Latest & greatest articles for depression

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Top results for depression

41. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials.

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. BACKGROUND: Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently needed. We assessed brexanolone injection (formerly SAGE-547 injection), a positive allosteric modulator of γ-aminobutyric-acid type A (GABA A ) receptors, for the treatment of moderate to severe post-partum depression. METHODS: We (...) did two double-blind, randomised, placebo-controlled, phase 3 trials, at 30 clinical research centres and specialised psychiatric units in the USA. Eligible women were aged 18-45 years, 6 months post partum or less at screening, with post-partum depression and a qualifying 17-item Hamilton Rating Scale for Depression (HAM-D) score (≥26 for study 1; 20-25 for study 2). Women with renal failure requiring dialysis, anaemia, known allergy to allopregnanolone or to progesterone, or medical history

Lancet2018

42. Talking therapies may prevent relapse of depression

Talking therapies may prevent relapse of depression Signal - Talking therapies may prevent relapse of depression Dissemination Centre Discover Portal NIHR DC Discover Talking therapies may prevent relapse of depression Published on 30 September 2015 This review looked at how effective different psychological "talking" therapies were at preventing relapse of depression. It found that cognitive behavioural therapy, mindfulness-based cognitive therapy and interpersonal psychotherapy all reduced (...) the risk of depression relapse over a year by 20 to 25% compared with a control treatment. There was further evidence that the effect for cognitive behavioural therapy was sustained up to two years. This reinforces NICE guidance, which recommends that cognitive behavioural therapy or mindfulness-based cognitive therapy be offered to people at risk of a relapse of depression. The trial results suggested factors like participant characteristics and treatment delivery affected treatment success

NIHR Dissemination Centre2018

43. E-Health interventions for anxiety and depression in children and adolescents with long-term physical conditions.

E-Health interventions for anxiety and depression in children and adolescents with long-term physical conditions. BACKGROUND: Long-term physical conditions affect 10% to 12% of children and adolescents worldwide; these individuals are at greater risk of developing psychological problems, particularly anxiety and depression. Access to face-to-face treatment for such problems is often limited, and available interventions usually have not been tested with this population. As technology improves, e (...) , or non-psychological treatments for treating anxiety and depression in children and adolescents with long-term physical conditions. SEARCH METHODS: We searched the Cochrane Common Mental Disorders Group's Controlled Trials Register (CCMDTR to May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 8, 2017), Web of Science (1900 - 18 August 2016, updated 31 August 2017) and Ovid MEDLINE, Embase, PsycINFO (cross-search 2016 to 18 Aug 2017). We hand-searched relevant conference

Cochrane2018

44. Cardiorespiratory fitness and response to exercise treatment in depression

Cardiorespiratory fitness and response to exercise treatment in depression 30140446 2018 11 14 2056-4724 4 5 2018 Sep BJPsych open BJPsych Open Cardiorespiratory fitness and response to exercise treatment in depression. 346-351 10.1192/bjo.2018.45 Exercise improves cardiorespiratory fitness (CRF) and reduces depressive symptoms in people with depression. It is unclear if changes in CRF are a predictor of the antidepressant effect of exercise in people with depression. To investigate whether (...) an increase in CRF is a predictor of depression severity reduction after 12 weeks of exercise (trial registration: DRKS study ID, DRKS00008745). The present study includes participants who took part in vigorous ( n = 33), moderate ( n = 38) and light ( n = 39) intensity exercise and had CRF information (as predicted maximal oxygen uptake, V̇ O 2max ) collected before and after the intervention. Depression severity was measured with the Montgomery-Åsberg Depression Rating Scale (MADRS). V̇ O 2max (L/min

BJPsych open2018 Full Text: Link to full Text with Trip Pro

45. Step-by-Step: a new WHO digital mental health intervention for depression

Step-by-Step: a new WHO digital mental health intervention for depression 30225240 2018 11 14 2306-9740 4 2018 mHealth Mhealth Step-by-Step: a new WHO digital mental health intervention for depression. 34 10.21037/mhealth.2018.08.01 The World Health Organization is developing a range of interventions, including technology supported interventions, to help address the mental health treatment gap, particularly in low and middle-income countries. One of these, Step-by-Step, is a guided, technology (...) supported, intervention for depression. It provides psychoeducation and training in behavioural activation through an illustrated narrative with additional therapeutic techniques such as stress management (slow breathing), identifying strengths, positive self-talk, increasing social support and relapse prevention. Step-by-Step has been designed so that it can be adapted for use in settings with different cultural contexts and resource availability and to be meaningful in communities affected

mHealth2018 Full Text: Link to full Text with Trip Pro

46. Simpler, cheaper therapy (behavioural activation) can be as good as CBT for treating depression

Simpler, cheaper therapy (behavioural activation) can be as good as CBT for treating depression Signal - Simpler, cheaper therapy (behavioural activation) can be as good as CBT for treating depression Dissemination Centre Discover Portal NIHR DC Discover Simpler, cheaper therapy (behavioural activation) can be as good as CBT for treating depression Published on 5 October 2016 A simpler therapy called behavioural activation can be as effective at treating adults with depression as cognitive (...) behavioural therapy (CBT). Also, it is delivered more cheaply, by trained junior mental health workers. CBT is commonly provided to adults with depression and it is recommended by NICE as first- line treatment. However, it is complex to deliver and therapists are highly skilled and expensive. Behavioural activation is a simpler type of talking therapy that encourages people to develop more positive behaviour such as planning activities and doing constructive things that they would usually avoid doing. We did not know

NIHR Dissemination Centre2018

47. Depression

Depression Top results for depression - Trip Database or use your Google+ account Turning Research Into Practice My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing (...) the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for depression The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines

Trip Latest and Greatest2018

48. Postnatal depression

Postnatal depression Top results for postnatal depression - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box (...) and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for postnatal depression The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews

Trip Latest and Greatest2018

49. A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression

A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression 29921144 2018 06 23 1535-7228 2018 Jun 20 The American journal of psychiatry Am J Psychiatry A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression. appiajp201818030321 10.1176/appi.ajp.2018.18030321 Clinical depression in children as young as age 3 has been validated, and prevalence rates are similar (...) to the school-age disorder. Homotypic continuity between early and later childhood depression has been observed, with alterations in brain function and structure similar to those reported in depressed adults. These findings highlight the importance of identifying and treating depression as early as developmentally possible, given the relative treatment resistance and small effect sizes for treatments later in life. The authors conducted a randomized controlled trial of a dyadic parent-child psychotherapy

EvidenceUpdates2018

50. Work status, retirement, and depression in older adults: An analysis of six countries based on the Study on Global Ageing and Adult Health (SAGE)

Work status, retirement, and depression in older adults: An analysis of six countries based on the Study on Global Ageing and Adult Health (SAGE) 30101185 2018 12 07 2352-8273 6 2018 Dec SSM - population health SSM Popul Health Work status, retirement, and depression in older adults: An analysis of six countries based on the Study on Global Ageing and Adult Health (SAGE). 1-8 10.1016/j.ssmph.2018.07.008 The aim of the present study was to analyse the association between the occurrence (...) of a major depressive episode among older adults and work status in low- and medium-income countries. A cross-sectional study was conducted with people 60 years of age and older from the six countries (Mexico, India, China, Russian Federation, Ghana and South Africa) included in the Study on Global Ageing and Adult Health (SAGE) and who participated in its first wave (2009-2010). The occurrence of a major depressive episode (MDE) over the previous 12 months was determined based on an adaptation

SSM - population health2018 Full Text: Link to full Text with Trip Pro

51. Systematic Review: Depression and Anxiety Prevalence in Bladder Cancer Patients

Systematic Review: Depression and Anxiety Prevalence in Bladder Cancer Patients 30112443 2018 11 14 2352-3727 4 3 2018 Jul 30 Bladder cancer (Amsterdam, Netherlands) Bladder Cancer Systematic Review: Depression and Anxiety Prevalence in Bladder Cancer Patients. 319-326 10.3233/BLC-180181 Depression affects more than 300 million people of all ages worldwide. In patients with cancer the reported prevalence is up to 24%. To systematically review the literature to report the prevalence (...) of depression and anxiety among patients with bladder cancer (BC). Web of Science, MEDLINE/PubMed, and The Cochrane Library were searched between January and March 2018 using the terms "bladder carcinoma OR bladder cancer AND depression OR anxiety". Thirteen studies encompassing 1659 patients with BC were included. Six studies assessed depression prior and after treatment at 1, 6 and 12 months. Three were conducted in the US, one each in Turkey, Sweden/Egypt and China. Four studies showed a reduction

Bladder cancer (Amsterdam, Netherlands)2018 Full Text: Link to full Text with Trip Pro

52. Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial.

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial. Importance: Depression has been associated with poorer medical outcomes in acute coronary syndrome (ACS), but there are few data on the effects of antidepressant treatment on long-term prognosis. Objective: To investigate the effect on long-term major adverse cardiac events (MACE) of escitalopram treatment of depression in patients (...) with recent ACS. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled trial conducted among 300 patients with recent ACS and depression enrolled from May 2007 to March 2013, with follow-up completed in June 2017, at Chonnam National University Hospital, Gwangju, South Korea. Interventions: Patients were randomly assigned to receive either escitalopram in flexible dosages of 5, 10, 15, or 20 mg/d (n = 149) or matched placebo (n = 151) for 24 weeks. Main Outcomes and Measures

JAMA2018

53. Cost-effectiveness of internet-based cognitive–behavioural therapy and physical exercise for depression

Cost-effectiveness of internet-based cognitive–behavioural therapy and physical exercise for depression 30057780 2018 11 14 2056-4724 4 4 2018 Jul BJPsych open BJPsych Open Cost-effectiveness of internet-based cognitive-behavioural therapy and physical exercise for depression. 265-273 10.1192/bjo.2018.38 Both internet-based cognitive-behavioural therapy (ICBT) and physical exercise are alternatives to treatment as usual (TAU) in managing mild to moderate depression in primary (...) and €14 571 for physical exercise compared with TAU. At the established willingness-to-pay threshold of €21 536 (£20 000) per QALY, the probability of ICBT being cost-effective is 90%, and for physical exercise is 76%, compared with TAU. From a primary care perspective, both ICBT and physical exercise for depression are likely to be cost-effective compared with TAU. None. Kraepelien Martin M 0000-0002-5294-4156 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet

BJPsych open2018 Full Text: Link to full Text with Trip Pro

54. Mindfulness therapy may provide an alternative to continuing antidepressants in preventing recurrence of depression

Mindfulness therapy may provide an alternative to continuing antidepressants in preventing recurrence of depression Signal - Mindfulness therapy may provide an alternative to continuing antidepressants in preventing recurrence of depression Dissemination Centre Discover Portal NIHR DC Discover Mindfulness therapy may provide an alternative to continuing antidepressants in preventing recurrence of depression Published on 25 April 2015 This NIHR-funded RCT found no evidence that mindfulness-based (...) cognitive therapy was better than continuing antidepressant drugs in reducing depression relapse or recurrence for people at the highest risk of depression. There was also no significant difference in cost. When interpreted alongside the broader evidence for mindfulness-based cognitive therapy and the need for patient choice, the findings suggest an alternative for those patients wishing to consider an alternative to maintenance anti-depressants, and reinforce NICE guidance. However, service limitations

NIHR Dissemination Centre2018

55. Evaluation of reliable improvement rates in depression and anxiety at the end of treatment in adolescents

Evaluation of reliable improvement rates in depression and anxiety at the end of treatment in adolescents 29998818 2018 11 14 2056-4724 4 4 2018 Jul BJPsych open BJPsych Open Evaluation of reliable improvement rates in depression and anxiety at the end of treatment in adolescents. 250-255 10.1192/bjo.2018.31 Literature has focused on effect sizes rather than individual-level improvement rates to determine how effectively services address burgeoning numbers of adolescents with anxiety (...) and depression.AimsTo consider how many adolescents report reliable improvement in anxiety, depression and comorbid depression and anxiety by end of treatment. The primary outcome was reliable improvement (i.e. change greater than likely the result of measurement error) in self-reported anxiety and depression for N = 4464 adolescents (mean age 14.5 years, s.d. = 1.9; 75% female; 61% White) seen in specialist mental health services in England. In total, 53% of those with anxiety, 44% with depression, and 35

BJPsych open2018 Full Text: Link to full Text with Trip Pro

56. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management

Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting (...) editor-chosen studies with the greatest impact on clinical care. Know what's next when you read AAP Journals, . . This policy is a revision of the policy in February 2018 From the American Academy of Pediatrics Statement of Endorsement Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management Amy H. Cheung , Rachel A. Zuckerbrot , Peter S. Jensen , Danielle Laraque , Ruth E.K. Stein , GLAD-PC STEERING GROUP Abstract OBJECTIVES: To update clinical

American Academy of Pediatrics2018

57. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management

Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos (...) ); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen studies with the greatest impact on clinical care. Know what's next when you read AAP Journals, . . This policy is a revision of the policy in From the American Academy of Pediatrics Statement of Endorsement Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management Rachel A. Zuckerbrot , Amy Cheung , Peter S. Jensen , Ruth E.K

American Academy of Pediatrics2018

58. Cognitive-behavioural therapy does not meaningfully reduce depression in most people with epilepsy: a systematic review of clinically reliable improvement

Cognitive-behavioural therapy does not meaningfully reduce depression in most people with epilepsy: a systematic review of clinically reliable improvement 29735512 2018 05 08 1468-330X 2018 May 07 Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Cognitive - behavioural therapy does not meaningfully reduce depression in most people with epilepsy: a systematic review of clinically reliable improvement. jnnp-2018-317997 10.1136/jnnp-2018-317997 Psychological (...) treatment is recommended for depression and anxiety in those with epilepsy. This review used standardised criteria to evaluate, for the first time, the clinical relevance of any symptom change these treatments afford patients. Databases were searched until March 2017 for relevant trials in adults. Trial quality was assessed and trial authors asked for individual participants' pre-treatment and post-treatment distress data. Jacobson's methodology determined the proportion in the different trial arms

EvidenceUpdates2018

59. Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials

Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials 29800984 2018 06 07 2168-6238 75 6 2018 Jun 01 JAMA psychiatry JAMA Psychiatry Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials. 566-576 10.1001/jamapsychiatry.2018.0572 The physical benefits of resistance exercise training (RET) are well (...) documented, but less is known regarding the association of RET with mental health outcomes. To date, no quantitative synthesis of the antidepressant effects of RET has been conducted. To estimate the association of efficacy of RET with depressive symptoms and determine the extent to which logical, theoretical, and/or prior empirical variables are associated with depressive symptoms and whether the association of efficacy of RET with depressive symptoms accounts for variability in the overall effect size

EvidenceUpdates2018

60. Postpartum depression

Postpartum depression Autosynthesis - Trip Database or use your Google+ account Find evidence fast My query is: English Français Deutsch Čeština Español Magyar Svenska ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search

Trip Evidence Maps2018