Latest & greatest articles for duloxetine

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Top results for duloxetine

21. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. Full Text available with Trip Pro

Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. There are no known effective treatments for painful chemotherapy-induced peripheral neuropathy.To determine the effect of duloxetine, 60 mg daily, on average pain severity.Randomized, double-blind, placebo-controlled crossover trial at 8 National Cancer Institute (NCI)-funded cooperative research networks that enrolled 231 patients who (...) were 25 years or older being treated at community and academic settings between April 2008 and March 2011. Study follow-up was completed July 2012. Stratified by chemotherapeutic drug and comorbid pain risk, patients were randomized to receive either duloxetine followed by placebo or placebo followed by duloxetine. Eligibility required that patients have grade 1 or higher sensory neuropathy according to the NCI Common Terminology Criteria for Adverse Events and at least 4 on a scale of 0 to 10

2013 JAMA Controlled trial quality: predicted high

22. Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments

Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments Executive Summary 1 Translation of the executive summary of the final report “Kosten-Nutzen-Bewertung von Venlafaxin, Duloxetin, Bupropion und Mirtazapin im Vergleich zu weiteren verordnungsfähigen medikamentösen Behandlungen” (Version 1.0; Status: 3 September 2013). Please note: This translation is provided as a service by IQWiG to English-language (...) readers. However, solely the German original text is absolutely authoritative and legally binding. IQWiG Reports – Commission No. G09-01 Health economic evaluation of venlafaxine, duloxetine, bupropion, and mirtazapine compared to further prescribable pharmaceutical treatments 1 Executive summary of final report G09-01 Version 1.0 Health economic evaluation of venlafaxine, duloxetine, bupropion, mirtazapine 3 Sep 2013 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details

2013 Institute for Quality and Efficiency in Healthcare (IQWiG)

23. Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial Full Text available with Trip Pro

Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect.the aim of the present study was to investigate the efficacy of duloxetine in reducing pain in older (...) adults with knee OA.totally, 288 patients aged 65 years and above with primary knee OA were enrolled in this study. Patients were randomised 1:1. Totally, 144 received 60 mg/day of duloxetine HCL and 144 received placebo for 16 weeks. Outcome measures included pain reduction and improvement in physical functioning scores. Pain was assessed using the visual analogue pain scale (VAS; 0-100 mm). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used to assess

2012 EvidenceUpdates Controlled trial quality: predicted high

24. Cost effectiveness of duloxetine in the treatment of fibromyalgia in the United States

Cost effectiveness of duloxetine in the treatment of fibromyalgia in the United States Cost effectiveness of duloxetine in the treatment of fibromyalgia in the United States Cost effectiveness of duloxetine in the treatment of fibromyalgia in the United States Beard SM, Roskell N, Le TK, Zhao Y, Coleman A, Ang D, Lawson K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of duloxetine for the treatment of moderate-to-severe pain from fibromyalgia. It focused on the best position for duloxetine in the treatment sequence. The authors concluded that adding duloxetine to the treatment sequence for fibromyalgia was cost-effective, particularly when it was the second-line treatment after

2012 NHS Economic Evaluation Database.

25. A systematic review of duloxetine and venlafaxine in major depression, including unpublished data

A systematic review of duloxetine and venlafaxine in major depression, including unpublished data Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

26. Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico

Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico Carlos F, Ramirez-Gamez J, Duenas H, Galindo-Suarez RM, Ramos E Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to evaluate the cost-effectiveness of duloxetine as a first treatment for adults with diabetic peripheral neuropathy and moderate-to-severe pain. The authors concluded that duloxetine was a cost-effective intervention, in Mexico. Overall, the study was adequate

2012 NHS Economic Evaluation Database.

27. A Comparative Evaluation of Amitriptyline and Duloxetine in Painful Diabetic Neuropathy: A randomized, double-blind, cross-over clinical trial Full Text available with Trip Pro

A Comparative Evaluation of Amitriptyline and Duloxetine in Painful Diabetic Neuropathy: A randomized, double-blind, cross-over clinical trial To compare the efficacy and safety of duloxetine and amitriptyline in painful diabetic neuropathy (PDN).In this randomized, double-blind, cross-over, active-control trial, 58 patients received amitriptyline and duloxetine orally once daily at bedtime, each for 6 weeks with optional dose uptitration fortnightly. Single-blinded placebo washout was given (...) improvement in pain with both treatments compared with their baseline values (P < 0.001 for both). Good, moderate, and mild pain relief was achieved in 55, 24, and 15% of patients, respectively, on amitriptyline and 59, 21, and 9% of patients, respectively, on duloxetine. There were no significant differences in various other outcome measures between the groups. Of the reported adverse events, dry mouth was significantly more common with amitriptyline than duloxetine (55 vs. 24%; P < 0.01). Although

2011 EvidenceUpdates Controlled trial quality: predicted high

28. Pain response profile of patients with fibromyalgia treated with duloxetine (Abstract)

Pain response profile of patients with fibromyalgia treated with duloxetine This study examined the time course for minimal clinically significant improvement in pain severity during the initial 12 weeks of treatment in patients with fibromyalgia taking duloxetine.Four double-blind, placebo-controlled trials of duloxetine were pooled. Patients received duloxetine 60 mg/d, 120 mg/d, or placebo. Clinically significant treatment response (>or=30% reduction in pain severity on the 24-hour average (...) pain severity of the Brief Pain Inventory scale) was assessed over 12 weeks.At endpoint, 46.9% of duloxetine 60-mg-, 48.6% of duloxetine 120-mg-, and 32.1% of placebo-treated patients (P<0.001 for both doses) had >or=30% improvement on average pain from baseline. The probabilities of achieving >or=30% response at Weeks 1, 2, 4, 8, and 12 among duloxetine 60-mg-treated patients were 27%, 44%, 45%, 47%, and 49%, respectively, and among duloxetine 120-mg-treated patients were 35%, 43%, 53%, 53

2010 EvidenceUpdates Controlled trial quality: uncertain

29. Cymbalta (duloxetine hydrochloride)

Cymbalta (duloxetine hydrochloride) Drug Approval Package: Cymbalta (duloxetine hydrochloride) NDA #022516 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Cymbalta (duloxetine hydrochloride), 20, 30, and 60 mg Capsules Company: Eli Lilly and Company Application No.: 022516 Approval Date: 11/04/2010 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2010 FDA - Drug Approval Package

30. Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland

Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland Economic evaluation of duloxetine versus serotonin selective reuptake inhibitors and venlafaxine XR in treating major depressive disorder in Scotland Benedict A, Arellano J, De Cock E, Baird J Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-utility of duloxetine, compared with selective serotonin re-uptake inhibitors (SSRIs), venlafaxine extended release, and mirtazapine, for the treatment of major

2010 NHS Economic Evaluation Database.

31. Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review

Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

32. Cost-effectiveness of duloxetine: the Stress Urinary Incontinence Treatment (SUIT) study Full Text available with Trip Pro

Cost-effectiveness of duloxetine: the Stress Urinary Incontinence Treatment (SUIT) study Cost-effectiveness of duloxetine: the Stress Urinary Incontinence Treatment (SUIT) study Cost-effectiveness of duloxetine: the Stress Urinary Incontinence Treatment (SUIT) study Mihaylova B, Pitman R, Tincello D, van der Vaart H, Tunn R, Timlin L, Quail D, Johns A, Sculpher M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to assess the cost-effectiveness of duloxetine compared with conservative therapy for women with stress urinary incontinence. The authors concluded that, although there were limitations due to the use of observational data, duloxetine therapy seemed to be cost-effective. The methods were good

2010 NHS Economic Evaluation Database.

33. Analytic model comparing the cost utility of TVT versus duloxetine in women with urinary stress incontinence

Analytic model comparing the cost utility of TVT versus duloxetine in women with urinary stress incontinence Analytic model comparing the cost utility of TVT versus duloxetine in women with urinary stress incontinence Analytic model comparing the cost utility of TVT versus duloxetine in women with urinary stress incontinence Jacklin P, Duckett J, Renganathan A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of duloxetine versus tension-free vaginal tape as the second-line treatment for urinary stress incontinence, using new data on drug discontinuation rates. The authors concluded that tension-free vaginal tape was more cost-effective than duloxetine and was below the recommended

2010 NHS Economic Evaluation Database.

34. Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain

Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

35. Duloxetine in acute major depression: review of comparisons to placebo and standard antidepressants using dissimilar methods

Duloxetine in acute major depression: review of comparisons to placebo and standard antidepressants using dissimilar methods Duloxetine in acute major depression: review of comparisons to placebo and standard antidepressants using dissimilar methods Duloxetine in acute major depression: review of comparisons to placebo and standard antidepressants using dissimilar methods Girardi P, Pompili M, Innamorati M, Mancini M, Serafini G, Mazzarini L, Del Casale A, Tatarelli R, Baldessarini RJ CRD (...) summary The review found that duloxetine appeared more effective than placebo for acute major depression in adults, and was comparable to selective serotonin-reuptake inhibitors, but that more research is needed. In view of poor reporting of review methods and adverse event outcomes, and lack of statistical evidence that the trials were suitable for pooling, the authors’ conclusions may not be reliable. Authors' objectives To evaluate the efficacy and tolerability of duloxetine for acute major

2009 DARE.

36. Duloxetine hydrochloride - Neuropathic pain, Diabetic

Duloxetine hydrochloride - Neuropathic pain, Diabetic Common Drug Review CEDAC Meeting – July 16, 2008 Page 1 of 3 Notice of CEDAC Final Recommendation – August 14, 2008 © 2008 CADTH CEDAC FINAL RECOMMENDATION and REASONS for RECOMMENDATION DULOXETINE (Cymbalta ™ – Eli Lilly Canada Inc.) Description: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) approved for the management of diabetic peripheral neuropathic pain. Duloxetine is also approved for the symptomatic relief (...) of major depressive disorder. This submission to the Common Drug Review relates solely to its use in diabetic peripheral neuropathic pain. Dosage Forms: 30 mg and 60 mg delayed-release capsules. The recommended dose is 60 mg daily. Recommendation: The Canadian Expert Drug Advisory Committee (CEDAC) recommends that duloxetine be listed for the treatment of neuropathic pain in diabetic patients who are unresponsive to two adequate courses of less costly alternative agents such as a tricyclic

2008 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

37. Duloxetine hydrochloride - Major Depressive Disorder (MDD)

Duloxetine hydrochloride - Major Depressive Disorder (MDD) Common Drug Review CEDAC Meeting – July 16, 2008 Page 1 of 2 Notice of CEDAC Final Recommendation – August 14, 2008 © 2008 CADTH CEDAC FINAL RECOMMENDATION and REASONS for RECOMMENDATION DULOXETINE (Cymbalta ™ – Eli Lilly Canada Inc.) Description: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) approved for the symptomatic relief of major depressive disorder in adults. Duloxetine is also approved (...) for the management of neuropathic pain associated with diabetic peripheral neuropathy. This submission to the Common Drug Review (CDR) deals only with its use in major depressive disorder. Dosage Forms: 30 mg and 60 mg delayed-release capsules. The recommended dose for depression is 60 mg daily. Recommendation: The Canadian Expert Drug Advisory Committee (CEDAC) recommends that duloxetine not be listed for the treatment of major depressive disorder. Reasons for the Recommendation: 1. There is insufficient

2008 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

38. Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial (Abstract)

Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial The primary objectives of this study were to assess the efficacy and safety of duloxetine for reducing pain severity in fibromyalgia patients with or without current major depressive disorder. This was a 6-month, multicenter, randomized, double-blind, placebo-controlled study. In total, 520 (...) patients meeting American College of Rheumatology criteria for fibromyalgia were randomly assigned to duloxetine (20 mg/day, 60 mg/day, or 120 mg/day) or placebo, administered once daily, for 6 months (after 3 months, the duloxetine 20-mg/day group titrated to 60 mg/day). The co-primary outcome measures were the Brief Pain Inventory (BPI) average pain severity score and Patient Global Impressions of Improvement (PGI-I) score. Safety was assessed via treatment-emergent adverse events, and changes

2008 EvidenceUpdates Controlled trial quality: predicted high

39. Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials

Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

40. Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK Full Text available with Trip Pro

Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK Beard S M, McCrink L, Le T K, Garcia-Cebrian A, Monz B, Malik R A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study investigated the six-month costs and health benefits of using duloxetine as an additional treatment to the recommended current practice, in the UK, in diabetic patients experiencing peripheral neuropathic pain. The authors concluded that second-line duloxetine created potential cost-savings to the health system

2008 NHS Economic Evaluation Database.