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Latest & greatest articles for elderly
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.
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Evaluation of Renal Function in Alzheimerâ€™s Disease and Geriatric Patients: Results from a Turkish Two-center Study Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric patients with dementia have rarely been reported. In this study, we aimed to disclose the importance of associated renal changes for the pathogenesis of AD.Patients with AD (n=107 (...) were geriatric patients without dementia. When we analyzed comparatively the AD and geriatric dementia patients study arms, a statistically significant difference was observed both in the median age (p<0.001), as well as in the biochemical parameters from Izmir Center: Na (p<0.001), K (p<0.001), Cl (p<0.05), Ca (p<0.001), BUN (p<0.05), creatinine (p<0.001), total protein (p<0.001) and MDRD [eGFR] (p<0.001). However, these were not significantly different between AD and geriatric patients without
to seasonal effects relative to 25(OH)D. Lowest levels of 25(OH)D were detected in peopleaged between 20 and 40 years whereas PTH hormone levels were gradually increasing in response to aging. The significant exponential inverse relationship that was found between PTH and 25(OH)D (PTH=exp(4.12-0.064*sqrt(25(OH)D)) (r=-0.325, R- squared=0.105, p<0.001)) suggested that the cut-off for sufficient 25(OH)D should be 75 nmol/L.Our retrospective study based on large data set supports the suitability (...) Analysis of Changes in Parathyroid Hormone and 25 (OH) Vitamin D Levels with Respect to Age, Gender and Season: A Data Mining Study 25 (OH) vitamin D3 (25(OH)D) and parathyroid hormone (PTH) are important regulators of calcium homeostasis. The aim of this study was to retrospectively determine the cut-off for sufficient 25(OH)D in a four-season region and the influence of age, seasons, and gender on serum 25(OH)D and PTH levels.Laboratory results of 9890 female and 2723 male individuals aged
A phase 2 study incorporating sorafenib into the chemotherapy for older adults with FLT3-mutated acute myeloid leukemia: CALGB 11001 The Cancer and Leukemia Group B (CALGB), now part of the Alliance for Clinical Trials in Oncology, conducted a multicenter, single-arm, phase 2 study in patients ≥60 years with FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML). In this study, sorafenib was added to daunorubicin and cytarabine-based induction and consolidation chemotherapy (...) and was also continued for 12 months of maintenance therapy. The primary end point of the study was overall survival (OS) at 1 year in the FLT3 internal tandem duplication (FLT3-ITD) cohort. Fifty-four patients with a median age of 67 years (range, 60.3-82.7 years) were enrolled; 39 were FLT3-ITD patients (71%) and 15 were FLT3-TKD (29%) patients. The observed 1-year OS (95% confidence interval [CI]) was 62% (45%-78%) for the FLT3-ITD patients (meeting the primary end point 62% vs 30% for a historical
Lymphadenectomy in elderly/high risk patients: should it be different? The global aging of population will lead a greater number of elderly patients to undergo surgical procedure in a near future. Concerning gastric cancer, the impact of lymphadenectomy on survival has been demonstrated in RCTs, and extended lymphadenectomy is now considered as gold standard of treatment in non-early tumors. However, the role of age as a prognostic factor and the benefit of extended surgery in elderly/high-risk (...) patients are not clearly defined yet. From our revision of literature, it seems that surgery for gastric cancer may have a further tailorization, considering not only the stage of disease, but also patients' age and comorbidities.
Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From the American College of Physicians and the American Academy of Family Physicians. The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure (...) and mortality related to stroke, major cardiac events (fatal and nonfatal myocardial infarction and sudden cardiac death), and harms. This guideline grades the evidence and recommendations using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) method.The target audience for this guideline includes all clinicians, and the target patient population includes all adults aged 60 years or older with hypertension.ACP and AAFP recommend that clinicians initiate treatment in adults aged
Septum resection for women of reproductive age with a septate uterus. Women with a septate uterus are at increased risk for subfertility, recurrent miscarriage, and preterm birth. Restoration of the anatomy of the uterus by hysteroscopic septum resection is an established intervention. This treatment has been assessed mainly in retrospective cohort studies, which suggested a positive effect on pregnancy outcomes. The major flaw in these studies is the before/after design, which will always (...) favour the tested intervention.To determine whether hysteroscopic septum resection in women of reproductive age with a septate uterus improves live birth rates and to assess the safety of this procedure.We searched the Cochrane Gynaecology and Fertility Group Specialised Register (inception to May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL CRSO) (inception to May 2016), MEDLINE (1946 to May 2016), Embase (1974 to May 2016), PsycINFO (1806 to May 2016), and CINAHL database
participants were recruited from the community-dwelling elderly population.We examined 768 women aged over 70 years.We collected blood samples, and lateral spine images captured during bone density assessment were used to score AAC with a validated 24-point scale.We tested the hypothesis that low Wnt antagonist levels of Dickkopf-1 (DKK1), secreted frizzled related protein 3 (sFRP3), and Wnt inhibitory factor 1 (WIF1) are associated with severe AAC (AAC24 score > 5).Severe AAC was present in 146 women (19 (...) Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women There is great interest in the biology of vascular calcification. Wnt/β-catenin signaling is an important mediator of mineralization and may play a role in vascular calcification.We assessed the association between circulating Wnt antagonists and abdominal aortic calcification (AAC) severity in elderly women.This was a cross-sectional analysis of the Calcium Intake Fracture Outcome Study.The
Evaluation of an Outpatient Rehabilitative Program to Address Mobility Limitations Among Older Adults Live Long Walk Strong is a clinical demonstration program for community-dwelling older patients. It was designed to be consistent with current fall prevention guidelines and reimbursed under the Medicare model. Patients were screened within primary care and referred to a physiatrist followed by systematic assessment and treatment within an outpatient rehabilitative care setting. The treatment (...) and demonstrates preliminary effectiveness in enhancing mobility among older adults.
Trends in marijuana use among pregnant and non-pregnant reproductive-aged women, 2002â€“2014 27992619 2017 02 09 2018 11 13 1538-3598 317 2 2017 01 10 JAMA JAMA Trends in Marijuana Use Among Pregnant and Nonpregnant Reproductive-Aged Women, 2002-2014. 207-209 10.1001/jama.2016.17383 Brown Qiana L QL Columbia University, New York, New York. Sarvet Aaron L AL Columbia University, New York, New York. Shmulewitz Dvora D Columbia University, New York, New York. Martins Silvia S SS Columbia
Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entrainment of peripheral clocks to external cues. We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland (...) to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring. Despite a decline in locomotor activity, peripheral clocks in aged mice exhibited normal oscillation amplitudes under light-dark, constant darkness, and simulated jet lag conditions, with some abnormal phase alterations. However, age-related impairments were observed in peripheral clock entrainment to stress and exercise stimuli. Conversely, age-related
Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the United States Prior improvements in multiple myeloma (MM) survival were not fully observed in racial and ethnic minorities and older individuals. We hypothesized that improvements in MM management in recent years have reduced these disparities. We used the Surveillance, Epidemiology, and End Results registries to calculate the incidence and relative survival rates (RSRs) of MM in the United States (...) . Ten-year RSRs (1993-1997 vs 2003-2007) improved for patients <65 years of age (19.6%-35%; P < .001), but not for patients ≥75 years of age (7.8%-9.3%; P = .3). Among patients 65 to 74 years of age, 10-year RSRs improved for NHWs (11.3% vs 20.5%; P < .001) and Hispanics (10.6% vs 20.2%; P = .02), but not for NHBs (12.6% vs 19.5%; P = .06.). These findings confirm consistent improvement in survival for MM patients and point to the challenge of further extending these improvements to older
Levels of ll-37 antimicrobial peptide in the gingival crevicular fluid of young and middle-aged subjects with or without gingivitis LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues.Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (...) (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay.No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However
In Patients over the age of 40 with plantarfasciopathy, is wearing a night splint nightly for 3 months effective in reducing pain when compared to exercise therapy? Getting Evidence into Clinical Practice: Musculoskeletal Research Facilitation Group (CAT Group) Date: 02/02/2017 CAT Leads: Date CAT completed: 02/02/2017 Dean Peer, Email: Dean.firstname.lastname@example.org Review date 02/02/02020 Michele Evans Email: Michele.Evans2@nhs.net Specific Question: In Patients over the age of 40 with plantarfasciopathy (...) for a sustained period to reduce pain from the plantarfascia (under surface of the foot). It is uncertain at present whether this provides any benefit in reducing pain when compared to standard stretches and exercises commonly given for this condition. Search timeframe (e.g. 2005-2015) Inclusion Criteria Description Search terms Population and Setting Age < 40 Diagnosis of or Plantar fasciopathy or Plantar fasciitis or Policeman’s heel or Jogger’s heel Intervention or Exposure Wearing of a night splint
Katie.Wills@nhs.net Clinical bottom line The search revealed no evidence to answer this question. Further research is required. Why is this important? Ankle fractures are the fifth most common fracture and have an incidence of 122/100,000 per year. A quarter of ankle fractures occur in patients over 60 years of age. For elderly patients with traumatic ankle fractures, current practice in many orthopaedic wards in the UK is to mobilise non-weight bearing (i.e hopping on the unaffected leg with the use (...) with a number of potential benefits to patients and health care utilisation (Bugler, 2015). Search timeframe 2006-2016 Inclusion Criteria Description Search terms Population and Setting Elderly in-patients (50+) with unilateral ankle fractures +/- Open Reduction Internal Fixation, unable to hop on the unaffected leg. Age >50 Patients with traumatic ankle fractures unable to safely hop on the unaffected leg to independently mobilise. Specific Question: In elderly patients with ankle fractures who are unable
% CI 4.09-5.96 for age >=40 (6) ? Adverse obstetric outcomes/pregnancy complications o From 47,951 singleton births, women aged 30-34 had 27% higher odds of an obstetric event compared to 25-29 year olds, while women aged 40 and older had 61% higher odds (9); this paper also states that “while women of extremely advanced maternal age face the highest risk as individuals, prevention of maternal and neonatal morbidity How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal (...) by socioeconomic status or age of mother? KLS Evidence Briefing November 29 th 2017 Question This briefing summarises the evidence on five risk factors in pregnancy (use of alcohol, smoking, maternal obesity, folic acid supplementation and timing of antenatal care) for women of different ages and socioeconomic status (SES), from Jan 2008 to Nov 2017. Key messages ? advanced maternal age (AMA) of 35yrs or older was often associated with an increased risk of stillbirth, low birthweight, preterm birth, Caesarean
Home-Based and Technology-Centered Childhood Obesity Prevention for Chinese Mothers With Preschool-Aged Children. Nearly a quarter of preschool-aged Chinese American children are overweight or obese. Children of overweight mothers are at higher risk for obesity. Efforts to prevent obesity among low-income minority children with overweight mothers should start in early childhood.This randomized pilot study consisted of 8 weekly sessions, examined feasibility of a tablet computer-based
of safety, efficiency, understanding of care plan and teamwork as well as job satisfaction. Journal of Multidisciplinary Healthcare 2015:8 33–37. Huynh E. et al. Structured interdisciplinary bedside rounds do not reduce length of hospital stay and 28-day re- admission rate among olderpeople hospitalised with acute illness: an Australian study. Australian Health Review 2016 http://dx.doi.org/10.1071/AH1601 Bhamidipati V. et al Structure and Outcomes of Interdisciplinary Rounds in Hospitalized Medicine (...) Structured interdisciplinary bedside rounds (SIBR) in sub-acute geriatric evaluation management and rehabilitation Rapid Review 1 Structured interdisciplinary bedside rounds (SIBR) in sub-acute geriatric evaluation management and rehabilitation Citation Structured interdisciplinary bedside rounds (SIBR) in geriatric evaluation management and rehabilitation: An Evidence Review. Centre for Clinical Effectiveness, Monash Health, Melbourne, Australia. Background The Director of Nursing, Operations
within the scope of the snapshot. Search strategy Table 1. Population Aged or elderly persons (>65 years) Setting Include: International and national residential aged care (RAC) facilities (nursing homes, hostel for aged, residential aged care homes) Exclude: Rural care, community care, home care, primary care (GP) Intervention Include: Models of care, models of service delivery or models of delivery of care Exclude: Interventions, strategies, treatments, programs, methods Outcomes Include: Peer (...) equipment • Positive attitudes from Shahbazim include - feelings of control, empowerment - professional fulfillment - reduced levels of fatigue and stress - mutuality, fellowship, Models of residential aged care services 6 and friendship with co- workers - increased confidence about care-giving abilities - enhanced abilities to cope under duress SilverHope  Principles • Recognising and valuing individuality of elders and staff • Honouring autonomy and choice • Supporting elders’ dignity • Offering
Advanced Reproductive Age and Fertility No. 346-Advanced Reproductive Age and Fertility - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 8, Pages 685–695 No. 346-Advanced Reproductive Age and Fertility x Kimberly E. Liu Correspondence Corresponding author: Dr. Kimberly E. Liu, Mount Sinai Hospital, Toronto, ON. , MD ∗ , x Kimberly E. Liu Correspondence Corresponding author: Dr. Kimberly E. Liu, Mount Sinai (...) Hospital, Toronto, ON. Toronto, ON x Allison Case , MD Saskatoon, SK No. 346, August 2017 (Replaces No. 269, November 2011) DOI: Publication History Published online: May 23, 2017 To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Figures Figure 1 Schematic representation of the number of primordial follicles present in the ovaries and the chromosomal quality of oocytes in relation to female age and corresponding reproductive events. 10–12 Figure