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Latest & greatest articles for elderly
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.
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Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products were dynamically changed and involved in postnatal brain development (...) and aging in tree shrews (Tupaia belangeri chinensis). The levels of 5hmC in multiple anatomic structures showed a gradual increase throughout postnatal development, whereas a significant decrease in 5hmC was found in several brain regions in aged tree shrews, including in the prefrontal cortex and hippocampus, but not the cerebellum. Active changes in Tet mRNA levels indicated that TET2 and TET3 predominantly contributed to the changes in 5hmC levels. Our findings provide new insight into the dynamic
Associations between sarcopenia and degenerative lumbar scoliosis in older women Age-related sarcopenia can cause various forms of physical disabilities. We investigated how sarcopenia affects degenerative lumbar scoliosis (DLS) and lumbar spinal canal stenosis (LSCS).Subjects comprised 40 elderly women (mean age 74 years) with spinal disease whose chief complaints were low back pain and lower limb pain. They included 15 cases of DLS (mean 74.8 years) and 25 cases of LSCS (mean age 72.9 years
Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma. Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter courses of radiotherapy are commonly used, but the benefit of adding temozolomide to a shorter course of radiotherapy is unknown.We (...) conducted a trial involving patients 65 years of age or older with newly diagnosed glioblastoma. Patients were randomly assigned to receive either radiotherapy alone (40 Gy in 15 fractions) or radiotherapy with concomitant and adjuvant temozolomide.A total of 562 patients underwent randomization, 281 to each group. The median age was 73 years (range, 65 to 90). The median overall survival was longer with radiotherapy plus temozolomide than with radiotherapy alone (9.3 months vs. 7.6 months; hazard ratio
Retrospectively self-reported age of childhood abuse onset in a United States nationally representative sample Child abuse is common and several studies have linked it to health outcomes throughout the lifecourse. Recent information about timing of abuse reported retrospectively is underrepresented in the literature, despite its importance to informing target populations for primary prevention of child abuse and studying effects of child abuse. This study uses data from Wave IV (2008-2009 (...) ) of The National Longitudinal Study of Adolescent Health to Adult Health (N = 14,776) to describe distributions of retrospectively self-reported age of onset of childhood emotional, physical, and sexual abuse perpetrated by parents/adult caregivers and sexual abuse perpetrated by other individuals. Information on childhood abuse history was collected when participants were between 24 and 32 years old.Parental/adult caregiver perpetrated abuse frequently started in early childhood, particularly sexual abuse
Femoral attachment of anterior cruciate ligament remnant tissue influences the stability of the anterior cruciate ligament-injured knee in patients over 40 years old 29392113 2018 11 13 2214-6873 9 2017 Jul Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology Asia Pac J Sports Med Arthrosc Rehabil Technol Femoral attachment of anterior cruciate ligament remnant tissue influences the stability of the anterior cruciate ligament-injured knee in patients over 40 years (...) old. 1-5 10.1016/j.asmart.2017.03.001 Takahashi Tsuneari T Gunma Sports Medicine Research Center, Zenshukai Hospital, Maebashi, Japan. Ohsawa Takashi T Department of Orthopedic Surgery, Faculty of Medicine, Gunma University, Maebashi, Japan. Hagiwara Keiichi K Gunma Sports Medicine Research Center, Zenshukai Hospital, Maebashi, Japan. Kimura Masashi M Gunma Sports Medicine Research Center, Zenshukai Hospital, Maebashi, Japan. Takeshita Katsushi K Department of Orthopedic Surgery, Jichi Medical
Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Vitamin A deficiency (VAD) is a major public health problem in low- and middle-income countries, affecting 190 million children under five years of age and leading to many adverse health consequences, including death. Based on prior evidence and a previous version of this review, the World Health Organization has continued to recommend vitamin A supplementation for children aged 6 (...) to 59 months. There are new data available from recently published randomised trials since the previous publication of this review in 2010, and this update incorporates this information and reviews the evidence.To assess the effects of vitamin A supplementation (VAS) for preventing morbidity and mortality in children aged six months to five years.In March 2016 we searched CENTRAL, Ovid MEDLINE, Embase, six other databases, and two trials registers. We also checked reference lists and contacted
Pemetrexed-cisplatin with concurrent thoracic radiation after pemetrexed-cisplatin induction in patients with unresectable locally advanced non-squamous NSCLC: results by age subgroup 28761728 2018 11 13 2059-7029 2 1 2017 ESMO open ESMO Open Pemetrexed-cisplatin with concurrent thoracic radiation after pemetrexed-cisplatin induction in patients with unresectable locally advanced non-squamous NSCLC: results by age subgroup. e000141 10.1136/esmoopen-2016-000141 Garrido Pilar P Medical Oncology (...) Cajal, Madrid, Spain. Visseren-Grul Carla C Medical-Oncology, Eli Lilly and Company, Houten, The Netherlands. Soldatenkova Victoria V Statistics, Oncology, Lilly Deutschland GmbH, Bad Homburg, Germany. Novello Silvia S Thoracic Oncology Unit, Department of Oncology, University of Turin, Turin, Italy. eng Journal Article 2017 03 09 England ESMO Open 101690685 2059-7029 Elderly concurrent radiation induction chemotherapy locally advanced non-squamous NSCLC pemetrexed Competing interests: NC, CVG
Healthy Longevity Study. Three pairs of cohorts aged 80-89 years, 90-99 years, and 100-105 years (in total, 19 528 oldest-old participants) were examined; the two cohorts in each pair were born 10 years apart, with the same age at the time of the assessment in the 1998 and 2008 surveys. Four health outcomes were investigated: annual death rate, Activities of Daily Living (ADL), physical performance in three tests and cognitive function measured by Mini-Mental State Examination (MMSE). We used (...) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. The oldest-old (those aged ≥80 years) are the most rapidly growing age group globally, and are most in need of health care and assistance. We aimed to assess changes in mortality, disability in activities of daily living, and physical and cognitive functioning among oldest-old individuals between 1998 and 2008.We used data from the Chinese Longitudinal
Comparison of outcomes between off-pump versus on-pump coronary artery bypass surgery in elderly patients: a meta-analysis. The aim of this study was to analyze if off-pump coronary artery bypass surgery (CABG) is associated with better treatment outcomes in elderly patients (>70 years of age) than on-pump CABG, using meta-analysis. Medline, PubMed, Cochrane and Google Scholar databases were searched until September 13, 2016. Sensitivity and quality assessment were performed. Twenty-two studies
Redefining universal health coverage in the age of global health security 28589029 2018 11 13 2059-7908 2 2 2017 BMJ global health BMJ Glob Health Redefining universal health coverage in the age of global health security. e000255 10.1136/bmjgh-2016-000255 Jain Vageesh V King's College London, School of Medicine, London, UK. Alam Azeem A King's College London, School of Medicine, London, UK. eng Journal Article 2017 03 07 England BMJ Glob Health 101685275 2059-7908 Health policies and all other
Experiences of family-staff relationships in the care of people with dementia in residential aged care: a qualitative systematic review protocol. The objective of this systematic review is to identify, critically appraise and synthesize the best available literature regarding experiences and perceptions of family-staff relationships in the care of people with dementia living in residential aged care facilities.More specifically, the objectives are to identify family caregiver and healthcare
Perceived barriers and facilitators to implementation of allied health physical activity programs in residential aged care facilities: a systematic review protocol. The review question is: What are the perceived barriers and facilitators to the implementation of allied health physical activity programs in residential aged care facilities?
Effectiveness of falls prevention interventions for older adults newly discharged from hospital: a systematic review protocol. The objective of this review is to synthesize the best available evidence on the effectiveness of falls prevention interventions provided just prior or immediately after discharge from hospital on falls rates and falls injuries among older adults living in the community in the first 6 months after discharge from hospital.
A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation Dialysis patients aged ≥70 years derive improved life expectancy through kidney transplantation compared to their waitlisted counterparts, but guidelines are not clear about how to identify appropriate transplantation candidates. We developed a clinical prediction score to identify elderly dialysis patients with expected 5-year survival appropriate for kidney transplantation (>5 years (...) ).Incident dialysis patients in 2006-2009 aged ≥70 were identified from the United States Renal Data System database and divided into derivation and validation cohorts. Using the derivation cohort, candidate variables with a significant crude association with 5-year all-cause mortality were included in a multivariable logistic regression model to generate a scoring system. The scoring system was tested in the validation cohort and a cohort of elderly transplant recipients.Characteristics most predictive
Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution Bacteria often adhere to surfaces, where they form communities known as biofilms. Recently, it has been shown that biofilm formation initiates with the microscopically heterogeneous deposition of a skeleton of extracellular polymeric substances (EPS) by individual cells crawling on the surface, followed by growth of the biofilm into a surface-covering (...) continuum. Here we report microfluidic experiments with Pseudomonas aeruginosa biofilms showing that their "hidden" heterogeneity can affect the later dynamics of their disruption. Using controlled air bubbles as a model for mechanical insult, we demonstrate that biofilm disruption is strongly dependent on biofilm age, and that disruption to early-stage biofilms can take the shape of a semi-regular pattern of ~15 µm diameter holes from which bacteria have been removed. We explain hole formation in terms
The Experience of Transitional Care for Non-Medically Complex Older Adults and Their Family Caregivers Transitional care research has mainly focused on the experiences of older adults with complex medical conditions. To date, few publications examine the experience of transitional care for non-medically complex older adults. In this article, we draw on and thematically analyze interview and audio-diary data collected at three hospitals in Eastern England, and we explore the experience (...) of transitional care of 18 older adults and family caregivers. Participants reported mixed experiences when describing their care transitions, which indicated variations in care quality. To achieve independence and overcome the difficulties with care transitions, participants used a range of interrogative techniques, such as questioning and information seeking. We contend that the existing transitional care interventions are inappropriate to address the care needs of non-medically complex older adults
An eHealth Intervention to Increase Physical Activity and Healthy Eating in Older Adult Cancer Survivors: Summative Evaluation Results A healthy lifestyle is associated with improved quality of life among cancer survivors, yet adherence to health behavior recommendations is low.This pilot trial developed and tested the feasibility of a tailored eHealth program to increase fruit and vegetable consumption and physical activity among older, long-term cancer survivors.American Cancer Society (ACS
Deflazacort (Emflaza) - To treat patients age 5 years and older with Duchenne muscular dystrophy (DMD) Emflaza (deflazacort) Oral Tablets U.S. Department of Health and Human Services Search FDA Submit search Emflaza (deflazacort) Oral Tablets Emflaza Company: Gilead Sciences, Inc. Application No.: 208684 and 208685 Approval Date: 02/09/2017 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF (...) ) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: March 9, 2017 Vision impaired people having problems accessing certain pages of a PDF file may call (301) 796-3634 for assistance. Note: Documents in PDF format require the . Note: If you need help accessing information in different file formats, see . Language Assistance Available: | | | | | | | | | | | | | | | FDA Popular Content Product Areas
N-acetylcarnosine (NAC) drops for age-related cataract. Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly-trained individuals with expensive operating facilities. Where these are not available, patients go untreated. A form of treatment that did not involve surgery would be a useful alternative for people with symptomatic cataract who are unable or unwilling to undergo surgery. If an eye drop existed that could (...) ) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 28 June 2016. We handsearched the American Society of Cataract and Refractive Surgery (ASCRS) and the European Society of Cataract and Refractive Surgeons (ESCRS) meetings from 2005 until September 2015.We planned to include randomized or quasi-randomised controlled trials where NAC was compared to control in people with age-related cataract.We
Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report Kawasaki disease (KD) is a vasculitis that mostly affects children under 5 years of age. This article presents a 2.5-year-old boy who presented with 6 days of fever, generalized maculopapular rash, bilateral non-exudative conjunctivitis, cracked lips, right cervical lymphadenopathy, erythematous extremities, and perianal desquamation. Laboratory studies showed leukocytosis and sterile pyuria. Because diagnosis