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Latest & greatest articles for elderly
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Sleep quality disturbances and cognitive functioning in elderly patients with COPD 27957482 2018 11 13 2312-0541 2 3 2016 Jul ERJ open research ERJ Open Res Sleep quality disturbances and cognitive functioning in elderly patients with COPD. 00054-2016 Information about the association between cognitive functions, such as copying function, and sleep disturbances in patients with chronic obstructive pulmonary disease (COPD) is lacking. This cross-sectional observational study aimed to investigate (...) the association between copying function and self-reported sleep quality disturbances and disease severity in an elderly COPD population. Cognitive function performances, assessed using the Mini-Mental State Examination, were compared in 562 ambulatory COPD patients with and without sleep disturbances; assessed using the Established Populations for Epidemiologic Studies of the Elderly questionnaire; and stratified by Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades. Sleep disturbances
Is there an association between altered baroreceptor sensitivity and obstructive sleep apnoea in the healthy elderly? 27957483 2018 11 13 2312-0541 2 3 2016 Jul ERJ open research ERJ Open Res Is there an association between altered baroreceptor sensitivity and obstructive sleep apnoea in the healthy elderly? 00072-2016 Obstructive sleep apnoea (OSA) is associated with a rise in cardiovascular risk in which increased sympathetic activity and depressed baroreceptor reflex sensitivity (BRS) have (...) been proposed. We examined this association in a sample of healthy elderly subjects with unrecognised OSA. 801 healthy elderly (aged ≥65 years) subjects undergoing clinical, respiratory polygraphy and vascular assessment were examined. According to the apnoea-hypopnoea index (AHI), the subjects were stratified into no OSA, mild-moderate OSA and severe OSA cases. OSA was present in 62% of the sample, 62% being mild-moderate and 38% severe. No differences were found for BRS value according to sex
Cardiac and Thermal Strain of Elderly Adults Exposed to Extreme Heat and Humidity With and Without Electric Fan Use 27599335 2016 10 31 2018 11 13 1538-3598 316 9 2016 Sep 06 JAMA JAMA Cardiac and Thermal Strain of Elderly Adults Exposed to Extreme Heat and Humidity With and Without Electric Fan Use. 989-91 10.1001/jama.2016.10550 Gagnon Daniel D Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center, Dallas. Romero Steven A SA Institute for Exercise (...) United States Clinical Trial Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States JAMA 7501160 0098-7484 AIM IM Cochrane Database Syst Rev. 2012 Jul 11;(7):CD009888 22786530 N Engl J Med. 1996 Jul 11;335(2):84-90 8649494 Med Sci Sports Exerc. 2014 Oct;46(10):1891-9 24598696 JAMA. 2015 Feb 17;313(7):724-5 25688786 JAMA. 2014 Oct 15;312(15):1565-80 25244362 Aged Air Movements Body Temperature Equipment Design Female
Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis in Elderly Patients (â‰¥75Â years): A Monocentric Cohort Study of 61 Cases 27747601 2018 11 13 2199-1154 3 4 2016 Dec Drugs - real world outcomes Drugs Real World Outcomes Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis in Elderly Patients (≥75 years): A Monocentric Cohort Study of 61 Cases. 393-399 Little data is currently available in the literature on neutropenia and agranulocytosis in the elderly, and (...) , to our knowledge, idiosyncratic drug-induced agranulocytosis is particularly poorly covered, or not at all. We herein describe the clinical picture and outcome of patients aged ≥75 years with established idiosyncratic drug-induced agranulocytosis. Data from 61 patients over 75 years old with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis (n = 203) in the Strasbourg University Hospitals (Strasbourg, France
Unrecognized human immunodeficiency virus infection and risk factors among elderly medical patients at the Korle Bu teaching hospital, Accra, Ghana 28883962 2018 11 13 2055-0936 2 2016 Tropical diseases, travel medicine and vaccines Trop Dis Travel Med Vaccines Unrecognized human immunodeficiency virus infection and risk factors among elderly medical patients at the Korle Bu teaching hospital, Accra, Ghana. 18 10.1186/s40794-016-0034-9 The human immunodeficiency virus (HIV) infection usually (...) infects persons in the reproductive age group (15-49 years), but elderly people are also susceptible. Many people in sub-Saharan Africa including Ghana believe that elderly people are not at risk for HIV. Despite numerous reports of the high prevalence of HIV infection among the elderly worldwide, there are no from Ghana. This work determined the sero-prevalence of HIV infection and risk factors for its transmission among 1,100 hospitalized elderly people at the Korle Bu Teaching Hospital (KBTH
A Simple Disease-Guided Approach to Personalize ACC/AHA-Recommended Statin Allocation in Elderly People: The BioImage Study 27561760 2016 08 26 2016 08 26 1558-3597 68 9 2016 Aug 30 Journal of the American College of Cardiology J. Am. Coll. Cardiol. A Simple Disease-Guided Approach to Personalize ACC/AHA-Recommended Statin Allocation in Elderly People: The BioImage Study. 881-91 10.1016/j.jacc.2016.05.084 S0735-1097(16)33608-7 The 2013 American College of Cardiology (ACC)/American Heart (...) (p = 0.001). For cardiovascular disease events, the NRI was 0.14 (CAC-guided) and 0.06 (cPB-guided). The positive NRIs were driven primarily by down-classifying the large subpopulation with CAC = 0 or cPB = 0. Withholding statins in individuals without CAC or carotid plaque could spare a significant proportion of elderly people from taking a pill that would benefit only a few. This individualized disease-guided approach is simple and easy to implement in routine clinical practice. Copyright
Platelet function monitoring to adjust antiplatelet therapy in elderly patients stented for an acute coronary syndrome (ANTARCTIC): an open-label, blinded-endpoint, randomised controlled superiority trial. BACKGROUND: Elderly patients are at high risk of ischaemic and bleeding events. Platelet function monitoring offers the possibility to individualise antiplatelet therapy to improve the therapeutic risk-benefit ratio. We aimed to assess the effect of platelet function monitoring with treatment (...) adjustment in elderly patients stented for an acute coronary syndrome. METHODS: We did this multicentre, open-label, blinded-endpoint, randomised controlled superiority study at 35 centres in France. Patients aged 75 years or older who had undergone coronary stenting for acute coronary syndrome were randomly assigned (1:1), via a central interactive voice-response system based on a computer-generated permuted-block randomisation schedule with randomly selected block sizes, to receive oral prasugrel 5 mg
The association between serum 25-hydroxyvitamin D level and recurrent falls in the elderly population: a cohort study 27757178 2018 11 13 2008-5842 8 8 2016 Aug Electronic physician Electron Physician The association between serum 25-hydroxyvitamin D level and recurrent falls in the elderly population: a cohort study. 2707-2712 Serum vitamin D concentration is a major contributing factor for increasing the risk of fall and fall-related injuries in older adults. However, when prescribed (...) and supplemented for these populations, the outcomes are controversial, and in several cases no improvement has been reported in reducing the risk of recurrent falls. This study aimed to examine the association between serum vitamin D concentration and recurrent falls in Iranian older adults. This cohort study was conducted in the emergency departments of two university hospitals. A cohort of 82 elderly participants aged over 60 and suffered from an unintentional episode of falling was evaluated six months
Interventions for preventing abuse in the elderly. BACKGROUND: Maltreatment of older people (elder abuse) includes psychological, physical, sexual abuse, neglect and financial exploitation. Evidence suggests that 10% of older adults experience some form of abuse, and only a fraction of cases are actually reported or referred to social services agencies. Elder abuse is associated with significant morbidity and premature mortality. Numerous interventions have been implemented to address the issue (...) of elder maltreatment. It is, however, unclear which interventions best serve to prevent or reduce elder abuse. OBJECTIVES: The objective of this review was to assess the effectiveness of primary, secondary and tertiary intervention programmes used to reduce or prevent abuse of the elderly in their own home, in organisational or institutional and community settings. The secondary objective was to investigate whether intervention effects are modified by types of abuse, types of participants, setting
Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. BACKGROUND: Delirium is a postoperative complication that occurs frequently in patients older than 65 years, and presages adverse outcomes. We investigated whether prophylactic low-dose dexmedetomidine, a highly selective α 2 adrenoceptor agonist, could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery. METHODS: We (...) did this randomised, double-blind, placebo-controlled trial in two tertiary-care hospitals in Beijing, China. We enrolled patients aged 65 years or older, who were admitted to intensive care units after non-cardiac surgery, with informed consent. We used a computer-generated randomisation sequence (in a 1:1 ratio) to randomly assign patients to receive either intravenous dexmedetomidine (0·1 μg/kg per h, from intensive care unit admission on the day of surgery until 0800 h on postoperative day 1
Exploring gender perceptions of risk of HIV infection and related behaviour among elderly men and women of Ga-Rankuwa, Gauteng Province, South Africa 27687151 2017 12 01 2018 11 13 1813-4424 13 1 2016 12 SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance SAHARA J Exploring gender perceptions of risk of HIV infection and related behaviour among elderly men and women of Ga-Rankuwa, Gauteng Province, South Africa. 88-95 The literature shows that there are important differences (...) between women and men in the underlying mechanisms of transmission of HIV infection and AIDS, as well as in the social and economic consequences of HIV/AIDS. These stem from sexual behaviour and socially constructed 'gender' differences between women and men in roles and responsibilities. Despite the fact that numerous gender-related sociocultural factors influence HIV/AIDS protective behaviours, little gender specificity is included in HIV prevention among the elderly. In order to close this gap
Potentially Inappropriate Medications in Elderly Haemodialysis Patients Using the STOPP Criteria 27747833 2018 11 13 2199-1154 3 3 2016 Sep Drugs - real world outcomes Drugs Real World Outcomes Potentially Inappropriate Medications in Elderly Haemodialysis Patients Using the STOPP Criteria. 359-363 Polypharmacy is commonly applied to elderly haemodialysis patients for treating terminal renal failure and multiple co-morbidities. Potentially inappropriate medications (PIMs) in multidrug regimens (...) in geriatric populations can be identified using specially designed screening tools. The aims of this study were to estimate the prevalence of PIMs by applying the Screening Tool of Older Persons' Prescriptions (STOPP) criteria and the Beers criteria to elderly haemodialysis patients and to assess the association of some risk factors with the presence of PIMs. Fifty-one elderly haemodialysis patients participated; their median age was 74 (range 65-89) years, and 77 % of them were male. Demographic data, co
Low performance of bleeding risk models in the very elderly with atrial fibrillation using vitamin K antagonists 27172860 2016 09 25 2016 09 25 1538-7836 14 9 2016 Sep Journal of thrombosis and haemostasis : JTH J. Thromb. Haemost. Low performance of bleeding risk models in the very elderly with atrial fibrillation using vitamin K antagonists. 1715-24 10.1111/jth.13361 Essentials Under-treatment of oral anticoagulation in the elderly with atrial fibrillation is common. As bleeding prediction (...) is challenging, we compared HAS-BLED, ATRIA and HEMORR2 HAGES. All three were associated with major bleeding in the elderly, but with poor predictive abilities. Future studies with focus on elderly-specific risk factors for bleeding are warranted. Background Anticipated bleeding complications contribute to underuse of oral anticoagulants, especially in elderly patients with atrial fibrillation (AF). Bleeding risk models could provide guidance; however, these were developed in the general AF population
Clinical impact of postâ€progression survival on overall survival in elderly patients with extensive disease smallâ€cell lung cancer 27755823 2017 03 17 2018 11 13 1759-7714 7 6 2016 Nov Thoracic cancer Thorac Cancer Clinical impact of post-progression survival on overall survival in elderly patients with extensive disease small-cell lung cancer. 655-662 10.1111/1759-7714.12381 The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies (...) in patients with small-cell lung cancer (SCLC). Therefore, the objective of our study was to determine the relationships between progression-free survival (PFS) or post-progression survival (PPS) and OS after first-line chemotherapy in elderly patients with extensive disease-SCLC (ED-SCLC), using individual level data. Between July 1998 and December 2014, we analyzed 57 cases of elderly patients with ED-SCLC who were treated with carboplatin and etoposide as first-line chemotherapy. The relationships
Potentially Inappropriate Medication Use in Multimorbid Elderly Inpatients: Differences Between the FORTA, PRISCUS and STOPP Ratings 27747830 2018 11 13 2199-1154 3 3 2016 Sep Drugs - real world outcomes Drugs Real World Outcomes Potentially Inappropriate Medication Use in Multimorbid Elderly Inpatients: Differences Between the FORTA, PRISCUS and STOPP Ratings. 317-325 Several classifications to identify and avoid use of potentially inappropriate medications (PIMs) in the elderly have been (...) published. To what extent these classifications match each other and whether there are differences in the prevalence of PIM use at admission, during the inpatient stay and at discharge are largely unreported. To determine the PIM prevalence in elderly patients at a university hospital, with a special focus on different classification systems and the chronological sequence, and to examine a possible association between PIM use and the reason for admission, as well as severe side effects and consequences
Development of a decision guide to support the elderly in decision making about location of care: an iterative, user-centered design 29062524 2018 11 13 2056-7529 2 2016 Research involvement and engagement Res Involv Engagem Development of a decision guide to support the elderly in decision making about location of care: an iterative, user-centered design. 26 10.1186/s40900-016-0040-0 For the elderly to get the care and services they need, they may need to make the difficult decision about (...) staying in their home or moving to another home. Many other people may be involved in their care too (friends, family and healthcare providers), and can support them in making the decision. We asked informal caregivers of elderly people to help us develop a decision guide to support them and their loved ones in making this decision. This guide will be used by health providers in home care who are trained to help people make decisions. The guide is in French and English. To design and test
Chemoradiation therapy with docetaxel in elderly patients with stage II/III esophageal cancer: A phase 2 trial 28740892 2018 11 13 2452-1094 1 4 2016 Oct-Dec Advances in radiation oncology Adv Radiat Oncol Chemoradiation therapy with docetaxel in elderly patients with stage II/III esophageal cancer: A phase 2 trial. 230-236 10.1016/j.adro.2016.07.002 The most effective treatments in elderly patients with esophageal cancer remain a subject of debate. This multicenter phase 2 study was designed (...) to evaluate the efficacy and toxicity of chemoradiation therapy (CRT) with docetaxel (DTX) in elderly patients with stage II/III (non-T4) esophageal cancer. Patients ≥70 years of age with clinical stage II/III esophageal cancer received DTX at a weekly dose of 10 mg/m 2 during 6 consecutive weeks and concurrent radiation therapy (60 Gy in 30 fractions). The primary endpoint was the 2-year survival rate, and the required number of enrolled patients was 37. Between July 2008 and January 2011, 16 patients
Long term survival with stereotactic ablative radiotherapy (SABR) versus thoracoscopic sublobar lung resection in elderly people: national population based study with propensity matched comparative analysis. OBJECTIVES: To compare cancer specific survival after thoracoscopic sublobar lung resection and stereotactic ablative radiotherapy (SABR) for tumors ≤2 cm in size and thoracoscopic resection (sublobar resection or lobectomy) and SABR for tumors ≤5 cm in size. DESIGN: National population (...) based retrospective cohort study with propensity matched comparative analysis. SETTING: Surveillance, Epidemiology, and End Results (SEER) registry linked with Medicare database in the United States. PARTICIPANTS: Patients aged ≥66 with lung cancer undergoing SABR or thoracoscopic lobectomy or sublobar resection from 1 Oct 2007 to 31 June 2012 and followed up to 31 December 2013. MAIN OUTCOME MEASURES: Cancer specific survival after SABR or thoracoscopic surgery for lung cancer. RESULTS: 690 (275
CPX-351 (VYXEOS) for elderly patients with newly diagnosed acute myeloid leukaemia - first line CPX-351 (VYXEOS) for elderly patients with newly diagnosed acute myeloid leukaemia – first line CPX-351 (VYXEOS) for elderly patients with newly diagnosed acute myeloid leukaemia – first line NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. CPX (...) -351 (VYXEOS) for elderly patients with newly diagnosed acute myeloid leukaemia – first line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Acute myeloid leukaemia is a rare type of cancer that affects the way blood cells are developed so that they do not work properly. This leads to an increased risk of infection, as well as symptoms such as anaemia and bruising. It can affect people at any age but is more common in people over