Latest & greatest articles for elderly

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This page lists the very latest high quality evidence on elderly and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Top results for elderly

101. Comparative effectiveness and safety of direct oral anticoagulants in the elderly with atrial fibrillation: are there differences between real-world practice and randomized controlled trials? A critical systematic review and meta-analysis

Comparative effectiveness and safety of direct oral anticoagulants in the elderly with atrial fibrillation: are there differences between real-world practice and randomized controlled trials? A critical systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission

2019 PROSPERO

102. Association of sleep duration and quality with sarcopenia in elderly residents in the community: a meta-analysis

Association of sleep duration and quality with sarcopenia in elderly residents in the community: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

103. Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults. (PubMed)

Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults. Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated in delay-of-onset clinical trials with at-risk individuals. Such ongoing clinical research can be advanced by developing a better understanding of how these drugs (...) affect intermediate brain phenotypes associated with both AD risk and pathophysiology.Using a randomized, parallel-group, placebo-controlled design in 55 healthy elderly volunteers, we explored the effects of oral, low-dose pioglitazone, a thiazolidinedione with promitochondrial effects, on hippocampal activity measured with functional magnetic resonance imaging during the encoding of novel face-name pairs.Compared with placebo, 0.6 mg of pioglitazone (but not 2.1 mg, 3.9 mg, or 6.0 mg) administered

2019 Alzheimer's & dementia (New York, N. Y.) Controlled trial quality: uncertain

104. No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model. (PubMed)

No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model. Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large-scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting. The present exploratory study is designed to determine the potentiation of the effects of donepezil by cotreatment with EVP-6124, an alpha-7 (...) nicotinic agonist, to reduce scopolamine-induced cognitive deficits in healthy elderly subjects. Secondary objectives are to explore safety and pharmacokinetic and pharmacodynamics effects of EVP-6124 alone and in combination with donepezil compared to placebo.A phase I randomized, single-center, placebo-controlled, double-blind, five-way, partial crossover study was performed with donepezil 2.5, 5 mg or placebo combined with EVP-6124 0.3, 1, 2, 4 mg or placebo in three cohorts of healthy elderly

2019 Alzheimer's & dementia (New York, N. Y.) Controlled trial quality: uncertain

105. Motivational interviewing can support physical activity in elderly patients with diastolic heart failure: results from a pilot study. (PubMed)

Motivational interviewing can support physical activity in elderly patients with diastolic heart failure: results from a pilot study. Patients suffering from heart failure with preserved ejection fraction (HFpEF) report similar symptoms and reduction in quality of life to those with reduced ejection fraction but remain largely untreated. We conducted a preliminary evaluation of the acceptance, feasibility, and efficacy of a motivational interviewing (MI) intervention to support elderly patients

2019 ESC heart failure Controlled trial quality: uncertain

106. The effect of exogenous melatonin on sleeplessness in the elderly population: a systematic review

The effect of exogenous melatonin on sleeplessness in the elderly population: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

107. The effectiveness of frailty assessment tools in elderly urological patients undergoing radical cystectomy and their predictability of postoperative complications and outcomes

The effectiveness of frailty assessment tools in elderly urological patients undergoing radical cystectomy and their predictability of postoperative complications and outcomes Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

108. The effectiveness of exercises on fall and fracture prevention amongst community elderlies: a systematic review and meta-analysis

The effectiveness of exercises on fall and fracture prevention amongst community elderlies: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

109. The effectiveness of dexmedetomidine on the prevention of postoperative delirium in elderly cardiac surgery patients: a systematic review

The effectiveness of dexmedetomidine on the prevention of postoperative delirium in elderly cardiac surgery patients: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

110. Influence of the economic and social factors in the nutritional status of elderly: systematic review and meta-analysis

Influence of the economic and social factors in the nutritional status of elderly: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

111. Investigating the risk between method of anaesthesia and development of post-operative delirium in elderly patients undergoing hip surgery: a systematic review

Investigating the risk between method of anaesthesia and development of post-operative delirium in elderly patients undergoing hip surgery: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

112. Which technique for caries removal presents better clinical results in elderly patients? A systematic review

Which technique for caries removal presents better clinical results in elderly patients? A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

113. What interventions provide optimal support for caregivers of the elderly chronically ill?: A systematic review

What interventions provide optimal support for caregivers of the elderly chronically ill?: A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

114. Risk factors of postoperative delirium in elderly spine surgery patients: a systematic review and meta-analysis

Risk factors of postoperative delirium in elderly spine surgery patients: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

115. Elderly pedestrian injury: a systematic review and meta-analysis of health outcomes

Elderly pedestrian injury: a systematic review and meta-analysis of health outcomes Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

116. Feasibility of perioperative eHealth interventions for elderly surgical patients: a systematic review

Feasibility of perioperative eHealth interventions for elderly surgical patients: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

117. Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial

Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial Functional decline is prevalent among acutely hospitalized older patients. Exercise and early rehabilitation protocols applied during acute hospitalization can prevent functional and cognitive decline in older patients.To assess the effects of an innovative multicomponent exercise intervention on the functional status of this patient population.A single-center (...) , single-blind randomized clinical trial was conducted from February 1, 2015, to August 30, 2017, in an acute care unit in a tertiary public hospital in Navarra, Spain. A total of 370 very elderly patients undergoing acute-care hospitalization were randomly assigned to an exercise or control (usual-care) intervention. Intention-to-treat analysis was conducted.The control group received usual-care hospital care, which included physical rehabilitation when needed. The in-hospital intervention included

Full Text available with Trip Pro

2018 EvidenceUpdates

118. Effect of Physical Disability on Mortality in Elderly Patients of >/=80 Years of Age Undergoing Percutaneous Coronary Intervention

Effect of Physical Disability on Mortality in Elderly Patients of >/=80 Years of Age Undergoing Percutaneous Coronary Intervention Functional decrease has been linked with adverse events in different clinical contexts. The predictive role of activity of daily living status as assessed by the Barthel index (BI) in elderly patients who underwent percutaneous coronary intervention (PCI) has not been investigated, yet. In this study, a total of 616 patients (≥80 years) who underwent PCI between (...) of daily living should be incorporated into the risk stratification of elderly patients with coronary artery disease.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 EvidenceUpdates

119. Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial

Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial Acute myeloid leukemia (AML) in elderly patients has a poor prognosis. In an attempt to improve outcome for these patients, the prospective open-label phase III LAM-SA 2007 (Adding Lomustine to Chemotherapy in Older Patients With Acute Myelogenous Leukemia (AML), and Allogeneic Transplantation for Patients From 60 to 65 Years (...) , were significantly higher in the ICL arm ( P = .04), and fewer patients required a second treatment after ICL.Adding lomustine to standard chemotherapy significantly improved the outcome of elderly patients with AML.

2018 EvidenceUpdates

120. Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial

Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial To determine the cost-effectiveness of the HiBalance training program for managing Parkinson's disease (PD)-related balance and gait disorders.Cost comparison design following the randomized controlled trial comparing a novel balance training intervention with care as usual.A total of 100 participants with mild-moderate PD were randomized to either

Full Text available with Trip Pro

2018 EvidenceUpdates