Latest & greatest articles for doxycycline

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Top results for doxycycline

21. Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever.

Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. 16837678 2006 07 13 2006 07 18 2016 06 21 1533-4406 355 2 2006 Jul 13 The New England journal of medicine N. Engl. J. Med. Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. 148-55 Tick-borne relapsing fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks. We examined the safety (...) and efficacy of postexposure treatment to prevent TBRF. In a double-blind, placebo-controlled trial, 93 healthy subjects with suspected tick exposure (52 with signs of tick bites and 41 close contacts--those without signs but with a similar risk of contact with ticks) were randomly assigned to receive either doxycycline (Dexxon, in a dose of 200 mg the first day and then 100 mg per day for four days) or placebo after presumed exposure to TBRF. Cases of TBRF were defined by fever and a positive blood smear

NEJM2006

22. Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial.

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. 15964448 2005 06 20 2005 09 06 2015 06 16 1474-547X 365 9477 2005 Jun 18-24 Lancet (London, England) Lancet Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. 2116-21 Wolbachia endosymbionts of filarial nematodes are vital for larval development and adult-worm fertility and viability (...) . This essential dependency on the bacterium for survival of the parasites has provided a new approach to treat filariasis with antibiotics. We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti. We undertook a double-blind, randomised, placebo-controlled field trial of doxycycline (200 mg per day) for 8 weeks in 72 individuals infected with W bancrofti from Kimang'a village, Pangani, Tanzania. Participants were randomly

Lancet2005

23. Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials

Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials Lau C Y, Qureshi A K Authors' objectives To evaluate the efficacy and tolerance of azithromycin versus doxycycline for genital chlamydial infection. Searching (...) Studies published in English were retrieved from the following databases: MEDLINE and Pre-MEDLINE (from 1975 to August 2001), HealthSTAR (from 1975 to August 2001), EBM Reviews: Best Evidence (from September 1991 to January/February 2001), EBM Reviews: Cochrane Database of Systematic Reviews (second quarter of 2001), and EBM Reviews: DARE (second quarter of 2001). The medical subject headings 'CT' and 'doxycycline' or 'CT' and 'azithromycin' were used as search terms. Bibliographies of computer

DARE.2002

24. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.

Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. 11450675 2001 06 28 2001 07 19 2013 11 21 0028-4793 345 2 2001 Jul 12 The New England journal of medicine N. Engl. J. Med. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. 79-84 It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease. In an area of New York where (...) Lyme disease is hyperendemic we conducted a randomized, double-blind, placebo-controlled trial of treatment with a single 200-mg dose of doxycycline in 482 subjects who had removed attached I. scapularis ticks from their bodies within the previous 72 hours. At base line, three weeks, and six weeks, subjects were interviewed and examined, and serum antibody tests were performed, along with blood cultures for Borrelia burgdorferi. Entomologists confirmed the species of the ticks and classified them

NEJM2001

25. Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial.

Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial. 11009140 2000 09 28 2000 10 27 2015 06 16 0140-6736 356 9235 2000 Sep 23 Lancet (London, England) Lancet Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial. 1057-61 Some strains of scrub typhus in northern Thailand are poorly responsive to standard antirickettsial drugs. We therefore did a masked, randomised trial to compare rifampicin (...) with standard doxycycline therapy for patients with scrub typhus. Adult patients with strictly defined, mild scrub typhus were initially randomly assigned 1 week of daily oral treatment with 200 mg doxycycline (n=40), 600 mg rifampicin (n=38), or doxycycline with rifampicin (n=11). During the first year of treatment, the combined regimen was withdrawn because of lack of efficacy and the regimen was replaced with 900 mg rifampicin (n=37). Treatment outcome was assessed by fever clearance time (the time

Lancet2000

26. Doxycycline is a cost-effective therapy for hospitalized patients with community-acquired pneumonia

Doxycycline is a cost-effective therapy for hospitalized patients with community-acquired pneumonia Doxycycline is a cost-effective therapy for hospitalized patients with community-acquired pneumonia Doxycycline is a cost-effective therapy for hospitalized patients with community-acquired pneumonia Ailani R K, Agastya G, Ailani R K, Mukunda B N, Shekar R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Doxycycline for hospitalised patients with community-acquired pneumonia. The dosage was 100mg given intravenously every 12 hours. This was switched to 100mg orally every 12 hours for patients in the intervention group who improved. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study

NHS Economic Evaluation Database.1999

27. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease.

Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. 9233865 1997 07 31 1997 07 31 2013 11 21 0028-4793 337 5 1997 Jul 31 The New England journal of medicine N. Engl. J. Med. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. 289-94 Localized Lyme disease, manifested by erythema migrans, is usually treated with oral doxycycline or amoxicillin. Whether acute disseminated Borrelia burgdorferi infection should (...) be treated differently from localized infection is unknown. We conducted a prospective, open-label, randomized, multicenter study comparing parenteral ceftriaxone (2 g once daily for 14 days) with oral doxycycline (100 mg twice daily for 21 days) in patients with acute disseminated B. burgdorferi infection but without meningitis. The erythema migrans skin lesion was required for study entry, and disseminated disease had to be indicated by either multiple erythema migrans lesions or objective evidence

NEJM1997

28. Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis

Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis Magid D, Douglas J, Schwartz S Record Status (...) . Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis infections: an incremental cost-effectiveness analysis. Annals of Internal Medicine 1996; 124(4): 389-399 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Analysis of Variance; Azithromycin /administration & Chlamydia Infections /drug therapy /economics; Chlamydia trachomatis; Cost-Benefit Analysis; Decision Trees; Doxycycline /administration & Drug Administration Schedule; Female; Genital Diseases

NHS Economic Evaluation Database.1996

29. Randomised controlled comparison of single-dose ciprofloxacin and doxycycline for cholera caused by Vibrio cholerae 01 or 0139.

Randomised controlled comparison of single-dose ciprofloxacin and doxycycline for cholera caused by Vibrio cholerae 01 or 0139. 8709688 1996 09 06 1996 09 06 2015 06 16 0140-6736 348 9023 1996 Aug 03 Lancet (London, England) Lancet Randomised controlled comparison of single-dose ciprofloxacin and doxycycline for cholera caused by Vibrio cholerae 01 or 0139. 296-300 Effective antimicrobial therapy can reduce the duration and volume of cholera diarrhoea by half. However, such treatment (...) is currently limited by Vibrio cholerae resistance to the drugs commonly prescribed for cholera, and by the difficulties involved in the administration of multi-drug doses under field conditions. Because of its favourable pharmacokinetics we thought it likely that single-dose ciprofloxacin would be effective in the treatment of cholera. In this double-blind study treatment was either a single 1 g oral dose of ciprofloxacin plus doxycycline placebo, or a single 300 mg oral dose of doxycycline plus

Lancet1996

30. Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers.

Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers. Failure of doxycycline as a causa... preview & related info | Mendeley E-mail address Password ( ) Remember me …or sign in with Search Main Navigation › Short URL Annals of Internal Medicine ( 1994 ) Volume: 120 , Issue: 4 , Pages: 294-299 PubMed: Available from or Find this paper at: Abstract OBJECTIVE: To determine whether doxycycline, 100 mg administered as a single (...) daily oral dose, is effective as a causal prophylactic agent, an agent active against the pre-erythrocytic liver stage of Plasmodium falciparum malaria parasites, in healthy nonimmune persons. If effective, the recommendation by the Centers for Disease Control and Prevention (CDC) that doxycycline be continued for 4 weeks after returning from malaria-endemic areas could be shortened to 1 week. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Medical ward at the U.S. Army Research

Annals of Internal Medicine1994

31. Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis.

Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis. 1978873 1991 01 10 1991 01 10 2015 06 16 0140-6736 336 8728 1990 Dec 08 Lancet (London, England) Lancet Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis. 1404-6 72 adults with erythema migrans (early Lyme borreliosis) were enrolled in a randomised prospective trial comparing amoxycillin 500 mg plus probenecid 500 mg three times a day with doxycycline 100 mg (...) twice a day for 21 days. These antibiotic regimens were chosen because of the known in-vitro sensitivity of Borrelia burgdorferi, the antibiotic tissue penetration, the pharmacokinetics of the drugs, and because the organism can disseminate early in the course of infection. 72 patients were evaluable (35 in the doxycycline group and 37 in the amoxycillin/probenecid group). The two regimens were equally effective for treatment of erythema migrans. Mild fatigue or arthralgia were the only post

Lancet1990

32. Randomised double blind trial of single dose doxycycline for treating cholera in adults.

Randomised double blind trial of single dose doxycycline for treating cholera in adults. 2196962 1990 08 24 1990 08 24 2013 11 21 0959-8138 300 6740 1990 Jun 23 BMJ (Clinical research ed.) BMJ Randomised double blind trial of single dose doxycycline for treating cholera in adults. 1619-21 To compare the efficacy of a single dose of doxycycline (200 or 300 mg) with the standard multiple doses of tetracycline in patients with cholera. Randomised double blind controlled trial. Patients were given (...) a single 200 mg dose of doxycycline, a single 300 mg dose of doxycycline, or multiple doses of tetracycline (500 mg, six hourly intervals). Hospital in Bangladesh treating diarrhoea. 261 Patients aged over 15 admitted to the hospital with severe dehydration due to acute watery diarrhoea associated with Vibrio cholerae. All vibrios isolated from the stools and rectal swabs of patients, including those patients with prolonged excretion of vibrios, were sensitive to tetracycline. The stools of all

BMJ1990 Full Text: Link to full Text with Trip Pro

33. Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection.

Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection. 2391738 1990 10 04 1990 10 04 2016 10 17 0098-7484 264 11 1990 Sep 19 JAMA JAMA Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection. 1418-21 We compared 7-day regimens of ciprofloxacin in dosages of 750 and 1000 mg twice daily with doxycycline 100 mg twice daily (...) for the treatment of nongonococcal urethritis in 178 men enrolled in a prospective, randomized, double-blind trial. The overall clinical response was comparable in the three treatment groups at both 2 and 4 weeks after therapy. However, among patients who initially had cultures positive for chlamydia, Chlamydia trachomatis was reisolated within 4 weeks after treatment in none of 10 doxycycline-treated patients, in 11 (52%) of 21 patients treated with 750 mg of ciprofloxacin twice daily, and in six (38%) of 16

JAMA1990

34. Doxycycline prophylaxis for falciparum malaria.

Doxycycline prophylaxis for falciparum malaria. 2883488 1987 06 24 1987 06 24 2015 06 16 0140-6736 1 8543 1987 May 23 Lancet (London, England) Lancet Doxycycline prophylaxis for falciparum malaria. 1161-4 188 schoolchildren aged 10-15 living in a malaria endemic area along the Thai-Burmese border were matched for age, splenomegaly, and weight and were then randomly assigned to receive either doxycycline (adult equivalent of 100 mg daily) or chloroquine (adult equivalent of 300 mg base weekly (...) ). All drugs were administered by the investigators and blood smears were done weekly. In 95 subjects taking doxycycline for 597 man-weeks there were 5 cases of falciparum malaria and in the 93 controls taking chloroquine for 488 man-weeks there were 31. Doxycycline was more effective than chloroquine in the prevention of falciparum malaria infections (p less than 0.0001). The doxycycline group did not have significantly more side-effects than the chloroquine group. Pang L W LW Limsomwong N N

Lancet1987

35. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis.

An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. 6363930 1984 03 06 1984 03 06 2013 11 21 0028-4793 310 8 1984 Feb 23 The New England journal of medicine N. Engl. J. Med. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. 497-500 Because leptospirosis has been an important cause of morbidity in U.S. soldiers training in the Republic of Panama, we conducted a randomized, double-blind, placebo-controlled field trial during the fall of 1982 (...) to determine whether doxycycline was an effective chemoprophylactic agent against this infection. Doxycycline (200 mg) or placebo was administered orally on a weekly basis and at the completion of training to 940 volunteers from two U.S. Army units deployed in Panama for approximately three weeks of jungle training. Twenty cases of leptospirosis occurred in the placebo group (an attack rate of 4.2 per cent), as compared with only one case in the doxycycline group (attack rate, 0.2 per cent, P less than

NEJM1984

36. Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya.

Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya. 342962 1978 04 26 1978 04 26 2013 11 21 0028-4793 298 14 1978 Apr 06 The New England journal of medicine N. Engl. J. Med. Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya. 758-63 We performed a randomized double-blind study to determine the efficacy of doxycycline (100 mg daily (...) ) in preventing travelers' diarrhea among 39 Peace Corps volunteers during their first five weeks in Kenya. The volunteers took either doxycycline or placebo for three weeks and were observed for an additional two weeks. Nine of 21 taking placebo and one of 18 taking doxycycline had travelers' diarrhea during the treatment period (P = 0.012). The protection seemed to persist for at least one week after the drug was stopped. Enterotoxigenic Escherichia coli was the only pathogen isolated from the placebo group

NEJM1978

37. Doxycycline treatment and human infertility.

Doxycycline treatment and human infertility. 47949 1975 07 14 1975 07 14 2015 06 16 0140-6736 1 7907 1975 Mar 15 Lancet (London, England) Lancet Doxycycline treatment and human infertility. 605-7 The role of mycoplasmas in infertility was studied in 120 couples. During the twelve months of the study 27 couples (22-5%) conceived. T mycoplasmas were isolated from 63% of these couples, and Mycoplasma hominis from 18%, compared with 56% and 13%, respectively, in those who did not conceive. 88 (...) , with primary infertility of unascertained cause, took part in a controlled trial with doxycycline. The couples in the trial were allocated randomly to three groups: 30 received doxycycline, 28 received a placebo, and 30 couples were untreated. Although a twenty-eight-day course of doxycycline eradicated M. hominis and T-strain mycoplasmas from 27 (96%) of the 28 couples harbouring them, the rate of conception was no higher in those treated with the drug than in control groups. It is concluded

Lancet1975