Latest & greatest articles for epilepsy

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Top results for epilepsy

81. Transcranial magnetic stimulation for the treatment of epilepsy.

Transcranial magnetic stimulation for the treatment of epilepsy. BACKGROUND: Epilepsy is a highly prevalent neurological condition characterized by repeated unprovoked seizures with various etiologies. Although antiepileptic medications produce clinical improvement in most individuals, nearly a third of individuals have drug-resistant epilepsy that carries significant morbidity and mortality. There remains a need for non-invasive and more effective therapies for this population. Transcranial (...) magnetic stimulation (TMS) uses electromagnetic coils to excite or inhibit neurons, with repetitive pulses at low-frequency producing an inhibitory effect that could conceivably reduce cortical excitability associated with epilepsy. OBJECTIVES: To assess the evidence for the use of TMS in individuals with drug-resistant epilepsy compared with other available treatments in reducing seizure frequency, improving quality of life, reducing epileptiform discharges, antiepileptic medication use, and side

Cochrane2016

82. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP).

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). BACKGROUND: Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in whom postmortem examination does not reveal a structural or toxicological cause for death. SUDEP has a reported incidence of 1 to 2 per 1000 patient years (...) and represents the most common epilepsy-related cause of death. The presence and frequency of generalised tonic-clonic seizures (GTCS), male sex, early age of seizure onset, duration of epilepsy, and polytherapy are all predictors of risk of SUDEP. The exact pathophysiology of SUDEP is currently unknown, although GTCS-induced cardiac, respiratory, and brainstem dysfunction appears likely. Appropriately chosen antiepileptic drug treatment can render around 70% of patients free of all seizures. However, around

Cochrane2016

83. Brivaracetam (Briviact) - partial-onset seizures with or without secondary generalisation in adult and adolescent patients from 16 years of age with epilepsy.

Brivaracetam (Briviact) - partial-onset seizures with or without secondary generalisation in adult and adolescent patients from 16 years of age with epilepsy.

Scottish Medicines Consortium2016

84. Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis

Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis Leggett LE, Coward S, Weaver C, Sevick LK, Zhang D, Mackean G, Lorenzetti D, Clement F Record (...) Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Leggett LE, Coward S, Weaver C, Sevick LK, Zhang D, Mackean G, Lorenzetti D, Clement F . Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis. Calgary: HTA Unit, University of Calgary 2016 Authors' conclusions Two studies

Health Technology Assessment (HTA) Database.2016

85. Briviact (brivaracetam) - To treat partial onset seizures in patients age 16 years and older with epilepsy.

Briviact (brivaracetam) - To treat partial onset seizures in patients age 16 years and older with epilepsy. Drug Approval Package: Briviact (brivaracetam) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: Briviact (brivaracetam) Company: UCB, Inc. Application No.: 205836, 205837 & 205838 Approval Date: February 18, 2016 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF

FDA - Drug Approval Package2016

86. Contraception for women with epilepsy: counseling, choices, and concerns

Contraception for women with epilepsy: counseling, choices, and concerns 29386938 2018 11 13 1179-1527 7 2016 Open access journal of contraception Open Access J Contracept Contraception for women with epilepsy: counseling, choices, and concerns. 69-76 10.2147/OAJC.S85541 Approximately 50% of all pregnancies in women with epilepsy (WWE) occur unplanned. This is worrying, given the increased occurrence of obstetrical complications in WWE, including the risk of seizures and their possible (...) 04 19 New Zealand Open Access J Contracept 101700100 1179-1527 antiepileptic drugs bone mineral density epilepsy ethinyl estradiol interactions pregnancy progestins seizure aggravation Disclosure The author reports no conflicts of interest in this work. 2018 2 2 6 0 2016 4 19 0 0 2016 4 19 0 1 epublish 29386938 10.2147/OAJC.S85541 oajc-7-069 PMC5683160 Int J Womens Health. 2015 Jan 05;7:19-29 25609999 Drugs. 1976;12(3):201-11 789046 Epilepsy Res. 2011 Nov;97(1-2):73-82 21820873 Cochrane Database

Open access journal of contraception2016 Full Text: Link to full Text with Trip Pro

87. Melatonin as add-on treatment for epilepsy.

Melatonin as add-on treatment for epilepsy. BACKGROUND: This is an updated version of the original Cochrane review published in Issue 6, 2012.Epilepsy is one of the most common chronic neurological disorders. Despite the plethora of antiepileptic drugs (AEDs) currently available, 30% of people continue having seizures. This group of people requires a more aggressive treatment, since monotherapy, the first choice scheme, fails to control seizures. Nevertheless, polytherapy often results (...) in a number of unwanted effects, including neurological disturbances (somnolence, ataxia, dizziness), psychiatric and behavioural symptoms, and metabolic alteration (osteoporosis, inducement or inhibition of hepatic enzymes, etc.). The need for better tolerated AEDs is even more urgent in this group of people. Reports have suggested an antiepileptic role of melatonin with a good safety profile. OBJECTIVES: To assess the efficacy and tolerability of melatonin as add-on treatment for epilepsy. SEARCH

Cochrane2016

88. Ketogenic diet and other dietary treatments for epilepsy.

Ketogenic diet and other dietary treatments for epilepsy. BACKGROUND: The ketogenic diet (KD), being high in fat and low in carbohydrates, has been suggested to reduce seizure frequency. It is currently used mainly for children who continue to have seizures despite treatment with antiepileptic drugs. Recently, there has been interest in less restrictive KDs including the modified Atkins diet (MAD) and the use of these diets has extended into adult practice. OBJECTIVES: To review the evidence (...) for efficacy and tolerability from randomised controlled trials regarding the effects of KD and similar diets. SEARCH METHODS: We searched the Cochrane Epilepsy Group's Specialized Register (30 March 2015), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO, 30 March 2015), MEDLINE (Ovid, 30 March 2015), ClinicalTrials.gov (30 March 2015) and the WHO International Clinical Trials Registry Platform (ICTRP, 30 March 2015). We imposed no language

Cochrane2016

89. Care delivery and self management strategies for adults with epilepsy.

Care delivery and self management strategies for adults with epilepsy. BACKGROUND: Researchers have criticised epilepsy care for adults for its lack of impact, stimulating the development of various service models and strategies to respond to perceived inadequacies. OBJECTIVES: To assess the effects of any specialised or dedicated intervention beyond that of usual care in adults with epilepsy. SEARCH METHODS: For the latest update of this review, we searched the Cochrane Epilepsy Group (...) Specialized Register (9 December 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (2013, Issue 11), MEDLINE (1946 to June 2013), EMBASE (1988 to June 2013), PsycINFO (1887 to December 2013) and CINAHL (1937 to December 2013). In addition, we contacted experts in the field to seek information on unpublished and ongoing studies, checked the websites of epilepsy organisations and checked the reference lists of included studies. SELECTION CRITERIA: We included randomised controlled trials

Cochrane2016

90. Epilepsy.

Epilepsy. This issue provides a clinical overview of epilepsy, focusing on diagnosis, prevention, treatment, and further considerations. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance

Annals of Internal Medicine2016

91. Cause of death and predictors of mortality in a community-based cohort of people with epilepsy

Cause of death and predictors of mortality in a community-based cohort of people with epilepsy 26773074 2016 02 23 2016 07 01 2016 02 23 1526-632X 86 8 2016 Feb 23 Neurology Neurology Cause of death and predictors of mortality in a community-based cohort of people with epilepsy. 704-12 10.1212/WNL.0000000000002390 The risk of premature mortality is increased in people with epilepsy. The reasons for this and how it may relate to epilepsy etiology remain unclear. The National General (...) Practice Study of Epilepsy is a prospective, community-based cohort that includes 558 people with recurrent unprovoked seizures of whom 34% died during almost 25 years of follow-up. We assessed the underlying and immediate causes of death and their relationship to epilepsy etiology. Psychiatric and somatic comorbidities of epilepsy as predictors of mortality were scrutinized using adjusted Cox proportional hazards models. The 3 most common underlying causes of death were noncerebral neoplasm, cardiovascular

EvidenceUpdates2016

93. Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high

Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search (...) for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Article Text Prognosis Cohort study Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Frank M C Besag Statistics from Altmetric.com Commentary on: Sundelin HE

Evidence-Based Medicine (Requires free registration)2016

95. Care delivery and self management strategies for children with epilepsy.

Care delivery and self management strategies for children with epilepsy. BACKGROUND: Epilepsy care for children has been criticised for its lack of impact. Various service models and strategies have been developed in response to perceived inadequacies in care provision for children and their families. OBJECTIVES: To compare the effectiveness of any specialised or dedicated intervention for the care of children with epilepsy and their families to the effectiveness of usual care. SEARCH METHODS (...) : We searched the Cochrane Epilepsy Group Specialized Register (9 December 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2013,Issue 11), MEDLINE (1946 to June week 2, 2013), EMBASE (1988 to week 25, 2013), PsycINFO (1887 to 11 December 2013) and CINAHL Plus (1937 to 11 December 2013). In addition, we contacted experts in the field to seek information on unpublished and ongoing studies, checked the websites of epilepsy organisations and checked

Cochrane2015

96. Interventions for psychotic symptoms concomitant with epilepsy.

Interventions for psychotic symptoms concomitant with epilepsy. BACKGROUND: This is an updated version of the original Cochrane review published in Issue 4, 2008.People suffering from epilepsy have an increased risk of experiencing psychotic symptoms. The psychotic syndromes associated with epilepsy have generally been classified as ictal, postictal, and interictal psychosis. Anticonvulsant drugs have been reported to precipitate psychosis. Moreover, all antipsychotic drugs have the propensity (...) to cause paroxysmal electroencephalogram abnormalities and induce seizures. OBJECTIVES: To evaluate the benefits of interventions used to treat clinically significant psychotic symptoms occurring in people with epilepsy with regard to global improvement, changes in mental state, hospitalization, behavior, quality of life, effect on the frequency of seizures, and interaction with antiepileptic drugs. SEARCH METHODS: We searched the Cochrane Epilepsy Group's Specialized Register (23 March 2015

Cochrane2015

97. Cannabinoids in the Treatment of Epilepsy.

Cannabinoids in the Treatment of Epilepsy. Cannabinoids in the Treatment of Epilepsy. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 26672645 Format MeSH and Other Data E-mail Subject Additional text E-mail (...) Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Jan 7;374(1):94-5. doi: 10.1056/NEJMc1512758. Epub 2015 Dec 16. Cannabinoids in the Treatment of Epilepsy. , . Comment on [N Engl J Med. 2016] [N Engl J Med. 2015] PMID: 26672645 DOI: [Indexed for MEDLINE] Free full text Publication types MeSH terms Substances Full Text Sources Medical PubMed Commons 0 comments How to cite this comment

NEJM2015

98. Cannabinoids in the Treatment of Epilepsy.

Cannabinoids in the Treatment of Epilepsy. Cannabinoids in the Treatment of Epilepsy. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 26672646 Format MeSH and Other Data E-mail Subject Additional text E-mail (...) Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Jan 7;374(1):94. Cannabinoids in the Treatment of Epilepsy. . Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2015] PMID: 26672646 DOI: [Indexed for MEDLINE] Publication types MeSH terms Substances Full Text Sources Medical PubMed Commons 0 comments How to cite this comment: Supplemental Content Full text links You are here

NEJM2015 Full Text: Link to full Text with Trip Pro

99. Subpial transection surgery for epilepsy.

Subpial transection surgery for epilepsy. BACKGROUND: Nearly 30% of patients with epilepsy continue to have seizures in spite of using several antiepileptic drug (AED) regimens. Such patients are regarded as having refractory, or uncontrolled, epilepsy. No definition of uncontrolled, or medically refractory, epilepsy has been universally accepted, but for the purposes of this review, we will consider seizures as drug resistant if they have failed to respond to a minimum of two AEDs (...) . It is believed that early surgical intervention may prevent seizures at a younger age, which, in turn, may improve the intellectual and social status of children. Many types of surgery are available for treatment of refractory epilepsy; one such procedure is known as subpial transection. OBJECTIVES: To determine the benefits and adverse effects of subpial transection for partial-onset seizures and generalised tonic-clonic seizures in children and adults. SEARCH METHODS: We searched the Cochrane Epilepsy

Cochrane2015

100. The Importance of Checking Impedance: Misinterpretation of Deep Brain Stimulation Dysfunction as Epilepsy

The Importance of Checking Impedance: Misinterpretation of Deep Brain Stimulation Dysfunction as Epilepsy 30363556 2018 11 14 2330-1619 3 2 2016 Mar-Apr Movement disorders clinical practice Mov Disord Clin Pract The Importance of Checking Impedance: Misinterpretation of Deep Brain Stimulation Dysfunction as Epilepsy. 206-208 10.1002/mdc3.12267 Wolf Marc E ME Department of Neurology Universitätsmedizin Mannheim University of Heidelberg Mannheim Germany. Blahak Christian C Department of Neurology (...) Universitätsmedizin Mannheim University of Heidelberg Mannheim Germany. Krauss Joachim K JK Department of Neurosurgery Hannover Medical School Hannover Germany. eng Journal Article 2015 11 27 United States Mov Disord Clin Pract 101630279 2330-1619 deep brain stimulation dystonia epilepsy globus pallidus internus side effects 2015 05 28 2015 09 01 2015 09 04 2018 10 27 6 0 2015 11 27 0 0 2015 11 27 0 1 epublish 30363556 10.1002/mdc3.12267 MDC312267 PMC6178714 N Engl J Med. 2006 Nov 9;355(19):1978-90 17093249

Movement disorders clinical practice2015 Full Text: Link to full Text with Trip Pro