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Dabigatran versus Warfarin for Acute Venous Thromboembolism in Elderly or Impaired Renal Function Patients: Pooled Analysis of RE-COVER and RE-COVER II 29202209 2017 12 20 2567-689X 117 11 2017 11 Thrombosis and haemostasis Thromb. Haemost. Dabigatran versus Warfarin for Acute Venous Thromboembolism in Elderly or Impaired Renal Function Patients: Pooled Analysis of RE-COVER and RE-COVER II. 2045-2052 10.1160/TH17-03-0176 Management of acute venous thromboembolism (VTE) with anticoagulants (...) in elderly patients and those with chronic kidney disease poses special challenges. The RE-COVER and RE-COVER II trials showed that dabigatran 150 mg twice daily was as effective as warfarin over 6 months in preventing recurrent VTE, with a lower bleeding risk. We now assess the effects of old age and renal impairment (RI) on pooled trial outcomes in 5,107 patients: 4,504 aged <75 years and 603 aged ≥75 years. The primary efficacy outcome was symptomatic VTE/VTE-related death. Safety outcomes were
DHA supplementation improves cognitive function via enhancing Abeta-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial 29142143 2017 11 16 1468-330X 2017 Nov 15 Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial. jnnp-2017-316176 (...) 10.1136/jnnp-2017-316176 Higher docosahexaenoic acid (DHA) intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in people with mild cognitive impairment (MCI) have not been fully examined. Our study aimed to assess the effect of a 24-month DHA supplementation on cognitive function and amyloid beta (Aβ)-mediated autophagy in elderly subjects with MCI. This was a randomised, double-blind, placebo-controlled trial in Tianjin, China
Utility of a Precision Medicine Test in Elderly Adults with Symptoms Suggestive of Coronary Artery Disease 29210056 2017 12 06 1532-5415 2017 Dec 06 Journal of the American Geriatrics Society J Am Geriatr Soc Utility of a Precision Medicine Test in Elderly Adults with Symptoms Suggestive of Coronary Artery Disease. 10.1111/jgs.15215 Diagnosing obstructive coronary artery disease (CAD) is challenging in elderly adults, and current diagnostic approaches for CAD expose these individuals to risks (...) from contrast dye and invasive procedures. A Registry to Evaluate Patterns of Care Associated with the Use of Corus CAD in Real World Clinical Care Settings (PRESET; NCT01677156), pragmatic clinical trial. Community, 21 primary care practices. Of 566 stable, nonacute outpatients presenting with symptoms suggestive of obstructive CAD, the 176 who were aged 65 and older (median age 70, 61% female) were the current study participants. Blood-based precision medicine test, incorporating age, sex
How Can You Best Address Polypharmacy in the Elderly? How Can You Best Address Polypharmacy in the Elderly? | Clinical Correlations How Can You Best Address Polypharmacy in the Elderly? December 21, 2017 By Michael Nguyen Peer Reviewed Polypharmacy has been defined as the use of multiple unnecessary medications, the use of more medications than is clinically warranted or indicated, .[1–3] Problematic polypharmacy should be differentiated from appropriate polypharmacy. Consideration of overall (...) appropriateness of therapy is more valuable than simply considering the . Overmedication and failure to perform prudent medication reconciliation is a growing problem in prescribing practice. In individuals over 65 years old, about 50% of the patient population takes over five prescription k.[5,6] The cost burden associated with adverse drug reactions is approximated to be between $37 and $50 billion. Elderly patients are at increased risk of adverse drug reactions, with increased . In the geriatric
Assessment of falls in the elderly Assessment of falls in the elderly - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Assessment of falls in the elderly Last reviewed: August 2018 Last updated: June 2018 Summary Falls are often multifactorial in origin. Deandrea S. Risk factors for falls in community-dwelling older people: a systematic review and meta-analysis. Epidemiology. 2010 Sep;21(5):658-68. http (...) ://www.ncbi.nlm.nih.gov/pubmed/20585256?tool=bestpractice.com The presence of the following factors is associated with greater probability of future falls, Rubenstein LZ, Josephson KR. Falls and their prevention in elderly people: what does the evidence show? Med Clin North Am. 2006 Sep;90(5):807-24. http://www.ncbi.nlm.nih.gov/pubmed/16962843?tool=bestpractice.com McInnes L, Gibbons E, Chandler-Oatts J. Clinical practice guideline for the assessment and prevention of falls in older people. Worldviews Evid Based Nurs
Medical Cannabis Use in the Elderly: Clinical Effectiveness and Guidelines Medical Cannabis Use in the Elderly: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Medical Cannabis Use in the Elderly: Clinical Effectiveness and Guidelines Medical Cannabis Use in the Elderly: Clinical Effectiveness and Guidelines Published on: December 21, 2017 Project Number: RA0944-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What (...) is the clinical effectiveness on the use of medical cannabis in the elderly? What are the evidence-based guidelines on the use of medical cannabis in the elderly? Key Message One systematic review, four randomized controlled trials, and two non-randomized studies were identified regarding the clinical effectiveness on the use of medical cannabis in the elderly. Tags geriatrics, aged, cannabinoids, cannabis, marijuana abuse, older adult, Elderly Files Rapid Response Reference List Published : December 21, 2017
Age Is Just a Number: Combating Muscle Loss in The Elderly Age Is Just a Number: Combating Muscle Loss in The Elderly | Clinical Correlations Age Is Just a Number: Combating Muscle Loss in The Elderly December 14, 2017 By Carl Preiksaitis Peer Reviewed The term “sarcopenia” was introduced in 1989 to characterize the loss of muscle mass that occurs as a consequence of advancing age.1 Use of the term has since grown to . The prevalence of sarcopenia is estimated to be approximately 29 (...) supports the implementation of a high-intensity resistance training program, with sessions 2-3 times a week. A 2009 Cochrane review concluded that progressive resistance training in older adults leads to improvements in gait speed and getting out of a chair.8 Additionally, a significant improvement in muscular strength as well as reduction in osteoarthritis-related pain was observed. An average of five months of resistance training demonstrated a 1.1 kg increase in lean body mass in aging adults
Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study 28383293 2017 11 07 1536-5409 33 12 2017 Dec The Clinical journal of pain Clin J Pain Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study. 1053-1059 10.1097/AJP.0000000000000502 Peripheral nerve block combined with general (...) anesthesia is a preferable anesthesia method for elderly patients receiving hip arthroplasty. The depth of sedation may influence patient recovery. Therefore, we investigated the influence of peripheral nerve blockade and different intraoperative sedation levels on the short-term recovery of elderly patients receiving total hip arthroplasty. Patients aged 65 years and older undergoing total hip arthroplasty were randomized into 3 groups: a general anesthesia without lumbosacral plexus block group, and 2
Blood Transfusion in Elderly Patients with Acute Myocardial Infarction: Data from the RICO Survey 29030059 2017 12 19 1555-7162 2017 Oct 10 The American journal of medicine Am. J. Med. Blood Transfusion in Elderly Patients with Acute Myocardial Infarction: Data from the RICO Survey. S0002-9343(17)31013-6 10.1016/j.amjmed.2017.09.027 Red blood cell transfusion benefit during acute myocardial infarction remains unclear in the elderly. We aimed to assess the transfusion impact on 1-year mortality (...) in acute myocardial infarction patients aged ≥65 years, according to their age and hemoglobin nadir. We included 3316 consecutive patients with acute myocardial infarction aged ≥65 years from the "obseRvatoire des Infarctus de Côte d'Or" (RICO) survey. They were categorized according to their hemoglobin nadir (≤8, >8 to ≤10, and >10 g/dL) and age (<80 or ≥80 years). A total of 1906 patients (57%) were 65-79 years old, and 1410 (43%) were aged ≥80 years, of whom 103 (5%) and 145 (10%) patients received
Interventions to prevent drug related death and harm amongst elderly Interventions to prevent drug related death and harm amongst elderly - NIPH Selected items added to basket Close Vis søkefelt How can we help you today? Search for: Søk Menu • • Interventions to prevent drug related death and harm amongst elderly Søk i Folkehelsa.no Search for: Søk Infectious diseases & Vaccines Close Mental & Physical health Close Environment & Lifestyle Close Health in Norway Close Quality & Knowledge Close (...) Research & Access to data Close Key message Background A national patient safety campaign, planned to start in 2011, is being prepared. To support decisions regarding interventions, we have performed a rapid summary of evidence supporting interventions to prevent drug related death and harm amongst elderly. Pre-stated interventions were medication reconciliation, education, interventions for handling of drugs that pose special risks, electronic ordination and control systems for transfer and discharge
Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial. BACKGROUND: Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration of DAPT in such patients. METHODS: In this randomised single-blind trial, we recruited patients from 44 centres (...) in nine countries. Patients were eligible if they were aged 75 years or older; had stable angina, silent ischaemia, or an acute coronary syndrome; and had at least one coronary artery with a stenosis of at least 70% (≥50% for the left main stem) deemed eligible for percutaneous coronary intervention (PCI). Exclusion criteria were indication for myocardial revascularisation by coronary artery bypass grafting; inability to tolerate, obtain, or comply with DAPT; requirement for additional surgery; non
Two cases of spontaneous cervical epidural hematoma without back or neck pain in elderly Japanese men 29657732 2018 11 14 2052-8817 5 2 2018 04 Acute medicine & surgery Acute Med Surg Two cases of spontaneous cervical epidural hematoma without back or neck pain in elderly Japanese men. 181-184 10.1002/ams2.317 Spontaneous spinal epidural hematoma (SSEH) is an uncommon disease. Most SSEH cases involve back and/or neck pain. We report the cases of two men who experienced SSEH with dysstasia (...) but without back or neck pain. This study presents two cases involving elderly Japanese men who visited an emergency department because of sudden dysstasia without back or neck pain. The results of the neurological examinations revealed ataxic gait. Cervical spinal epidural hematomas were observed by computed tomography and magnetic resonance imaging. One patient underwent hematoma removal and decompression by corpectomy, whereas the other patient received conservative treatment and observation
Ibrutinib in combination with obinutuzumab for the treatment of chronic lymphocytic leukaemia/small lymphocytic lymphoma in elderly – first line Ibrutinib in combination with obinutuzumab for the treatment of chronic lymphocytic leukaemia/small lymphocytic lymphoma in elderly – first line ‐ NIHR Innovation Observatory ☰ Menu Search Filter by Specialty Filter by Year Ibrutinib in combination with obinutuzumab for the treatment of chronic lymphocytic leukaemia/small lymphocytic lymphoma in (...) elderly – first line October 2017 Technology Description: The combination of ibrutinib (oral capsules) and obinutuzumab (intravenous injection) is being developed as a new treatment option for CLL/SLL in elderly patients. Both drugs act in different unique ways to improve the body’s natural defence to fight the cancer cells and their combined effect may significantly reduce symptoms of the disease and increase survival. Specialty You may also be interested in: Apr 2015 Specialty: Apr 2015 Specialty