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Latest & greatest articles for diazepam
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Diazepam Top results for diazepam - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted
A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over
Diazepam Use With Standard Management for Acute Low Back Pain Diazepam Use With Standard Management for Acute Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Diazepam Use With Standard (...) Intervention/treatment Phase Low Back Pain Drug: Naproxen Drug: Placebo Drug: Diazepam Phase 2 Phase 3 Detailed Description: Low back pain (LBP) causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In general, outcomes for these patients are poor. One week after ED discharge, 70% of patients report persistent back-pain related functional impairment and 69% report analgesic use within the previous 24 hours. Three months after the ED visit, 48% of these patients
Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours when the rectal temperature was greater than or equal to 38.5 degree C. Children (...) admitted on odd days were given treatment with phenobarbitone, 3.5 +/- 1 mg/kg per day. 156 children completed treatment and outpatient control for a year, 83 in the diazepam and 73 in the phenobarbitone group. The rate of recurrence was independent of the prophylactic and 15--16 % of the children in both groups had new febrile convulsions within a year. The recurrence rate after 6 months was also similar, 11% in the diazepam group and 9% in the phenobarbitone group. New convulsions were of similar
Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin
What is the evidence, or otherwise, for giving diazepam for acute back pain? What is the evidence, or otherwise, for giving diazepam for acute back pain? - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing (...) including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org What is the evidence, or otherwise, for giving diazepam for acute back pain? ATTRACT found very little evidence with which to answer this query. The CKS guidance on acute low back pain (1) recommends on the use of diazepam
Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help | BMJ EBM Spotlight by By Dr. Geoffrey Modest An urban emergency room study found lack of utility of diazepam in patients with acute low back pain (see ). Details: 114 patients with acute, nontraumatic, nonradicular low back pain (LBP) of <2 weeks and Roland-Morris Disability Questionnaire (RMDQ) >5 points (a 24-item patient self (...) , with either diazepam 5mg or placebo, to take 1-2 tabs every 12 hours prn. All patients got a 10-minute LBP educational session Results: 112 patients (98%) provided 1-week follow-up At 1 week: Frequency of med use: Naproxen: 70% more than 1x/d, 17% 1x/d Diazepam: 38% more than 1x/d, 32% 1x/d Placebo: 38% more than 1x/d, 29% 1x/d 18 of 57 patients on diazepam (32%) reported moderate or severe LBP 12 of 55 on placebo (22%) had moderate or severe LBP At 3 months: 6 of 50 patients on diazepam (12%) reported
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial. To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children.Randomized clinical trial.Pediatric emergency department.Children aged 2 months to 14 years admitted to the study facility with seizures.Patients were randomized to receive DZP-IV or MDZ-IM.Groups were compared
Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug.This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system (...) infection. The patients were randomly prescribed with oral clobazam (37 cases) or diazepam (35 cases) when they developed a febrile disease. They were advised to use the medications during the first 48 h of the onset of fever. All the patients were monitored regarding developing seizure and adverse effects of the drugs. All patients were followed for 12 months.Overall, 243 episodes of fever occurred during the period, including 116 episodes in the clobazam group and 127 episodes in the diazepam group
Midazolam and diazepam for pediatric seizures in the prehospital setting. The objective of this study was to compare the efficacy and adverse events associated with the use of diazepam and midazolam for the treatment of pediatric seizures in the prehospital setting.This was a retrospective cohort study of all patients younger than 18 years treated for a seizure with a benzodiazepine by emergency medical services in Multnomah County, Oregon, from 1998 to 2001. The emergency medical services (...) system consists of a single private advanced life support transporting ambulance service with fire department first responders that are all advanced life support capable. The benzodiazepine used changed from diazepam to midazolam at the midpoint of this period. The primary outcomes were termination of the seizure by arrival to the emergency department (ED), recurrence of seizure while in the ED, or the requirement for active airway interventions including intubation. The two cohorts were also
DiazepamDiazepam - Wikipedia Diazepam From Wikipedia, the free encyclopedia Diazepam Clinical data Pronunciation Valium, Vazepam, others / : (Evidence of risk) Moderate Moderate By mouth, , , ( ) Legal status (Prescription only) for higher doses) In general: ℞ (Prescription only) data 76% (64–97%) by mouth, 81% (62–98%) rectal — (minor route) to , (major route) to inactive metabolites, (major route) to desmethyldiazepam (50 hours); 20–100 hours (36–200 hours for main active metabolite (...) desmethyldiazepam) Identifiers 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-3 H -1,4-benzodiazepin-2-one Y N Y Y Y Y Chemical and physical data C 16 H 13 Cl N 2 O 7002284740000000000♠ 284.74 g·mol −1 3D model ( ) CN1C2=C(C(C3=CC=CC=C3)=NCC1=O)C=C(Cl)C=C2 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 Y Key:AAOVKJBEBIDNHE-UHFFFAOYSA-N Y N Y Diazepam , first marketed as Valium , is a medicine of the family that typically produces a calming effect. It is commonly used
Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia Preferred anticonvulsant used to treat and prevent fits in eclampsia currently is magnesium sulphate. Clinical monitoring of tendon reflexes, respiration rate and measuring hourly urine output should be done to ensures safe administration of magnesium sulphate.This study was conducted to evaluate maternal outcomes of magnesium sulphate and diazepam use in the management (...) was considered statistically significant in all tests.A total of 357 patient charts, 217 from magnesium sulphate and 140 from diazepam treated pregnant women group, were reviewed and analyzed. Three pregnant women from the magnesium sulphate treated group and eleven pregnant women from diazepam treated group had at least one convulsion after taking the drug. Greater proportion of patients in the magnesium sulphate treated group had less than four days postpartum stay as compared to the diazepam treated
Intravenous diazepam, midazolam and lorazepam in acute seizure control. To evaluate the safety and efficacy of three benzodiazepine drugs: Lorazepam, Midazolam and Diazepam, when given parenterally in the control of acute seizure.One hundred and twenty children of either sex in the age group 6 month to 14 years brought convulsing to the pediatric emergency services, were enrolled in the study. These were randomised to three equal groups of 40 patients each; Group A-received diazepam, Group B (...) was analysed statistically using student's t-test and chi-square test.Mean duration to clinical seizure cessation was comparable among the three groups. For diazepam group it was 84.94 ± 38.56 s, for midazolam group it was 92.69 ± 25.97 s, for lorazepam group it was 91.12 ± 23.58 s. Number of patients with any abnormality in seizure cessation were significantly higher in diazepam group [11/40 (27.5%)] when compared to the midazolam [4/40 (10%)] and lorazepam group [2/40 (5%)]. Number of patients requiring
Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Masuko A H, Castro A A, Santos G R, Atallah A N, do Prado L B, de Carvalho L B, do Prado G F CRD summary (...) This review examined the effectiveness of phenobarbital and diazepam for the prophylaxis of febrile seizures in children. The authors stated that no conclusions could be drawn regarding the effectiveness of the two drugs, owing to the differing nature of the primary studies. Overall, the authors' conclusions are in line with the evidence reviewed and appear warranted. Authors' objectives To assess the effectiveness of phenobarbital and diazepam versus placebo for the prophylaxis of febrile seizures
The Lorazepam and Diazepam Protocol for Catatonia Due to General Medical Condition and Substance in Liaison Psychiatry. The lorazepam-diazepam protocol had been proved to rapidly and effectively relieve catatonia in patients with schizophrenia or mood disorder. This study aims to investigate the efficacy of lorazepam-diazepam protocol in catatonia due to general medical conditions (GMC) and substance.Patients with catatonia that required psychiatric intervention in various settings of a medical (...) center were included. The lorazepam-diazepam protocol had been used to treat the catatonia due to GMC or substance according to DSM-IV criteria. The treatment response had been assessed by two psychiatrists.Eighteen (85.7%) of 21 catatonic patients due to GMC or substance became free of catatonia after the lorazepam-diazepam protocol. Five (23.8%) of the 21 patients had passed away with various causes of death and wide range of time periods after catatonia.Our results showed that the lorazepam
Sedative effect of oral diazepam and chloral hydrate in the dental treatment of children. The purpose was to evaluate two sedation protocols during dental sessions in anxious children.It was a randomized and double-blind study, with each individual being his/her own control within each protocol. Furthermore, the two protocols were compared. Twenty children (36 to 84 months old) who exhibited "definitely negative" behavior according to the Frankl scale were assigned to receive oral chloral (...) hydrate (40 mg/kg) (Group I) or Diazepam (5 mg) (Group II). Behavior during local anesthesia, application of rubber dam, cavity preparation, restorative procedures was evaluated, considering the degree of sleep, body movement, crying and overall behavior. Vital signs were assessed at three different times. The Wilcoxon, Mann-Whitney, Exact Fisher's and Spearman correlation tests were used to analyze the data.Group I presented higher scores for sleep during the CH session than placebo session during
A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures. The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures. A randomized controlled study was conducted in a pediatric emergency department in a tertiary general hospital. Fifty children aged from 1 month to 12 years presenting with acute seizures of at least 10 min (...) duration were enrolled during a 12 month period. Intranasal midazolam (0.2 mg/kg) and intravenous diazepam (0.3 mg/kg) were administered. The main outcome measures were interval between arrival at hospital and starting treatment and interval between arrival at hospital and cessation of seizures. Intranasal midazolam and intravenous diazepam were equally effective. Overall 18 of 27 seizures were controlled with midazolam and 15 of 23 with diazepam. The mean interval between arrival at hospital
Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial. Anterior shoulder dislocation is one of the most common complaints of patients referred to emergency departments. Intravenous opiates and benzodiazepines are traditionally prescribed in order to relieve the pain in this group of patients; however, complications always pose a problem.To compare the pain relief and complications following intra-articular lidocaine (...) and intravenous meperidine/diazepam in patients with anterior shoulder dislocation.48 patients with non-habitual traumatic anterior dislocation of the glenohumoral joint admitted to Imam Khomeini hospital emergency department were enrolled in this randomised clinical trial. They were divided into two groups: one group of patients received intra-articular lidocaine 1%, while the other received intravenous meperidine and diazepam. Closed reduction using the countertraction-traction method was performed
[Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. 4272092 1974 03 02 2013 11 21 0025-8512 24 45 1973 Nov 09 Die Medizinische Welt Med Welt [Therapy of acute lumbovertebral syndromes through optimal muscle relaxation using diazepam. Results of a double-blind study on 68 cases]. 1747-51 Moll W W ger Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial Zur Therapie akuter (...) lumbovertebraler Syndrome durch optimale medikamentöse Muskelrelaxation mittels Diazepam. Germany Med Welt 0376641 0025-8512 0 Muscle Relaxants, Central 0 Placebos Q3JTX2Q7TU Diazepam IM Adult Aged Back Pain drug therapy Clinical Trials as Topic Diazepam adverse effects therapeutic use Female Humans Intervertebral Disc drug effects Lumbar Vertebrae Male Middle Aged Muscle Relaxants, Central therapeutic use Placebos 1973 11 9 1973 11 9 0 1 1973 11 9 0 0 ppublish 4272092
Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment. The mechanisms underlying autism spectrum disorder (ASD) remain unclear, and clinical biomarkers are not yet available for ASD. Differences in dysregulated proteins in ASD have shown little reproducibility, which is partly due to ASD heterogeneity. Recent studies have demonstrated that subgrouping ASD cases based on clinical (...) , including ASD with severe language impairment, and transcriptome profiling identified dysregulated genes in each subgroup. Screening via proteome analysis revealed 82 altered proteins in the ASD subgroup with severe language impairment. Eighteen of these proteins were further identified by nano-LC-MS/MS. Among these proteins, fourteen were predicted by IPA to be associated with neurological functions and inflammation. Among these proteins, diazepam-binding inhibitor (DBI) protein was confirmed