Latest & greatest articles for diazepam

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on diazepam or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on diazepam and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for diazepam

1. Diazepam

Diazepam Top results for diazepam - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for diazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

2. Acute Liver Failure due to Trazodone and Diazepam (PubMed)

Acute Liver Failure due to Trazodone and Diazepam Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone (...) and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians' awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.

Full Text available with Trip Pro

2016 GE Portuguese journal of gastroenterology

3. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. (PubMed)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin

Full Text available with Trip Pro

2014 JAMA

4. Diazepam

Diazepam USE OF DIAZEPAM IN PREGNANCY 0344 892 0909 USE OF DIAZEPAM IN PREGNANCY (Date of issue: January 2012 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Diazepam is a long-acting benzodiazepine used as a hypnotic, anxiolytic, anticonvulsant and muscle relaxant. Its actions are mediated (...) by enhancement of the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. Data on the risk of congenital malformation following use of diazepam in pregnancy are highly confounded by the research techniques employed in the majority of the available studies. Evidence is therefore conflicting; with some older studies suggesting possible increased risks of congenital malformation, including orofacial clefts and cardiac malformations. More recent, better designed studies

2014 UK Teratology Information Service

5. For Child Patients With Anxiety In The Dental Office, The Use Of Nitrous Oxide Augments The Sedative Effects Of Orally Administered Diazepam

For Child Patients With Anxiety In The Dental Office, The Use Of Nitrous Oxide Augments The Sedative Effects Of Orally Administered Diazepam UTCAT2422, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Child Patients With Anxiety In The Dental Office, The Use Of Nitrous Oxide Augments The Sedative Effects Of Orally Administered Diazepam Clinical Question In a child patient undergoing dental treatment, will sedation (...) with nitrous oxide and diazepam, as compared to treatment with diazepam alone, reduce patient anxiety and improve the overall quality of the sedation? Clinical Bottom Line For child patients with anxiety in the dental office, the use of nitrous oxide augments the sedative effects of orally administered diazepam. The evaluation of the overall sedative effects of the diazepam and nitrous oxide together were better than the sedative effects of diazepam alone. Best Evidence (you may view more info by clicking

2013 UTHSCSA Dental School CAT Library

6. Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy (PubMed)

Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy.Prospective randomized study.Patients' homes and a freestanding children's hospital that serves as a referral center for 5 states.A total of 358 pediatric patients who visited a pediatric neurology clinic from July

Full Text available with Trip Pro

2010 EvidenceUpdates

7. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. (PubMed)

Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children.This was a single-blind, randomized clinical trial in which 330 patients were randomly assigned to receive buccal midazolam or rectal diazepam. The trial was conducted in the pediatric emergency unit (...) of the national referral hospital of Uganda. Consecutive patients who were aged 3 months to 12 years and presented while convulsing or who experienced a seizure that lasted >5 minutes were randomly assigned to receive buccal midazolam plus rectal placebo or rectal diazepam plus buccal placebo. The primary outcome of this study was cessation of visible seizure activity within 10 minutes without recurrence in the subsequent hour.Treatment failures occurred in 71 (43.0%) of 165 patients who received rectal

2008 EvidenceUpdates

8. Lorazepam or diazepam in paediatric status epilepticus

Lorazepam or diazepam in paediatric status epilepticus BestBets: Lorazepam or diazepam in paediatric status elipticus Lorazepam or diazepam in paediatric status elipticus Report By: Vince Choudhery - Specialist Registrar Search checked by Will Townend - Specialist Registrar Emergency Medicine Institution: North Western Emergency Medicine Specialist Registrar NW Rotation Current web editor: Richard Body - Clinical Research Fellow Date Submitted: 1st March 2000 Date Completed: 24th May 2006 Last (...) Modified: 21st April 2006 Status: Green (complete) Three Part Question In [children in status epilepticus] is [lorazepam better than diazepam] at [safely terminating the seizure]? Clinical Scenario A 2 year old is brought to the emergency department with a first presentation of fitting secondary to febrile illness. She has been fitting for >30 minutes. You obtain intravenous access and wonder if lorazepam or diazepam would be best at terminating the fit safely. Search Strategy Medline 1966-9/99 using

2006 BestBETS

9. Diazepam (as Diazemuls and Stesolid)

Diazepam (as Diazemuls and Stesolid) Diazepam (as Diazemuls and Stesolid) - updated guidance DZP Drugs May 2010 Page 1 of 2 PRESENTATION Ampoule containing 10 milligrams diazepam in an oil-in-water emulsion making up 2ml of milky white ?uid (Diazemuls). Rectal tube containing 2.5 milligrams, 5 milligrams or 10 milligrams diazepam (Stesolid). INDICATIONS Fits longer than 5 minutes and STILL FITTING. Repeated ?ts – not secondary to an uncorrected hypoxia or hypoglycaemic episode. Status (...) and safely obtained, which is particularly likely in the case of children. In small children Stesolid should be considered the ?rst choice treatment and IV access sought subsequently. The earlier the drug is given the more likely the patient is to respond, which is why the rectal route is preferred in children, while the IV route is sought. Diazepam should only be used if the patient has been ?tting for >5 minutes (and is still ?tting), or if ?ts recur in rapid succession without time for full recovery

2006 Joint Royal Colleges Ambulance Liaison Committee

10. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. (PubMed)

Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Rectal diazepam and buccal midazolam are used for emergency treatment of acute febrile and afebrile (epileptic) seizures in children. We aimed to compare the safety and efficacy of these drugs.A multicentre, randomised controlled trial was undertaken to compare buccal midazolam with rectal diazepam for emergency-room treatment of children aged 6 months (...) ) for buccal midazolam and 27% (30 of 110) for rectal diazepam (percentage difference 29%, 95% CI 16-41). Analysing only initial episodes revealed a similar result. The rate of respiratory depression did not differ between groups. When centre, age, known diagnosis of epilepsy, use of antiepileptic drugs, prior treatment, and length of seizure before treatment were adjusted for with logistic regression, buccal midazolam was more effective than rectal diazepam.Buccal midazolam was more effective than rectal

2005 Lancet

11. Intranasal midazolam or rectal diazepam in patients with fits

Intranasal midazolam or rectal diazepam in patients with fits BestBets: Intranasal midazolam or rectal diazepam in patients with fits Intranasal midazolam or rectal diazepam in patients with fits Report By: Martin Smith - Consultant in Emergency Medicine Search checked by Simon Carley - Consultant in Emergency Medicine Institution: Manchester STEM Current web editor: Russell Boyd - Consultant in Emergency Medicine Date Submitted: 1st March 2000 Date Completed: 31st May 2005 Last Modified: 19th (...) May 2005 Status: Green (complete) Three Part Question In [a fitting patient with no intravenous access] can [intranasal midazolam or rectal diazepam] stop [the fit]? Clinical Scenario A 14 year old known epileptic attends the Emergency department having had a fit at school. His teacher is with him. She tells you that he was fitting for approximately twenty minutes. She also tells you that they have rectal diazepam at school but the staff were reluctant to administer it. You check the patient

2005 BestBETS

12. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence

Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence BestBets: Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence Report By: Richard Body - SHO, A&E Rotation Search checked by Mawra Ijaz - Staff Grade, Paediatrics Institution: Stepping Hill Hospital Date Submitted: 27th January 2004 (...) Date Completed: 18th May 2005 Last Modified: 18th May 2005 Status: Green (complete) Three Part Question In [children with prolonged seizures] does [buccal midazolam or rectal diazepam] lead to [quicker resolution of seizures]? Clinical Scenario An 11 year-old girl, known to be epileptic, is brought to the Emergency Department with a prolonged seizure. You have no intravenous access at this point. A colleague recently mentioned that buccal midazolam is an available alternative to rectal diazepam

2005 BestBETS

13. Cost-effectiveness of venlafaxine XL compared with diazepam in the treatment of generalised anxiety disorder in the United Kingdom

Cost-effectiveness of venlafaxine XL compared with diazepam in the treatment of generalised anxiety disorder in the United Kingdom Cost-effectiveness of venlafaxine XL compared with diazepam in the treatment of generalised anxiety disorder in the United Kingdom Cost-effectiveness of venlafaxine XL compared with diazepam in the treatment of generalised anxiety disorder in the United Kingdom Guest J F, Russ J, Lenox-Smith A Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study compared the effectiveness and costs of venlafaxine XL (Efexor XL) and diazepam for the treatment of generalised anxiety disorder (GAD) among non-depressed patients. Patients received either 75 mg venlafaxine XL once daily or 5 mg diazepam 3

2005 NHS Economic Evaluation Database.

14. Magnesium sulphate versus diazepam for eclampsia. (PubMed)

Magnesium sulphate versus diazepam for eclampsia. Eclampsia, the occurrence of a convulsion in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further fits.The objective of this review was to assess the effects of magnesium sulphate compared with diazepam when used for the care of women with eclampsia. Magnesium sulphate is compared with phenytoin and with lytic cocktail (...) in other Cochrane reviews.We searched the Cochrane Pregnancy and Childbirth trials register (28 November 2002) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2002).Randomised trials comparing magnesium sulphate (intravenous or intramuscular administration) with diazepam for women with a clinical diagnosis of eclampsia.Both reviewers assessed and extracted data.Seven trials involving 1441 women are included. Most of the data are from trials of good quality

2003 Cochrane

15. Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis

Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Masuko A H, Castro A A, Santos G R, Atallah A N, do Prado L B, de Carvalho L B, do Prado G F CRD summary (...) This review examined the effectiveness of phenobarbital and diazepam for the prophylaxis of febrile seizures in children. The authors stated that no conclusions could be drawn regarding the effectiveness of the two drugs, owing to the differing nature of the primary studies. Overall, the authors' conclusions are in line with the evidence reviewed and appear warranted. Authors' objectives To assess the effectiveness of phenobarbital and diazepam versus placebo for the prophylaxis of febrile seizures

2003 DARE.

16. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

2002 NHS Economic Evaluation Database.

17. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. (PubMed)

A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus.We conducted a randomized, double-blind trial to evaluate intravenous benzodiazepines administered by paramedics for the treatment of out-of-hospital status epilepticus. Adults with prolonged (lasting five minutes or more) or repetitive (...) generalized convulsive seizures received intravenous diazepam (5 mg), lorazepam (2 mg), or placebo. An identical second injection was given if needed.Of the 205 patients enrolled, 66 received lorazepam, 68 received diazepam, and 71 received placebo. Status epilepticus had been terminated on arrival at the emergency department in more patients treated with lorazepam (59.1 percent) or diazepam (42.6 percent) than patients given placebo (21.1 percent) (P=0.001). After adjustment for covariates, the odds

2001 NEJM

18. Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. (PubMed)

Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study. To compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of children with prolonged febrile seizures.Prospective randomised study.Paediatric emergency department in a general hospital.47 children aged six months to five years with prolonged febrile seizure (at least 10 minutes) during a 12 month (...) period.Intranasal midazolam (0.2 mg/kg) and intravenous diazepam (0.3 mg/kg).Time from arrival at hospital to starting treatment and cessation of seizures.Intranasal midazolam and intravenous diazepam were equally effective. Overall, 23 of 26 seizures were controlled with midazolam and 24 out of 26 with diazepam. The mean time from arrival at hospital to starting treatment was significantly shorter in the midazolam group (3.5 (SD 1.8) minutes, 95% confidence interval 3.3 to 3.7) than the diazepam group (5.5

Full Text available with Trip Pro

2000 BMJ

19. Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study

Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2000 PedsCCM Evidence-Based Journal Club

20. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. (PubMed)

Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Convulsive status epilepticus is the most common neurological medical emergency and has high morbidity and mortality. Early treatment before admission to hospital is best with an effective medication that can be administered safely. We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal (...) administration of liquid diazepam in the acute treatment of seizures.At a residential school with on-site medical facilities 42 young people with severe epilepsy were enrolled. Continuous seizures of more than 5 min duration were randomly treated with buccal midazolam or rectal diazepam. If the seizure did not stop within 10 min additional medication chosen by the attending physician was administered. We monitored oxygen saturation and blood pressure for 30 min after treatment. The main outcome measures were

1999 Lancet