Latest & greatest articles for elderly

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Top results for elderly

161. Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer (PubMed)

Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer Limited data are available about the tolerability and clinical outcomes of elderly patients with metastatic castration-resistant prostate cancer (mCRPC) who are treated with docetaxel. We evaluated the efficacy and safety of docetaxel as first-line chemotherapy for patients with mCRPC who were treated in our institution.We retrospectively identified patients with mCRPC and a Karnosfky (...) groups. The median OS was longer in the group of patients younger than age 65 years (19.6 v 12.4 v 12.3 months; P = .012). Rates of any grade 3 or higher adverse event were not different among groups (63.2% v 71.8% v 54.5%; P = .14).Administration of docetaxel in elderly patients who had good performance status was well tolerated. Rates of PSA decline and TTP were similar to those of younger patients, but median survival was lower.

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2017 Journal of global oncology

162. The association between death anxiety with spiritual experiences and life satisfaction in elderly people (PubMed)

The association between death anxiety with spiritual experiences and life satisfaction in elderly people Death anxiety is a concept with greater importance among the elderly as they approach inevitability of death. Identifying the correlates of death anxiety among old people is important in order to reduce the burden of this problem. Therefore, the present study was performed with the aim to examine the association between spiritual experiences and life satisfaction with death anxiety (...) in this stage of life.This cross-sectional study with descriptive-analytical design included 190 elderly people visiting the health and medical centers of Neyshabur city, Iran, during fall and winter, 2016. Participants were asked to complete three questionnaires including a 16-item spiritual experiences scale, life satisfaction index proposed by Wood and Shifor with 13 items, and a 27-item death anxiety scale developed by Aminpour. Analytical statistics (Spearman's correlation coefficient, Pearson's

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2017 Electronic physician

163. The necessity of colorectal cancer screening for elderly patients (PubMed)

The necessity of colorectal cancer screening for elderly patients 28447054 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol The necessity of colorectal cancer screening for elderly patients. 19 10.21037/tgh.2017.03.03 Kudo Shin-Ei SE Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan. Kudo Toyoki T Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan. eng Editorial Comment

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2017 Translational gastroenterology and hepatology

164. Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost (...) -Effectiveness, and Guidelines Published on: March 20, 2017 Project Number: RA0902-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of case management for frail elderly in the community? What is the cost-effectiveness of case management for frail elderly in the community? What are the evidence-based guidelines regarding case management interventions for frail elderly in the community? Key Message One health

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

165. Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma. (PubMed)

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma. Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter courses of radiotherapy are commonly used, but the benefit of adding temozolomide to a shorter course of radiotherapy is unknown.We (...) patients with unmethylated MGMT status, the median overall survival was 10.0 months with radiotherapy plus temozolomide and 7.9 months with radiotherapy alone (hazard ratio for death, 0.75; 95% CI, 0.56 to 1.01; P=0.055; P=0.08 for interaction). Quality of life was similar in the two trial groups.In elderly patients with glioblastoma, the addition of temozolomide to short-course radiotherapy resulted in longer survival than short-course radiotherapy alone. (Funded by the Canadian Cancer Society

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2017 NEJM

166. Comparison of outcomes between off-pump versus on-pump coronary artery bypass surgery in elderly patients: a meta-analysis. (PubMed)

Comparison of outcomes between off-pump versus on-pump coronary artery bypass surgery in elderly patients: a meta-analysis. The aim of this study was to analyze if off-pump coronary artery bypass surgery (CABG) is associated with better treatment outcomes in elderly patients (>70 years of age) than on-pump CABG, using meta-analysis. Medline, PubMed, Cochrane and Google Scholar databases were searched until September 13, 2016. Sensitivity and quality assessment were performed. Twenty-two studies

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2017 Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

167. A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation (PubMed)

A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation Dialysis patients aged ≥70 years derive improved life expectancy through kidney transplantation compared to their waitlisted counterparts, but guidelines are not clear about how to identify appropriate transplantation candidates. We developed a clinical prediction score to identify elderly dialysis patients with expected 5-year survival appropriate for kidney transplantation (>5 years (...) ).Incident dialysis patients in 2006-2009 aged ≥70 were identified from the United States Renal Data System database and divided into derivation and validation cohorts. Using the derivation cohort, candidate variables with a significant crude association with 5-year all-cause mortality were included in a multivariable logistic regression model to generate a scoring system. The scoring system was tested in the validation cohort and a cohort of elderly transplant recipients.Characteristics most predictive

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2017 Kidney international reports

168. Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? (PubMed)

Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR).We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web

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2017 European journal of rheumatology

169. [Elderly patients and intensive care: Systematic review and geriatrician's point of view]. (PubMed)

[Elderly patients and intensive care: Systematic review and geriatrician's point of view]. The global population is aging and intensive care unit admission rate of elderly patients is dramatically increasing. The objective of this review is to provide an overview of the literature about the management of elderly patients in intensive care unit and more specifically about epidemiology, admission criteria, mortality, functional prognosis and ethical aspects. We also discuss the data (...) on cardiorespiratory arrest, shock, acute respiratory failure and delirium. The mortality rate of patients over 80 years old in intensive care unit can reach up to 70% at 1year, but is dependent on many factors, such as comorbidities or frailty. Above all, more than half of elderly patients recover their long-term autonomy. Their quality of life is comparable to that of the same age population. Considering that the first 3months after an intensive care unit stay are the most decisive in terms of vital

2017 La Revue de medecine interne

170. Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial (PubMed)

Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial In the cetuximab after progression in KRAS wild-type colorectal cancer patients (CAPRI) trial patients with metastatic colorectal cancer (mCRC) received 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) and cetuximab in first line followed by 5-Fluorouracil, folinic acid, oxaliplatin (FOLFOX) with or without cetuximab until progression. Limited (...) data are available on the efficacy and safety of anti-epidermal growth factor receptor (anti-EGFR) agents on elderly patients with mCRC. In the current study we evaluated the efficacy and safety of FOLFIRI plus cetuximab in age-defined subgroups.A post-hoc analysis was performed in CAPRI trial patients; outcomes (progression-free survival (PFS), overall response rate (ORR), safety) were analysed by age-groups and stratified according to molecular characterisation. 3 age cut-offs were used to define

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2017 ESMO open

171. Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program: A Randomized Single Arm Crossover Study. (PubMed)

Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program: A Randomized Single Arm Crossover Study. Objective: To develop and assess the efficacy of a multimodal balance-enhancing exercise program (BEEP) designed to be regularly self-administered by community-dwelling elderly. The program aims to promote sensory reweighting, facilitate motor control, improve gaze stabilization, and stimulate continuous improvement (...) and Go speeds increased (p ≤ .001), as did scores in Berg Balance and balance confidence scales (p ≤ .018). Discussion: Multimodal balance exercises offer an efficient, cost-effective way to improve balance control and confidence in elderly.

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2017 Gerontology & geriatric medicine

172. [Psychiatry in elderly prisoners].

[Psychiatry in elderly prisoners]. The high prevalence of psychiatric disorders in prison and the aging of inmates should lead to the consideration of gerontopsychiatry in the prison environment.This review aims to emphasize the clinical characteristics and associated comorbidities of elderly prisoners with psychiatric disorders. We examined the international literature in September 2013 and performed the literature search with PubMed electronic database using the following Mesh headings (...) : "prisons", "prisoners", "geriatric psychiatry", "geriatric assessment", "geriatric nursing".Fourteen studies were retained by the literature search strategy and were included in the qualitative analysis. More than one out of two elderly prisoners (>60 year-old) suffer from a psychiatric disorder. Major depressive disorder (MDD) is the first psychiatric disorder diagnosed among elderly prisoners, affecting 30 to 50% of them. Personality disorders are also very common demonstrating a prevalence of about

2017 L'Encephale

173. Lymphadenectomy in elderly/high risk patients: should it be different? (PubMed)

Lymphadenectomy in elderly/high risk patients: should it be different? The global aging of population will lead a greater number of elderly patients to undergo surgical procedure in a near future. Concerning gastric cancer, the impact of lymphadenectomy on survival has been demonstrated in RCTs, and extended lymphadenectomy is now considered as gold standard of treatment in non-early tumors. However, the role of age as a prognostic factor and the benefit of extended surgery in elderly/high-risk

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2017 Translational gastroenterology and hepatology

174. Effectiveness of probiotics in reducing the incidence of Clostridium difficile-associated diarrhea in elderly patients: a systematic review. (PubMed)

Effectiveness of probiotics in reducing the incidence of Clostridium difficile-associated diarrhea in elderly patients: a systematic review. Clostridium difficile bacteria are a leading cause of infectious diarrhea. This is an anaerobic, gram-positive and spore-forming rod responsible for significant morbidity and mortality, especially among elderly hospitalized patients. Standard management of C. difficile-associated diarrhea (CDAD) consists of discontinuing a causative antibiotic, correcting (...) fluid-electrolytes imbalance and initiating an antibiotic treatment for CDAD. Alternative approaches for prevention of CDAD include probiotics. This systematic review will provide a comprehensive, unbiased summary of the available research on the effectiveness of probiotics in decreasing the incidence of infectious diarrhea in elderly hospitalized patients.To conduct a systematic review to determine the best available evidence related to the effectiveness of probiotics in the prevention of CDAD

2017 JBI database of systematic reviews and implementation reports

175. Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women (PubMed)

Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women There is great interest in the biology of vascular calcification. Wnt/β-catenin signaling is an important mediator of mineralization and may play a role in vascular calcification.We assessed the association between circulating Wnt antagonists and abdominal aortic calcification (AAC) severity in elderly women.This was a cross-sectional analysis of the Calcium Intake Fracture Outcome Study.The (...) participants were recruited from the community-dwelling elderly population.We examined 768 women aged over 70 years.We collected blood samples, and lateral spine images captured during bone density assessment were used to score AAC with a validated 24-point scale.We tested the hypothesis that low Wnt antagonist levels of Dickkopf-1 (DKK1), secreted frizzled related protein 3 (sFRP3), and Wnt inhibitory factor 1 (WIF1) are associated with severe AAC (AAC24 score > 5).Severe AAC was present in 146 women (19

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2017 Journal of the Endocrine Society

176. Cross-sectional study: High proportion of elderly patients who are admitted to hospital are entering the last year of their lives

Cross-sectional study: High proportion of elderly patients who are admitted to hospital are entering the last year of their lives High proportion of elderly patients who are admitted to hospital are entering the last year of their lives | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here High proportion of elderly patients who are admitted to hospital are entering the last year of their lives Article Text Care of the older person Cross-sectional study

2017 Evidence-Based Nursing