Latest & greatest articles for diclofenac

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on diclofenac or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on diclofenac and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for diclofenac

1. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy

Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02428777 Recruitment Status : Unknown Verified January 2017 by AbdelGany Hassan, Cairo University. Recruitment status was: Recruiting First Posted

2015 Clinical Trials

2. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

2016 Prescrire

3. Single-dose intravenous diclofenac for acute postoperative pain in adults. (PubMed)

Single-dose intravenous diclofenac for acute postoperative pain in adults. Postoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) reduces patient opioid requirements and, in turn, reduces the incidence and severity of opioid-induced adverse events (AEs).To assess the analgesic efficacy and adverse effects of single-dose intravenous diclofenac, compared with placebo or an active comparator, for moderate to severe postoperative pain in adults.We searched the following (...) databases without language restrictions: the Cochrane Central Register of Controlled Trials (Cochrane Register of Studies Online), MEDLINE, and Embase on 22 May 2018. We checked clinical trials registers and reference lists of retrieved articles for additional studies.We included randomized trials that compared a single postoperative dose of intravenous diclofenac with placebo or another active treatment, for treating acute postoperative pain in adults following any surgery.We used standard

2018 Cochrane

4. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2018 NIHR Dissemination Centre

5. Diclofenac: new contraindications and warnings

Diclofenac: new contraindications and warnings Diclofenac: new contraindications and warnings - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Diclofenac: new contraindications and warnings New recommendations after a Europe-wide review of cardiovascular safety. Published 11 December 2014 From: Therapeutic area: , , Contents Article date: June 2013 An increased risk of heart attack and stroke with some non-selective non-steroidal anti-inflammatory drugs (NSAIDs (...) )—such as diclofenac—is well recognised, particularly with long-term use of high doses and in patients who are already at high risk. Warnings for healthcare professionals and patients have been included in the product information and in the British National Formulary for some years. The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee has recently recommended updates to the treatment advice for diclofenac in light of the findings of a Europe-wide review of the cardiovascular safety of NSAIDs

Full Text available with Trip Pro

2013 MHRA Drug Safety Update

6. Randomized controlled study of the antipyretic efficacy of oral paracetamol, intravenous paracetamol, and intramuscular diclofenac in patients presenting with fever to the emergency department. (PubMed)

Randomized controlled study of the antipyretic efficacy of oral paracetamol, intravenous paracetamol, and intramuscular diclofenac in patients presenting with fever to the emergency department. Fever is a common problem in adults visiting the emergency department. Extensive studies have been done in children comparing the efficacy of various antipyretics. However, studies on the efficacy of antipyretic drugs in adults are very scarce. To the best of our knowledge, no controlled trial has been (...) carried out comparing the antipyretic efficacy of paracetamol (oral and intravenous) and intramuscular diclofenac in adults.In this parallel-group, open-label trial, participants aged 14-75 years presenting with fever who had a temperature of more than 38.5°C were enrolled and treated. Participants were randomly allocated to receive treatment with 1,000 mg oral paracetamol (n = 145), 1,000 mg intravenous paracetamol (n = 139), or 75 mg intramuscular diclofenac (n = 150). The primary outcome was degree

Full Text available with Trip Pro

2013 Therapeutics and clinical risk management

7. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial (PubMed)

Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial Acute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain.This prospective, multicentre (...) , randomised, blinded, active-control and non-inferiority study involved 449 physically active adults sustaining unilateral grade 1 or 2 ankle sprain within the past 24 h. Participants were randomised to receive 2 g of Traumeel ointment (T-O) (n = 152) or Traumeel gel (T-G) (n = 150) or diclofenac gel (D-G) (n = 147), administered topically to the ankle three times a day for 14 days, with 6-weeks follow up.Day 7 median percentage reductions in Visual Analogue Scale pain score were 60.6%, 71.1% and 68.9

Full Text available with Trip Pro

2013 EvidenceUpdates

8. Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions

Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

9. Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). (PubMed)

Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus). Low back pain is common and associated with a considerable burden to patients and society. There is uncertainty regarding the relative benefit of paracetamol and diclofenac and regarding the additional effect of pain medication compared with advice only in patients with acute low back pain. This trial will assess the effectiveness of paracetamol (...) , diclofenac and placebo for acute low back pain over a period of 4 weeks. Furthermore, this trial will assess the additional effectiveness of paracetamol, diclofenac and placebo compared with advice only for acute low back pain over a period of 4 weeks.The PACE Plus trial is a multi-center, placebo-blinded, superiority randomized controlled trial in primary care, with a follow-up of 12 weeks. Patients with acute low back pain aged 18-60 years presenting in general practice will be included. Patients

Full Text available with Trip Pro

2017 BMC Musculoskeletal Disorders

10. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Discover Portal Discover Portal A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 doi: This Cochrane systematic review found that the same (...) single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low and there was no difference between the two

2018 NIHR Dissemination Centre

11. Celecoxib and Diclofenac Plus Omeprazole are Similarly Effective in the Treatment of Arthritis in Patients at High GI Risk in the CONDOR Trial. (PubMed)

Celecoxib and Diclofenac Plus Omeprazole are Similarly Effective in the Treatment of Arthritis in Patients at High GI Risk in the CONDOR Trial. Compare effectiveness of celecoxib versus diclofenac plus omeprazole in improving arthritis signs and symptoms in patients at high gastrointestinal (GI) risk who were enrolled in the CONDOR (Celecoxib vs Omeprazole and Diclofenac in Patients With Osteoarthritis and Rheumatoid Arthritis) trial.CONDOR was a 6-month, prospective, double-blind, triple-dummy (...) , parallel-group, randomized, multicenter trial comparing celecoxib 200 mg twice daily versus diclofenac slow release (SR) 75 mg twice daily plus omeprazole 20 mg daily. Patients were Helicobacter pylori negative, had osteoarthritis (OA) or rheumatoid arthritis (RA), were aged ≥60 years, were with or without a history of gastroduodenal ulceration, or were ≥18 years with previous gastroduodenal ulceration. Patients' Global Assessment of Arthritis was determined at each study visit.A total of 4484 patients

Full Text available with Trip Pro

2013 The open rheumatology journal

12. Diclofenac epolamine topical patch relieves pain associated with ankle sprain. (PubMed)

Diclofenac epolamine topical patch relieves pain associated with ankle sprain. Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs), which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclofenac epolamine topical patch (DETP, 1.3%), a topical NSAID for the treatment of acute minor sprains

Full Text available with Trip Pro

2011 Journal of pain research

13. A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol

A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01421433 Recruitment Status : Unknown Verified

2011 Clinical Trials

14. Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. (PubMed)

Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. Currently approved monoamine modulating antidepressant and anxiolytic pharmaceutics fail in over one third of patients due to delayed and variable therapeutic effect, adverse reactions preceding the therapeutic action, and adherence issues. Even with adequate adherence to the regimen and tolerability, one third of the patients do (...) of anxiety by a factor of 2.86 (OR 0.35 [0.22, 0.56]), diclofenac with decreased depression reports by a factor of 2.22 (OR 0.45 [0.40, 0.49]) and anxiety by a factor of 2.13 (OR 0.47 [0.41, 0.54]), while naproxen decreased depression reports by a factor of 1.92 (OR 0.52 [0.49, 0.57]) and anxiety by a factor of 1.23 (OR 0.81 [0.75, 0.88]). Other NSAIDs did not exhibit any noticeable antidepressant and/or anxiolytic effect.

Full Text available with Trip Pro

2018 PLoS ONE

15. Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations. (PubMed)

Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations. To compare the effectiveness of different oral analgesics for relieving pain and distress in adults following the extraction of teeth and deep cavity preparations under local anesthesia. Methods: This randomized controlled study was conducted between November 2015 and May 2016. One hundred and twenty patients were randomly allocated to 3 groups. Forty (...) patients were in the paracetamol (1 gram) group, 40 in the ibuprofen (400 mg) group and 40 in the diclofenac potassium (50 mg) group. Evaluation of the post extraction and deep cavity preparations pain was made by patients immediately postoperatively, 2, 4 and 6 hours postoperatively on standard 100 mm visual analogue scales (VAS). Furthermore, each patient was observed preoperatively and immediately postoperatively for signs of distress by using a 5 point face scale. Results: There were significant

Full Text available with Trip Pro

2017 Saudi medical journal

16. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Discover Portal Discover Portal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 doi: This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were the most effective non (...) for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95% credibility interval [CI] -0.69

2019 NIHR Dissemination Centre

17. ANALGESIC EFFECTS OF ACETAMINOPHEN, DICLOFENAC AND HYOSCINE N-BUTYLBROMIDE IN SECOND TRIMESTER PREGNANCY TERMINATION: A PROSPECTIVE RANDOMIZED STUDY. (PubMed)

ANALGESIC EFFECTS OF ACETAMINOPHEN, DICLOFENAC AND HYOSCINE N-BUTYLBROMIDE IN SECOND TRIMESTER PREGNANCY TERMINATION: A PROSPECTIVE RANDOMIZED STUDY. This prospective, randomized study aimed to compare the analgesic effects of acetaminophen, diclofenac and hyoscine-N-butylbromide (HnBB) in cases of second trimester pregnancy termination.In 60 women with indications for second trimester pregnancy termination, three analgesic agents were randomized into three groups: group 1, acetaminophen; group (...) 2, diclofenac; and group 3, HnBB. A visual analog scale (VAS) used for the evaluation of pain perception. The primary outcome of the study was mean VAS score during the procedure and last VAS score before the completion of termination. The secondary outcomes were the induction-to-abortion interval, the percentage of aborted cases within the first 24 h and finally the need for parenteral analgesia.Demographic characteristics were similar among the groups. The mean VAS and last VAS scores before

2016 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

18. Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy

Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02419651 Recruitment Status : Unknown Verified January 2017 by AbdelGany Hassan, Cairo University. Recruitment status was: Recruiting First Posted : April 17, 2015 Last Update

2015 Clinical Trials

19. Indomethacin and diclofenac in the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis of controlled trials

Indomethacin and diclofenac in the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis of controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2016 PROSPERO

20. Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis

Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy (...) and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00426621 Recruitment Status : Completed First Posted : January 25, 2007 Last Update Posted : December 18, 2007 Sponsor: Novartis Information provided by: Novartis Study Details Study

2007 Clinical Trials