Latest & greatest articles for diazepam

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Top results for diazepam

1. Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. (PubMed)

Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. Febrile seizure is the most common neurologic problem in children between 3 months to 5 years old. Two to five percent of children aged less than five yr old will experience it at least one time. This type of seizure is age dependent and its recurrence rate is about 33% overalls and 50% in children less than one yr old. The prophylactic treatment is still controversial (...) , so we conducted a randomized controlled clinical trial to find out the effectiveness of continuous phenobarbital versus intermittent diazepam for febrile seizure.This clinical trial was conducted in the Department of Pediatric Neurology, Babol University of Medical Sciences, Babol, Iran between March 2008 and October 2010. All children from 6 month to 5 yr old referred to Amirkola Children's Hospital, Babol, Iran were enrolled in the study. Children with febrile seizure that had indication

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2016 Iranian journal of child neurology

2. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

2002 NHS Economic Evaluation Database.

3. Prospective Randomized Study of Oral Diazepam and Baclofen on Spasticity in Cerebral Palsy. (PubMed)

Prospective Randomized Study of Oral Diazepam and Baclofen on Spasticity in Cerebral Palsy. Spastic cerebral palsy (CP) is the most common form of CP. Diazepam and Baclofen are the most commonly used oral drugs to manage spasticity. Study was designed to evaluate and compare their effects and safety in CP children.Study was aimed to assess and compare outcome of oral Diazepam and Baclofen in spastic cerebral palsy children in terms of extent of reduction of spasticity and side effects (...) profile.Randomized prospective follow-up study was done for one year after giving Diazepam and Baclofen in weekly incremental doses upto recommended maximum dose to 60 children for three months. Two primary outcome measures were spasticity reduction and adverse effect profile. Spasticity reduction was measured by Modified Ashworth's Scale (MAS) and Range of Motion improvement (ROM).After random allocation, there was no baseline difference between groups. Mean MAS score improved from 1.96±0.4 at baseline to 1.63

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2016 Journal of clinical and diagnostic research : JCDR

4. Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. (PubMed)

Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours when the rectal temperature was greater than or equal to 38.5 degree C. Children (...) admitted on odd days were given treatment with phenobarbitone, 3.5 +/- 1 mg/kg per day. 156 children completed treatment and outpatient control for a year, 83 in the diazepam and 73 in the phenobarbitone group. The rate of recurrence was independent of the prophylactic and 15--16 % of the children in both groups had new febrile convulsions within a year. The recurrence rate after 6 months was also similar, 11% in the diazepam group and 9% in the phenobarbitone group. New convulsions were of similar

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1978 Archives of disease in childhood

5. Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial. (PubMed)

Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial. To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children.Randomized clinical trial.Pediatric emergency department.Children aged 2 months to 14 years admitted to the study facility with seizures.Patients were randomized to receive DZP-IV or MDZ-IM.Groups were compared

2014 Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias

6. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. (PubMed)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin

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2014 JAMA

7. Use of diazepam in treatment of severe convulsive status epilepticus. (PubMed)

Use of diazepam in treatment of severe convulsive status epilepticus. 4961468 1967 09 03 2018 11 13 0007-1447 3 5557 1967 Jul 08 British medical journal Br Med J Use of diazepam in treatment of severe convulsive status epilepticus. 85-8 Parsonage M J MJ Norris J W JW eng Journal Article England Br Med J 0372673 0007-1447 Q3JTX2Q7TU Diazepam AIM IM Adolescent Adult Child Diazepam therapeutic use Epilepsy, Tonic-Clonic drug therapy Female Humans Infusions, Parenteral Injections, Intramuscular

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1967 British medical journal

8. Diazepam

Diazepam USE OF DIAZEPAM IN PREGNANCY 0344 892 0909 USE OF DIAZEPAM IN PREGNANCY (Date of issue: January 2012 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Diazepam is a long-acting benzodiazepine used as a hypnotic, anxiolytic, anticonvulsant and muscle relaxant. Its actions are mediated (...) by enhancement of the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. Data on the risk of congenital malformation following use of diazepam in pregnancy are highly confounded by the research techniques employed in the majority of the available studies. Evidence is therefore conflicting; with some older studies suggesting possible increased risks of congenital malformation, including orofacial clefts and cardiac malformations. More recent, better designed studies

2014 UK Teratology Information Service

9. Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. (PubMed)

Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug.This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system (...) infection. The patients were randomly prescribed with oral clobazam (37 cases) or diazepam (35 cases) when they developed a febrile disease. They were advised to use the medications during the first 48 h of the onset of fever. All the patients were monitored regarding developing seizure and adverse effects of the drugs. All patients were followed for 12 months.Overall, 243 episodes of fever occurred during the period, including 116 episodes in the clobazam group and 127 episodes in the diazepam group

2011 Indian journal of pediatrics

10. Midazolam and diazepam for pediatric seizures in the prehospital setting. (PubMed)

Midazolam and diazepam for pediatric seizures in the prehospital setting. The objective of this study was to compare the efficacy and adverse events associated with the use of diazepam and midazolam for the treatment of pediatric seizures in the prehospital setting.This was a retrospective cohort study of all patients younger than 18 years treated for a seizure with a benzodiazepine by emergency medical services in Multnomah County, Oregon, from 1998 to 2001. The emergency medical services (...) system consists of a single private advanced life support transporting ambulance service with fire department first responders that are all advanced life support capable. The benzodiazepine used changed from diazepam to midazolam at the midpoint of this period. The primary outcomes were termination of the seizure by arrival to the emergency department (ED), recurrence of seizure while in the ED, or the requirement for active airway interventions including intubation. The two cohorts were also

2017 Prehospital emergency care

11. Diazepam

Diazepam Top results for diazepam - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

12. Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. (PubMed)

Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. Seizures are very common in children. They frequently happen in outpatient settings, in the presence of caregivers who are not always trained in their management. First-line rescue therapy is based on benzodiazepine, historically diazepam. Recent studies have investigated the use of other benzodiazepines in the treatment of acute seizures.The aims of this study were to evaluate (...) the management of pediatric seizures carried out by parents or caregivers in an outpatient setting and to evaluate the differences in terms of immediate management and subsequent outcome when comparing the use of rectal diazepam versus buccal midazolam.In this retrospective study, medical records of children consulting for seizures at the Robert Debré Pediatric Emergency Department of Paris, France, over 18 months were analyzed to evaluate seizure characteristics, management by caregivers, received

2017 Pediatric Emergency Care

13. Prophylactic diazepam in febrile convulsions. (PubMed)

Prophylactic diazepam in febrile convulsions. 434919 1979 06 29 2018 11 13 1468-2044 54 3 1979 Mar Archives of disease in childhood Arch. Dis. Child. Prophylactic diazepam in febrile convulsions. 244-5 Dianese G G eng Letter England Arch Dis Child 0372434 0003-9888 Q3JTX2Q7TU Diazepam AIM IM Child Child, Preschool Diazepam therapeutic use Female Humans Infant Male Seizures prevention & control Seizures, Febrile prevention & control 1979 3 1 1979 3 1 0 1 1979 3 1 0 0 ppublish 434919 PMC1545219

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1979 Archives of Disease in Childhood

14. Intravenous diazepam, midazolam and lorazepam in acute seizure control. (PubMed)

Intravenous diazepam, midazolam and lorazepam in acute seizure control. To evaluate the safety and efficacy of three benzodiazepine drugs: Lorazepam, Midazolam and Diazepam, when given parenterally in the control of acute seizure.One hundred and twenty children of either sex in the age group 6 month to 14 years brought convulsing to the pediatric emergency services, were enrolled in the study. These were randomised to three equal groups of 40 patients each; Group A-received diazepam, Group B (...) was analysed statistically using student's t-test and chi-square test.Mean duration to clinical seizure cessation was comparable among the three groups. For diazepam group it was 84.94 ± 38.56 s, for midazolam group it was 92.69 ± 25.97 s, for lorazepam group it was 91.12 ± 23.58 s. Number of patients with any abnormality in seizure cessation were significantly higher in diazepam group [11/40 (27.5%)] when compared to the midazolam [4/40 (10%)] and lorazepam group [2/40 (5%)]. Number of patients requiring

2012 Indian journal of pediatrics

15. Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial. (PubMed)

Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial. Anterior shoulder dislocation is one of the most common complaints of patients referred to emergency departments. Intravenous opiates and benzodiazepines are traditionally prescribed in order to relieve the pain in this group of patients; however, complications always pose a problem.To compare the pain relief and complications following intra-articular lidocaine (...) and intravenous meperidine/diazepam in patients with anterior shoulder dislocation.48 patients with non-habitual traumatic anterior dislocation of the glenohumoral joint admitted to Imam Khomeini hospital emergency department were enrolled in this randomised clinical trial. They were divided into two groups: one group of patients received intra-articular lidocaine 1%, while the other received intravenous meperidine and diazepam. Closed reduction using the countertraction-traction method was performed

2008 Emergency Medicine Journal

16. Sedative effect of oral diazepam and chloral hydrate in the dental treatment of children. (PubMed)

Sedative effect of oral diazepam and chloral hydrate in the dental treatment of children. The purpose was to evaluate two sedation protocols during dental sessions in anxious children.It was a randomized and double-blind study, with each individual being his/her own control within each protocol. Furthermore, the two protocols were compared. Twenty children (36 to 84 months old) who exhibited "definitely negative" behavior according to the Frankl scale were assigned to receive oral chloral (...) hydrate (40 mg/kg) (Group I) or Diazepam (5 mg) (Group II). Behavior during local anesthesia, application of rubber dam, cavity preparation, restorative procedures was evaluated, considering the degree of sleep, body movement, crying and overall behavior. Vital signs were assessed at three different times. The Wilcoxon, Mann-Whitney, Exact Fisher's and Spearman correlation tests were used to analyze the data.Group I presented higher scores for sleep during the CH session than placebo session during

2007 Journal of the Indian Society of Pedodontics and Preventive Dentistry

17. Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. (PubMed)

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. Status epilepticus (SE) is a life-threatening and commonly drug-refractory condition. Novel therapies are needed to rapidly terminate seizures to prevent mortality and morbidity. Monoacylglycerol lipase (MAGL) is the key enzyme responsible for the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG) and a major contributor to the brain (...) pool of arachidonic acid (AA). Inhibiting of monoacylglycerol lipase modulates synaptic activity and neuroinflammation, 2 mediators of excessive neuronal activation underlying seizures. We studied the effect of a potent and selective irreversible MAGL inhibitor, CPD-4645, on SE that was refractory to diazepam, its neuropathologic sequelae, and the mechanism underlying the drug's effects.Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor

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2017 Epilepsia

18. Diazepam Is No Better Than Placebo When Added to Naproxen for Acute Low Back Pain. (PubMed)

Diazepam Is No Better Than Placebo When Added to Naproxen for Acute Low Back Pain. Low back pain causes more than 2.5 million visits to US emergency departments (EDs) annually. Low back pain patients are often treated with nonsteroidal anti-inflammatory drugs and benzodiazepines. The former is an evidence-based intervention, whereas the efficacy of the latter has not been established. We compare pain and functional outcomes 1 week and 3 months after ED discharge among patients randomized to a 1 (...) -week course of naproxen+diazepam versus naproxen+placebo.This was a randomized, double-blind, comparative efficacy clinical trial conducted in an urban health care system. Patients presenting with acute, nontraumatic, nonradicular low back pain of no more than a duration of 2 weeks were eligible for enrollment immediately before discharge from an ED if they had a score greater than 5 on the Roland-Morris Disability Questionnaire, a validated 24-item inventory of functional impairment caused by low

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2017 Annals of Emergency Medicine

19. Diazepam

Diazepam Diazepam Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diazepam Diazepam Aka: Diazepam , Valium From Related Chapters II (...) administering with VI. Adverse Reactions Common ral affects Drowsiness with withdrawal symptoms Local injection side affects (inject slowly) Venous thrombosis Phlebitis VII. Dosing Dose: 2 to 10 mg PO bid to qid Maximum Daily Dose: 40 mg Acute First day: 10 mg PO tid to qid Next days: 5 mg PO tid to qid Musculoskeletal spasm Dose: 2 to 10 mg PO tid to qid disorder Dose: 2 to 10 mg PO qd Older patients or with comorbid condition Dose: 2 to 2.5 mg PO qd to bid VIII. Preparations Equivalents to 10 mg Diazepam

2018 FP Notebook

20. Non-intravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: a systematic review

Non-intravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2015 PROSPERO