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Latest & greatest articles for epilepsy
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on epilepsy or other clinical topics then use Trip today.
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Flowchart: Neonatal seizures, Abnormal movements in newborn babies Queensland Health State of Queensland (Queensland Health) 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Abnormal movements in newborn babies Queensland Clinical Guideline: Neonatal seizures. Flowchart version: F17.23-3-V1-R22 Clinical • Clonic-recurrent muscle contraction • Tonic-sustained (...) muscle contraction • Myoclonic-brief active muscle contraction • Subtle-automatisms o Autonomic phenomena o Ocular-orbital phenomena o Orolingual phenomena o Hypomotor Seizure Activity Non-seizure activity Electrographical Abnormal movements in newborn baby • Jitteriness • Excessive startles • Benign neonatal sleep clonus • Tremors • Clonus Focal Seizure activity involves one area of brain affecting one side of body Multifocal Seizure activity involves more than one area of brain affecting several
: newborn, baby, infant, preterm, premature; seizures, convulsion, fit, epilepsy, spasms, electroencephalogram, EEG, clonic, tonic, myoclonic, subtle, neurological, neurodevelopmental medication, drugs, antiepileptic drugs. Other keywords may have been used for specific aspects of the guideline. Queensland Clinical Guideline Supplement: Neonatal Seizures Refer to online version, destroy printed copies after use Page 6 of 13 2.6 Consultation Major consultative and development processes occurred between (...) Guideline supplement: Neonatal seizures Refer to online version, destroy printed copies after use Page 1 of 13 Maternity and Neonatal C linical G uideline Queensland Health Guideline Supplement: Neonatal seizures Queensland Clinical Guideline Supplement: Neonatal Seizures Refer to online version, destroy printed copies after use Page 2 of 13 Table of Contents List of Tables 2 Version Control Error! Bookmark not defined. 1 Introduction 3 1.1 Funding 3 1.2 Conflict of interest 3 1.3 Guideline
Flowchart: Neonatal seizures, Investigations Queensland Health State of Queensland (Queensland Health) 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Neonatal seizures: Investigations Queensland Clinical Guideline: Neonatal seizures. Flowchart version: F17.23-2-V1-R22 Guided by specific clinical features of baby or expert advice Pathology Blood • Lactate (...) • Commence continuous EEG monitoring if available • Record EEG if available Treat underlying cause(s) as indicated • Hypoglycaemia-Refer to QCG Newborn hypoglycaemia • Infection- Refer to QCG EOGBS • HIE-Refer to QCG HIE • Other Subsequent investigations as indicated Yes No Acute symptomatic seizure Subsequent investigations Pathology Blood • BGL • Urea and electrolytes Ca, Mg, Na • FBC • Blood culture CSF • Microscopy and bacterial culture • Glucose • Protein Urine • Culture Imaging • Cranial USS
Flowchart: Neonatal seizures, Assessment and management Queensland Health State of Queensland (Queensland Health) 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Neonatal seizures: Assessment and management Queensland Clinical Guideline: Neonatal seizures Flowchart version: F17.23-1-V1-R22 Baby with suspected seizure activity Observe and monitor: • Seizure (...) activity • Temperature, heart rate, respiratory rate & effort, BP, O 2 saturation Treat cardiorespiratory compromise Assessment: • Review history (maternal, perinatal, family) • Physical examination • Neurological examination • Investigate for underlying cause as required o Refer to flowchart: Investigations Management: • Treat underlying cause o Refer to other QCG guidelines • Commence AEDs if seizures: o Duration > 3 minutes o More than 2 brief episodes o Detected on EEG • Initiate ongoing
approaches. Technology Description: Intravenous immunoglobulin (IVIG) is a purified blood product pooled from thousands of human blood donors. When provided in high doses, IVIG has an immunomodulatory effect, although its precise mechanism of action remains unclear. IVIG is increasingly being used as a therapeutic option for a variety of neurological autoimmune and inflammatory disorders, and has been proposed for the treatment of epilepsy. Controversy: Seizure recurrence following a single unprovoked (...) for treatment of intractable epilepsy in pediatric patients. Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2017 Authors' conclusions Health Problem: Intractable epilepsy is diagnosed in 5% to 20% of pediatric patients with new-onset epilepsy. If uncontrolled, seizures in childhood may have a detrimental or even catastrophic impact on the developing brain. A connection has been made between inflammatory processes and neurological disease, including epilepsy, which may present new therapeutic
, Pfizer, SK Life Science, Sunovion, UCB, Upsher-Smith, and Vertex; has received grants from the noncommercial entities Epilepsy Research Foundation, Epilepsy Study Consortium, Epilepsy Therapy Project, and the National Institute of Neurological Disorders and Stroke of the NIH; serves on the editorial boards of Lancet Neurology , Neurology Today , and EpilepticDisorders ; is scientific officer for the Epilepsy Foundation of America, for which NYU receives salary support; and has received travel (...) Health & Science University, Portland; Department of Neurology (J.A.F.), New York University, New York; and Clinical Epilepsy Section (W.H.T.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD. David Gloss From the Department of Neurology (J.P.S.), University of Alabama at Birmingham; Department of Neurology (D.G.), Charleston Area Medical Center, WV; Department of Neurology (J.R.B., S.J.S.), Medical College of Wisconsin, Milwaukee; Children's National Medical Center (W.D.G
seizures due to acute brain injury or metabolic derangements, or unprovoked seizures that are the initial manifestation of epilepsy. A patient history and physical examination may identify features more consistent with an epileptic event and laboratory studies and brain imaging can identify an acute insult contributing to the presentation. Patients diagnosed with first-time unprovoked seizure require electroencephalography and epilepsy protocol-specific magnetic resonance imaging of the brain, which (...) New-Onset Seizure in Adults and Adolescents: A Review. Approximately 8% to 10% of the population will experience a seizure during their lifetime. Only about 2% to 3% of patients go on to develop epilepsy. Understanding the underlying etiology leading to an accurate diagnosis is necessary to ensure appropriate treatment and that patients with low risk for recurrence are not treated unnecessarily.Patients can present with new-onset seizure for a variety of reasons such as acute symptomatic
Hypothermia for Neuroprotection in Convulsive Status Epilepticus. Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus.In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard (...) groups in the other secondary outcomes. Adverse events were more frequent in the hypothermia group than in the control group.In this trial, induced hypothermia added to standard care was not associated with significantly better 90-day outcomes than standard care alone in patients with convulsive status epilepticus. (Funded by the French Ministry of Health; HYBERNATUS ClinicalTrials.gov number, NCT01359332 .).
seizure activity from genetic or acquired brain disorder general prevalence of epilepsy is 3% in population 10% of population will have a seizure at some point Seizure categorization: 1) Cause: Primary or Secondary (provoked) 2) Effect on mentation: Generalized (tonic-clonic, absence, atonic, myoclonic) or focal 3) Motor activity: convulsive or non-convulsive There are 6 factors that define an ictal event: 1. abrupt onset 2. brief duration 3. loss of consciousness 4. purposeless activity 5. unprovoked (...) CRACKCast E018 – Seizures CRACKCast E018 - Seizures - CanadiEM CRACKCast E018 – Seizures In , , by Adam Thomas December 15, 2016 This episode of CRACKCast covers Rosen’s Chapter 18, Seizures. This topic covers the basics of seizures, and the management of status epilepticus. PDF Show Notes – Rosen’s in Perspective: seizures are a pathologic excess of neuronal activity that disrupt normal cortical or deep limbic system functioning the term epilepsy refers specifically to recurrent unprovoked
, up to 70% of individuals with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy.Worldwide, carbamazepine and phenobarbitone are commonly used broad-spectrum antiepileptic drugs, suitable for most epilepticseizure types. Carbamazepine is a current first-line treatment for partial onset seizures, and is used in the USA and Europe. Phenobarbitone is no longer considered (...) Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. This is an updated version of the original Cochrane Review, first published in Issue 1, 2003 and updated in 2015. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment