Latest & greatest articles for diclofenac

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on diclofenac or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on diclofenac and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for diclofenac

1. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Signal - Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Dissemination Centre Discover Portal NIHR DC Discover Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. High dose diclofenac or etoricoxib were (...) an uncertain potential for conflict of interest. What did it find? Irrespective of dose, all non-steroidal anti-inflammatory drugs and paracetamol improved reported osteoarthritis pain compared to placebo, but only three drugs gave a clinically significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at a dose of 150 mg/day was the most effective drug for pain relief compared with placebo (effect size -0.57 95

NIHR Dissemination Centre2018

2. Diclofenac use and cardiovascular risks: series of nationwide cohort studies.

Diclofenac use and cardiovascular risks: series of nationwide cohort studies. OBJECTIVE: To examine the cardiovascular risks of diclofenac initiation compared with initiation of other traditional non-steroidal anti-inflammatory drugs, initiation of paracetamol, and no initiation. DESIGN: Series of 252 nationwide cohort studies, each mimicking the strict design criteria of a clinical trial (emulated trial design). SETTING: Danish, nationwide, population based health registries (1996-2016 (...) ). PARTICIPANTS: Individuals eligible for inclusion were all adults without malignancy; schizophrenia; dementia; or cardiovascular, kidney, liver, or ulcer diseases (that is, with low baseline risk). The study included 1 370 832 diclofenac initiators, 3 878 454 ibuprofen initiators, 291 490 naproxen initiators, 764 781 healthcare seeking paracetamol initiators matched by propensity score, and 1 303 209 healthcare seeking non-initiators also matched by propensity score. MAIN OUTCOME MEASURES: Cox proportional

BMJ2018

3. Single-dose intravenous diclofenac for acute postoperative pain in adults.

Single-dose intravenous diclofenac for acute postoperative pain in adults. BACKGROUND: Postoperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) reduces patient opioid requirements and, in turn, reduces the incidence and severity of opioid-induced adverse events (AEs). OBJECTIVES: To assess the analgesic efficacy and adverse effects of single-dose intravenous diclofenac, compared with placebo or an active comparator, for moderate to severe postoperative pain in adults (...) . SEARCH METHODS: We searched the following databases without language restrictions: the Cochrane Central Register of Controlled Trials (Cochrane Register of Studies Online), MEDLINE, and Embase on 22 May 2018. We checked clinical trials registers and reference lists of retrieved articles for additional studies. SELECTION CRITERIA: We included randomized trials that compared a single postoperative dose of intravenous diclofenac with placebo or another active treatment, for treating acute postoperative

Cochrane2018

4. Diclofenac

Diclofenac Top results for diclofenac - Trip Database or use your Google+ account Liberating the literature My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diclofenac The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

5. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Signal - A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Dissemination Centre Discover Portal NIHR DC Discover A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 This Cochrane systematic (...) review found that the same single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low

NIHR Dissemination Centre2018

6. Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis

Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis NIHR DC | Signal - Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Diclofenac or etoricoxib, but not paracetamol, is effective for treating osteoarthritis Published on 26 May 2016 This review aimed to identify the most effective drugs for pain relief in hip or knee osteoarthritis. Maximum dose diclofenac (...) significant improvement: diclofenac, etoricoxib and rofecoxib. Rofecoxib has been withdrawn from the market due to safety concerns. Diclofenac at the maximum daily dose of 150 mg/day was the most effective drug for pain relief (effect size 0.57 compared with placebo). It also significantly improved physical function. Etoricoxib at the maximum dose of 60 mg/day was as effective as diclofenac 150 mg/day for osteoarthritis pain (effect size 0.58 compared with placebo), but its effect on physical function

NIHR Dissemination Centre2018

7. A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium

A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium NIHR DC | Signal - A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal A single dose of diclofenac potassium is more effective for postoperative pain than the more commonly used diclofenac sodium Published on 10 September 2015 (...) This Cochrane systematic review found that the same single dose of fast-acting diclofenac potassium tablets is more effective for moderate to severe short-term postoperative pain relief than coated diclofenac sodium tablets. Both versions were compared with a placebo, rather than each other. On average, only two people need to be treated with a single dose of the fast acting pill instead of the dummy pill for one to experience adequate pain relief. The rate of adverse effects after a single dose was low

NIHR Dissemination Centre2018

8. Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment (...) of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Published on: November 8, 2017 Project Number: RB1159-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation? What is the cost-effectiveness of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation? What

Canadian Agency for Drugs and Technologies in Health - Rapid Review2017

9. Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Prescrire IN ENGLISH - Spotlight ''Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen'', 1 January 2016 {1} {1} {1} | | > > > Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |  (...)  |   |   |   |   |   |   |  Spotlight Nonsteroidal anti-inflammatory drugs (NSAIDs): avoid cox-2 inhibitors, diclofenac and high-dose ibuprofen When pain medication is required, paracetamol (alias acetaminophen) is the reference drug. Among the nonsteroidal anti-inflammatories (NSAIDs), naproxen or ibuprofen (not exceeding 1200 mg a day) are the drugs that carry the least exposure to cardiac disorders. When pain medication is needed

Prescrire2016

10. Does topical diclofenac relieve osteoarthritis pain?

Does topical diclofenac relieve osteoarthritis pain? Does topical diclofenac relieve osteoarthritis pain? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Does topical diclofenac relieve osteoarthritis pain? View/ Open Date 2015-02 Contributor Format Metadata Abstract Q: Does topical diclofenac relieve osteoarthritis (...) pain? Evidence-based answer: Yes, at least in the short term. Topical diclofenac, with and without dimethyl sulfoxide (DMSO), modestly improves pain and function scores (by 4%-8%) for as long as 12 weeks in patients with osteoarthritis (OA) of the knee (strength of recommendation [SOR]: A, meta-analyses of multiple randomized controlled trials [RCTs]). Topical diclofenac modestly decreases pain scores in patients with OA of the hand in the short term (by 9% at 6 weeks) but no more than placebo at 8

Clinical Inquiries2015

12. Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors

Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors From: Published: 22 January 2015 Therapeutic area: and Aceclofenac is now contraindicated in patients with certain (...) only start aceclofenac treatment after careful consideration of any significant risk factors for cardiovascular events, eg hypertension hyperlipidaemia diabetes mellitus smoking Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) licensed for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac has little pharmacological activity itself; its main mode of action is through its metabolites which include diclofenac

MHRA Drug Safety Update2015

13. Oral diclofenac no longer available without prescription

Oral diclofenac no longer available without prescription Oral diclofenac no longer available without prescription Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Oral diclofenac no longer available without prescription From: Published: 22 January 2015 Therapeutic area: and Oral diclofenac is associated with a small increased risk of cardiovascular side effects and is therefore no longer available over the counter. When prescribing or dispensing diclofenac (...) , consider that: oral diclofenac must not be sold without prescription a for non-prescription diclofenac the in June 2013 topical formulations of diclofenac (eg gel and cream) remain available for sale over the counter Advice to give to patients: if you have recently bought diclofenac tablets without a prescription and continue to need pain relief, speak to your prescriber or pharmacist who can advise you on suitable alternatives - there is no problem if you wish to stop taking diclofenac in the meantime

MHRA Drug Safety Update2015

15. Flector (diclofenac epolamine) - short-term symptomatic treatment of acute episodes of: extra-articular rheumatism such as scapulohumeral periarthritis, tendonitis, bursitis; microcrystalline arthritis; osteoarthritis etc

Flector (diclofenac epolamine) - short-term symptomatic treatment of acute episodes of: extra-articular rheumatism such as scapulohumeral periarthritis, tendonitis, bursitis; microcrystalline arthritis; osteoarthritis etc

Haute Autorite de sante2014

17. Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever

Voltarendolo (diclofenac potassium) - Symptomatic treatment of painful conditions of mild to moderate intensity and/or fever

Haute Autorite de sante2014

18. Diclofenac

Diclofenac USE OF DICLOFENAC IN PREGNANCY 0344 892 0909 USE OF DICLOFENAC IN PREGNANCY (Date of issue: July 2014 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to (...) treat acute and chronic pain (including dysmenorrhoea) and in the management of rheumatoid arthritis. Some studies have suggested that use of NSAIDs in early pregnancy may be associated with an increased risk of spontaneous abortion. Data regarding diclofenac use are insufficient to assess the risk for this specific NSAID. NSAID use in pregnancy has been associated with increased risks of various different congenital malformations, including cardiovascular defects and oral clefts. No association

UK Teratology Information Service2014

19. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial

Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial 23889885 2013 09 30 2014 04 30 2017 02 20 1742-1241 67 10 2013 Oct International journal of clinical practice Int. J. Clin. Pract. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial. 979-89 10.1111/ijcp.12219 (...) Acute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain. This prospective, multicentre, randomised, blinded, active-control and non-inferiority study involved 449 physically active adults sustaining unilateral grade 1 or 2 ankle sprain within the past 24 h. Participants

EvidenceUpdates2013 Full Text: Link to full Text with Trip Pro

20. Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial

Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial 23852695 2014 08 02 2014 10 16 2017 02 03 1468-2060 73 9 2014 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel (...) -group, multicentre phase III randomised clinical trial. 1665-72 10.1136/annrheumdis-2012-203164 Tanezumab, a monoclonal antibody, inhibits nerve growth factor and reduces chronic pain. This randomised, double-blind, controlled multicentre study was conducted to evaluate the efficacy and safety of tanezumab added to oral diclofenac sustained release (DSR) in patients with hip or knee osteoarthritis (OA) pain. Patients (N=604) with moderate to severe knee or hip OA tolerating stable DSR were

EvidenceUpdates2013