Latest & greatest articles for diazepam

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Top results for diazepam

1. Diazepam

Diazepam Top results for diazepam - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

2. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

2002 NHS Economic Evaluation Database.

3. Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. (Full text)

Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. Febrile seizure is the most common neurologic problem in children between 3 months to 5 years old. Two to five percent of children aged less than five yr old will experience it at least one time. This type of seizure is age dependent and its recurrence rate is about 33% overalls and 50% in children less than one yr old. The prophylactic treatment is still controversial (...) , so we conducted a randomized controlled clinical trial to find out the effectiveness of continuous phenobarbital versus intermittent diazepam for febrile seizure.This clinical trial was conducted in the Department of Pediatric Neurology, Babol University of Medical Sciences, Babol, Iran between March 2008 and October 2010. All children from 6 month to 5 yr old referred to Amirkola Children's Hospital, Babol, Iran were enrolled in the study. Children with febrile seizure that had indication

2016 Iranian journal of child neurology Controlled trial quality: uncertain PubMed abstract

4. Prospective Randomized Study of Oral Diazepam and Baclofen on Spasticity in Cerebral Palsy. (Full text)

Prospective Randomized Study of Oral Diazepam and Baclofen on Spasticity in Cerebral Palsy. Spastic cerebral palsy (CP) is the most common form of CP. Diazepam and Baclofen are the most commonly used oral drugs to manage spasticity. Study was designed to evaluate and compare their effects and safety in CP children.Study was aimed to assess and compare outcome of oral Diazepam and Baclofen in spastic cerebral palsy children in terms of extent of reduction of spasticity and side effects (...) profile.Randomized prospective follow-up study was done for one year after giving Diazepam and Baclofen in weekly incremental doses upto recommended maximum dose to 60 children for three months. Two primary outcome measures were spasticity reduction and adverse effect profile. Spasticity reduction was measured by Modified Ashworth's Scale (MAS) and Range of Motion improvement (ROM).After random allocation, there was no baseline difference between groups. Mean MAS score improved from 1.96±0.4 at baseline to 1.63

2016 Journal of clinical and diagnostic research : JCDR Controlled trial quality: uncertain PubMed abstract

5. Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. (Full text)

Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours when the rectal temperature was greater than or equal to 38.5 degree C. Children (...) admitted on odd days were given treatment with phenobarbitone, 3.5 +/- 1 mg/kg per day. 156 children completed treatment and outpatient control for a year, 83 in the diazepam and 73 in the phenobarbitone group. The rate of recurrence was independent of the prophylactic and 15--16 % of the children in both groups had new febrile convulsions within a year. The recurrence rate after 6 months was also similar, 11% in the diazepam group and 9% in the phenobarbitone group. New convulsions were of similar

1978 Archives of disease in childhood Controlled trial quality: uncertain PubMed abstract

6. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. (Full text)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin

2014 JAMA Controlled trial quality: predicted high PubMed abstract

7. Diazepam

Diazepam USE OF DIAZEPAM IN PREGNANCY 0344 892 0909 USE OF DIAZEPAM IN PREGNANCY (Date of issue: January 2012 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Diazepam is a long-acting benzodiazepine used as a hypnotic, anxiolytic, anticonvulsant and muscle relaxant. Its actions are mediated (...) by enhancement of the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. Data on the risk of congenital malformation following use of diazepam in pregnancy are highly confounded by the research techniques employed in the majority of the available studies. Evidence is therefore conflicting; with some older studies suggesting possible increased risks of congenital malformation, including orofacial clefts and cardiac malformations. More recent, better designed studies

2014 UK Teratology Information Service

8. Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help

Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help Primary Care Corner with Geoffrey Modest MD: Acute low back pain diazepam not help | BMJ EBM Spotlight by By Dr. Geoffrey Modest An urban emergency room study found lack of utility of diazepam in patients with acute low back pain (see ). Details: 114 patients with acute, nontraumatic, nonradicular low back pain (LBP) of <2 weeks and Roland-Morris Disability Questionnaire (RMDQ) >5 points (a 24-item patient self (...) , with either diazepam 5mg or placebo, to take 1-2 tabs every 12 hours prn. All patients got a 10-minute LBP educational session Results: 112 patients (98%) provided 1-week follow-up At 1 week: Frequency of med use: Naproxen: 70% more than 1x/d, 17% 1x/d Diazepam: 38% more than 1x/d, 32% 1x/d Placebo: 38% more than 1x/d, 29% 1x/d 18 of 57 patients on diazepam (32%) reported moderate or severe LBP 12 of 55 on placebo (22%) had moderate or severe LBP At 3 months: 6 of 50 patients on diazepam (12%) reported

2017 Evidence-Based Medicine blog

9. Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. (Abstract)

Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. Seizures are very common in children. They frequently happen in outpatient settings, in the presence of caregivers who are not always trained in their management. First-line rescue therapy is based on benzodiazepine, historically diazepam. Recent studies have investigated the use of other benzodiazepines in the treatment of acute seizures.The aims of this study were to evaluate (...) the management of pediatric seizures carried out by parents or caregivers in an outpatient setting and to evaluate the differences in terms of immediate management and subsequent outcome when comparing the use of rectal diazepam versus buccal midazolam.In this retrospective study, medical records of children consulting for seizures at the Robert Debré Pediatric Emergency Department of Paris, France, over 18 months were analyzed to evaluate seizure characteristics, management by caregivers, received

2017 Pediatric Emergency Care

10. Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial. (Abstract)

Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial. To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children.Randomized clinical trial.Pediatric emergency department.Children aged 2 months to 14 years admitted to the study facility with seizures.Patients were randomized to receive DZP-IV or MDZ-IM.Groups were compared

2014 Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias Controlled trial quality: uncertain

11. Use of diazepam in treatment of severe convulsive status epilepticus. (Full text)

Use of diazepam in treatment of severe convulsive status epilepticus. 4961468 1967 09 03 2018 11 13 0007-1447 3 5557 1967 Jul 08 British medical journal Br Med J Use of diazepam in treatment of severe convulsive status epilepticus. 85-8 Parsonage M J MJ Norris J W JW eng Journal Article England Br Med J 0372673 0007-1447 Q3JTX2Q7TU Diazepam AIM IM Adolescent Adult Child Diazepam therapeutic use Epilepsy, Tonic-Clonic drug therapy Female Humans Infusions, Parenteral Injections, Intramuscular

1967 British medical journal PubMed abstract

12. Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. (Abstract)

Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug.This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system (...) infection. The patients were randomly prescribed with oral clobazam (37 cases) or diazepam (35 cases) when they developed a febrile disease. They were advised to use the medications during the first 48 h of the onset of fever. All the patients were monitored regarding developing seizure and adverse effects of the drugs. All patients were followed for 12 months.Overall, 243 episodes of fever occurred during the period, including 116 episodes in the clobazam group and 127 episodes in the diazepam group

2011 Indian journal of pediatrics Controlled trial quality: uncertain

13. Midazolam and diazepam for pediatric seizures in the prehospital setting. (Abstract)

Midazolam and diazepam for pediatric seizures in the prehospital setting. The objective of this study was to compare the efficacy and adverse events associated with the use of diazepam and midazolam for the treatment of pediatric seizures in the prehospital setting.This was a retrospective cohort study of all patients younger than 18 years treated for a seizure with a benzodiazepine by emergency medical services in Multnomah County, Oregon, from 1998 to 2001. The emergency medical services (...) system consists of a single private advanced life support transporting ambulance service with fire department first responders that are all advanced life support capable. The benzodiazepine used changed from diazepam to midazolam at the midpoint of this period. The primary outcomes were termination of the seizure by arrival to the emergency department (ED), recurrence of seizure while in the ED, or the requirement for active airway interventions including intubation. The two cohorts were also

2006 Prehospital emergency care

14. Diazepam

Diazepam Diazepam - Wikipedia Diazepam From Wikipedia, the free encyclopedia Diazepam Clinical data Pronunciation Valium, Vazepam, others / : (Evidence of risk) Moderate Moderate By mouth, , , ( ) Legal status (Prescription only) for higher doses) In general: ℞ (Prescription only) data 76% (64–97%) by mouth, 81% (62–98%) rectal — (minor route) to , (major route) to inactive metabolites, (major route) to desmethyldiazepam (50 hours); 20–100 hours (36–200 hours for main active metabolite (...) desmethyldiazepam) Identifiers 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-3 H -1,4-benzodiazepin-2-one Y N Y Y Y Y Chemical and physical data C 16 H 13 Cl N 2 O 7002284740000000000♠ 284.74 g·mol −1 3D model ( ) CN1C2=C(C(C3=CC=CC=C3)=NCC1=O)C=C(Cl)C=C2 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 Y Key:AAOVKJBEBIDNHE-UHFFFAOYSA-N Y N Y Diazepam , first marketed as Valium , is a medicine of the family that typically produces a calming effect. It is commonly used

2012 Wikipedia

15. Intravenous diazepam, midazolam and lorazepam in acute seizure control. (Abstract)

Intravenous diazepam, midazolam and lorazepam in acute seizure control. To evaluate the safety and efficacy of three benzodiazepine drugs: Lorazepam, Midazolam and Diazepam, when given parenterally in the control of acute seizure.One hundred and twenty children of either sex in the age group 6 month to 14 years brought convulsing to the pediatric emergency services, were enrolled in the study. These were randomised to three equal groups of 40 patients each; Group A-received diazepam, Group B (...) was analysed statistically using student's t-test and chi-square test.Mean duration to clinical seizure cessation was comparable among the three groups. For diazepam group it was 84.94 ± 38.56 s, for midazolam group it was 92.69 ± 25.97 s, for lorazepam group it was 91.12 ± 23.58 s. Number of patients with any abnormality in seizure cessation were significantly higher in diazepam group [11/40 (27.5%)] when compared to the midazolam [4/40 (10%)] and lorazepam group [2/40 (5%)]. Number of patients requiring

2012 Indian journal of pediatrics Controlled trial quality: uncertain

16. Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia (Full text)

Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia Preferred anticonvulsant used to treat and prevent fits in eclampsia currently is magnesium sulphate. Clinical monitoring of tendon reflexes, respiration rate and measuring hourly urine output should be done to ensures safe administration of magnesium sulphate.This study was conducted to evaluate maternal outcomes of magnesium sulphate and diazepam use in the management (...) was considered statistically significant in all tests.A total of 357 patient charts, 217 from magnesium sulphate and 140 from diazepam treated pregnant women group, were reviewed and analyzed. Three pregnant women from the magnesium sulphate treated group and eleven pregnant women from diazepam treated group had at least one convulsion after taking the drug. Greater proportion of patients in the magnesium sulphate treated group had less than four days postpartum stay as compared to the diazepam treated

2014 Pharmacy Practice PubMed abstract

17. Prophylactic diazepam in febrile convulsions. (Full text)

Prophylactic diazepam in febrile convulsions. 434919 1979 06 29 2018 11 13 1468-2044 54 3 1979 Mar Archives of disease in childhood Arch. Dis. Child. Prophylactic diazepam in febrile convulsions. 244-5 Dianese G G eng Letter England Arch Dis Child 0372434 0003-9888 Q3JTX2Q7TU Diazepam AIM IM Child Child, Preschool Diazepam therapeutic use Female Humans Infant Male Seizures prevention & control Seizures, Febrile prevention & control 1979 3 1 1979 3 1 0 1 1979 3 1 0 0 ppublish 434919 PMC1545219

1979 Archives of Disease in Childhood PubMed abstract

18. Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis

Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Masuko A H, Castro A A, Santos G R, Atallah A N, do Prado L B, de Carvalho L B, do Prado G F CRD summary (...) This review examined the effectiveness of phenobarbital and diazepam for the prophylaxis of febrile seizures in children. The authors stated that no conclusions could be drawn regarding the effectiveness of the two drugs, owing to the differing nature of the primary studies. Overall, the authors' conclusions are in line with the evidence reviewed and appear warranted. Authors' objectives To assess the effectiveness of phenobarbital and diazepam versus placebo for the prophylaxis of febrile seizures

2003 DARE.

19. Sedative effect of oral diazepam and chloral hydrate in the dental treatment of children. (Abstract)

Sedative effect of oral diazepam and chloral hydrate in the dental treatment of children. The purpose was to evaluate two sedation protocols during dental sessions in anxious children.It was a randomized and double-blind study, with each individual being his/her own control within each protocol. Furthermore, the two protocols were compared. Twenty children (36 to 84 months old) who exhibited "definitely negative" behavior according to the Frankl scale were assigned to receive oral chloral (...) hydrate (40 mg/kg) (Group I) or Diazepam (5 mg) (Group II). Behavior during local anesthesia, application of rubber dam, cavity preparation, restorative procedures was evaluated, considering the degree of sleep, body movement, crying and overall behavior. Vital signs were assessed at three different times. The Wilcoxon, Mann-Whitney, Exact Fisher's and Spearman correlation tests were used to analyze the data.Group I presented higher scores for sleep during the CH session than placebo session during

2007 Journal of the Indian Society of Pedodontics and Preventive Dentistry Controlled trial quality: uncertain

20. Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial. (Abstract)

Intra-articular lidocaine versus intravenous meperidine/diazepam in anterior shoulder dislocation: a randomised clinical trial. Anterior shoulder dislocation is one of the most common complaints of patients referred to emergency departments. Intravenous opiates and benzodiazepines are traditionally prescribed in order to relieve the pain in this group of patients; however, complications always pose a problem.To compare the pain relief and complications following intra-articular lidocaine (...) and intravenous meperidine/diazepam in patients with anterior shoulder dislocation.48 patients with non-habitual traumatic anterior dislocation of the glenohumoral joint admitted to Imam Khomeini hospital emergency department were enrolled in this randomised clinical trial. They were divided into two groups: one group of patients received intra-articular lidocaine 1%, while the other received intravenous meperidine and diazepam. Closed reduction using the countertraction-traction method was performed

2008 Emergency Medicine Journal Controlled trial quality: uncertain