Latest & greatest articles for epilepsy

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Top results for epilepsy

301. Positron emission tomography (PET) for epilepsy

Positron emission tomography (PET) for epilepsy Positron emission tomography (PET) for epilepsy Positron emission tomography (PET) for epilepsy Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical Services Advisory Committee. Positron emission tomography (PET) for epilepsy. Canberra: Medical Services (...) Advisory Committee (MSAC) 2004: 65 Authors' objectives This report is a systematic review of literature on positron emission tomography (PET) imaging using the radionuclide 2-[18F]fluoro-2-deoxy-D-glucose (FDG) for the indication of epilepsy. Authors' conclusions In relation to positron emission tomography prior to surgery in patients with refractory epilepsy, where there is no focus with concordant results on usual structural imaging and electroencephalogram, this assessment finds the technology

Health Technology Assessment (HTA) Database.2004

302. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care

The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care National Institute for Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation National Institute for Clinical Excellence. The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. London: National Institute for Clinical Excellence (NICE) 2004: 73 Authors' objectives This report aims to provide guidelines on the diagnosis and management of the epilepsies in adults and children in primary and secondary care. Authors' conclusions Diagnosis - All

Health Technology Assessment (HTA) Database.2004

303. Vagus nerve stimulation for refractory epilepsy in children

Vagus nerve stimulation for refractory epilepsy in children Vagus nerve stimulation for refractory epilepsy in children Vagus nerve stimulation for refractory epilepsy in children National Institute for Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation National Institute for Clinical Excellence. Vagus nerve stimulation for refractory epilepsy (...) in children. London: National Institute for Clinical Excellence (NICE) 2004: 2 Authors' objectives This study aims to assess the current evidence on the safety and efficacy of vagus nerve stimulation for refractory epilepsy in children. Authors' conclusions 1.1 Current evidence on the safety and efficacy of vagus nerve stimulation for refractory epilepsy in children appears adequate to support the use of this procedure, provided that the normal arrangements are in place for consent, audit and clinical

Health Technology Assessment (HTA) Database.2004

304. Newer drugs for epilepsy in adults

Newer drugs for epilepsy in adults Newer drugs for epilepsy in adults Newer drugs for epilepsy in adults National Institute for Clinical Excellence Citation National Institute for Clinical Excellence. Newer drugs for epilepsy in adults. London: National Institute for Clinical Excellence (NICE). Technology Appraisal Guidance 76. 2004 Authors' objectives To provide guidance on the use of newer drugs for epilepsy in adults. Authors' conclusions 1.1 The newer antiepileptic drugs gabapentin (...) , lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate and vigabatrin, within their licensed indications, are recommended for the management of epilepsy in people who have not benefited from treatment with the older antiepileptic drugs such as carbamazepine or sodium valproate, or for whom the older antiepileptic drugs are unsuitable because: - there are contraindications to the drugs - they could interact with other drugs the person is taking (notably oral contraceptives) - they are already

Health Technology Assessment (HTA) Database.2004

305. Topiramate (Topamax) - Epilepsy

Topiramate (Topamax) - Epilepsy Secretariat - Delta House 50 West Nile Street Glasgow G1 2NP Telephone 0141 225 6997 Fax 0141 248 3778 E-mail jmitchell@htbs.org.uk Chairman Professor David Lawson Scottish Medicines Consortium Topiramate (Topamax Ò ) (No. 75/03) Janssen Cilag Summary of Recommendation 12 January, 2004 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and ADTCs on its use in NHS Scotland. The recommendation (...) is summarised as follows: Advice: following a full submission. Topiramate is accepted for restricted use within NHS Scotland for its extended (monotherapy) indication. It should be initiated only by physicians who have appropriate experience in the treatment of epilepsy. Topiramate should be used principally in patients who have not benefited from treatment with an older anti-convulsant drug such as carbamazepine or sodium valproate, or for whom these drugs are unsuitable because of contraindications

Scottish Medicines Consortium2004

306. Common antiepileptic drugs in pregnancy in women with epilepsy.

Common antiepileptic drugs in pregnancy in women with epilepsy. BACKGROUND: The potential adverse effects of antiepileptic drug (AED) exposure in pregnancy have been well recognised but the relative risks of specific antiepileptic drug exposures remain poorly understood. OBJECTIVES: To assess the adverse effects of commonly used antiepileptic drugs on maternal and fetal outcomes in pregnancy in women with epilepsy. Comparison of outcomes following specific antiepileptic drug exposures in utero (...) to unexposed pregnancies in the general population or women with epilepsy are described. The current manuscript reports the first phase of this review which focuses upon neurodevelopmental outcomes in children exposed to antiepileptic drugs in utero. SEARCH STRATEGY: We searched MEDLINE, Pharmline, EMBASE, Reprotox and TERIS from 1966 to December 2003. Review articles and conference abstracts were also hand searched. SELECTION CRITERIA: All randomized controlled trials, prospective cohorts of children

Cochrane2004

307. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. BACKGROUND: One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple antiepileptic drugs, the mode of resistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 (...) and P-glycoprotein 170). We hypothesized that the CC genotype at the ABCB1 C3435T polymorphism, which is associated with increased expression of the protein, influences the response to antiepileptic-drug treatment. METHODS: ABCB1 3435 was genotyped in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 control subjects without epilepsy. Recently devised methods were used to control for population stratification, and linkage disequilibrium

NEJM2003

308. Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies

Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Non-drug treatment strategies Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD (...) summary This review evaluated non-drug treatments for patients with treatment-resistant epilepsy, and concluded that effective treatments are available, but all have disadvantages. Given the exclusion of several interventions, the paucity of good-quality data for those included, and the limitations of the review, the conclusions should be viewed with caution. Authors' objectives To determine which methods of non-drug treatment for epilepsy, after initial treatment failure, lead to improved outcomes

DARE.2003

309. Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies

Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Management of treatment-resistant epilepsy. Volume 1: evidence report and appendices. Volume 2: evidence tables. Drug treatment strategies Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD summary (...) This review concluded that polytherapy is clinically preferable to sequential monotherapy, and monotherapy is more likely to be harmful than beneficial, for patients with treatment-resistant epilepsy. The potential for publication and language bias, and error and bias during the review process, should be kept in mind when considering the conclusions. Authors' objectives To determine which drug treatment strategy (sequential monotherapy, polytherapy, or optimised current therapy) leads to improved outcomes

DARE.2003

310. Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis

Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Management of treatment-resistant epilepsy. Volumes 1: evidence report and appendices. Volume 2: evidence tables. Diagnosis Chapell R, Reston J, Snyder D, Treadwell J, Tregear S, Turkelson C CRD summary This review planned to evaluate which methods (...) of re-evaluating refractory epilepsy can lead to improved patient outcomes. The authors addressed a different question, and concluded it was unclear whether blood prolactin levels can differentiate between epileptic and non-eplieptic seizures. The conclusion seems appropriate given that it was based on only five poor-quality trials and no review methodology was reported. Authors' objectives To determine which methods of rediagnosing or re-evaluating treatment-resistant epilepsy lead to, or can

DARE.2003

311. Epilepsy surgery

Epilepsy surgery Epilepsy surgery Epilepsy surgery Pichon Riviere A, Augustovski F, Cernadas C, Ferrante D, Regueiro A, Garcia Marti S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Cernadas C, Ferrante D, Regueiro A, Garcia Marti S. Epilepsy surgery. Ciudad de Buenos Aires: Institute for Clinical (...) Effectiveness and Health Policy (IECS) 2003 Authors' objectives This study aims to summarise the available evidence on epilepsy surgery. Authors' conclusions It is important to point out that, in general, reports come from state-of-the-art centers with wide experience in this surgical field. On the other hand, these procedures are not adverse-event-free, in many cases severe and disabling; consequently, patient selection should be carefully carried out once more conservative therapeutic approaches have been

Health Technology Assessment (HTA) Database.2003

312. A Markov model of treatment of newly diagnosed epilepsy in the UK

A Markov model of treatment of newly diagnosed epilepsy in the UK A Markov model of treatment of newly diagnosed epilepsy in the UK A Markov model of treatment of newly diagnosed epilepsy in the UK Remak E, Hutton J, Price M, Peeters K, Adriaenssen I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology The use of topiramate (TPM) as monotherapy for treating newly diagnosed adult epilepsy patients. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical cohort of adult patients with newly diagnosed epilepsy. Setting The setting was secondary care. The economic study was conducted in the UK. Dates to which data relate The effectiveness data were derived

NHS Economic Evaluation Database.2003

313. Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy

Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Cost-utility analysis of vagus nerve stimulators for adults with medically refractory epilepsy Forbes R B, MacDonald S, Eljamel S, Roberts R C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of vagus nerve stimulators (VNS) for the treatment of medically refractory epilepsy (MRE). The comparator was not explicitly stated, but it appears to have been no implantation of the device. Type of intervention Treatment and palliative care. Economic study type Cost-utility analysis. Study population The target population comprised

NHS Economic Evaluation Database.2003

314. Ketogenic diet for epilepsy.

Ketogenic diet for epilepsy. BACKGROUND: The ketogenic diet is a diet high in fat but low in carbohydrate and it is suggested that this diet reduces seizure frequency. Currently, this diet is used mainly for children who continue to have seizures despite treatment with antiepileptic drugs. OBJECTIVES: To overview the evidence from randomized controlled trials regarding the effects of ketogenic diets. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group trials register (26 March 2003 (...) ), the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2003), MEDLINE (January 1966 to March 2003) and EMBASE (1980 to March 2003). SELECTION CRITERIA: Randomized controlled trials of ketogenic diets for people with epilepsy. DATA COLLECTION AND ANALYSIS: We planned for two reviewers to independently apply inclusion criteria and extract data. MAIN RESULTS: No randomized controlled trials were found. REVIEWER'S CONCLUSIONS: There is no reliable evidence from randomized controlled

Cochrane2003

315. Psychological treatments for epilepsy.

Psychological treatments for epilepsy. BACKGROUND: Psychological interventions such as relaxation therapy, cognitive behaviour therapy, electroencephalogram (EEG) bio-feedback and educational interventions have been used alone or in combination in the treatment of epilepsy, to reduce the seizure frequency and improve the quality of life. OBJECTIVES: To assess whether the treatment of epilepsy with psychological methods is effective in reducing seizure frequency and/or leads to a better quality (...) of life. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group trial register (11 June 2003), the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 2, 2003), MEDLINE (on 11 June 2003) and cross references from identified publications. SELECTION CRITERIA: Randomized or quasi-randomized studies assessing one or more types of psychological or behaviour modification techniques for people with epilepsy. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the trials

Cochrane2003

316. Socioeconomic variation in incidence of epilepsy: prospective community based study in south east England.

Socioeconomic variation in incidence of epilepsy: prospective community based study in south east England. OBJECTIVE: To determine the incidence of epilepsy in a general practice population and its variation with socioeconomic deprivation. DESIGN: Prospective surveillance for new cases over an 18 or 24 month period. PARTICIPANTS: All patients on practice registers categorised for deprivation with the Carstairs score of their postcode. SETTING: 20 general practices in London and south east (...) England. MAIN OUTCOME MEASURE: Confirmed diagnosis of epilepsy. RESULTS: 190 new cases of epilepsy were identified during 369 283 person years of observation (crude incidence 51.5 (95% confidence interval 44.4 to 59.3) per 100 000 per year). The incidence was 190 (138 to 262) per 100 000 in children aged 0-4 years, 30.8 (21.3 to 44.6) in those aged 45-64 years, and 58.7 (42.5 to 81.0) in those aged > or =65 years. There was no apparent difference in incidence between males and females

BMJ2002 Full Text: Link to full Text with Trip Pro

317. Death in children with epilepsy: a population-based study.

Death in children with epilepsy: a population-based study. BACKGROUND: Families of children with newly diagnosed epilepsy worry about death during a seizure. We aimed to assess the frequency and causes of death of children with epilepsy. METHOD: We did a population-based cohort study. The Nova Scotia epilepsy cohort includes all children who developed epilepsy during 1977-85. In 1999, we matched names and birth dates with provincial health-care, death, and marriage registries. We examined death (...) certificates, necropsy reports, and physician records of children who had died and contacted families if sudden unexpected death in epilepsy could have occurred. We measured the effect of sex, age, epilepsy type, and disorder sufficient to cause functional neurological deficit on death rate. We compared cohort mortality with rates in a reference population matched for age and sex. FINDINGS: 26 (3.8%) of 692 children with epilepsy died. Frequency of death was 5.3 times higher (95% CI 2.29-8.32) than

Lancet2002

318. Diffusion tensor imaging in refractory epilepsy.

Diffusion tensor imaging in refractory epilepsy. Diffusion tensor imaging is an imaging method that is sensitive to the molecular movement of water, which indicates cellular integrity and pathology. A patient with refractory epilepsy and normal conventional MRI was examined with diffusion tensor imaging. An area of abnormal diffusion in the right frontal lobe was identified and surgically resected. The patient had a good clinical outcome. Histopathological examination of the resected tissue

Lancet2002

319. The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy

The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy The effectiveness of psychological interventions for patients with relatively well-controlled epilepsy Engelberts N H, Klein M, Kasteleijn-Nolst Trenite D G, Heimans J J, van der Ploeg H M Authors' objectives To assess the effectiveness of psychological interventions in participants (...) with relatively well-controlled epilepsy. Searching MEDLINE and PsycINFO were searched from inception to March 2002 for studies published in English in peer-reviewed journals, book chapters or editorials; the search terms were reported. Only English language publications were included in the review. Study selection Study designs of evaluations included in the review No inclusion criteria were stated in relation to study design. The included studies were randomised controlled trials (RCTs), cross-sectional

DARE.2002

320. Ketogenic diet for epilepsy</a>

Ketogenic diet for epilepsy Ketogenic diet for epilepsy We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Ketogenic diet for epilepsy Share: Reading time approx. 2 minutes This document was published more than 2 years ago. The nature of the evidence may have changed. Findings by SBU Alert This is a translation of version 1, published on May 18 (...) , 1998. The latest version of this report is not available in English. The ketogenic diet has been used for intractable epilepsy in children, and is a method that has been used sporadically for years. However, only recently has the ketogenic diet been used more systematically in Sweden. Although the treatment has been available for many years, there is little evidence about active mechanisms of diet. Several uncontrolled studies show markedly good effects in terms of seizure reduction. Known

Swedish Council on Technology Assessement2002