Latest & greatest articles for epilepsy

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Top results for epilepsy

181. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy

Responsive cortical stimulation for the treatment of medically intractable partial epilepsy 21917777 2011 09 28 2011 11 15 2014 07 30 1526-632X 77 13 2011 Sep 27 Neurology Neurology Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. 1295-304 10.1212/WNL.0b013e3182302056 This multicenter, double-blind, randomized controlled trial assessed the safety and effectiveness of responsive cortical stimulation as an adjunctive therapy for partial onset seizures (...) in adults with medically refractory epilepsy. A total of 191 adults with medically intractable partial epilepsy were implanted with a responsive neurostimulator connected to depth or subdural leads placed at 1 or 2 predetermined seizure foci. The neurostimulator was programmed to detect abnormal electrocorticographic activity. One month after implantation, subjects were randomized 1:1 to receive stimulation in response to detections (treatment) or to receive no stimulation (sham). Efficacy and safety

EvidenceUpdates2011

182. The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study.

The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. BACKGROUND: Surgery is increasingly used as treatment for refractory focal epilepsy; however, few rigorous reports of long-term outcome exist. We did this study to identify long-term outcome of epilepsy surgery in adults by establishing patterns of seizure remission and relapse after surgery. METHODS: We report long-term outcome of surgery for epilepsy in 615 adults (497 anterior (...) awareness than did those with no SPS (2·4, 1·5-3·9). Relapse was less likely the longer a person was seizure free and, conversely, remission was less likely the longer seizures continued. In 18 (19%) of 93 people, late remission was associated with introduction of a previously untried antiepileptic drug. 104 of 365 (28%) seizure-free individuals had discontinued drugs at latest follow-up. INTERPRETATION: Neurosurgical treatment is appealing for selected people with refractory focal epilepsy. Our data

Lancet2011

183. Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy

Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Widjaja E, Li B, Schinkel CD, Ritchie LP, Weaver J, Snead OC, Rutka JT, Coyte PC Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of epilepsy surgery in children with intractable epilepsy. The authors concluded that surgical treatment was cost-effective compared with medical therapy, but larger samples and longer follow-up were required

NHS Economic Evaluation Database.2011

184. [Vagus nerve stimulation for refractory epilepsy]

[Vagus nerve stimulation for refractory epilepsy] Estimulacion del nervio vago para la epilepsia refractaria [Vagus nerve stimulation for refractory epilepsy] Estimulacion del nervio vago para la epilepsia refractaria [Vagus nerve stimulation for refractory epilepsy] Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Regueiro A, Alcaraz A, Valanzasca P, Elorriaga N, Romano M, Rojas J Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Regueiro A, Alcaraz A, Valanzasca P, Elorriaga N, Romano M, Rojas J. Estimulacion del nervio vago para la epilepsia refractaria. [Vagus nerve stimulation for refractory epilepsy] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de

Health Technology Assessment (HTA) Database.2011

185. [Usefulness of video EEG for the assessment of patients with refractory epilepsy]

[Usefulness of video EEG for the assessment of patients with refractory epilepsy] Utilidad del video EEG en la evaluacion de paciente con epilepsia refractaria [Usefulness of video EEG for the assessment of patients with refractory epilepsy] Utilidad del video EEG en la evaluacion de paciente con epilepsia refractaria [Usefulness of video EEG for the assessment of patients with refractory epilepsy] Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Lopez A, Rey-Ares L, Bardach (...) of patients with refractory epilepsy] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No 220. 2011 Authors' objectives To assess the available evidence on the efficacy, safety and issues related coverage policies for the use of Video EEG. Authors' conclusions In patients with refractory epilepsy who have previously been studied using the standard diagnostic tests, telemetry video electroencephalography (V-EEG) seems to be an adequate diagnostic test

Health Technology Assessment (HTA) Database.2011

187. Challenges and recommendations for conducting epidemiological studies in the field of epilepsy pharmacogenetics

Challenges and recommendations for conducting epidemiological studies in the field of epilepsy pharmacogenetics 21747586 2011 07 12 2011 07 14 2017 02 20 0971-6866 17 Suppl 1 2011 May Indian journal of human genetics Indian J Hum Genet Challenges and recommendations for conducting epidemiological studies in the field of epilepsy pharmacogenetics. S4-S11 10.4103/0971-6866.80351 Epilepsy is one of the most prevalent neurological disorders, afflicting approximately 50 million Indians. Owing (...) to affordability and easy availability, use of first-generation antiepileptic drugs (AEDs) is heavily encouraged for the treatment of epilepsy in resource-limited countries such as India. Although first-generation AEDs are at par with second-generation AEDs in terms of efficacy, adverse drug reactions (ADRs) are quite common with them. This could be attributed to the inferior pharmacokinetic parameters such as nonlinear metabolism, narrow therapeutic index and formation of toxic intermediates. In addition

Indian journal of human genetics2011 Full Text: Link to full Text with Trip Pro

188. Felbamate as an add-on therapy for refractory epilepsy.

Felbamate as an add-on therapy for refractory epilepsy. BACKGROUND: Epilepsy is a chronic and disabling neurologic disorder, affecting approximately one per cent of the population. Up to 30% of people with epilepsy have seizures that are resistant to currently available drugs. Felbamate is one of the second generation antiepileptic drugs and its effects as an add-on therapy to standard drugs are assessed in this review. OBJECTIVES: To evaluate the efficacy and tolerability of felbamate versus (...) placebo when used as an add-on treatment for people with refractory partial-onset epilepsy. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group Specialized Register (6 December 2010), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, 6 December 2010), and PubMed (6 December 2010). There were no language restrictions. We reviewed the reference lists of retrieved studies to search for additional reports of relevant studies. We also contacted the manufacturers

Cochrane2011

189. Strategies for improving adherence to antiepileptic drug treatment in patients with epilepsy.

Strategies for improving adherence to antiepileptic drug treatment in patients with epilepsy. BACKGROUND: Poor adherence to antiepileptic medications is associated with increased mortality and morbidity. In this review we focus on interventions designed to assist patients with adherence to antiepileptic medications. OBJECTIVES: To determine the effectiveness of interventions aimed at improving adherence to antiepileptic medications in adults and children with epilepsy. SEARCH STRATEGY: We (...) searched the Epilepsy Group's Specialised Register (24 June 2010), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 2) and electronic databases: MEDLINE (OVID) (1950 to June 2010); EMBASE (OVID) (1980 to 2010 Week 24); CINAHL (1982 to June 2010) and PsycINFO (22 June 2010), and the reference lists of relevant articles. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials of adherence-enhancing interventions aimed at patients with clinical

Cochrane2011

190. Intravenous immunoglobulins for epilepsy.

Intravenous immunoglobulins for epilepsy. BACKGROUND: Epilepsy is a common neurological condition, with an estimated incidence of 50 per 100,000 persons. People with epilepsy may present with various types of immunological abnormalities, such as low serum IgA level, lack of IgG subclass and identification of certain types of antibodies. Intravenous immunoglobulin (IVIg) treatment may represent a valuable approach and its efficacy has important implications for epilepsy management. OBJECTIVES (...) : To examine the effects of IVIg on the frequency and duration of seizures, quality of life and adverse effects, when used as monotherapy or as add-on treatment for people with epilepsy. SEARCH STRATEGY: We searched the Cochrane Epilepsy Group Specialized Register (14 June 2010), the Cochrane Central Register of Controlled Trials (Issue 2 of 4, The Cochrane Library, 2010), MEDLINE (1950 to June 2010), Web of Science (14 June 2010), Current Controlled Trials (11 June 2010), the National Research Register

Cochrane2011

191. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates

Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates Sherman EM, Wiebe S, Fay-McClymont TB, Tellez-Zenteno J, Metcalfe A, Hernandez-Ronquillo L, Hader WJ, Jette N CRD summary The review concluded that epilepsy surgery was associated with specific cognitive changes, but may also (...) improve cognition in some patients. Given the possibility of bias, limited and variable evidence of unknown quality and major methodological shortcomings in the review, the authors' conclusions should be treated with caution. Authors' objectives To assess the effects of epilepsy surgery on neuropsychological function. Searching PubMed, EMBASE and The Cochrane Library were searched for relevant studies published in English up to June 2008; search terms were reported. The reference lists of retrieved

DARE.2011

192. Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder

Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Current use of antiepileptic drugs is associated with an increased risk of suicidality in people with depression but not in people with epilepsy or bipolar disorder Article Text

Evidence-Based Mental Health2011

193. Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response

Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response; a review Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response; a review Englot DJ, Chang EF, Auguste KI CRD summary The review found that vagus nerve stimulation was effective and relatively safe as an adjunctive therapy for individuals with refractory epilepsy (...) not amenable to resection. In view of limitations in the review that included a suboptimal search, poor reporting, failure to assess study quality, heterogeneity between the studies and lack of randomised evidence, the authors' conclusions may not be reliable. Authors' objectives To evaluate the efficacy of vagus nerve stimulation for reducing the frequency of seizures in individuals with medically refractory epilepsy. Searching PubMed was searched up to November 2010 for studies published in English

DARE.2011

195. Lacosamide (Vimpat) for epilepsy ? first and second line

Lacosamide (Vimpat) for epilepsy ? first and second line Lacosamide (Vimpat) for epilepsy – first and second line Lacosamide (Vimpat) for epilepsy – first and second line NHSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NHSC. Lacosamide (Vimpat) for epilepsy – first and second line. Birmingham: National Horizon Scanning Centre (NHSC (...) ). Horizon Scanning Review. 2011 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Acetamides; Anticonvulsants; Epilepsys Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP

Health Technology Assessment (HTA) Database.2011

197. Generalized Epilepsy with Febrile Seizures Plus (GEFS+)

Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Citation Generalized Epilepsy with Febrile Seizures Plus (GEFS+) Lansdale: HAYES, Inc.. Genetic Testing Publication. 2011 Authors' conclusions Febrile seizures (seizures triggered by fever) occur in 2% to 5% of children in the general population, generally occurring between the ages of 6 months and 6 years, with spontaneous (...) remission by the age of 6. The persistence of febrile seizures beyond 6 years of age, or febrile seizures in conjunction with afebrile convulsions, is referred to as febrile seizures plus (FS+). A heritable disorder characterized by febrile seizures is known as generalized epilepsy with febrile seizures plus (GEFS+). GEFS+ is a spectrum disorder typified by febrile seizures or FS+ in multiple family members, some of whom progress to epilepsy. The range of seizure types that may occur in families

Health Technology Assessment (HTA) Database.2011

198. [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy]

[Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Rodríguez MG, Espallargues M, Fité A, Gironell A, Rocamora R, Rumia J, Toledo M (...) , Montalbán X Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Rodríguez MG, Espallargues M, Fité A, Gironell A, Rocamora R, Rumia J, Toledo M, Montalbán X. Malaltia de Parkinson i epilèpsia:criteris d'indicació i tractament quirúrgic. [Criteria for indication and surgical treatment in Parkinson´s disease and epilepsy] Barcelona: Catalan Agency

Health Technology Assessment (HTA) Database.2011