed on different drug classes using continuous variable data. MAIN RESULTS: Forty-five trials met the inclusion criteria. Only 27 of these trials involving 6746 participants were judged to have used a sufficiently robust measure of fatigue and thus were deemed suitable for detailed analysis. The drugs were analysed by class (psychostimulants
Drug therapy effective for cancer related fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared as an educational resource and do not replace clinician judgement in the management of individual cases. View PEARLS online (...) at: www.cochraneprimarycare.org Drug therapy effective for cancer related fatigue Clinical question How effective and safe are drugs for the management of cancer related fatigue (CRF)? Bottom line Compared to placebo, haemopoietic growth factors such as erythropoietin and darbopoietin (for anaemic patients on chemotherapy), and psychostimulants such as methylphenidate, showed small but significant improvements in CRF. Antidepressants such as paroxetine and progestational steroids demonstrated no superiority over placebo
Exercise can help reduce cancer-related fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared as an educational resource and do not replace clinician judgement in the management of individual cases. View PEARLS online at: www.cochraneprimarycare.org (...) Exercise can help reduce cancer-related fatigue Clinical Question Is exercise effective for the management of cancer- related fatigue in adults? Bottom Line In adults, physical exercise can help to reduce fatigue both during and after treatment for cancer. However, the evidence is not sufficient to demonstrate the best type or intensity of exercise for reducing the symptoms of fatigue. Therefore, exercise should be considered as one component of the management strategy for fatigue that may include
Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients Kangas M, Bovbjerg D H, Montgomery G H CRD summary The authors concluded that both psychosocial and exercise interventions are of clinically significant (...) benefit for cancer-related fatigue, but that it was unclear which was most effective. In view of methodological problems in the review, especially the failure to adequately address statistical heterogeneity between the studies, these conclusions should be interpreted with caution. Authors' objectives To assess the effectiveness of psychosocial and physical exercise interventions for reducing fatigue and improving vigour and vitality in adult cancer patients. Searching The following databases were
Nursing intervention for fatigue during the treatment for cancer Nursing intervention for fatigue during the treatment for cancer Nursing intervention for fatigue during the treatment for cancer de Nijs EJ, Ros W, Grijpdonck MH CRD summary This review concluded that exercise interventions delivered by nurses seem to be effective for preventing the worsening of cancer related fatigue during treatment. Evidence for other interventions was unclear. The review had methodological and reporting (...) weaknesses and many included studies had a weak design and/or small sample size. These limitations suggest that the conclusions should be treated with caution. Authors' objectives To identify interventions that can be used by nurses to prevent or reduce fatigue during cancer treatment. Searching The authors searched PubMed and CINAHL from 1995 to February 2005. Search terms were reported. Study selection Studies of non-pharmacological interventions that could be applied by nurses to prevent or reduce
Treatment of fatigue in multiple sclerosis: a systematic review of the literature Treatment of fatigue in multiple sclerosis: a systematic review of the literature Treatment of fatigue in multiple sclerosis: a systematic review of the literature Lee D, Newell R, Ziegler L, Topping A CRD summary The review concluded there was limited evidence of the effectiveness of pharmacological or psychosocial/psychological approaches in the management of fatigue for people with Multiple Sclerosis (...) . The authors’ cautious conclusion appeared reasonable, but it should be borne in mind that it was based on a number of small and quite variable poor-quality studies. Authors' objectives To evaluate pharmacological and psychosocial or psychological interventions for fatigue in multiple sclerosis (MS). Searching MEDLINE, LILACS, PsycINFO, Web of Knowledge, Cochrane Database of Systematic Reviews, DARE, Ingenta, Zetoc, ADOLEC, National Research Register, HMIC, NeLH and GALE databases were searched for studies
Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Fatigue improvement following endoscopic sinus surgery: a systematic review and meta-analysis Chester A C, Sindwani R, Smith T L, Bhattacharyya N CRD summary This study assessed whether endoscopic sinus surgery improved fatigue levels associated with chronic rhinosinusitis. The authors concluded (...) that there was a notable improvement in patients with chronic rhinosinusitis-related fatigue following surgery. However, given some methodological shortcomings the findings may be compromised. Authors' objectives To assess whether endoscopic sinus surgery improved fatigue levels associated with chronic rhinosinusitis. Searching MEDLINE, EMBASE, Web of Science, Cochrane databases and web-based sources such as Google Scholar and open-access journal sites were searched from January 1980 to the end of July 2007