Latest & greatest articles for diazepam

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Top results for diazepam

1. Diazepam

Diazepam Top results for diazepam - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

2. Diazepam Use With Standard Management for Acute Low Back Pain

Diazepam Use With Standard Management for Acute Low Back Pain Diazepam Use With Standard Management for Acute Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Diazepam Use With Standard (...) Intervention/treatment Phase Low Back Pain Drug: Naproxen Drug: Placebo Drug: Diazepam Phase 2 Phase 3 Detailed Description: Low back pain (LBP) causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In general, outcomes for these patients are poor. One week after ED discharge, 70% of patients report persistent back-pain related functional impairment and 69% report analgesic use within the previous 24 hours. Three months after the ED visit, 48% of these patients

2015 Clinical Trials

3. What is the evidence, or otherwise, for giving diazepam for acute back pain?

What is the evidence, or otherwise, for giving diazepam for acute back pain? What is the evidence, or otherwise, for giving diazepam for acute back pain? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing (...) including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com What is the evidence, or otherwise, for giving diazepam for acute back pain? ATTRACT found very little evidence with which to answer this query. The CKS guidance on acute low back pain (1) recommends on the use of diazepam

2014 TRIP Answers

4. Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help Full Text available with Trip Pro

Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help | BMJ EBM Spotlight by By Dr. Geoffrey Modest An urban emergency room study found lack of utility of diazepam in patients with acute low back pain (see ). Details: 114 patients with acute, nontraumatic, nonradicular low back pain (LBP) of <2 weeks and Roland-Morris Disability Questionnaire (RMDQ) >5 points (a 24-item patient self (...) , with either diazepam 5mg or placebo, to take 1-2 tabs every 12 hours prn. All patients got a 10-minute LBP educational session Results: 112 patients (98%) provided 1-week follow-up At 1 week: Frequency of med use: Naproxen: 70% more than 1x/d, 17% 1x/d Diazepam: 38% more than 1x/d, 32% 1x/d Placebo: 38% more than 1x/d, 29% 1x/d 18 of 57 patients on diazepam (32%) reported moderate or severe LBP 12 of 55 on placebo (22%) had moderate or severe LBP At 3 months: 6 of 50 patients on diazepam (12%) reported

2017 Evidence-Based Medicine blog

5. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

2002 NHS Economic Evaluation Database.

6. The Lorazepam and Diazepam Protocol for Catatonia Due to General Medical Condition and Substance in Liaison Psychiatry. Full Text available with Trip Pro

The Lorazepam and Diazepam Protocol for Catatonia Due to General Medical Condition and Substance in Liaison Psychiatry. The lorazepam-diazepam protocol had been proved to rapidly and effectively relieve catatonia in patients with schizophrenia or mood disorder. This study aims to investigate the efficacy of lorazepam-diazepam protocol in catatonia due to general medical conditions (GMC) and substance.Patients with catatonia that required psychiatric intervention in various settings of a medical (...) center were included. The lorazepam-diazepam protocol had been used to treat the catatonia due to GMC or substance according to DSM-IV criteria. The treatment response had been assessed by two psychiatrists.Eighteen (85.7%) of 21 catatonic patients due to GMC or substance became free of catatonia after the lorazepam-diazepam protocol. Five (23.8%) of the 21 patients had passed away with various causes of death and wide range of time periods after catatonia.Our results showed that the lorazepam

2017 PLoS ONE

7. [Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. (Abstract)

[Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. 4272092 1974 03 02 2013 11 21 0025-8512 24 45 1973 Nov 09 Die Medizinische Welt Med Welt [Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. 1747-51 Moll W W ger Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Zur Therapie akuter (...) lumbovertebraler Syndrome durch optimale medikamentöse Muskelrelaxation mittels Diazepam. Germany Med Welt 0376641 0025-8512 0 Muscle Relaxants, Central 0 Placebos Q3JTX2Q7TU Diazepam IM Adult Aged Back Pain drug therapy Clinical Trials as Topic Diazepam adverse effects therapeutic use Female Humans Intervertebral Disc drug effects Lumbar Vertebrae Male Middle Aged Muscle Relaxants, Central therapeutic use Placebos 1973 11 9 1973 11 9 0 1 1973 11 9 0 0 ppublish 4272092

1974 Die Medizinische Welt Controlled trial quality: uncertain

8. Diazepam

Diazepam USE OF DIAZEPAM IN PREGNANCY 0344 892 0909 USE OF DIAZEPAM IN PREGNANCY (Date of issue: January 2012 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Diazepam is a long-acting benzodiazepine used as a hypnotic, anxiolytic, anticonvulsant and muscle relaxant. Its actions are mediated (...) by enhancement of the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. Data on the risk of congenital malformation following use of diazepam in pregnancy are highly confounded by the research techniques employed in the majority of the available studies. Evidence is therefore conflicting; with some older studies suggesting possible increased risks of congenital malformation, including orofacial clefts and cardiac malformations. More recent, better designed studies

2014 UK Teratology Information Service

9. Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. Full Text available with Trip Pro

Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical (...) , including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed

2019 PLoS ONE

10. Comparison of Effectiveness of Topiramate and Diazepam in Preventing Risk of Recurrent Febrile Seizure in Children under Age of 2 Years. (Abstract)

Comparison of Effectiveness of Topiramate and Diazepam in Preventing Risk of Recurrent Febrile Seizure in Children under Age of 2 Years. Febrile seizures are the most common type of convulsions. Medicinal prophylaxis is sometimes used for children at high risk of recurrent febrile seizure. In certain circumstances, conventional drugs such as diazepam and phenobarbital cannot be used and the need for alternative medicines is felt. This study compared the effectiveness of topiramate and diazepam (...) in preventing the risk of recurrent febrile seizure in children under 2 yr old.This randomized controlled trial, in Besat Hospital in Hamedan, Iran from 22 Nov 2013 to 22 Nov 2015 (Registered code: IRCT Number: IRCT2015010120527N1), included 54 patients, at risk of recurrent febrile seizure, inhibited from taking phenobarbital. Samples were randomly divided into two groups. The first group received diazepam treatment during fever episodes and the second group received daily dose of topiramate. A one-year

2018 Iranian journal of child neurology Controlled trial quality: uncertain

11. Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures

Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03631901 Recruitment Status : Recruiting

2018 Clinical Trials

12. Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. (Abstract)

Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. Seizures are very common in children. They frequently happen in outpatient settings, in the presence of caregivers who are not always trained in their management. First-line rescue therapy is based on benzodiazepine, historically diazepam. Recent studies have investigated the use of other benzodiazepines in the treatment of acute seizures.The aims of this study were to evaluate (...) the management of pediatric seizures carried out by parents or caregivers in an outpatient setting and to evaluate the differences in terms of immediate management and subsequent outcome when comparing the use of rectal diazepam versus buccal midazolam.In this retrospective study, medical records of children consulting for seizures at the Robert Debré Pediatric Emergency Department of Paris, France, over 18 months were analyzed to evaluate seizure characteristics, management by caregivers, received

2017 Pediatric Emergency Care

13. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Full Text available with Trip Pro

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin

2014 JAMA Controlled trial quality: predicted high

14. Diazepam Full Text available with Trip Pro

Diazepam Diazepam - Wikipedia Diazepam From Wikipedia, the free encyclopedia Diazepam Clinical data Pronunciation Valium, Vazepam, others / : (Evidence of risk) Moderate Moderate By mouth, , , ( ) Legal status (Prescription only) for higher doses) In general: ℞ (Prescription only) data 76% (64–97%) by mouth, 81% (62–98%) rectal — (minor route) to , (major route) to inactive metabolites, (major route) to desmethyldiazepam (50 hours); 20–100 hours (36–200 hours for main active metabolite (...) desmethyldiazepam) Identifiers 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-3 H -1,4-benzodiazepin-2-one Y N Y Y Y Y Chemical and physical data C 16 H 13 Cl N 2 O 7002284740000000000♠ 284.74 g·mol −1 3D model ( ) CN1C2=C(C(C3=CC=CC=C3)=NCC1=O)C=C(Cl)C=C2 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 Y Key:AAOVKJBEBIDNHE-UHFFFAOYSA-N Y N Y Diazepam , first marketed as Valium , is a medicine of the family that typically produces a calming effect. It is commonly used

2012 Wikipedia

15. Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. Full Text available with Trip Pro

Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. Febrile seizure is the most common neurologic problem in children between 3 months to 5 years old. Two to five percent of children aged less than five yr old will experience it at least one time. This type of seizure is age dependent and its recurrence rate is about 33% overalls and 50% in children less than one yr old. The prophylactic treatment is still controversial (...) , so we conducted a randomized controlled clinical trial to find out the effectiveness of continuous phenobarbital versus intermittent diazepam for febrile seizure.This clinical trial was conducted in the Department of Pediatric Neurology, Babol University of Medical Sciences, Babol, Iran between March 2008 and October 2010. All children from 6 month to 5 yr old referred to Amirkola Children's Hospital, Babol, Iran were enrolled in the study. Children with febrile seizure that had indication

2016 Iranian journal of child neurology Controlled trial quality: uncertain

16. Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile. (Abstract)

Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile. Vaginal diazepam is frequently used to treat pelvic floor tension myalgia and pelvic pain despite limited knowledge of systemic absorption.To determine the pharmacokinetic and adverse event profile of diazepam vaginal suppositories.We used a prospective pharmacokinetic design with repeated assessments of diazepam levels. Eight healthy volunteers were administered a 10-mg compounded vaginal diazepam (...) suppository in the outpatient gynecologic clinic. Serum samples were collected at 0, 45, 90, 120, and 180 minutes; 8, 24, and 72 hours; and 1 week following administration of a 10-mg vaginal suppository. The occurrence of adverse events was assessed using the alternate step and tandem walk tests, the Brief Confusion Assessment Method, and numerical ratings. Plasma concentrations of diazepam and active long-acting metabolites were measured. Pharmacokinetic parameters were calculated by standard

2019 Journal Of Sexual Medicine

17. Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia Full Text available with Trip Pro

Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia Preferred anticonvulsant used to treat and prevent fits in eclampsia currently is magnesium sulphate. Clinical monitoring of tendon reflexes, respiration rate and measuring hourly urine output should be done to ensures safe administration of magnesium sulphate.This study was conducted to evaluate maternal outcomes of magnesium sulphate and diazepam use in the management (...) was considered statistically significant in all tests.A total of 357 patient charts, 217 from magnesium sulphate and 140 from diazepam treated pregnant women group, were reviewed and analyzed. Three pregnant women from the magnesium sulphate treated group and eleven pregnant women from diazepam treated group had at least one convulsion after taking the drug. Greater proportion of patients in the magnesium sulphate treated group had less than four days postpartum stay as compared to the diazepam treated

2014 Pharmacy Practice

18. Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure. Full Text available with Trip Pro

Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure. Altered autonomic activity has been implicated in the development of cardiac dysfunction during seizures. This study investigates whether intervening in seizure progression with diazepam will reduce seizure-induced cardiomyopathy. Second, this study examines the hypothesis that combining atenolol with diazepam, as an intervention after seizure onset, will combat cardiac injury during status epilepticus.Male (...) Sprague-Dawley rats were implanted with electroencephalographic/electrocardiographic electrodes to allow simultaneous recordings during seizures induced by intrahippocampal (2 nmol, 1 μL) kainic acid (KA). Subcutaneous saline, atenolol (5 mg·kg-1 ), diazepam (5 mg·kg-1 ), or atenolol and diazepam (n = 12/group) were administered at 60 minutes post-KA and daily for 7 days, at which point echocardiography, susceptibility to aconitine-induced arrhythmias, and histology were evaluated.Seizure activity

2018 Epilepsia

19. Oral Olanzapine Versus Haloperidol or Diazepam

Oral Olanzapine Versus Haloperidol or Diazepam Oral Olanzapine Versus Haloperidol or Diazepam - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral Olanzapine Versus Haloperidol or Diazepam The safety (...) , Hong Kong Information provided by (Responsible Party): Dr. Esther Wai Yin Chan, The University of Hong Kong Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether oral olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or diazepam when used in the management of acute agitation in the emergency. Condition or disease Intervention/treatment Phase Acute Agitation Behavioural Emergency

2017 Clinical Trials

20. [Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam]. Full Text available with Trip Pro

[Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam]. to summarize the previously published results of a multicenter randomized clinical research phase III study trial of afobazole (INN: fabomotizole) versus diazepam in the treatment of patients with generalized anxiety disorder (GAD) and adjustment disorders (AD).Five investigating (...) centers included 150 patients aged 18 to 60 years (60 patients with GAD and 90 with AD) a simple structure of anxiety disorders without concurrent mental, neurological or somatic disorders. Patients were randomized to take afobazole (30 mg/day; n=100) or diazepam (30 mg/day; n=50) for 30 days. Prior to drug administration, patients susceptible to placebo were excluded according to the results of its 7-day use. Withdrawal syndrome was evaluated within 10 days after completion of active therapy

2016 Terapevticheskii Arkhiv Controlled trial quality: uncertain