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Latest & greatest articles for elderly
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.
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Effect of Resveratrol on Walking Performance in OlderPeople With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial Research shows that resveratrol, a sirtuin activator in red wine, improves exercise endurance and skeletal-muscle oxidative metabolism in animals and may enhance vascular function in humans. Resveratrol supplement sales exceed $30 million annually in the United States, but few data are available regarding its efficacy in humans.To determine whether resveratrol, 125 (...) mg/d or 500 mg/d, improves the 6-minute walk performance in patients with peripheral artery disease (PAD).This parallel-design, double-blind, randomized clinical trial, called Resveratrol to Improve Outcomes in OlderPeople With PAD (RESTORE), was conducted at Northwestern University. Sixty-six participants 65 years or older with PAD were randomized to receive a daily capsule of resveratrol, 125 mg or 500 mg, or placebo for 6 months. Participants were randomized using a randomly permuted block
Drought and the risk of hospital admissions and mortality in older adults in western USA from 2000 to 2013: a retrospective study Occurrence, severity and geographic extent of droughts are anticipated to increase under climate change, but the health consequences of drought conditions are unknown. We estimate risks of cardiovascular and respiratory-related hospitalization and mortality associated with drought conditions for the western U.S. elderly population.For counties in the western U.S. (N (...) =618) and for the period 2000 to 2013, we use data from the U.S. Drought Monitor to identify: 1) full drought periods; 2) non-drought periods; and 3) worsening drought periods stratified by low- and high-severity. We use Medicare claims to calculate daily rates of cardiovascular admissions, respiratory admissions, and deaths among adults 65 years or older. Using a two-stage hierarchical model, we estimated the percentage change in health risks when comparing drought to non-drought period days
Genetics of Sex Hormone-Binding Globulin and Testosterone Levels in Fertile and Infertile Men of Reproductive Age Testosterone (T) is a central androgenic hormone, and sex hormone-binding globulin (SHBG) is the major determinant of its bioactivity. There are no acknowledged genetic variants with clear-cut clinical implications, modulating T levels in men.To confirm genetic associations of top loci (SHBG, GCKR, SLCO1B1, and JMJD1C) from genome-wide association (GWA) studies for serum SHBG (...) are hypotestosteronemia among aging men and pharmacogenetics of hormone replacement therapy.
Nurses' experiences of medication administration to people with swallowing difficulties in aged care facilities: a systematic review protocol. The objective of this review is to identify the experiences of nurses in administering oral medications to residents of aged care facilities with swallowing difficulties.More specifically, the review question is:What problems do nurses experience when administering oral medicines to people with swallowing difficulties living in aged care facilities?
Effectiveness of non-pharmacological interventions in treating orthostatic hypotension in the elderly and people with a neurological condition: a systematic review protocol. The objectives of the review are to determine:Specifically, the review question is:What is the evidence base for non-pharmacological interventions in treating orthostatic hypotension (OH) in elderlypeople and people with a neurological condition?
-CHOP-14 and R-CHOP-21 in newly diagnosed DLBCL patients aged 19-88 years, but data on elderly patients have not been reported in detail so far. Here, we provide a subgroup analysis of patients ≥60 years treated on the R-CHOP14v21 trial with extended follow-up.Six hundred and four R-CHOP14v21 patients ≥60 years were included in this subgroup analysis, with a median follow-up of 77.7 months. To assess the impact of MYC rearrangements (MYC-R) and double-hit-lymphoma (DHL) on outcome in elderly (...) Outcome of Elderly Patients with Diffuse Large B-cell Lymphoma Treated with R-CHOP: Results from the UK NCRI R-CHOP14v21 trial with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial. There is an on-going debate whether 2- or 3-weekly administration of R-CHOP is the preferred first-line treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL). The UK NCRI R-CHOP14v21 randomized phase 3 trial did not demonstrate a difference in outcomes between R
syndromes were prominently present with higher CCMM counts. Among fee-for-service Medicare beneficiaries aged 50-64 years, 26.7% of the participants presented with ≥10 CCMM, but incurred 48% of the expenditure. In those aged ≥65 years, these percentages were 16.9% and 34.4%, respectively.Functional limitations and geriatric syndromes considerably add to the MM burden in midlife and older adults. This burden is much higher than previously reported. (...) Multimorbidity: constellations of conditions across subgroups of midlife and older individuals, and related Medicare expenditures The Department of Health and Human Services' 2010 Strategic Framework on Multiple Chronic Conditions called for the identification of common constellations of conditions in older adults.To analyze patterns of conditions constituting multimorbidity (CCMM) and expenditures in a US representative sample of midlife and older adults (50-64 and ≥65 years of age
Relationship between skeletal muscle mass and cardiac function during exercise in communityâ€dwelling older adults This study aimed to investigate the relationship between skeletal muscle mass and cardiac functional parameters in older adults during cardiopulmonary exercise testing (CPET).Sixty-three Japanese community-dwelling older adults were enrolled (20 men and 43 women; mean age 80 years, range 65-97 years). Cardiac functional parameters during exercise were assessed using CPET. Skeletal
Survival outcomes in the very elderly with DLBCL prior to and after the introduction of rituximab: a US population-based study 29296703 2018 11 13 2473-9529 1 10 2017 Apr 11 Blood advances Blood Adv Survival outcomes in the very elderly with DLBCL prior to and after the introduction of rituximab: a US population-based study. 615-618 10.1182/bloodadvances.2016002675 Giri Upama U 0000-0002-3676-6193 Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN
Rates of Cortical Atrophy in Adults 80 Years and Older With Superior vs Average Episodic Memory 28384819 2017 06 06 2018 11 13 1538-3598 317 13 2017 04 04 JAMA JAMA Rates of Cortical Atrophy in Adults 80 Years and Older With Superior vs Average Episodic Memory. 1373-1375 10.1001/jama.2017.0627 Cook Amanda H AH Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois. Sridhar Jaiashre J Cognitive Neurology and Alzheimer's Disease Center, Northwestern (...) and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois. eng P30 AG013854 AG NIA NIH HHS United States R01 AG045571 AG NIA NIH HHS United States T32 NS047987 NS NINDS NIH HHS United States Letter Research Support, N.I.H., Extramural United States JAMA 7501160 0098-7484 AIM IM JAMA. 2017 May 9;317(18):1912 28492883 Aged, 80 and over Atrophy Cerebral Cortex pathology Cognition Female Humans Longitudinal Studies Male Memory, Episodic 2017 4 7 6 0 2017 4 7 6 0 2017 6 7 6 0 ppublish 28384819
Methodological issues in measuring subjective well-being and quality-of-life: Applications to assessment of affect in older, chronically and cognitively impaired, ethnically diverse groups using the Feeling Tone Questionnaire Quality of life assessment includes measurement of positive affect. Methods artifacts associated with positively and negatively worded items can manifest as negative items loading on a second factor, despite the conceptual view that the items are measuring one underlying (...) and institutional residents receiving long-term supportive services. The mean age was 82 (s.d.=11.0); 73% were female. Two thirds were cognitively impaired. Methods effects were assessed using confirmatory factor analyses (CFA), and reliability with McDonald's omega and item response theory (IRT) generated estimates. Measurement equivalence was examined using IRT-based Wald tests. Methods effects associated with negatively worded items were observed; these provided little IRT information, and as a composite
Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age. Dexamethasone to prevent bronchopulmonary dysplasia in very preterm neonates was associated with adverse neurodevelopmental events. Early low-dose hydrocortisone treatment has been reported to improve survival without bronchopulmonary dysplasia but its safety with regard to neurodevelopment remains to be assessed.To assess whether early hydrocortisone (...) therapy in extremely preterm infants is associated with neurodevelopmental impairment at 2 years of age.An exploratory secondary analysis of the PREMILOC (Early Low-Dose Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia in Extremely Preterm Infants) randomized clinical trial conducted between 2008 and 2014 in 21 French neonatal intensive care units. Randomization was stratified by gestational age groups. Neurodevelopmental assessments were completed from 2010 to 2016.After birth
: The elderly and “oldest” old population is growing. Because the elderly population are becoming an ever increasing proportion of ER patients we need to be aware of elder abuse and neglect We need to start screening for it more often! One review from 2008 identified 6% of olderpeople living in the community experiencing abuse in the last month! with only 1 of 14 being reported The elderly are a very vulnerable group: Financially Due to cognitive decline Physical deconditioning Isolation Physicians may (...) be the only person an aged individual sees outside their family – so we may the patient’s only chance to get to safety Most perpetrators are family members/caregivers that live with the abused/neglected/taken advantage of 1) List 6 types of elder abuse Six types (one study’s breakdown of each): Physical abuse – 11% Physical / bodily injury Also includes over/under medication**** Restraints Force-feeding Sexual abuse – 1% Any non-consensual (or incapacitated) sexual activity Can include physical/sexual
Evaluation of styloid process morphology and calcification types in both genders with different ages and dental status The purpose of this study was to investigate the morphology and calcification pattern of the styloid process (SP) and to determine their relations with subjects' age, gender, and dental status.910 panoramic radiographs were stratified by age, dental status and gender. The distance between the points where SP leaves the tympanic plate of the temporal bone and the bony tip of SP (...) visible.The right SPs were found to be longer than the left (p<0.05). Types D (right 42.9%, left 42%) and E (right 33.3%, left 30.8%) were the most common morphological calcifications on both sides. No statistical difference was found for bilateral SP length between gender, age, and dental status groups. A significant difference was found only for right SP morphological calcification types as to age groups in both genders (p<0.05). No significant difference was found for SP morphological calcification
The obesity paradox, extreme obesity, and long-term outcomes in older adults with ST-segment elevation myocardial infarction: results from the NCDR To investigate the obesity paradox and association of extreme obesity with long-term outcomes among older ST-segment elevation myocardial infarction (STEMI) patients.Nineteen thousand four hundred and ninety-nine patients ≥65 years with STEMI surviving to hospital discharge in NCDR ACTION Registry-GWTG linked to Centers for Medicare and Medicaid (...) /obese and 3% extremely obese. Normal weight patients were older and more likely to smoke; while extremely obese patients were younger and more likely to be female and black, with lower socioeconomic status and more comorbidity (P ≤ 0.001). A U-shaped association was observed between BMI categories and mortality: patients with class I obesity were at lowest risk, while normal weight [hazard ratio (HR) 1.30, 95% confidence interval (CI) 1.15-1.47] and extremely obese patients (HR 1.33, 95% CI 1.02
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition.We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter (...) questionnaire at 1 year (range of each scale is 0 to 100, with higher scores indicating more symptoms or tiredness, respectively; minimum clinically important difference, 9 points).The mean age of the patients was 74.4 years, and 396 patients (53.7%) were women. The mean (±SD) thyrotropin level was 6.40±2.01 mIU per liter at baseline; at 1 year, this level had decreased to 5.48 mIU per liter in the placebo group, as compared with 3.63 mIU per liter in the levothyroxine group (P<0.001), at a median dose
Home or foster home care versus institutional long-term care for functionally dependent olderpeople. Changing population demographics have led to an increasing number of functionally dependent olderpeople who require care and medical treatment. In many countries, government policy aims to shift resources into the community from institutional care settings with the expectation that this will reduce costs and improve the quality of care compared.To assess the effects of long-term home or foster (...) (95% CI 0.72 to 0.93), showing a slightly reduced risk for the same group. We did not pool data due to the high degree of heterogeneity (I2 = 99%).There are insufficient high-quality published data to support any particular model of care for functionally dependent olderpeople. Community-based care was not consistently beneficial across all the included studies; there were some data suggesting that community-based care may be associated with improved quality of life and physical function compared
studies used multidomain interventions, and potentially none have explored the possibility of cumulative or synergistic effects. Timing and measurement choices affect cognitive decline prevention studies. Researchers can recruit participants at any point along the cognitive continuum. Various proposed strategies target young and middle-aged adults with no evidence of cognitive decline, older adults worried about age-related changes, people with documented MCI, and those with major neurocognitive (...) Studies 13 Data Synthesis 13 Assessing the Strength of Evidence for Major Comparisons and Outcomes 14 Assessing Applicability 15 Peer Review and Public Commentary 15 Chapter 3. Search Results 16 Chapter 4A. Results: Cognitive Training 18 Key Messages 18 Eligible Studies 18 Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) Trial 18 Other Studies 24 Effect of Training on Adults With Normal Cognition 25 Effect of Training on People With Mild Cognitive Impairment 30 Interpreting
and Mortality Canada’s drinking-age laws have a significant effect on youth mortality, the most serious and most costly alcohol-related harm. Callaghan, Sanches, Gatley and Stockwell (2014) examined the causes of death of Canadians ages 16–22 years from 1980 to 2009, and compared the number of deaths among people just older than the legal drinking age to those just younger than the legal drinking age. For males just older than the MLDA there were immediate, sharp and significant increases in mortality (...) The Impact and Effectiveness of Minimum Legal Drinking Age Legislation in Canada www.ccsa.ca • www.cclt.ca Canadian Centre on Substance Abuse • Centre canadien de lutte contre les toxicomanies Page 1 The Impact and Effectiveness of Minimum Legal Drinking Age Legislation in Canada Alcohol is the leading psychoactive substance used by Canadian youth and young adults ages 15–24 years. In 2014, 41.8% of 12–19 year olds reported having consumed alcohol in the past year and 27.8% engaged in heavy