Latest & greatest articles for diphenhydramine

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Top results for diphenhydramine

1. Diphenhydramine

Diphenhydramine Top results for diphenhydramine - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diphenhydramine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

2. Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used.To evaluate the effect of doxepin mouthwash or diphenhydramine (...) -lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain.A phase 3 randomized trial was conducted from November 1, 2014, to May 16, 2016, at 30 US institutions and included 275 patients who underwent definitive head and neck radiotherapy, had an oral mucositis pain score of 4 points or greater (scale, 0-10), and were followed up for a maximum of 28 days.Ninety-two patients were randomized to doxepin mouthwash (25 mg/5 mL water); 91 patients to diphenhydramine-lidocaine-antacid

2019 JAMA Controlled trial quality: predicted high

3. Diphenhydramine

Diphenhydramine Diphenhydramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diphenhydramine Diphenhydramine Aka: Diphenhydramine (...) , Benadryl From Related Chapters II. Indications See for Allergy III. Dosing: Standard Adult: 25-50 mg PO/IV/IM q6h Child: 5 mg/kg/day divided qid (12.5 mg/5 ml) IV. Preparation: Diphenhydramine 1% (for Local Anesthesia) Dilute Diphenhydramine 5% in (1:4) Longer delay to onset of action than Shorter duration of action than Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Diphenhydramine." Click on the image (or right click) to open

2015 FP Notebook

4. Diphenhydramine

Diphenhydramine Diphenhydramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diphenhydramine Diphenhydramine Aka: Diphenhydramine (...) , Benadryl From Related Chapters II. Indications See for Allergy III. Dosing: Standard Adult: 25-50 mg PO/IV/IM q6h Child: 5 mg/kg/day divided qid (12.5 mg/5 ml) IV. Preparation: Diphenhydramine 1% (for Local Anesthesia) Dilute Diphenhydramine 5% in (1:4) Longer delay to onset of action than Shorter duration of action than Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Diphenhydramine." Click on the image (or right click) to open

2018 FP Notebook

5. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. Full Text available with Trip Pro

A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. Coughing is a prevalent symptom of upper respiratory infections (URIs) that cause disturbance in the sleep of children and their parents. There is as yet no reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world. The aim of this study is to compare

2010 Journal of Alternative and Complementary Medicine Controlled trial quality: uncertain

6. Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents. Full Text available with Trip Pro

Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents. Coughing in a child induced by upper respiratory tract infections (URTIs) can be a problem, both for the child and its parents. Current studies show a lack of proven efficacy for over-the counter (OTC) medications, but promising data support the use of honey for children. The aim of this study was to compare the effects of two kinds (...) of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents. This was a clinical trial (registered in IRCT; No.: 28.20.7932, 15 October 2013). The study consisted of 87 patients. All the parents completed a standard previously validated questionnaire. The children were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3

2017 PloS one Controlled trial quality: uncertain

7. Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine

Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02389829 Recruitment Status : Completed First Posted : March 17, 2015 Results First Posted : June 5, 2018 Last Update Posted : August 31, 2018 Sponsor: Montefiore Medical Center

2015 Clinical Trials

8. Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine Full Text available with Trip Pro

Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine To determine outcomes among patients with migraine in the emergency department (ED) who receive IV hydromorphone vs IV prochlorperazine + diphenhydramine.This study was conducted in 2 EDs in New York City. Patients who met international criteria for migraine were eligible for participation if they had not used an opioid within the previous month. Clinicians, participants, investigators, and research (...) personnel were blinded to treatment. Patients were randomized in blocks of 4. Participants received hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg. Diphenhydramine was administered to prevent akathisia, a common side effect of IV prochlorperazine. The primary outcome was sustained headache relief, defined as achieving a headache level of mild or none within 2 hours of medication administration and maintaining that level for 48 hours without the requirement of rescue medication

2017 EvidenceUpdates

9. Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. Full Text available with Trip Pro

Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. 21945608 2011 12 12 2018 11 13 1097-6825 128 5 2011 Nov The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Comparison of cetirizine and diphenhydramine in the treatment of acute food-induced allergic reactions. 1127-8 10.1016/j.jaci.2011.08.026 Park Joon H JH Godbold James H JH Chung Danna D Sampson Hugh A HA Wang Julie J eng RR026134 RR NCRR NIH HHS United States (...) Allergy Clin Immunol 1275002 0091-6749 0 Anti-Allergic Agents 0 Hypnotics and Sedatives 8GTS82S83M Diphenhydramine YO7261ME24 Cetirizine AIM IM Acute Disease Adolescent Anti-Allergic Agents therapeutic use Cetirizine therapeutic use Child Child, Preschool Diphenhydramine therapeutic use Food Hypersensitivity drug therapy Humans Hypnotics and Sedatives Young Adult 2011 03 30 2011 08 19 2011 08 31 2011 9 28 6 0 2011 9 29 6 0 2011 12 14 6 0 ppublish 21945608 S0091-6749(11)01392-3 10.1016/j.jaci

2011 The Journal of allergy and clinical immunology Controlled trial quality: uncertain

10. Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02062710 Recruitment Status : Completed First

2014 Clinical Trials

11. Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis

Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Bender B G, Berning S, Dudden R, Milgrom H, Tran Z V CRD summary This poorly reported review compared the sedating and performance-impairing effects of diphenhydramine (...) versus placebo and second-generation antihistamines. The authors' concluded that no clear and consistent differences existed between diphenhydramine and second-generation antihistamines. Although the review has a number of methodological limitations, the authors' are right to call for further research to clarify the mixed results of the included studies. Authors' objectives To compare the effect of diphenhydramine with placebo and second-generation antihistamines on sedation and performance

2003 DARE.

12. A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. (Abstract)

A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. Antihistamines are often used for treating allergic rhinitis. However, many older antihistamines cause sedative side effects. The sedative effects of antihistamines on car-driving have been investigated. This has not been investigated for levocetirizine, a new-generation antihistamine, in Asian populations, and so we evaluated its sedative (...) effects in healthy Japanese subjects.In this double-blind, placebo-controlled, four-way crossover study, healthy volunteers received single doses of levocetirizine 5 mg, fexofenadine 60 mg, diphenhydramine 50 mg, and placebo at intervals of at least 6 days. Simple brake reaction time and choice brake reaction time task (CBRT), a lateral tracking (LT) task, and a multiple task, a mixture of CBRT and LT task, were used to compare driving performance between the four drugs. Subjective sedation was also

2016 Human psychopharmacology Controlled trial quality: uncertain

13. Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. Full Text available with Trip Pro

Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. More than 1 million patients present to US emergency departments (EDs) annually seeking care for acute migraine. Parenteral antihistamines have long been used in combination with antidopaminergics such as metoclopramide to treat acute migraine in the ED. High-quality data supporting this practice do not exist. We determine whether administration of diphenhydramine 50 mg (...) for futility. Baseline characteristics were comparable between the groups. Fourteen percent (29/208) of the sample reported allergic symptoms. Of patients randomized to diphenhydramine, 40% (40/100) reported sustained relief at 48 hours, as did 37% (38/103) of patients randomized to placebo (95% confidence interval [CI] for difference of 3%: -10% to 16%). One hour after medication administration, patients randomized to diphenhydramine improved by a mean of 5.1 on the 0 to 10 scale versus 4.8 for those

2015 Annals of Emergency Medicine Controlled trial quality: predicted high

14. Cardiac arrest caused by diphenhydramine overdose Full Text available with Trip Pro

Cardiac arrest caused by diphenhydramine overdose A 45-year-old man presented to our emergency department with disturbance of consciousness; he had mentioned to his family earlier about a drug overdose. When first responders arrived, he suffered cardiac arrest. Cardiac arrest due to drug overdose was diagnosed.The patient was supported with venoarterial extracorporeal membrane oxygenation. Arterial blood gas showed mixed acidosis, and electrocardiogram showed junctional rhythm and complete (...) right bundle branch block.The patient's blood pressure gradually decreased, and he died on the third day of hospitalization. After death, his serum diphenhydramine concentration at the time of arrival was found to be 18.7 μg/mL.Although diphenhydramine is regarded as a safe medication, it shows dose-dependent toxicity. High intake is associated with death; therefore, caution should be exercised in cases of drug overdose. Developing a procedure for rapid measurement in the emergency department should

2018 Acute medicine & surgery

15. Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration. Full Text available with Trip Pro

Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration. Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history. Several case reports implicate propofol as the likely causative agent producing these symptoms, which include ballismus, dystonia, choreoathetosis, and opisthotonus. Currently, there is no clear consensus on first-line treatment (...) of these symptoms. In each of the published cases, anticholinergic medications and benzodiazepines were central to initial management, although the speed and extent of symptom resolution were variable. Here we present a case of a 17-year-old boy with ulcerative colitis who presented with ballismus, torticollis, tongue thrusting, and oculogyric movements after colonoscopy under general anesthesia with propofol. The patient responded promptly to treatment with diphenhydramine. This is the first reported case

2017 Pediatrics

16. Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. (Abstract)

Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without drug respectively placebo administration were

2013 European journal of radiology Controlled trial quality: uncertain

17. Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection Full Text available with Trip Pro

Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection Currently available over-the-counter cough remedies historically have been criticized for lack of scientific evidence supporting their efficacy. Although the first-generation antihistamine diphenhydramine is classified as an antitussive by the United States Food and Drug Administration, to the authors' knowledge it has never been shown to inhibit cough reflex sensitivity in subjects (...) with pathological cough.To evaluate the effect of diphenhydramine on cough reflex sensitivity.Montefiore Medical Center, an academic medical center in New York City.Twenty two subjects with acute viral upper respiratory tract infection (common cold) underwent cough reflex sensitivity measurement employing capsaicin challenge on 3 separate days, 2 h after ingesting single doses of study drug (to coincide with peak blood concentrations), administered in randomized, double-blind manner: a multicomponent syrup

2015 International journal of clinical pharmacy Controlled trial quality: uncertain

18. Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial (Abstract)

Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial A randomized, controlled, crossover clinical study compared 14-night treatment with 15 mg temazepam, 50 mg diphenhydramine, and placebo in elderly individuals with insomnia (mean age, 73.9 years; range, 70-89 years). Primary outcome measures were subjective assessments of sleep recorded on sleep diaries. Secondary measures were the morning-after psychomotor impairment (...) were seen with diphenhydramine treatment compared with placebo on the number of awakenings only (mean, 1.7 +/- 1.1 vs 2.0 +/- 1.2; P < 0.05). Numbers of adverse events reported were similar after all treatments, although there was 1 fall during temazepam treatment. Findings indicate that temazepam is more effective than diphenhydramine when compared with placebo at the doses tested, although this advantage is mitigated by the risk of falls associated with temazepam use. The choice of agent to use

2008 EvidenceUpdates Controlled trial quality: predicted high

19. Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. (Abstract)

Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. Diphenhydramine (DPH) is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. However, many hospice patients are unable to take oral medications and/or do not have IV access. Moreover, topical administration has a relatively slow rate of absorption. For this reason (...) , in the hospice setting it is not uncommon for diphenhydramine to be administered via the subcutaneous (SC) route secondary to its ease of access, low infection rates and its low levels of discomfort. In contrast, outside the hospice setting, subcutaneous DPH has not been widely used, primarily because of a handful of case reports published in the 1990's that report skin necrosis following subcutaneous administration of DPH for local anesthesia. Since these early case reports, however, there has been very

2016 American Journal of Hospice and Palliative Medicine

20. Acute Diphenhydramine Hydrochloride Poisoning Full Text available with Trip Pro

Acute Diphenhydramine Hydrochloride Poisoning 13051559 2003 05 01 2018 12 01 0007-1447 2 4826 1953 Jul 04 British medical journal Br Med J A case of acute diphenhydramine hydrochloride poisoning. 24 AARON F E FE eng Journal Article England Br Med J 0372673 0007-1447 0 Salts 8GTS82S83M Diphenhydramine OM Diphenhydramine poisoning Drug-Related Side Effects and Adverse Reactions Humans Salts 5324:22096:195 DIPHENHYDRAMINE/poisoning 1953 7 4 1953 7 4 0 1 1953 7 4 0 0 ppublish 13051559 PMC2028543 Br

1953 British medical journal