Latest & greatest articles for elderly

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Top results for elderly

101. Outcome of Elderly Patients with Diffuse Large B-cell Lymphoma Treated with R-CHOP: Results from the UK NCRI R-CHOP14v21 trial with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial.

Outcome of Elderly Patients with Diffuse Large B-cell Lymphoma Treated with R-CHOP: Results from the UK NCRI R-CHOP14v21 trial with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial. 28398499 2017 04 11 2017 04 11 1569-8041 2017 Apr 07 Annals of oncology : official journal of the European Society for Medical Oncology Ann. Oncol. Outcome of Elderly Patients with Diffuse Large B-cell Lymphoma Treated with R-CHOP: Results from the UK NCRI R-CHOP14v21 trial (...) with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial. 10.1093/annonc/mdx128 There is an on-going debate whether 2- or 3-weekly administration of R-CHOP is the preferred first-line treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL). The UK NCRI R-CHOP14v21 randomized phase 3 trial did not demonstrate a difference in outcomes between R-CHOP-14 and R-CHOP-21 in newly diagnosed DLBCL patients aged 19-88 years, but data on elderly patients have not been

Annals of oncology : official journal of the European Society for Medical Oncology2017 Full Text: Link to full Text with Trip Pro

102. Survival outcomes in the very elderly with DLBCL prior to and after the introduction of rituximab: a US population-based study

Survival outcomes in the very elderly with DLBCL prior to and after the introduction of rituximab: a US population-based study 29296703 2018 11 13 2473-9529 1 10 2017 Apr 11 Blood advances Blood Adv Survival outcomes in the very elderly with DLBCL prior to and after the introduction of rituximab: a US population-based study. 615-618 10.1182/bloodadvances.2016002675 Giri Upama U 0000-0002-3676-6193 Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN

Blood advances2017 Full Text: Link to full Text with Trip Pro

103. Silver Diamine Fluoride is More Effective in Arresting and Preventing Root Caries in the Elderly Population than Sodium Fluoride Varnish

Silver Diamine Fluoride is More Effective in Arresting and Preventing Root Caries in the Elderly Population than Sodium Fluoride Varnish UTCAT3173, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Silver Diamine Fluoride is More Effective in Arresting and Preventing Root Caries in the Elderly Population than Sodium Fluoride Varnish Clinical Question Is silver diamine fluoride (SDF) more effective in arresting (...) and preventing root caries in the elderly population than sodium fluoride varnish? Clinical Bottom Line Silver diamine fluoride was shown to provide better prevention of root caries when compared with sodium fluoride varnish. SDF caused greater than 70% reduction in development of root caries as opposed to sodium fluoride varnish with reduction in the range of 40-65%. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence

UTHSCSA Dental School CAT Library2017

104. Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients.

Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients. 28352842 2017 03 29 2017 04 03 11 1 2016 Open medicine (Warsaw, Poland) Open Med (Wars) Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients. 497-508 10.1515/med-2016-0087 Laparoscopic transabdominal preperitoneal inguinal hernia repair

Open medicine (Warsaw, Poland)2017 Full Text: Link to full Text with Trip Pro

105. Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial.

Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. 28344755 2017 03 27 2017 08 16 2008-5842 8 11 2016 Nov Electronic physician Electron Physician Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. 3193-3197 10.19082/3193 Limited evidence supports Nigella sativa's role as an effective complementary (...) and alternative medicine and the anti-inflammatory effects of Nigella sativa on patients with allergic rhinitis. The aim of this study was to investigate the effect of topical application of Nigella sativa oil and oral acetaminophen on pain in the elderly with knee osteoarthritis residing in a parents' home in Sabzevar. This study is done as a crossover clinical trial. After obtaining written consent of elderly patients with osteoarthritis of the knee, they were randomly divided into two groups. In step 1

Electronic physician2017 Full Text: Link to full Text with Trip Pro

106. Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer

Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer 30241182 2018 12 07 2378-9506 4 2018 Sep Journal of global oncology J Glob Oncol Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer. 1-9 10.1200/JGO.2016.007807 Limited data are available about the tolerability and clinical outcomes of elderly patients with metastatic castration-resistant prostate cancer (mCRPC) who are treated (...) cumulative dose of docetaxel (450 mg/m 2 v 382 mg/m 2 v 300 mg/m 2 ; P = .004). The rates of PSA decline of 50% or greater (41% v 47% v 36.4%; P = .51) and the median TTP (5.13 v 5.13 v 4.7 months; P = .15) were comparable among all groups. The median OS was longer in the group of patients younger than age 65 years (19.6 v 12.4 v 12.3 months; P = .012). Rates of any grade 3 or higher adverse event were not different among groups (63.2% v 71.8% v 54.5%; P = .14). Administration of docetaxel in elderly

Journal of global oncology2017 Full Text: Link to full Text with Trip Pro

107. The association between death anxiety with spiritual experiences and life satisfaction in elderly people

The association between death anxiety with spiritual experiences and life satisfaction in elderly people 28461873 2018 11 13 2008-5842 9 3 2017 Mar Electronic physician Electron Physician The association between death anxiety with spiritual experiences and life satisfaction in elderly people. 3980-3985 10.19082/3980 Death anxiety is a concept with greater importance among the elderly as they approach inevitability of death. Identifying the correlates of death anxiety among old people (...) is important in order to reduce the burden of this problem. Therefore, the present study was performed with the aim to examine the association between spiritual experiences and life satisfaction with death anxiety in this stage of life. This cross-sectional study with descriptive-analytical design included 190 elderly people visiting the health and medical centers of Neyshabur city, Iran, during fall and winter, 2016. Participants were asked to complete three questionnaires including a 16-item spiritual

Electronic physician2017 Full Text: Link to full Text with Trip Pro

108. The necessity of colorectal cancer screening for elderly patients

The necessity of colorectal cancer screening for elderly patients 28447054 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol The necessity of colorectal cancer screening for elderly patients. 19 10.21037/tgh.2017.03.03 Kudo Shin-Ei SE Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan. Kudo Toyoki T Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan. eng Editorial Comment

Translational gastroenterology and hepatology2017 Full Text: Link to full Text with Trip Pro

109. Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Case Management for Frail Elderly in the Community Setting: Clinical Effectiveness, Cost (...) -Effectiveness, and Guidelines Published on: March 20, 2017 Project Number: RA0902-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of case management for frail elderly in the community? What is the cost-effectiveness of case management for frail elderly in the community? What are the evidence-based guidelines regarding case management interventions for frail elderly in the community? Key Message One health

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

110. Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma.

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma. Background Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter courses of radiotherapy are commonly used, but the benefit of adding temozolomide to a shorter course of radiotherapy is (...) , 0.53; 95% CI, 0.38 to 0.73; P<0.001). Among 189 patients with unmethylated MGMT status, the median overall survival was 10.0 months with radiotherapy plus temozolomide and 7.9 months with radiotherapy alone (hazard ratio for death, 0.75; 95% CI, 0.56 to 1.01; P=0.055; P=0.08 for interaction). Quality of life was similar in the two trial groups. Conclusions In elderly patients with glioblastoma, the addition of temozolomide to short-course radiotherapy resulted in longer survival than short

NEJM2017

111. A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation

A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation 28845472 2018 11 13 2468-0249 2 4 2017 Jul Kidney international reports Kidney Int Rep A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation. 645-653 10.1016/j.ekir.2017.02.014 Dialysis patients aged ≥70 years derive improved life expectancy through kidney transplantation compared to their waitlisted counterparts, but guidelines (...) are not clear about how to identify appropriate transplantation candidates. We developed a clinical prediction score to identify elderly dialysis patients with expected 5-year survival appropriate for kidney transplantation (>5 years). Incident dialysis patients in 2006-2009 aged ≥70 were identified from the United States Renal Data System database and divided into derivation and validation cohorts. Using the derivation cohort, candidate variables with a significant crude association with 5-year all-cause

Kidney international reports2017 Full Text: Link to full Text with Trip Pro

112. Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients?

Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? 28638694 2018 11 13 2147-9720 4 2 2017 Jun European journal of rheumatology Eur J Rheumatol Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? 157-160 10.5152/eurjrheum.2016.039 To report two patients with giant cell arteritis (GCA) who

European journal of rheumatology2017 Full Text: Link to full Text with Trip Pro

113. Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial

Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial 28848656 2018 11 13 2059-7029 1 6 2016 ESMO open ESMO Open Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial. e000086 10.1136/esmoopen-2016-000086 In the cetuximab after progression in KRAS wild-type colorectal cancer patients (CAPRI) trial patients (...) with metastatic colorectal cancer (mCRC) received 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) and cetuximab in first line followed by 5-Fluorouracil, folinic acid, oxaliplatin (FOLFOX) with or without cetuximab until progression. Limited data are available on the efficacy and safety of anti-epidermal growth factor receptor (anti-EGFR) agents on elderly patients with mCRC. In the current study we evaluated the efficacy and safety of FOLFIRI plus cetuximab in age-defined subgroups. A post-hoc analysis

ESMO open2017 Full Text: Link to full Text with Trip Pro

115. Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program: A Randomized Single Arm Crossover Study.

Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program: A Randomized Single Arm Crossover Study. 28138495 2017 01 31 2017 02 24 2 2016 Jan-Dec Gerontology & geriatric medicine Gerontol Geriatr Med Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program: A Randomized Single Arm Crossover Study. 2333721416644149 10.1177/2333721416644149 (...) Objective: To develop and assess the efficacy of a multimodal balance-enhancing exercise program (BEEP) designed to be regularly self-administered by community-dwelling elderly. The program aims to promote sensory reweighting, facilitate motor control, improve gaze stabilization, and stimulate continuous improvement by being constantly challenging. Method: Forty participants aged 60 to 80 years performed 6 weeks of BEEP training, on average for 16 min four times weekly, in a randomized one-arm crossover

Gerontology & geriatric medicine2017 Full Text: Link to full Text with Trip Pro

116. Lymphadenectomy in elderly/high risk patients: should it be different?

Lymphadenectomy in elderly/high risk patients: should it be different? 28217755 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Lymphadenectomy in elderly/high risk patients: should it be different? 5 10.21037/tgh.2016.12.07 The global aging of population will lead a greater number of elderly patients to undergo surgical procedure in a near future. Concerning gastric cancer, the impact of lymphadenectomy on survival has been demonstrated (...) in RCTs, and extended lymphadenectomy is now considered as gold standard of treatment in non-early tumors. However, the role of age as a prognostic factor and the benefit of extended surgery in elderly/high-risk patients are not clearly defined yet. From our revision of literature, it seems that surgery for gastric cancer may have a further tailorization, considering not only the stage of disease, but also patients' age and comorbidities. Ruspi Laura L Department of General Surgery, University

Translational gastroenterology and hepatology2017 Full Text: Link to full Text with Trip Pro

117. Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women

Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women 29264443 2018 11 13 2472-1972 1 1 2017 Jan 01 Journal of the Endocrine Society J Endocr Soc Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women. 26-38 10.1210/js.2016-1040 There is great interest in the biology of vascular calcification. Wnt/ β -catenin signaling is an important mediator of mineralization and may play a role in vascular (...) calcification. We assessed the association between circulating Wnt antagonists and abdominal aortic calcification (AAC) severity in elderly women. This was a cross-sectional analysis of the Calcium Intake Fracture Outcome Study. The participants were recruited from the community-dwelling elderly population. We examined 768 women aged over 70 years. We collected blood samples, and lateral spine images captured during bone density assessment were used to score AAC with a validated 24-point scale. We tested

Journal of the Endocrine Society2017 Full Text: Link to full Text with Trip Pro

118. Depression in the elderly.

Depression in the elderly. In elderly people, depression mainly affects those with chronic medical illnesses and cognitive impairment, causes suffering, family disruption, and disability, worsens the outcomes of many medical illnesses, and increases mortality. Ageing-related and disease-related processes, including arteriosclerosis and inflammatory, endocrine, and immune changes compromise the integrity of frontostriatal pathways, the amygdala, and the hippocampus, and increase vulnerability (...) to depression. Heredity factors might also play a part. Psychosocial adversity-economic impoverishment, disability, isolation, relocation, caregiving, and bereavement-contributes to physiological changes, further increasing susceptibility to depression or triggering depression in already vulnerable elderly individuals. Treatment with antidepressants is well tolerated by elderly people and is, overall, as effective as in young adults. Evidence-based guidelines for prevention of new episodes of depression

Lancet2017

119. Process of care and outcomes for elderly patients hospitalized with peptic ulcer disease: results from a quality improvement project.

Process of care and outcomes for elderly patients hospitalized with peptic ulcer disease: results from a quality improvement project. CONTEXT: Since publication in 1994 of guidelines for management of peptic ulcer disease (PUD), trends in physician practice and outcomes related to guideline application have not been evaluated. OBJECTIVES: To describe changes in process of care that occurred in a quality improvement program for patients hospitalized with PUD and to evaluate associations between (...) pylori was not associated with a reduction in rehospitalization within 1 year (adjusted odds ratio [OR], 1.24; 95% confidence interval [CI], 0.65-2.36) or with a reduction in mortality (adjusted OR, 1.08; 95% CI, 0.68-1.71). Counseling about NSAID use was associated with a decrease in risk of 1-year rehospitalization for PUD (adjusted OR, 0.47; 95% CI, 0.22-0.99) and risk of all-cause mortality (adjusted OR, 0.44; 95% CI, 0.26-0.75). CONCLUSIONS: This quality improvement program for elderly patients

JAMA2017

120. Long-term persistence in use of statin therapy in elderly patients.

Long-term persistence in use of statin therapy in elderly patients. CONTEXT: Knowledge of long-term persistence with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) therapy is limited because previous studies have observed patients for short periods of time, in closely monitored clinical trials, or in other unrepresentative settings. OBJECTIVE: To describe the patterns and predictors of long-term persistence with statin therapy in an elderly US population. DESIGN, SETTING (...) , AND PATIENTS: Retrospective cohort study including 34 501 enrollees in the New Jersey Medicaid and Pharmaceutical Assistance to the Aged and Disabled programs who were 65 years of age and older, initiated statin treatment between 1990 and 1998, and who were followed up until death, disenrollment, or December 31, 1999. MAIN OUTCOME MEASURES: Proportion of days covered (PDC) by a statin in each quarter during the first year of therapy and every 6 months thereafter; predictors of suboptimal persistence during

JAMA2017