Latest & greatest articles for cyclobenzaprine

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Top results for cyclobenzaprine

1. Cyclobenzaprine

Cyclobenzaprine Top results for cyclobenzaprine - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 (...) or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for cyclobenzaprine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other

2018 Trip Latest and Greatest

2. Is cyclobenzaprine useful for pain?

Is cyclobenzaprine useful for pain? RCT bias 5 - 15mg spasticity anti-muscarinic High dose CNS depressant T1/2 > 18h sedative Parkinsons rigidity Is cyclobenzaprine useful for pain? March - April 2017 Mailing Address: Therapeutics Initiative The University of British Columbia Department of Anesthesiology, Pharmacology & Therapeutics 2176 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 Tel.: 604 822 0700 Fax: 604 822 0701 E-mail: info@ti.ubc.ca www.ti.ubc.ca 105 C yclobenzaprine is a tricyclic (...) molecule discovered in 1956 that is structurally related to amitriptyline and imipramine. Evaluated first as a possible tranquilizer, it was noted to have atropine-like properties in animals. 1 In Can- ada, Merck Frosst Research Laboratories envisaged cyclo- benzaprine as a centrally active skeletal muscle relaxant. 2 However, it was soon apparent that despite being sedative and anti-muscarinic, cyclobenzaprine was not useful for spasticity 3 , nor for rigidity in Parkinson’s disease 4 . Health Canada

2017 Therapeutics Letter

3. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. (PubMed)

Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination.To compare functional outcomes and pain at 1 week and 3 months after an ED visit for acute LBP among (...) patients randomized to a 10-day course of (1) naproxen + placebo; (2) naproxen + cyclobenzaprine; or (3) naproxen + oxycodone/acetaminophen.This randomized, double-blind, 3-group study was conducted at one urban ED in the Bronx, New York City. Patients who presented with nontraumatic, nonradicular LBP of 2 weeks' duration or less were eligible for enrollment upon ED discharge if they had a score greater than 5 on the Roland-Morris Disability Questionnaire (RMDQ). The RMDQ is a 24-item questionnaire

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2015 JAMA

4. Cyclobenzaprine and back pain: a meta-analysis

Cyclobenzaprine and back pain: a meta-analysis Cyclobenzaprine and back pain: a meta-analysis Cyclobenzaprine and back pain: a meta-analysis Browning R, Jackson J L, O'Malley P G Authors' objectives To perform a systematic review of the effectiveness of cyclobenzaprine in the treatment of back pain. Searching MEDLINE (from January 1966 to December 1999), PsycLIT (from November 1887 to December 1999), CINAHL (from 1982 to 1999), EMBASE (from January 1974 to December 1999), AIDSLINE, HealthSTAR (...) , Cancerlit and MICROMEDEX were searched. The searches were conducted using the textwords and keywords (all languages) 'cyclobenzaprine', and the MeSH terms 'dibenzocycloheptenes' and 'propylamines' combined with the following textwords: 'back pain', 'backache', 'low back pain', 'lumbago', 'acute muscle spasm' or 'muscle spasm'. Other databases searched were the Cochrane Controlled Trials Register for randomised trials, the Cochrane Database of Systematic Reviews, and Federal Research in Progress

2001 DARE.

5. Cyclobenzaprine in intractable pain syndromes with muscle spasm. (PubMed)

Cyclobenzaprine in intractable pain syndromes with muscle spasm. The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by skeletal muscle spasm and tenderness. The investigation was double-blind and randomized, comparing cyclobenzaprine hydrochloride (10 mg three times a day) with diazepam (5 mg three times a day) and with placebo. After two weeks of treatment (...) , the 16 patients in the cyclobenzaprine group showed an overall improvement in pain variables as did the 16 patients in the diazepam group. No serious adverse reactions to cyclobenzaprine were observed in the study. However, dry mouth due to cyclobenzaprine's anticholinergic action and mild degrees of drowsiness were encountered more often than with diazepam or placebo.

1978 JAMA