Latest & greatest articles for diclofenac

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on diclofenac or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on diclofenac and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for diclofenac

1. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

2016 Prescrire

2. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy

Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02428777 Recruitment Status : Unknown Verified January 2017 by AbdelGany Hassan, Cairo University. Recruitment status was: Recruiting First Posted

2015 Clinical Trials

3. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2019 NIHR Dissemination Centre

4. Diclofenac

Diclofenac Top results for diclofenac - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diclofenac The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

5. Single-dose intravenous diclofenac for acute postoperative pain in adults. Full Text available with Trip Pro

Single-dose intravenous diclofenac for acute postoperative pain in adults. Postoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) reduces patient opioid requirements and, in turn, reduces the incidence and severity of opioid-induced adverse events (AEs).To assess the analgesic efficacy and adverse effects of single-dose intravenous diclofenac, compared with placebo or an active comparator, for moderate to severe postoperative pain in adults.We searched the following (...) databases without language restrictions: the Cochrane Central Register of Controlled Trials (Cochrane Register of Studies Online), MEDLINE, and Embase on 22 May 2018. We checked clinical trials registers and reference lists of retrieved articles for additional studies.We included randomized trials that compared a single postoperative dose of intravenous diclofenac with placebo or another active treatment, for treating acute postoperative pain in adults following any surgery.We used standard

2018 Cochrane

6. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2018 NIHR Dissemination Centre

7. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Discover Portal Discover Portal A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 doi: This Cochrane systematic review found that the same (...) single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low and there was no difference between the two

2018 NIHR Dissemination Centre

8. Diclofenac: new contraindications and warnings Full Text available with Trip Pro

Diclofenac: new contraindications and warnings Diclofenac: new contraindications and warnings - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Diclofenac: new contraindications and warnings New recommendations after a Europe-wide review of cardiovascular safety. Published 11 December 2014 From: Therapeutic area: , , Contents Article date: June 2013 An increased risk of heart attack and stroke with some non-selective non-steroidal anti-inflammatory drugs (NSAIDs (...) )—such as diclofenac—is well recognised, particularly with long-term use of high doses and in patients who are already at high risk. Warnings for healthcare professionals and patients have been included in the product information and in the British National Formulary for some years. The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee has recently recommended updates to the treatment advice for diclofenac in light of the findings of a Europe-wide review of the cardiovascular safety of NSAIDs

2013 MHRA Drug Safety Update

9. Randomized controlled study of the antipyretic efficacy of oral paracetamol, intravenous paracetamol, and intramuscular diclofenac in patients presenting with fever to the emergency department. Full Text available with Trip Pro

Randomized controlled study of the antipyretic efficacy of oral paracetamol, intravenous paracetamol, and intramuscular diclofenac in patients presenting with fever to the emergency department. Fever is a common problem in adults visiting the emergency department. Extensive studies have been done in children comparing the efficacy of various antipyretics. However, studies on the efficacy of antipyretic drugs in adults are very scarce. To the best of our knowledge, no controlled trial has been (...) carried out comparing the antipyretic efficacy of paracetamol (oral and intravenous) and intramuscular diclofenac in adults.In this parallel-group, open-label trial, participants aged 14-75 years presenting with fever who had a temperature of more than 38.5°C were enrolled and treated. Participants were randomly allocated to receive treatment with 1,000 mg oral paracetamol (n = 145), 1,000 mg intravenous paracetamol (n = 139), or 75 mg intramuscular diclofenac (n = 150). The primary outcome was degree

2013 Therapeutics and clinical risk management Controlled trial quality: predicted high

10. ANALGESIC EFFECTS OF ACETAMINOPHEN, DICLOFENAC AND HYOSCINE N-BUTYLBROMIDE IN SECOND TRIMESTER PREGNANCY TERMINATION: A PROSPECTIVE RANDOMIZED STUDY. (Abstract)

ANALGESIC EFFECTS OF ACETAMINOPHEN, DICLOFENAC AND HYOSCINE N-BUTYLBROMIDE IN SECOND TRIMESTER PREGNANCY TERMINATION: A PROSPECTIVE RANDOMIZED STUDY. This prospective, randomized study aimed to compare the analgesic effects of acetaminophen, diclofenac and hyoscine-N-butylbromide (HnBB) in cases of second trimester pregnancy termination.In 60 women with indications for second trimester pregnancy termination, three analgesic agents were randomized into three groups: group 1, acetaminophen; group (...) 2, diclofenac; and group 3, HnBB. A visual analog scale (VAS) used for the evaluation of pain perception. The primary outcome of the study was mean VAS score during the procedure and last VAS score before the completion of termination. The secondary outcomes were the induction-to-abortion interval, the percentage of aborted cases within the first 24 h and finally the need for parenteral analgesia.Demographic characteristics were similar among the groups. The mean VAS and last VAS scores before

2016 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

11. Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). Full Text available with Trip Pro

Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). Low back pain is common and associated with a considerable burden to patients and society. There is uncertainty regarding the relative benefit of paracetamol and diclofenac and regarding the additional effect of pain medication compared with advice only in patients with acute low back pain. This trial will assess the effectiveness of paracetamol (...) , diclofenac and placebo for acute low back pain over a period of 4 weeks. Furthermore, this trial will assess the additional effectiveness of paracetamol, diclofenac and placebo compared with advice only for acute low back pain over a period of 4 weeks.The PACE Plus trial is a multi-center, placebo-blinded, superiority randomized controlled trial in primary care, with a follow-up of 12 weeks. Patients with acute low back pain aged 18-60 years presenting in general practice will be included. Patients

2017 BMC Musculoskeletal Disorders Controlled trial quality: predicted high

12. Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions

Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

13. Celecoxib and Diclofenac Plus Omeprazole are Similarly Effective in the Treatment of Arthritis in Patients at High GI Risk in the CONDOR Trial. Full Text available with Trip Pro

Celecoxib and Diclofenac Plus Omeprazole are Similarly Effective in the Treatment of Arthritis in Patients at High GI Risk in the CONDOR Trial. Compare effectiveness of celecoxib versus diclofenac plus omeprazole in improving arthritis signs and symptoms in patients at high gastrointestinal (GI) risk who were enrolled in the CONDOR (Celecoxib vs Omeprazole and Diclofenac in Patients With Osteoarthritis and Rheumatoid Arthritis) trial.CONDOR was a 6-month, prospective, double-blind, triple-dummy (...) , parallel-group, randomized, multicenter trial comparing celecoxib 200 mg twice daily versus diclofenac slow release (SR) 75 mg twice daily plus omeprazole 20 mg daily. Patients were Helicobacter pylori negative, had osteoarthritis (OA) or rheumatoid arthritis (RA), were aged ≥60 years, were with or without a history of gastroduodenal ulceration, or were ≥18 years with previous gastroduodenal ulceration. Patients' Global Assessment of Arthritis was determined at each study visit.A total of 4484 patients

2013 The open rheumatology journal Controlled trial quality: uncertain

14. A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol

A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01421433 Recruitment Status : Unknown Verified

2011 Clinical Trials

15. Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations. Full Text available with Trip Pro

Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations. To compare the effectiveness of different oral analgesics for relieving pain and distress in adults following the extraction of teeth and deep cavity preparations under local anesthesia. Methods: This randomized controlled study was conducted between November 2015 and May 2016. One hundred and twenty patients were randomly allocated to 3 groups. Forty (...) patients were in the paracetamol (1 gram) group, 40 in the ibuprofen (400 mg) group and 40 in the diclofenac potassium (50 mg) group. Evaluation of the post extraction and deep cavity preparations pain was made by patients immediately postoperatively, 2, 4 and 6 hours postoperatively on standard 100 mm visual analogue scales (VAS). Furthermore, each patient was observed preoperatively and immediately postoperatively for signs of distress by using a 5 point face scale. Results: There were significant

2017 Saudi medical journal Controlled trial quality: uncertain

16. Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy

Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02419651 Recruitment Status : Unknown Verified January 2017 by AbdelGany Hassan, Cairo University. Recruitment status was: Recruiting First Posted : April 17, 2015 Last Update

2015 Clinical Trials

17. Artotec (diclofenac sodium, misoprostol) - treatment of rheumatic diseases

Artotec (diclofenac sodium, misoprostol) - treatment of rheumatic diseases HAS - Medical, Economic and Public Health Assessment Division 1/39 The legally binding text is the original French version T TR RA AN NS SP PA AR RE EN NC CY Y C CO OM MM MI IT TT TE EE E Opinion 5 February 2014 ARTOTEC 50 mg/0.2 mg, tablet B/30 (CIP: 34009 336 492 6 5) ARTOTEC 75 mg/0.2 mg, tablet B/20 (CIP: 34009 352 654 7 0) Applicant: PFIZER INN diclofenac sodium, misoprostol ATC code (2012) M01AB55 (Antiinflammatory (...) and antirheumatic products, non-steroids) Reason for the review Re-assessment of the Actual Benefit of all systemically administered diclofenac-based medicines at the Committee’s request, in compliance with Article R-163-21 of the French Social Security Code Lists concerned National Health Insurance (French Social Security Code L.162-17) Inclusion for hospital use (French Public Health Code L.5123-2) Indications concerned ARTOTEC 50 mg/0.2 mg: “Symptomatic treatment of rheumatic diseases in at-risk patients

2014 Haute Autorite de sante

18. Diclofenac epolamine topical patch relieves pain associated with ankle sprain. Full Text available with Trip Pro

Diclofenac epolamine topical patch relieves pain associated with ankle sprain. Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs), which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclofenac epolamine topical patch (DETP, 1.3%), a topical NSAID for the treatment of acute minor sprains

2011 Journal of pain research Controlled trial quality: uncertain

19. Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis

Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy (...) and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00426621 Recruitment Status : Completed First Posted : January 25, 2007 Last Update Posted : December 18, 2007 Sponsor: Novartis Information provided by: Novartis Study Details Study

2007 Clinical Trials

20. Diclofenac systemic bioavailability of a topical 1% diclofenac + 3% menthol combination gel vs. an oral diclofenac tablet in healthy volunteers: a randomized, open-label, crossover study
. (Abstract)

Diclofenac systemic bioavailability of a topical 1% diclofenac + 3% menthol combination gel vs. an oral diclofenac tablet in healthy volunteers: a randomized, open-label, crossover study
. Evaluate systemic exposure with repeated topical application of a fixed-combination topical gel product containing 1% diclofenac sodium and 3% menthol in either of 2 formulation packages relative to oral administration.In this phase 1, single-center, 4-way crossover study, healthy volunteers aged 18 - 50 (...) years underwent consecutive 3-day treatment regimens in a randomly assigned sequence with each of 4 treatment groups: 4 g of topical 1% diclofenac + 3% menthol gel administered via an aluminum tube or roll-on device applied 4 times daily; 4 g of topical 1% diclofenac sodium gel (Voltaren Gel) applied 4 times daily; and oral diclofenac sodium tablets 50 mg 3 times daily. Treatment regimens were separated by 2-day washout periods.A total of 18 subjects enrolled and completed the study. Relative

2016 International journal of clinical pharmacology and therapeutics Controlled trial quality: uncertain