Latest & greatest articles for cyanocobalamin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on cyanocobalamin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on cyanocobalamin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for cyanocobalamin

1. Cyanocobalamin

Cyanocobalamin Top results for cyanocobalamin - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for cyanocobalamin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

2. Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients Full Text available with Trip Pro

Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients Standard treatment of cobalamin (vitamin B12) deficiency involvesregular (1000 μg/mo) IM cyanocobalamin administration. It has been suggested that high-dose (>2000 μg/d) oral cyanocobalamin may be effective in patients with pernicious anemia.The aim of this study was to assess the efficacy and tolerability of oral crystalline cyanocobalamin 1000 μg/d (...) in patients with cobalamin deficiency related to established pernicious anemia.This open-label, prospective study was conducted at StrasbourgUniversity Hospital, Strasbourg, France. Patients aged ≥18 years with well-documented cobalamin deficiency related to pernicious anemia were enrolled. Patients received crystalline cyanocobalamin 1000 μg QD PO (capsule) for at least 3 months. Serum cobalamin, folate, iron, and homocysteine concentrations were measured, and a complete blood count was obtained, before

2005 Current therapeutic research, clinical and experimental

3. Sensitivity to cyanocobalamin and hydroxocobalamin. Full Text available with Trip Pro

Sensitivity to cyanocobalamin and hydroxocobalamin. 5572387 1971 06 19 2018 11 13 0007-1447 2 5756 1971 May 01 British medical journal Br Med J Sensitivity to cyanocobalamin and hydroxocobalamin. 262 James J J Warin R P RP eng Journal Article England Br Med J 0372673 0007-1447 P6YC3EG204 Vitamin B 12 Q40X8H422O Hydroxocobalamin AIM IM Administration, Oral Aged Anemia, Pernicious complications Drug Hypersensitivity Dyspnea chemically induced Female Headache chemically induced Humans

1971 British medical journal

4. The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk Full Text available with Trip Pro

The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk 14351201 2003 05 01 2018 12 01 0264-6021 59 2 1955 Feb The Biochemical journal Biochem. J. The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk. 329-34 GREGORY M E ME HOLDSWORTH E S ES eng Journal Article England Biochem J 2984726R 0264-6021 0 Carrier Proteins 0 Hematinics 0 Proteins

1955 Biochemical Journal

5. Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing

Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing National Horizon Scanning Centre Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation National Horizon Scanning Centre. Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing. Birmingham: National Horizon Scanning Centre (NHSC). 2007 Authors' objectives This study examines the use of Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Vitamin B 12 Deficiency /drug therapy Language Published English

2007 Health Technology Assessment (HTA) Database.

6. Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects. (Abstract)

Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects. Vitamin B12 (cobalamin) deficiency may be caused by inadequate dietary intake of B12 or by conditions that result in malabsorption of the vitamin. Crystalline vitamin B12, usually in the form of cyanocobalamin, is administered parenterally (ie, intramuscularly) or orally for treating deficiency states (...) . Intramuscular administration is widely accepted as a treatment method. Oral B12 supplementation is also used, but it is considered to be less reliable.This study was conducted to compare the pharmacokinetics and tolerability of 2 oral formulations of cyanocobalamin-a marketed cyanocobalamin tablet (immediate-release B12 5 mg) and cyanocobalamin formulated with a proprietary carrier, sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC)-to establish the feasibility of using an absorption enhancer with B12

2011 Clinical therapeutics Controlled trial quality: uncertain

7. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12) (Abstract)

Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12) To evaluate protein-bound cyanocobalamin (vitamin B12) absorption before and after omeprazole (Prilosec) therapy in healthy male volunteers.Clinical trial in which each volunteer served as his own control.Outpatient department of a university medical center.Ten healthy, male volunteers 22 to 50 years old.Each participant had a modified Schilling test (protein-bound cyanocobalamin) and a gastric analysis, as well (...) as measurements of serum vitamin B12, gastrin, and folate levels. Five patients were then randomly assigned to take either 20 mg or 40 mg of omeprazole daily. After 2 weeks of omeprazole therapy, these tests were repeated.The modified Schilling test, gastric analysis, serum gastrin level, folate level, and cyanocobalamin level.At the end of the 2-week treatment period, cyanocobalamin absorption decreased from 3.2% to 0.9% (P = 0.031) in participants receiving 20 mg of omeprazole daily. In patients taking 40

1994 Annals of internal medicine Controlled trial quality: uncertain

8. Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status

Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02679833 Recruitment Status : Completed First Posted : February 10, 2016 Last Update Posted : May 11, 2018 Sponsor: Saarland University Collaborator: Institute of Alternative and Sustainable

2016 Clinical Trials

9. Oral Cyanocobalamin (Eligen B12) Bioavailability Study

Oral Cyanocobalamin (Eligen B12) Bioavailability Study Oral Cyanocobalamin (Eligen B12) Bioavailability Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral Cyanocobalamin (Eligen B12) Bioavailability (...) : The purpose of this study is to assess and compare the pharmacokinetics (PK) of cyanocobalamin after the oral administration of Eligen® B12 (cyanocobalamin/SNAC), oral cyanocobalamin alone (commercially-available formulation) and cyanocobalamin administered intravenously (IV) (also a commercially-available formulation) to healthy male subjects under fasting conditions. The safety and tolerability of oral Eligen® B12 (cyanocobalamin/SNAC) versus oral cyanocobalamin alone and versus IV cyanocobalamin

2011 Clinical Trials

10. Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration

Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01306123 Recruitment Status : Completed First Posted : March 1, 2011 Last Update Posted

2011 Clinical Trials

11. Update on oral cyanocobalamin (vitamin b(12)) treatment in elderly patients. (Abstract)

Update on oral cyanocobalamin (vitamin b(12)) treatment in elderly patients. The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1) and prospective studies in a well defined population (n=5) provide evidence that oral cobalamin (...) therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature does not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment. This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections.

2008 Drugs & Aging

12. Short communication: Casein hydrolysate and whey proteins as excipients for cyanocobalamin to increase intestinal absorption in the lactating dairy cow. Full Text available with Trip Pro

Short communication: Casein hydrolysate and whey proteins as excipients for cyanocobalamin to increase intestinal absorption in the lactating dairy cow. Bioavailability of vitamin B12 is low in humans and animals. Improving vitamin B12 absorption is important for optimal performance in dairy cows and for increasing vitamin B12 concentrations in milk for human consumption. However, when supplemented in the diet, 80% of synthetic vitamin B12, cyanocobalamin (CN-CBL), is degraded in the rumen

2015 Journal of dairy science Controlled trial quality: uncertain

13. STUDIES ON THE ABSORPTION BY GUINEA PIG INTESTINE OF CYANOCOBALAMIN INCUBATED WITH INTRINSIC FACTOR Full Text available with Trip Pro

STUDIES ON THE ABSORPTION BY GUINEA PIG INTESTINE OF CYANOCOBALAMIN INCUBATED WITH INTRINSIC FACTOR 13881120 1998 11 01 2018 12 01 0021-9738 41 1962 Feb The Journal of clinical investigation J. Clin. Invest. Studies on the absorption by guinea pig intestine of cyanocobalamin incubated with intrinsic factor. 370-7 COOPER B A BA PARANCHYCH W W LOWENSTEIN L L eng Journal Article United States J Clin Invest 7802877 0021-9738 9008-12-2 Intrinsic Factor P6YC3EG204 Vitamin B 12 OM Gastric Fistula

1962 Journal of Clinical Investigation

14. EXCHANGE BETWEEN FREE AND GASTRIC JUICE-BOUND CYANOCOBALAMIN Full Text available with Trip Pro

EXCHANGE BETWEEN FREE AND GASTRIC JUICE-BOUND CYANOCOBALAMIN 14028585 1998 11 01 2018 12 01 0021-9738 42 1963 Apr The Journal of clinical investigation J. Clin. Invest. Exchange between free and gastric juice-bound cyanocobalamin. 534-45 DONALDSON R M RM Jr KATZ J H JH eng Journal Article United States J Clin Invest 7802877 0021-9738 P6YC3EG204 Vitamin B 12 OM Gastric Juice Vitamin B 12 GASTRIC JUICE VITAMIN B 12 1963 4 1 1963 4 1 0 1 1963 4 1 0 0 ppublish 14028585 10.1172/JCI104742 PMC289313

1963 Journal of Clinical Investigation

15. Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial

Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study (...) record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial The safety

2017 Clinical Trials

16. Estimation of intrinsic factor and detection of intrinsic factor antibodies using non-radioactive cyanocobalamin and microbiological assay Full Text available with Trip Pro

Estimation of intrinsic factor and detection of intrinsic factor antibodies using non-radioactive cyanocobalamin and microbiological assay A method employing non-radioactive vitamin B(12) and microbiological assay is described for estimating intrinsic factor in gastric juice and for detecting antibody to intrinsic factor in serum. Satisfactory agreement was obtained between the results by this method and by a modification of the method of Ardeman and Chanarin (1963). During the first hour after

1967 Journal of Clinical Pathology

17. An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption. Full Text available with Trip Pro

An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption. 5717560 1969 05 15 2013 11 21 0021-9746 21 6 1968 Nov Journal of clinical pathology J. Clin. Pathol. An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption. 792 Donaldson D D Lascelles P T PT eng Journal Article England J Clin Pathol 0376601 0021-9746 0 Cobalt Isotopes P6YC3EG204 Vitamin B 12 AIM IM Anemia, Pernicious blood metabolism Cobalt Isotopes Folic Acid Deficiency blood Humans

1968 Journal of Clinical Pathology

18. An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption1 Full Text available with Trip Pro

An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption1 A technique has been developed for accurately assaying serum and urine (57)Co cyanocobalamin during the conventional Schilling test. Serum and urine radioactivity in a large number of patients has been correlated and the precise normal limits have been determined by statistical analysis. The implications of this for investigating conditions other than pernicious anaemia and the malabsorption syndromes are stressed.

1970 Journal of Clinical Pathology

19. An evaluation of simultaneously administered free and intrinsic factor bound radioactive cyanocobalamin in the diagnosis of pernicious anaemia in the elderly Full Text available with Trip Pro

An evaluation of simultaneously administered free and intrinsic factor bound radioactive cyanocobalamin in the diagnosis of pernicious anaemia in the elderly The definitive diagnosis of pernicious anaemia (PA) in the elderly is by no means always straightforward, particularly when inappropriate medication has been introduced before the institution of specific investigatory procedures. A detailed haematological study was carried out on 301 patients aged 60-95 with a serum B(12) concentration

1979 Journal of Clinical Pathology

20. Some properties of the cyanocobalamin-protein complex from sow's milk, and the mode of linkage of cyanocobalamin with protein Full Text available with Trip Pro

Some properties of the cyanocobalamin-protein complex from sow's milk, and the mode of linkage of cyanocobalamin with protein 14351202 2003 05 01 2018 12 01 0264-6021 59 2 1955 Feb The Biochemical journal Biochem. J. Some properties of the cyanocobalamin-protein complex from sow's milk, and the mode of linkage of cyanocobalamin with protein. 335-40 GREGORY M E ME HOLDSWORTH E S ES eng Journal Article England Biochem J 2984726R 0264-6021 0 Proteins P6YC3EG204 Vitamin B 12 OM Animals Female Milk

1955 Biochemical Journal