Latest & greatest articles for epilepsy

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on epilepsy or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on epilepsy and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for epilepsy

1. Emergency management of the paediatric patient with convulsive status epilepticus

of timely pharmacological management of CSE, and includes some guidance for diagnostic approach and supportive care. Keywords: Convulsions; Emergency management; Paediatrics; Seizures; Status epilepticus (...) Emergency management of the paediatric patient with convulsive status epilepticus This guideline addresses the emergency management of convulsive status epilepticus (CSE) in children and infants older than one month of age. It replaces a previous position statement from 2011, and includes a new treatment algorithm and table of recommended medications based on new evidence and reflecting the evolution of clinical practice over the past several years. This statement emphasizes the importance

2021 Canadian Paediatric Society

2. Adulterants, Contaminants and Co-occurring Substances in Drugs on the Illegal Market in Canada: An Analysis of Data from Drug Seizures, Drug Checking and Urine Toxicology

Adulterants, Contaminants and Co-occurring Substances in Drugs on the Illegal Market in Canada: An Analysis of Data from Drug Seizures, Drug Checking and Urine Toxicology www.ccsa.ca • www.ccdus.ca Adulterants, Contaminants and Co-occurring Substances in Drugs on the Illegal Market in Canada An Analysis of Data from Drug Seizures, Drug Checking and Urine Toxicology April 2020 Adulterants, Contaminants and Co-occurring Substances in Drugs on the Illegal Market in Canada An Analysis of Data from (...) Drug Seizures, Drug Checking and Urine Toxicology This document was published by the Canadian Centre on Substance Use and Addiction (CCSA). Suggested citation: Payer, D.E., Young, M.M., Maloney-Hall, B., Mill, C., Leclerc, P., Buxton, J., the Canadian Community Epidemiology Network on Drug Use, & the National Drug Checking Working Group. (2020). Adulterants, contaminants and co-occurring substances in drugs on the illegal market in Canada: An analysis of data from drug seizures, drug checking

2021 Canadian Centre on Substance Abuse

3. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures

A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from (...) of Bumetanide to Treat Neonatal Seizures , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 2 Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 3 Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 4 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 5 Division

2021 EvidenceUpdates

4. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Dravet syndrome is a rare, treatment-resistant developmental epileptic encephalopathy characterised by multiple types of frequent, disabling seizures. Fenfluramine has been reported to have antiseizure activity in observational studies of photosensitive epilepsy and Dravet syndrome. The aim of the present study was to assess the efficacy and safety of fenfluramine (...) in patients with Dravet syndrome.In this randomised, double-blind, placebo-controlled clinical trial, we enrolled children and young adults with Dravet syndrome. After a 6-week observation period to establish baseline monthly convulsive seizure frequency (MCSF; convulsive seizures were defined as hemiclonic, tonic, clonic, tonic-atonic, generalised tonic-clonic, and focal with clearly observable motor signs), patients were randomly assigned through an interactive web response system in a 1:1:1 ratio

2020 Lancet

5. Do Antiepileptics Reduce the Risk of Poor Neurologic Outcomes and Prevent Seizures in Patients With Spontaneous Intracerebral Hemorrhage?

spontaneous intracerebral hemorrhage:a systematicreviewandmeta- analysis. Stroke. 2019;50:1095-1099. 3. Gilad R, Boaz M, Dabby R, et al. Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment? Epilepsy Res. 2011;95:227-231. 4. Gilmore EJ, Maciel CB, Hirsch LJ, et al. Review of the utility of prophylactic anticonvulsant use in critically ill patients with intracerebral hemorrhage. Stroke. 2016;47:2666-2672. 5. De Herdt V, Dumont F, Hénon H, et al. Early seizures in intracerebral (...) - ume, and surgical evacuation. 6-8 Sei- zurescanresultincerebralischemia, cerebral edema, and increased metabolic demand. 9 Although phy- sicians commonly administer anti- epileptic drugs to patients with traumatic brain injury and subarach- noid hemorrhage, use of an antiepi- leptic drug to prevent seizures after spontaneous intracerebral hemor- rhage is more controversial, 10 and it is uncertain whether early or late seizures affect clinical outcomes in patients with spontaneous intrace

2020 Annals of Emergency Medicine Systematic Review Snapshots

6. Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial Full Text available with Trip Pro

) vs 106 days (95% CI = 11-149)]. At 24 months, our pooled analysis showed preventive treatment reduced the risk of clinical seizures (odds ratio [OR] = 0.21, p = 0.032), drug-resistant epilepsy (OR = 0.23, p = 0.022), and infantile spasms (OR = 0, p Interpretation: Preventive treatment with vigabatrin was safe and modified the natural history of seizures in TSC, reducing the risk and severity of epilepsy. ANN NEUROL 2020. © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC (...) :217-240. Dragoumi P, O'Callaghan F, Zafeiriou DI. Diagnosis of tuberous sclerosis complex in the fetus. Eur J Paediatr Neurol 2018;22:1027-1034. Overwater IE, Bindels-de Heus K, Rietman AB, et al. Epilepsy in children with tuberous sclerosis complex: chance of remission and response to antiepileptic drugs. Epilepsia 2015;56:1239-1245. Nabbout R, Belousova E, Benedik MP, et al. Epilepsy in tuberous sclerosis complex: findings from the TOSCA study. Epilepsia Open 2019;4:73-84. Fisher RS, Acevedo C

2020 EvidenceUpdates

7. Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis

, Qatar PowellC7@cardiff.ac.uk. 4 Division of Population Medicine, Cardiff University School of Medicine, Cardiff, UK. PMID: 33060105 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Importance: Prolonged seizures are life-threatening emergencies associated with significant morbidity. Objective: To determine the efficacy and safety of levetiracetam in treating convulsive status epilepticus (CSE) in childhood. Data sources and study selections: PubMed, Embase (...) Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health

2020 EvidenceUpdates

8. Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults

Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving (...) disease is associated with increased incidence of epilepsy: a population based study of older adults , , , Affiliations Expand Affiliations 1 Department of Neurology, Division of Health Outcomes and Knowledge Translational Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

2020 EvidenceUpdates

9. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAEEurope consensus review

Foundation, Pavia, Italy; and w Department of Neurology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Keywords: clinical and diagnostic investigations, clinical neurophysiology, electroencephalography (EEG), epilepsy, guideline, insomnia, juvenile myoclonic epilepsy, neurological disorders, nocturnal seizures, panayiotopoulos syndrome, polysomnography, research methods, restless legs syndrome, rolandic epilepsy, seizure questionnaire, sleep- related epilepsies, sleep- disordered breathing (...) ] and other epilepsy syndromes are characterized by seizures nearly exclusively arising from sleep or shortly after awakening, or are characterized by an extreme poten- tiation of epileptiform activity during sleep. These epi- lepsy syndromes are de?ned under the term sleep- related epilepsies (SREs) [6,11,12]. Several clinical studies have shown that the presence of a comorbid sleep disorder is common in these patients, with a potentially negative impact on seizure control as well as reducing the quality

2020 European Academy of Neurology

10. Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Full Text available with Trip Pro

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This trial found that levetiracetam was not superior to phenytoin in the time taken to terminate convulsive status epilepticus, and concluded that it may be an alternative to phenytoin. {{author}} {{($index , , , , , , , , , , , , , , & . Richard E Appleton 1, * , Naomi E A Rainford 2 , Carrol Gamble 2 , Shrouk Messahel 3 , Amy

2020 NIHR HTA programme

11. Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Full Text available with Trip Pro

Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please

2020 NIHR HTA programme

12. Seizures-Child

of classifications of seizures: a preliminary study with 28 participants and 48 seizures. Epilepsy Behav. 2005;6(4):607-612. 5. Pellock JM. The classification of childhood seizures and epilepsy syndromes. Neurol Clin. 1990;8(3):619- 632. 6. Scheuer ML, Pedley TA. The evaluation and treatment of seizures. N Engl J Med. 1990;323(21):1468-1474. 7. Engel J, Jr. Report of the ILAE classification core group. Epilepsia. 2006;47(9):1558-1568. 8. Panayiotopoulos CP. Neonatal Epileptic Seizures and Syndromes. Available (...) Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470-472. 3. Weitemeyer L, Kellinghaus C, Weckesser M, et al. The prognostic value of [F]FDG-PET in nonrefractory partial epilepsy. Epilepsia. 2005;46(10):1654-1660. ACR Appropriateness Criteria ® 9 Seizures — Child 4. Baykan B, Ertas NK, Ertas M, Aktekin B, Saygi S, Gokyigit A. Comparison

2020 American College of Radiology

13. Incidence and Association of Reperfusion Therapies With Poststroke Seizures: A Systematic Review and Meta-Analysis

Incidence and Association of Reperfusion Therapies With Poststroke Seizures: A Systematic Review and Meta-Analysis Incidence and Association of Reperfusion Therapies With Poststroke Seizures: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation (...) of Reperfusion Therapies With Poststroke Seizures: A Systematic Review and Meta-Analysis , , Affiliations Expand Affiliations 1 Department of Neurology (A.L.), Penn State University, Hershey, PA. 2 Division of Epidemiology, Department of Public Health Sciences (A.L., P.S.), Penn State University, Hershey, PA. 3 Department of Neurology, Medical University of South Carolina, Charleston (J.F.). PMID: 32772682 DOI: Item in Clipboard Incidence and Association of Reperfusion Therapies With Poststroke Seizures

2020 EvidenceUpdates

14. Efficacy of statins in the prevention of epilepsy: a systematic review and meta-analysis of cohort studies Full Text available with Trip Pro

Efficacy of statins in the prevention of epilepsy: a systematic review and meta-analysis of cohort studies Inplasy Protocol 813 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

15. Cannabidiol (Epidyolex) in certain severe forms of childhood epilepsy: an option to consider, but liver function must be monitored

with antiepileptic treatment including at least clobazam. How do Prescrire's editors rate this treatment in this situation? Full text (3 pages) available for download by subscribers. Lennox-Gastaut syndrome and Dravet syndrome are severe forms of epilepsy that affect children and infants. Pharmacological treatment is based on combinations of antiepileptic drugs, sometimes including valproic acid and cloba­zam.These combinations frequently fail to fully prevent seizures. An oral solution of cannabidiol (...) , the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Cannabidiol (Epidyolex°) in certain severe forms of childhood epilepsy: an option to consider, but liver function must be monitored FEATURED REVIEW Cannabidiol (Epidyolex°) has been granted marketing authorisation in the European Union for patients aged 2 years and older with Lennox-Gastaut syndrome or Dravet syndrome, in combination

2020 Prescrire

16. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Lennox?Gastaut syndrome (LGS) in conjunction with clobazam, for patients 2 years of age and older.

estimated using a direct elicitation exercise, where 11 patients with epilepsy and 19 caregivers of patients with epilepsy were asked to value a series of vignettes through the perspective of a patient with Lennox-Gastaut Syndrome using a Visual Analogue Scale (VAS). Although not derived using a ‘choice-based’ approach, the company utilised mean estimates from this exercise in the base case (utilities ranged from 0.75 [‘seizure-free’] to 0.235 [= 3 seizure-free days with more than 110 seizures (...) providing tertiary epilepsy specialist care and when treatment with lamotrigine, rufinamide and topiramate has proved ineffective or not tolerated. 11 The Scottish Intercollegiate Guidelines Network (SIGN) issued publication number 148: diagnosis and management of epilepsy in adults in May 2015 and it was updated in 2018. This makes no specific recommendations on the treatment of Lennox-Gastaut syndrome, but notes that drop attacks in patients with Lennox-Gastaut syndrome may respond to rufinamide. 15

2020 Scottish Medicines Consortium

17. Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with  Dravet syndrome (DS) in conjunction with clobazam, for patients 2 years of age and older.

with Dravet syndrome (70% to 80%) have abnormalities in the sodium channel a1 subunit gene (SCN1A). 2 6 Stiripentol 6 is the only other medicine specifically licensed for Dravet syndrome, although sodium valproate and clobazam, licensed for use in epilepsy, 2,7,8 are widely used in Dravet syndrome. Sodium valproate is often used to prevent initial recurrence of convulsive seizures, and benzodiazepines (for example, diazepam, midazolam, clonazepam, or clobazam) are frequently co- administered to limit (...) as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Dravet syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced convulsive seizure frequency in the clobazam-treated subgroup of children (aged 2 to 18 years) with Dravet syndrome

2020 Scottish Medicines Consortium

18. Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial

. doi: 10.1001/jamapediatrics.2020.2282. Online ahead of print. Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial , , , , , , , , , , Affiliations Expand Affiliations 1 Center of Excellence & Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. 2 Department of Pediatrics, All (...) Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial Vishal Sondhi et al. JAMA Pediatr . 2020 . Show details Display options Display options Format JAMA Pediatr Actions . 2020 Aug 3;e202282. doi: 10.1001/jamapediatrics.2020.2282. Online ahead of print. Authors , , , , , , , , , , Affiliations 1 Center of Excellence & Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi

2020 EvidenceUpdates

19. Seizure Detection and Tracking Through Portable Technologies: Study Protocol of a Systematic Review Full Text available with Trip Pro

and a higher risk of sudden unexpected death in epilepsy (SUDEP). The only way to minimize the risk of SUDEP is having a control of seizures. However, epileptics living or get a seizure alone can’t report the exact information to their physicians. Then, the level of gravity of their disease is inexact. Currently, the only way to identify a seizure is by electroencephalography (EEG), used by healthcare resources. It requires medical staff for its installation and interpretation. Nonetheless, a lot of new (...) technologies developed for recording seizures at home have been developed. These one hasn’t optimally included epileptics and only a few went to a clinical trial; thus, scientific evidence is limited regarding their effectiveness. Methods The methodological approach is based in the Cochrane handbook for conducting systematic review . All studies in any languages about the technologies detecting seizures will be compared for any type of epilepsy and for any outcome measured. Two reviewers will independently

2020 Research Square

20. Association between epilepsy and challenging behaviour in adults with intellectual disabilities: systematic review and meta-analysis Full Text available with Trip Pro

with over 70% in intellectual disabilities). Diagnosing epilepsy and seizure type can be difficult in this population, and both false-positive (stereotypy, cardiac syncope, non-epileptic attack disorder may all mimic epileptic seizure) and false-negative (difficulty diagnosing absence, focal seizures) diagnoses are possible. Also, these people are more prone to die from sudden unexpected death in epilepsy (SUDEP). , Relationship between epilepsy and challenging behaviour in adults with intellectual (...) ), Lennox–Gastaut syndrome, Landau–Kleffner syndrome and Dravet syndrome, are more commonly associated with intellectual disabilities. Compared with the general population of adults who do not have intellectual disabilities, epilepsy among adults with intellectual disabilities is not only more prevalent, but it also often manifests as multiple seizure types, starts at an early age, is of longer duration and is resistant to anti-epileptic treatment (in over 30% in the general population, compared

2020 BJPsych open