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Latest & greatest articles for fatigue
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Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease. BACKGROUND: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is terminal, progressive neurological condition for which there are no curative treatments. Among people with ALS/MND, fatigue is a common and debilitating symptom, which is characterised by reversible motor weakness and whole-body tiredness that is only partially relieved by rest. The effectiveness of pharmacological or non (...) -pharmacological treatments for fatigue in ALS/MND is not yet established. OBJECTIVES: To assess the effects of pharmacological and non-pharmacological interventions for fatigue in ALS/MND. SEARCH METHODS: We searched the following databases on 5 September 2017: Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL Plus, and ERIC. We also searched two clinical trials registries. SELECTION CRITERIA: We selected randomised and quasi-randomised controlled trials of any
Physical Activity to Reduce Fatigue in Rheumatoid Arthritis: A Randomized Controlled Trial 28378441 2017 12 23 2151-4658 70 1 2018 Jan Arthritis care & research Arthritis Care Res (Hoboken) Physical Activity to Reduce Fatigue in Rheumatoid Arthritis: A Randomized Controlled Trial. 1-10 10.1002/acr.23230 Effective treatments for rheumatoid arthritis (RA) fatigue are limited. We tested the effect of a pedometer-based intervention on increasing physical activity and decreasing fatigue among (...) individuals with RA. Participants completed baseline questionnaires; had 1 week of activity monitoring; were randomized to control (education [EDUC]), pedometer and step-monitoring diary (PED), or pedometer and diary plus step targets (PED+) groups, and were followed for 21 weeks. At week 10, questionnaires were administered by phone to all participants. During the final week, all participants again had 1 week of activity monitoring. Primary outcomes were changes in average weekly steps and fatigue
Assessment of fatigue Assessment of fatigue - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Assessment of fatigue Last reviewed: August 2018 Last updated: June 2018 Summary Fatigue may be a symptom of almost any medical condition. For the purpose of this topic, the differentials discussed concentrate on people presenting with fatigue or where fatigue is the only symptom. Conditions in which fatigue may (...) not necessarily be an initial complaint, but is still regarded as a markedly significant and debilitating symptom, are also included. Definition There are numerous definitions and classifications of fatigue, reflecting the multitude of interpretations, depending on being a patient, a physician, a biologist, or a physiologist. A common and practical definition defined fatigue as a sensation of exhaustion during or after usual activities, or a feeling of inadequate energy to begin these activities. Chen MK
Chronic fatigue syndrome/Myalgic encephalomyelitis Chronic fatigue syndrome/Myalgic encephalomyelitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Chronic fatigue syndrome/Myalgic encephalomyelitis Last reviewed: August 2018 Last updated: September 2018 Summary Chronic fatigue syndrome/encephalomyelitis (CFS/ME) can be distinguished from medical and psychiatric conditions in the differential diagnosis of fatigue (...) by the presence of debilitating fatigue for more than 6 months; combinations of cognitive dysfunction, total body pain, and unrefreshing sleep that does not restore normal function; and postexertional malaise, where exertion or other stressors leads to exacerbation of these symptoms with onset immediately or delayed by several hours or overnight The World Health Organization classifies CFS/ME as a neurological illness. There are no objective diagnostic tests, verified biomarkers, curative medications
Static and fatigue strength of a novel anatomically contoured implant compared to five current open-wedge high tibial osteotomy plates RESEARCH Open Access Static and fatigue strength of a novel anatomically contoured implant compared to five current open-wedge high tibial osteotomy plates Arnaud Diffo Kaze 1,2,4* , Stefan Maas 1,4 , James Belsey 5 , Alexander Hoffmann 2,3,4 and Dietrich Pape 2,3,4 Abstract Background: The purpose of the present study was to compare the mechanical static (...) and fatigue strength of the size 2 osteotomy plate “Activmotion” with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. Methods: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates. All bone-implant constructs were
The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression 28933604 2017 09 21 1477-0873 31 10 2017 Oct Clinical rehabilitation Clin Rehabil The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression. 1406-1415 10.1177/0269215517695857 To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression (...) . Cross-sectional cohort study. Recruitment was from four stroke units in the UK. Participants were assessed within four to six weeks of first stroke; those with high levels of depressive symptoms (score ⩾7 Brief Assessment Schedule Depression Cards) were excluded. Participants were assessed after stroke on the Fatigue Severity Scale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Beck Anxiety Index, Sleep Hygiene Index, 6m walk
Exercise performance, haemodynamics, and respiratory pattern do not identify heart failure patients who end exercise with dyspnoea from those with fatigue Exercise performance, haemodynamics, and respiratory pattern do not identify heart failure patients who end exercise with dyspnoea from those with fatigue † Marco Morosin 1,2 , Stefania Farina 1 , Carlo Vignati 1 , Emanuele Spadafora 1 , Susanna Sciomer 3 , Elisabetta Salvioni 1 , Gianfranco Sinagra 2 and Piergiuseppe Agostoni 1,4 * 1 Centro (...) failure (HF) patients as the causes of exercise termination during maximal cardiopulmonary exercise testing (CPET) are muscular fatigue and dyspnoea. So far, a physiological explanation why some HF patients end exercise because of dyspnoea and others because of fatigue is not available. We assessed whether patients referring dyspnoea or muscular fatigue may be distinguished by different ventilator or haemodynamic behaviours during exercise. Methods and results We analysed exercise data of 170 consecutive
Effects of nurse-led home-based exercise & cognitive behavioral therapy on reducing cancer-related fatigue in patients with ovarian cancer during and after chemotherapy: A randomized controlled trial 28939343 2017 09 23 2017 09 23 1873-491X 2017 Aug 24 International journal of nursing studies Int J Nurs Stud Effects of nurse-led home-based exercise & cognitive behavioral therapy on reducing cancer-related fatigue in patients with ovarian cancer during and after chemotherapy: A randomized (...) controlled trial. S0020-7489(17)30188-8 10.1016/j.ijnurstu.2017.08.010 High levels of fatigue have been documented in ovarian cancer patients. However, increased levels of fatigue are positively associated with a high risk of sleep disturbance and depression. To investigate the feasibility of a nurse-led home-based exercise and cognitive behavioral therapy (E&CBT) for ovarian cancer adults with cancer-related fatigue on outcomes of fatigue, plus other secondary outcomes (sleep disturbance and depression
Adalimumab impact on fatigue measured by FACIT-F: a study of rheumatoid arthritis patients in Saudi Arabia 29089788 2018 11 13 1179-156X 9 2017 Open access rheumatology : research and reviews Open Access Rheumatol Adalimumab impact on fatigue measured by FACIT-F: a study of rheumatoid arthritis patients in Saudi Arabia. 181-184 10.2147/OARRR.S142411 The objective of the study was to assess the effectiveness of adalimumab as a treatment for fatigue in patients with rheumatoid arthritis (RA (...) ). Fatigue was monitored in patients with RA who were already on an adalimumab treatment regimen. Fatigue, general well-being, comorbidities, and disease activity were measured at baseline and ~8, 16, and 24 weeks, thereafter. Significant reductions in fatigue scores and disease activity were observed from baseline to 6 months after. A predictive regression model of fatigue severity was proposed and was found to be significant, with RA disease activity as the most significant predictor of fatigue
FatigueFatigue | ONS Search the ONS website FatigueFatigue PEP Topics Fatigue has been defined as a distressing, persistent, and subjective sense of tiredness or exhaustion that is not proportional to activity and interferes with usual function. Fatigue is one of the most common problems in patients with cancer. It may be related to the disease itself or cancer treatment and may continue beyond completion of treatment among long-term cancer survivors. Among people with cancer, 80% to 100 (...) % report experiencing fatigue. Fatigue may be an isolated problem or occur as one element in a cluster of symptoms, such as pain, depression, dyspnea, anorexia, and sleep disturbance. Immune-Related Adverse Events With Immunotherapy Fatigue is a multicomponent symptom that is common among all patients with cancer, so it may not be unexpected in patients receiving immunotherapy treatment. However, with immunotherapies, fatigue may be a presenting symptom of an endocrine disorder secondary
Correlation between medication errors with job satisfaction and fatigue of nurses 28979754 2018 11 13 2008-5842 9 8 2017 Aug Electronic physician Electron Physician Correlation between medication errors with job satisfaction and fatigue of nurses. 5142-5148 10.19082/5142 Medication errors which can cause several medical malfunctions, have been in the spotlight recently. Job satisfaction and fatigue seems to be related to the increase of medication errors in nursing. This study aimed (...) to determine the correlation between the amount and type of medication errors with job satisfaction and fatigue of nurses working in Shahid Sadoughi hospital in Yazd-Iran. This is a descriptive study by a cross-sectional and correlational approach conducted on all the nurses working in an educational hospital who have characteristics of samples. Participants were 170 nurses working in Shahid Sadooghi hospital in Yazd, Iran in 2012. The questionnaires of demographic characteristics, medication
Cancer-Related Fatigue in Post-Treatment Cancer Survivors: Theory-Based Development of a Web-Based Intervention 28676465 2018 11 13 2369-1999 3 2 2017 Jul 04 JMIR cancer JMIR Cancer Cancer-Related Fatigue in Post-Treatment Cancer Survivors: Theory-Based Development of a Web-Based Intervention. e8 10.2196/cancer.6987 Cancer-related fatigue (CrF) is the most common and disruptive symptom experienced by cancer survivors. We aimed to develop a theory-based, interactive Web-based intervention (...) intervention was developed. This evidence-based Web-based program is the ﬁrst intervention of its kind based on self-regulation model theory, with the primary aim of targeting the representations of fatigue and enhancing self-management of CrF, speciﬁcally. This research sought to integrate psychological theory, existing evidence of effective interventions, empirically derived principles of Web design, and the views of potential users into the systematic planning and design of the intervention of an easy
Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial. BACKGROUND: Graded exercise therapy is an effective and safe treatment for chronic fatigue syndrome, but it is therapist intensive and availability is limited. We aimed to test the efficacy and safety of graded exercise delivered as guided self-help. METHODS: In this pragmatic randomised controlled trial, we recruited (...) adult patients (18 years and older) who met the UK National Institute for Health and Care Excellence criteria for chronic fatigue syndrome from two secondary-care clinics in the UK. Patients were randomly assigned to receive specialist medical care (SMC) alone (control group) or SMC with additional guided graded exercise self-help (GES). Block randomisation (randomly varying block sizes) was done at the level of the individual with a computer-generated sequence and was stratified by centre
MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial 28404841 2017 04 13 2017 04 28 1524-4628 48 5 2017 May Stroke Stroke MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. 1293-1298 10.1161/STROKEAHA.116.016293 This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue ≥3 months after stroke. We (...) hypothesized that 200 mg of modafinil daily for 6 weeks would result in reduced symptoms of fatigue compared with placebo. This single-center phase 2 trial used a randomized, double-blind, placebo-controlled, crossover design. The key inclusion criterion was a multidimensional fatigue inventory score of ≥60. Patients were randomized to either modafinil or placebo for 6 weeks of therapy, then after a 1 week washout period swapped treatment arms for a second 6 weeks of therapy. The primary outcome
The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses 28500483 2018 11 13 2197-1153 4 1 2017 Dec Journal of experimental orthopaedics J Exp Orthop The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses. 16 10.1186/s40634-017-0091-7 The biomechanical mechanisms of failure of FSUs have been studied (...) but the correlation of repetitive flexion and extension loadings to the initial phase of fatigue in young FSUs are still not known. The purpose of the study was to examine the fatigue results of low magnitude repetitive flexion and extension loading on porcine lumbar Functional Spinal Units (FSUs) with Magnetic Resonance Imaging (MRI) and histology. Eight FSUs were subject to repetitive pivot flexion and eight to extension loading by a protocol of 20 000 cycles at 1 Hz with a load of 700 N. All loaded FSUs (N
Recruitment of reviewers is becoming harder at some journals: a test of the influence of reviewer fatigue at six journals in ecology and evolution 29451533 2018 11 13 2058-8615 2 2017 Research integrity and peer review Res Integr Peer Rev Recruitment of reviewers is becoming harder at some journals: a test of the influence of reviewer fatigue at six journals in ecology and evolution. 3 10.1186/s41073-017-0027-x It is commonly reported by editors that it has become harder to recruit reviewers (...) for peer review and that this is because individuals are being asked to review too often and are experiencing reviewer fatigue. However, evidence supporting these arguments is largely anecdotal. We examine responses of individuals to review invitations for six journals in ecology and evolution. The proportion of invitations that lead to a submitted review has been decreasing steadily over 13 years (2003-2015) for four of the six journals examined, with a cumulative effect that has been quite
Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial. Background: Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS). Objective: To evaluate the effect of subcutaneous anakinra versus placebo on fatigue severity in female patients with CFS. Design: Randomized, placebo-controlled trial from July 2014 to May 2016. Patients, providers, and researchers were blinded to treatment assignment (...) . (ClinicalTrials.gov: NCT02108210 ). Setting: University hospital in the Netherlands. Patients: 50 women aged 18 to 59 years with CFS and severe fatigue leading to functional impairment. Intervention: Participants were randomly assigned to daily subcutaneous anakinra, 100 mg (n = 25), or placebo (n = 25) for 4 weeks and were followed for an additional 20 weeks after treatment (n = 50). Measurements: The primary outcome was fatigue severity, measured by the Checklist Individual Strength subscale (CIS-fatigue) at 4
Improvements in Fatigue in 1536 Patients with Rheumatoid Arthritis and Correlation with Other Treatment Outcomes: A Post Hoc Analysis of Three Randomized Controlled Trials of Abatacept 28251584 2018 11 13 2198-6576 4 1 2017 Jun Rheumatology and therapy Rheumatol Ther Improvements in Fatigue in 1536 Patients with Rheumatoid Arthritis and Correlation with Other Treatment Outcomes: A Post Hoc Analysis of Three Randomized Controlled Trials of Abatacept. 99-109 10.1007/s40744-017-0054-6 A post hoc (...) analysis of three randomized controlled trials of abatacept in rheumatoid arthritis (RA) was conducted to explore the effect of abatacept on fatigue in RA and its correlation with other outcomes. In this analysis of AGREE (early RA) and AIM and ATTAIN (established RA), changes in baseline fatigue (0-100 mm scale), pain, sleep (AIM and ATTAIN only) and Disease Activity Score (DAS) 28 (C-reactive protein; CRP) were calculated at days 29, 85, and 169. Agreement between improvements ≥minimum clinically
Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association | Circulation Search for this keyword Search Search for this keyword Search Header Publisher Menu AHA Scientific Statement Cardiopulmonary Resuscitation in Adults and Children With Mechanical (...) result in device malfunction ( ). Although driveline wiring has built-in redundancy as a safety measure, driveline trauma can cause internal damage and lead to pump failure. Damage can be acute such as a cutting or crush injury or the result of chronic stress/fatigue on the line. In these settings, there will often be alarms preceding or accompanying the pump stoppage, but alarms will cease once the batteries are drained. There is a risk of de novo thrombus formation within the pump, which can cause