Latest & greatest articles for diphenhydramine

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Top results for diphenhydramine

1. Diphenhydramine

Diphenhydramine Diphenhydramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diphenhydramine Diphenhydramine Aka: Diphenhydramine (...) , Benadryl From Related Chapters II. Indications See for Allergy III. Dosing: Standard Adult: 25-50 mg PO/IV/IM q6h Child: 5 mg/kg/day divided qid (12.5 mg/5 ml) IV. Preparation: Diphenhydramine 1% (for Local Anesthesia) Dilute Diphenhydramine 5% in (1:4) Longer delay to onset of action than Shorter duration of action than Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Diphenhydramine." Click on the image (or right click) to open

2015 FP Notebook

2. Diphenhydramine

Diphenhydramine Diphenhydramine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diphenhydramine Diphenhydramine Aka: Diphenhydramine (...) , Benadryl From Related Chapters II. Indications See for Allergy III. Dosing: Standard Adult: 25-50 mg PO/IV/IM q6h Child: 5 mg/kg/day divided qid (12.5 mg/5 ml) IV. Preparation: Diphenhydramine 1% (for Local Anesthesia) Dilute Diphenhydramine 5% in (1:4) Longer delay to onset of action than Shorter duration of action than Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Diphenhydramine." Click on the image (or right click) to open

2018 FP Notebook

3. Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection (PubMed)

Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection Currently available over-the-counter cough remedies historically have been criticized for lack of scientific evidence supporting their efficacy. Although the first-generation antihistamine diphenhydramine is classified as an antitussive by the United States Food and Drug Administration, to the authors' knowledge it has never been shown to inhibit cough reflex sensitivity in subjects (...) with pathological cough.To evaluate the effect of diphenhydramine on cough reflex sensitivity.Montefiore Medical Center, an academic medical center in New York City.Twenty two subjects with acute viral upper respiratory tract infection (common cold) underwent cough reflex sensitivity measurement employing capsaicin challenge on 3 separate days, 2 h after ingesting single doses of study drug (to coincide with peak blood concentrations), administered in randomized, double-blind manner: a multicomponent syrup

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2015 International journal of clinical pharmacy

4. Diphenhydramine

Diphenhydramine Top results for diphenhydramine - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diphenhydramine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

5. Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children. (PubMed)

Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children. To evaluate the safety and efficacy of Linkus, Aminophylline with Diphenhydramine group and Acefyllin Piperazine with Diphenhydramine cough syrup on children having cough and sleep difficulty associated with cough. To determine the effects of Linkus polyherbal syrup (group A) and compared with other parallel allopathic groups (Group B and C) for cough on children (...) and associated sleep quality and improvement. 360 children having cough inducted in 3 different groups randomly selected. Three parallel groups were the part of the study. The first study group was the herbal syrup Linkus, second group of children were taking a syrup of multinational pharmaceutical industry having Aminophylline plus Diphenhydramine however the third group received another famous brand having Acefyllin Piperazine with Diphenhydramine. Informed assent and informed consent have taken from

2016 Pakistan journal of pharmaceutical sciences

6. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. (PubMed)

A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. Coughing is a prevalent symptom of upper respiratory infections (URIs) that cause disturbance in the sleep of children and their parents. There is as yet no reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world. The aim of this study is to compare

2010 Journal of Alternative and Complementary Medicine

7. Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial

Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2014 Clinical Trials

8. Motion sickness: comparison of metoclopramide and diphenhydramine to placebo. (PubMed)

Motion sickness: comparison of metoclopramide and diphenhydramine to placebo. This is an evaluation of the efficacy of metoclopramide (MTCP) or diphenhydramine (DPH) to relieve symptoms of motion sickness in patients being transported via ambulance in a mountainous setting.This is a prospective, randomized, double-blinded, placebo-controlled study of patients transported by ambulance in the Sierra Nevada mountains of Fresno County. Consenting patients who met the inclusion criteria were asked (...) groups.During ambulance transport in a mountainous setting, the administration of MTCP is superior to both DPH and placebo in the treatment of motion sickness. Diphenhydramine is not superior to placebo.

2011 Prehospital and disaster medicine

9. Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis

Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis Bender B G, Berning S, Dudden R, Milgrom H, Tran Z V CRD summary This poorly reported review compared the sedating and performance-impairing effects of diphenhydramine (...) versus placebo and second-generation antihistamines. The authors' concluded that no clear and consistent differences existed between diphenhydramine and second-generation antihistamines. Although the review has a number of methodological limitations, the authors' are right to call for further research to clarify the mixed results of the included studies. Authors' objectives To compare the effect of diphenhydramine with placebo and second-generation antihistamines on sedation and performance

2003 DARE.

10. Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02062710 Recruitment Status : Completed First

2014 Clinical Trials

11. Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia. (PubMed)

Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia. The aim of this study was to evaluate the efficacy and tolerability of novel combination naproxen sodium (NS) and diphenhydramine (DPH) in subjects with postoperative dental pain along with transient insomnia induced by 5 h sleep phase advance. The present studies aimed to demonstrate the added

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2015 International journal of clinical practice

12. Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration. (PubMed)

Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration. Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history. Several case reports implicate propofol as the likely causative agent producing these symptoms, which include ballismus, dystonia, choreoathetosis, and opisthotonus. Currently, there is no clear consensus on first-line treatment (...) of these symptoms. In each of the published cases, anticholinergic medications and benzodiazepines were central to initial management, although the speed and extent of symptom resolution were variable. Here we present a case of a 17-year-old boy with ulcerative colitis who presented with ballismus, torticollis, tongue thrusting, and oculogyric movements after colonoscopy under general anesthesia with propofol. The patient responded promptly to treatment with diphenhydramine. This is the first reported case

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2017 Pediatrics

13. Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine

Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine To determine outcomes among patients with migraine in the emergency department (ED) who receive IV hydromorphone vs IV prochlorperazine + diphenhydramine.This study was conducted in 2 EDs in New York City. Patients who met international criteria for migraine were eligible for participation if they had not used an opioid within the previous month. Clinicians, participants, investigators, and research (...) personnel were blinded to treatment. Patients were randomized in blocks of 4. Participants received hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg. Diphenhydramine was administered to prevent akathisia, a common side effect of IV prochlorperazine. The primary outcome was sustained headache relief, defined as achieving a headache level of mild or none within 2 hours of medication administration and maintaining that level for 48 hours without the requirement of rescue medication

2017 EvidenceUpdates

14. Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. (PubMed)

Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine with continued midazolam in such patients.Patients undergoing elective colonoscopy with moderate sedation (...) were eligible. Sedation was measured with the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score with adequate sedation defined as 3 on a 0- to 5-point scale. Patients not adequately sedated with midazolam 5 mg and fentanyl 100 μg were randomly assigned to diphenhydramine 25 mg versus continued midazolam 1.5 mg. Adequacy of sedation was assessed 3 minutes after each study medication dose. If MOAA/S was 4 to 5, study medication was repeated, to a maximum of 3 doses. The primary

2017 Gastrointestinal endoscopy

15. A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. (PubMed)

A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. Antihistamines are often used for treating allergic rhinitis. However, many older antihistamines cause sedative side effects. The sedative effects of antihistamines on car-driving have been investigated. This has not been investigated for levocetirizine, a new-generation antihistamine, in Asian populations, and so we evaluated its sedative (...) effects in healthy Japanese subjects.In this double-blind, placebo-controlled, four-way crossover study, healthy volunteers received single doses of levocetirizine 5 mg, fexofenadine 60 mg, diphenhydramine 50 mg, and placebo at intervals of at least 6 days. Simple brake reaction time and choice brake reaction time task (CBRT), a lateral tracking (LT) task, and a multiple task, a mixture of CBRT and LT task, were used to compare driving performance between the four drugs. Subjective sedation was also

2016 Human psychopharmacology

16. Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. (PubMed)

Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. More than 1 million patients present to US emergency departments (EDs) annually seeking care for acute migraine. Parenteral antihistamines have long been used in combination with antidopaminergics such as metoclopramide to treat acute migraine in the ED. High-quality data supporting this practice do not exist. We determine whether administration of diphenhydramine 50 mg (...) for futility. Baseline characteristics were comparable between the groups. Fourteen percent (29/208) of the sample reported allergic symptoms. Of patients randomized to diphenhydramine, 40% (40/100) reported sustained relief at 48 hours, as did 37% (38/103) of patients randomized to placebo (95% confidence interval [CI] for difference of 3%: -10% to 16%). One hour after medication administration, patients randomized to diphenhydramine improved by a mean of 5.1 on the 0 to 10 scale versus 4.8 for those

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2015 Annals of Emergency Medicine

17. Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. (PubMed)

Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 4513854 1973 08 09 2018 11 13 0003-3006 20 3 1973 May-Jun Anesthesia progress Anesth Prog Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry. 76-82 Malamed S F SF eng Journal Article United States Anesth Prog 0043533 0003-3006 0 Anesthetics, Local 8GTS82S83M Diphenhydramine D Anesthesia, Dental Anesthetics, Local Diphenhydramine administration & dosage 1973 5 1 1973 5 1 0 1 1973 5 1 0 0 ppublish

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1973 Anesthesia progress

18. The influence of diphenhydramine on the absorption of methaqualone in man (PubMed)

The influence of diphenhydramine on the absorption of methaqualone in man 1 The effects of diphenhydramine on the buccal absorption, in vivo absorption and the in vitro dissolution of methaqualone have been studied. 2 Diphenhydramine significantly reduced the buccal absorption of methaqualone and the effect was dose and pH dependent. In vivo, diphenhydramine did not alter the rate of absorption or the distribution of methaqualone in blood. In vitro, the presence of diphenhydramine increased (...) the rate of dissolution of methaqualone and the effect was more marked when the particle size was small. 3 The reasons for and the implications of these apparently contradictory results are discussed and it is concluded that any increased efficacy resulting from combining diphenhydramine with methaqualone cannot be due to increased plasma drug levels.

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1974 British journal of clinical pharmacology

19. Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging. (PubMed)

Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging. Diphenhydramine, a sedative histamine H1-receptor (H1R) antagonist, was evaluated as a probe to measure drug/H+-antiporter function at the blood-brain barrier. In situ brain perfusion experiments in mice and rats showed that diphenhydramine transport at the blood-brain barrier was saturable, following Michaelis-Menten kinetics (...) with a Km = 2.99 mM and Vmax = 179.5 nmol s-1 g-1. In the pharmacological plasma concentration range the carrier-mediated component accounted for 77% of diphenhydramine influx while passive diffusion accounted for only 23%. [14C]Diphenhydramine blood-brain barrier transport was proton and clonidine sensitive but was influenced by neither tetraethylammonium, a MATE1 (SLC47A1), and OCT/OCTN (SLC22A1-5) modulator, nor P-gp/Bcrp (ABCB1a/1b/ABCG2) deficiency. Brain and plasma kinetics of [11C]diphenhydramine

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2016 Journal of Cerebral Blood Flow and Metabolism

20. Comparison of cimetidine and diphenhydramine in the treatment of acute urticaria. (PubMed)

Comparison of cimetidine and diphenhydramine in the treatment of acute urticaria. Recent case reports have suggested that H2-antihistamines used alone may be effective in the treatment of acute urticaria, a common complaint of patients presenting to the emergency department. This contradicts accepted doctrine on the treatment of acute urticaria. Based on theories of H1- and H2-receptor interaction at the cellular level, it has been stated that H2-blockade before H1-blockade may exacerbate (...) symptoms. The purpose of our study was to compare diphenhydramine, an H1-blocker, with cimetidine, an H2-blocker, in a randomized, prospective, double-blind clinical trial. Ninety-three patients presenting to the ED with clinical evidence of acute urticaria were treated with either 50 mg diphenhydramine IM or 300 mg cimetidine IM. Patients' signs and symptoms were quantitated on a numeric scale before receiving medications and 30 minutes after treatment. Parameters measured included degree of itching

1990 Annals of Emergency Medicine