Latest & greatest articles for elderly

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on elderly and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for elderly

1. Effect of Physical Disability on Mortality in Elderly Patients of >/=80 Years of Age Undergoing Percutaneous Coronary Intervention

Effect of Physical Disability on Mortality in Elderly Patients of >/=80 Years of Age Undergoing Percutaneous Coronary Intervention 30205884 2018 09 12 1879-1913 122 4 2018 Aug 15 The American journal of cardiology Am. J. Cardiol. Effect of Physical Disability on Mortality in Elderly Patients of ≥80 Years of Age Undergoing Percutaneous Coronary Intervention. 537-541 S0002-9149(18)31056-7 10.1016/j.amjcard.2018.04.055 Functional decrease has been linked with adverse events in different clinical (...) contexts. The predictive role of activity of daily living status as assessed by the Barthel index (BI) in elderly patients who underwent percutaneous coronary intervention (PCI) has not been investigated, yet. In this study, a total of 616 patients (≥80 years) who underwent PCI between January 2009 and December 2014 and with available activity of daily living data on admission were stratified according to BI (low BI <85, intermediate BI 85 to 95, high BI 100). The primary end point was all-cause

EvidenceUpdates2018

2. Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial

Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial 30260758 2018 09 27 1527-7755 2018 Sep 27 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial (...) . JCO2018787366 10.1200/JCO.2018.78.7366 Acute myeloid leukemia (AML) in elderly patients has a poor prognosis. In an attempt to improve outcome for these patients, the prospective open-label phase III LAM-SA 2007 (Adding Lomustine to Chemotherapy in Older Patients With Acute Myelogenous Leukemia (AML), and Allogeneic Transplantation for Patients From 60 to 65 Years Old) trial randomly assigned patients to a standard induction regimen with lomustine added or to a consolidation regimen with cytarabine

EvidenceUpdates2018

3. Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial

Cost-effectiveness of the HiBalance training program for elderly with Parkinson`s disease: analysis of data from a randomized controlled trial 30246557 2018 09 24 1477-0873 2018 Sep 24 Clinical rehabilitation Clin Rehabil Cost-effectiveness of the HiBalance training program for elderly with Parkinson's disease: analysis of data from a randomized controlled trial. 269215518800832 10.1177/0269215518800832 To determine the cost-effectiveness of the HiBalance training program for managing

EvidenceUpdates2018

4. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. Background In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo. Methods From 2010 through 2014 (...) and was attributed primarily to cancer-related death. In the context of previous studies, this result was unexpected and should be interpreted with caution. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).

NEJM2018

5. Effect of Aspirin on Disability-free Survival in the Healthy Elderly.

Effect of Aspirin on Disability-free Survival in the Healthy Elderly. Background Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear. Methods From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics (...) and 11.1 events per 1000 person-years in the placebo group), dementia, or persistent physical disability. The rate of major hemorrhage was higher in the aspirin group than in the placebo group (3.8% vs. 2.8%; hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001). Conclusions Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo. (Funded by the National Institute on Aging and others; ASPREE

NEJM2018

6. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. Background Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk. Methods From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among (...) events per 1000 person-years and 6.2 events per 1000 person-years, respectively (hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001). Conclusions The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).

NEJM2018

7. Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study

Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study 29528863 2018 08 01 1536-5409 34 9 2018 Sep The Clinical journal of pain Clin J Pain Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study. 811-817 10.1097/AJP.0000000000000605 Peripheral nerve block is a preferable method (...) for elderly patients receiving hip arthroplasty. Sedation with dexmedetomidine may reduce postoperative delirium (POD). The aim of this study was to investigate whether intraoperative sedation with dexmedetomidine, as a supplementary to peripheral nerve block for elderly patients receiving total hip arthroplasty, can decrease the prevalence of POD. A prospective, randomized controlled study was conducted with patients 65 years of age or older who underwent total hip arthroplasty between June 2016 and June

EvidenceUpdates2018

8. Caregiver-Based Interventions to Optimize Medication Safety in Vulnerable Elderly Adults: A Systematic Evidence-Based Review

Caregiver-Based Interventions to Optimize Medication Safety in Vulnerable Elderly Adults: A Systematic Evidence-Based Review 30136714 2018 08 30 1532-5415 2018 Aug 23 Journal of the American Geriatrics Society J Am Geriatr Soc Caregiver-Based Interventions to Optimize Medication Safety in Vulnerable Elderly Adults: A Systematic Evidence-Based Review. 10.1111/jgs.15556 To study the effect of caregiver-focused interventions to support medication safety in older adults with chronic disease (...) and reductions in healthcare visits and warrant further study with respect to medication safety. © 2018, Copyright the Author Journal compilation © 2018, The American Geriatrics Society. Wagle Kamal C KC Division of General Internal Medicine and Geriatrics, School of Medicine, Indiana University, Indianapolis, Indiana. Skopelja Elaine N EN Ruth Lilly Medical Library, School of Medicine, Indiana University, Indianapolis, Indiana. Campbell Noll L NL College of Pharmacy, Purdue University, Lafayette, Indiana

EvidenceUpdates2018

9. Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials

Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials 30028656 2018 08 29 1527-7755 36 25 2018 Sep 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials. 2585-2592 10.1200/JCO (...) .2017.76.8390 Purpose To test the efficacy of adding cisplatin to first-line treatment for elderly patients with advanced non-small-cell lung cancer (NSCLC) within a combined analysis of two parallel phase III trials, MILES-3 and MILES-4. Patients and Methods Patients with advanced NSCLC who were older than age 70 years with Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned to gemcitabine or pemetrexed, without or with cisplatin. In each trial, 382 events were required

EvidenceUpdates2018

10. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.

Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients (...) . Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA

Cochrane2018

11. Derivation and Validation of a Prediction Model for Risk Stratification of Post-Thrombotic Syndrome in Elderly Patients with a First Deep Vein Thrombosis

Derivation and Validation of a Prediction Model for Risk Stratification of Post-Thrombotic Syndrome in Elderly Patients with a First Deep Vein Thrombosis 29960276 2018 07 30 2567-689X 118 8 2018 Aug Thrombosis and haemostasis Thromb. Haemost. Derivation and Validation of a Prediction Model for Risk Stratification of Post-Thrombotic Syndrome in Elderly Patients with a First Deep Vein Thrombosis. 1419-1427 10.1055/s-0038-1661392 Not all patients carry the same risk of developing a post-thrombotic

EvidenceUpdates2018

12. Prediction of short-term prognosis in elderly patients with acute pulmonary embolism: validation of the RIETE score

Prediction of short-term prognosis in elderly patients with acute pulmonary embolism: validation of the RIETE score 29733493 2018 07 04 1538-7836 16 7 2018 Jul Journal of thrombosis and haemostasis : JTH J. Thromb. Haemost. Prediction of short-term prognosis in elderly patients with acute pulmonary embolism: validation of the RIETE score. 1313-1320 10.1111/jth.14137 Essentials The RIETE score was derived to predict 10-day adverse outcomes in acute pulmonary embolism (PE). We externally (...) prognostic performance with the Pulmonary Embolism Severity Index (PESI), its simplified version (sPESI) and the Geneva Prognostic Score (GPS). Methods In a prospective multicenter cohort, we studied 687 elderly patients with acute PE. The primary outcome was 10-day overall complications (death, recurrent PE or major bleeding); the secondary outcome was 30-day overall mortality. We compared complications and mortality in low-risk vs. higher-risk patients and the area under

EvidenceUpdates2018

13. Discharge planning conference prior to discharge of the elderly

Discharge planning conference prior to discharge of the elderly Discharge planning conference prior to discharge of the elderly We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Discharge planning conference prior to discharge of the elderly Share: Reading time approx. 1 minute Many patients who are admitted to hospital still require care after

Swedish Council on Technology Assessement2018

14. Elderly

Elderly Top results for elderly - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search (...) button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for elderly The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory

Trip Latest and Greatest2018

16. Low-dose computed tomography for the diagnosis of pneumonia in elderly patients: a prospective, interventional cohort study

Low-dose computed tomography for the diagnosis of pneumonia in elderly patients: a prospective, interventional cohort study 29650558 2018 06 07 1399-3003 51 5 2018 May The European respiratory journal Eur. Respir. J. Low-dose computed tomography for the diagnosis of pneumonia in elderly patients: a prospective, interventional cohort study. 1702375 10.1183/13993003.02375-2017 The diagnosis of pneumonia is challenging. Our objective was to assess whether low-dose computed tomography (LDCT (...) ) modified the probability of diagnosing pneumonia in elderly patients.We prospectively included patients aged over 65 years with a suspicion of pneumonia treated with antimicrobial therapy (AT). All patients had a chest radiograph and LDCT within 72 h of inclusion. The treating clinician assessed the probability of pneumonia before and after the LDCT scan using a Likert scale. An adjudication committee retrospectively rated the probability of pneumonia and was considered as the reference for diagnosis

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

17. Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization

Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization 29459361 2018 06 05 1524-4539 137 23 2018 Jun 05 Circulation Circulation Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization. 2435-2445 10.1161/CIRCULATIONAHA.117.032180 Elderly patients are at elevated risk of both (...) ischemic and bleeding complications after an acute coronary syndrome and display higher on-clopidogrel platelet reactivity compared with younger patients. Prasugrel 5 mg provides more predictable platelet inhibition compared with clopidogrel in the elderly, suggesting the possibility of reducing ischemic events without increasing bleeding. In a multicenter, randomized, open-label, blinded end point trial, we compared a once-daily maintenance dose of prasugrel 5 mg with the standard clopidogrel 75 mg

EvidenceUpdates2018

18. Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial

Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial 29742525 2018 05 09 1528-1140 2018 May 08 Annals of surgery Ann. Surg. Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. 10.1097/SLA.0000000000002801 The aim was to compare the long-term outcomes of low-dose dexmedetomidine versus placebo in a randomized controlled trial (...) (ChiCTR-TRC-10000802). Low-dose dexmedetomidine infusion decreased delirium occurrence within 1 week after surgery in elderly admitted to the intensive care unit (ICU) after noncardiac surgery, but the long-term outcome of this intervention is unknown. Patients or their family members were telephone-interviewed for a 3-year follow-up data collection of survival, cognitive function assessed with the modified Telephone Interview for Cognitive Status, and quality of life evaluated with the World Health

EvidenceUpdates2018

19. A High-yield Fall Risk and Adverse Events Screening Questions From the Stopping Elderly Accidents, Death, and Injuries (STEADI) Guideline for Older Emergency Department Fall Patients

A High-yield Fall Risk and Adverse Events Screening Questions From the Stopping Elderly Accidents, Death, and Injuries (STEADI) Guideline for Older Emergency Department Fall Patients 29575248 2018 05 30 1553-2712 2018 Mar 25 Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Acad Emerg Med A High-yield Fall Risk and Adverse Events Screening Questions From the Stopping Elderly Accidents, Death, and Injuries (STEADI) Guideline for Older Emergency (...) Department Fall Patients. 10.1111/acem.13413 The objectives were to examine whether responses to the Stopping Elderly Accidents, Death, and Injuries (STEADI) questions responses predicted adverse events after an older adult emergency department (ED) fall visits and to identify factors associated with such recurrent fall. We conducted a prospective study at two urban, teaching hospitals. We included patients aged ≥ 65 years who presented to the ED for an accidental fall. Data were gathered for fall

EvidenceUpdates2018

20. Is Frailty a Predictor of Outcomes in Elderly Inpatients with Acute Kidney Injury?

Is Frailty a Predictor of Outcomes in Elderly Inpatients with Acute Kidney Injury? 29626429 2018 05 25 1555-7162 2018 Apr 04 The American journal of medicine Am. J. Med. Is Frailty a Predictor of Outcomes in Elderly Inpatients with Acute Kidney Injury? A Prospective Cohort Study. S0002-9343(18)30293-6 10.1016/j.amjmed.2018.03.012 Frailty and acute kidney injury are independently associated with an increased risk of morbidity and mortality. The degree of frailty can be assessed by the Clinical (...) Frailty Score (CFS). This study assessed whether an individual's CFS was associated with acute kidney injury in acute elderly medical admissions and recorded the short-term outcomes. This was a single-center prospective observational cohort study. All patients aged ≥65 years admitted under an acute medical take over 12 nonconsecutive days were included. Patient demographics, comorbidities, baseline CFS, and renal status on admission were recorded. Outcomes of death, length of stay, and hospital re

EvidenceUpdates2018