Latest & greatest articles for cyanocobalamin

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Top results for cyanocobalamin

1. Update on oral cyanocobalamin (vitamin b(12)) treatment in elderly patients. (PubMed)

Update on oral cyanocobalamin (vitamin b(12)) treatment in elderly patients. The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1) and prospective studies in a well defined population (n=5) provide evidence that oral cobalamin (...) therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature does not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment. This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections.

2008 Drugs & Aging

2. Short communication: Casein hydrolysate and whey proteins as excipients for cyanocobalamin to increase intestinal absorption in the lactating dairy cow. (PubMed)

Short communication: Casein hydrolysate and whey proteins as excipients for cyanocobalamin to increase intestinal absorption in the lactating dairy cow. Bioavailability of vitamin B12 is low in humans and animals. Improving vitamin B12 absorption is important for optimal performance in dairy cows and for increasing vitamin B12 concentrations in milk for human consumption. However, when supplemented in the diet, 80% of synthetic vitamin B12, cyanocobalamin (CN-CBL), is degraded in the rumen

2015 Journal of dairy science

3. The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk (PubMed)

The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk 14351201 2003 05 01 2018 12 01 0264-6021 59 2 1955 Feb The Biochemical journal Biochem. J. The occurrence of a cyanocobalamin-binding protein in milk and the isolation of a cyanocobalamin-protein complex from sow's milk. 329-34 GREGORY M E ME HOLDSWORTH E S ES eng Journal Article England Biochem J 2984726R 0264-6021 0 Carrier Proteins 0 Hematinics 0 Proteins

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1955 Biochemical Journal

4. Sensitivity to cyanocobalamin and hydroxocobalamin. (PubMed)

Sensitivity to cyanocobalamin and hydroxocobalamin. 5572387 1971 06 19 2018 11 13 0007-1447 2 5756 1971 May 01 British medical journal Br Med J Sensitivity to cyanocobalamin and hydroxocobalamin. 262 James J J Warin R P RP eng Journal Article England Br Med J 0372673 0007-1447 P6YC3EG204 Vitamin B 12 Q40X8H422O Hydroxocobalamin AIM IM Administration, Oral Aged Anemia, Pernicious complications Drug Hypersensitivity Dyspnea chemically induced Female Headache chemically induced Humans

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1971 British medical journal

5. Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients (PubMed)

Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients Standard treatment of cobalamin (vitamin B12) deficiency involvesregular (1000 μg/mo) IM cyanocobalamin administration. It has been suggested that high-dose (>2000 μg/d) oral cyanocobalamin may be effective in patients with pernicious anemia.The aim of this study was to assess the efficacy and tolerability of oral crystalline cyanocobalamin 1000 μg/d (...) in patients with cobalamin deficiency related to established pernicious anemia.This open-label, prospective study was conducted at StrasbourgUniversity Hospital, Strasbourg, France. Patients aged ≥18 years with well-documented cobalamin deficiency related to pernicious anemia were enrolled. Patients received crystalline cyanocobalamin 1000 μg QD PO (capsule) for at least 3 months. Serum cobalamin, folate, iron, and homocysteine concentrations were measured, and a complete blood count was obtained, before

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2005 Current therapeutic research, clinical and experimental

6. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12) (PubMed)

Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12) To evaluate protein-bound cyanocobalamin (vitamin B12) absorption before and after omeprazole (Prilosec) therapy in healthy male volunteers.Clinical trial in which each volunteer served as his own control.Outpatient department of a university medical center.Ten healthy, male volunteers 22 to 50 years old.Each participant had a modified Schilling test (protein-bound cyanocobalamin) and a gastric analysis, as well (...) as measurements of serum vitamin B12, gastrin, and folate levels. Five patients were then randomly assigned to take either 20 mg or 40 mg of omeprazole daily. After 2 weeks of omeprazole therapy, these tests were repeated.The modified Schilling test, gastric analysis, serum gastrin level, folate level, and cyanocobalamin level.At the end of the 2-week treatment period, cyanocobalamin absorption decreased from 3.2% to 0.9% (P = 0.031) in participants receiving 20 mg of omeprazole daily. In patients taking 40

1994 Annals of internal medicine

7. Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects. (PubMed)

Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects. Vitamin B12 (cobalamin) deficiency may be caused by inadequate dietary intake of B12 or by conditions that result in malabsorption of the vitamin. Crystalline vitamin B12, usually in the form of cyanocobalamin, is administered parenterally (ie, intramuscularly) or orally for treating deficiency states (...) . Intramuscular administration is widely accepted as a treatment method. Oral B12 supplementation is also used, but it is considered to be less reliable.This study was conducted to compare the pharmacokinetics and tolerability of 2 oral formulations of cyanocobalamin-a marketed cyanocobalamin tablet (immediate-release B12 5 mg) and cyanocobalamin formulated with a proprietary carrier, sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC)-to establish the feasibility of using an absorption enhancer with B12

2011 Clinical therapeutics

8. Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing

Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing National Horizon Scanning Centre Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation National Horizon Scanning Centre. Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing. Birmingham: National Horizon Scanning Centre (NHSC). 2007 Authors' objectives This study examines the use of Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Vitamin B 12 Deficiency /drug therapy Language Published English

2007 Health Technology Assessment (HTA) Database.

9. Oral Cyanocobalamin (Eligen B12) Bioavailability Study

Oral Cyanocobalamin (Eligen B12) Bioavailability Study Oral Cyanocobalamin (Eligen B12) Bioavailability Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral Cyanocobalamin (Eligen B12) Bioavailability (...) : The purpose of this study is to assess and compare the pharmacokinetics (PK) of cyanocobalamin after the oral administration of Eligen® B12 (cyanocobalamin/SNAC), oral cyanocobalamin alone (commercially-available formulation) and cyanocobalamin administered intravenously (IV) (also a commercially-available formulation) to healthy male subjects under fasting conditions. The safety and tolerability of oral Eligen® B12 (cyanocobalamin/SNAC) versus oral cyanocobalamin alone and versus IV cyanocobalamin

2011 Clinical Trials

10. Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow. (PubMed)

Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow. The aim of the study reported in this Research Communication was to investigate the effect of a combined acetylmethionine, cyanocobalamin and α-lipoic acid treatment, on some metabolic parameters of early lactating high-yielding dairy cows. Thirty cows were randomly divided into two groups: experimental group (EG, n = 20) and control group (CG, n = 10). EG received 20 ml

2017 The Journal of dairy research

11. Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status

Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02679833 Recruitment Status : Completed First Posted : February 10, 2016 Last Update Posted : May 11, 2018 Sponsor: Saarland University Collaborator: Institute of Alternative and Sustainable

2016 Clinical Trials

12. Effects of a combination butaphosphan and cyanocobalamin product and insulin on ketosis resolution and milk production. (PubMed)

Effects of a combination butaphosphan and cyanocobalamin product and insulin on ketosis resolution and milk production. The objective of this study was to determine the effects of butaphosphan-cyanocobalamin (B+C), glargine insulin, and propylene glycol on resolution of ketosis and average daily milk yield after treatment. Cows from 16 herds in Ontario, Canada, and 1 herd in Michigan were tested at weekly intervals between 3 and 16 DIM. Ketosis was defined as blood β-hydroxybutyrate (BHB) ≥1.2

2017 Journal of dairy science

13. Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production. (PubMed)

Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production. The purpose of this study was to determine the effects of a butaphosphan-cyanocobalamin combination product (B+C) and 2 durations of propylene glycol treatment (PG; 3 versus 5 d) on ketosis resolution and early lactation milk yield. Cows from 9 freestall herds (8 in Ontario and 1 in Michigan) were tested at weekly intervals between 3 and 16 d in milk

2017 Journal of dairy science

14. Anaphylactic Reaction to Cyanocobalamin: A Case Report (PubMed)

Anaphylactic Reaction to Cyanocobalamin: A Case Report Vitamin B12 is essential for the development of healthy nerves and red blood cells. Vitamin B12 deficiency is becoming widespread and most commonly affects elderly, pregnant women, vegetarians, and patients with renal or intestinal diseases. Either parenteral vitamin B12 treatment or high-dose oral vitamin B12 treatment is an effective therapy regardless of etiology. Parenteral therapy using the intramuscular route is considered the most (...) familiar treatment for vitamin B12 deficiency. Anaphylactic reaction after intramuscular injection is an uncommon and potentially serious side effect. In this study, we are documenting a case of anaphylactic reaction in a 55-year-old woman after her second dose of intramuscular injection of cyanocobalamin. The purpose of this case report is to highlight the need to understand the rare life-threatening side effect of intramuscular cyanocobalamin. Health care providers should be vigilant while

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2018 Cureus

15. Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial

Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study (...) record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial The safety

2017 Clinical Trials

16. Increase in circulating holotranscobalamin after oral administration of cyanocobalamin or hydroxocobalamin in healthy adults with low and normal cobalamin status. (PubMed)

Increase in circulating holotranscobalamin after oral administration of cyanocobalamin or hydroxocobalamin in healthy adults with low and normal cobalamin status. To investigate the absorption of synthetic cyanocobalamin and natural occurring hydroxocobalamin in populations with low and normal cobalamin (vitamin B12) status.We included adults with low (n = 59) and normal (n = 42) cobalamin status and measured the change in serum holotranscobalamin (ΔholoTC) before and after 2 day administration (...) of different doses of cyanocobalamin and hydroxocobalamin (CobaSorb test). In the low status group, the test was performed using a cross-over design with identical doses of both cobalamin forms (1.5, 3, and 6 µg, respectively). In the normal status group, the test was performed with either 3, 6, and 9 µg cyanocobalamin (n = 28), or with 9 µg cyanocobalamin and 9 µg hydroxocobalamin (n = 14).In both groups, median ΔholoTC (pmol/L) was higher after intake of cyanocobalamin compared to (hydroxocobalamin) [low

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2018 European journal of nutrition

17. [Use of the combination of adrenal cortex extract, pyridoxal-5-phosphate, cyanocobalamin and ascorbic acid in the treatment of hypocorticism in pregnancy]. (PubMed)

[Use of the combination of adrenal cortex extract, pyridoxal-5-phosphate, cyanocobalamin and ascorbic acid in the treatment of hypocorticism in pregnancy]. 7121892 1982 12 02 2013 11 21 0026-4784 34 7-8 1982 Jul-Aug Minerva ginecologica Minerva Ginecol [Use of the combination of adrenal cortex extract, pyridoxal-5-phosphate, cyanocobalamin and ascorbic acid in the treatment of hypocorticism in pregnancy]. 619-23 Ferruti M M MM Speranza R R ita Clinical Trial English Abstract Journal Article

1982 Minerva ginecologica

18. Cyanocobalamin

Cyanocobalamin Top results for cyanocobalamin - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for cyanocobalamin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

19. Estimation of intrinsic factor and detection of intrinsic factor antibodies using non-radioactive cyanocobalamin and microbiological assay (PubMed)

Estimation of intrinsic factor and detection of intrinsic factor antibodies using non-radioactive cyanocobalamin and microbiological assay A method employing non-radioactive vitamin B(12) and microbiological assay is described for estimating intrinsic factor in gastric juice and for detecting antibody to intrinsic factor in serum. Satisfactory agreement was obtained between the results by this method and by a modification of the method of Ardeman and Chanarin (1963). During the first hour after

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1967 Journal of Clinical Pathology

20. Withdrawal of cyanocobalamin. (PubMed)

Withdrawal of cyanocobalamin. 519368 1980 03 27 2013 11 21 0007-1447 2 6199 1979 Nov 10 British medical journal Br Med J Withdrawal of cyanocobalamin. 1219-20 Davidson N M NM eng Letter England Br Med J 0372673 0007-1447 P6YC3EG204 Vitamin B 12 Q40X8H422O Hydroxocobalamin AIM IM Humans Hydroxocobalamin adverse effects Vitamin B 12 adverse effects 1979 11 10 1979 11 10 0 1 1979 11 10 0 0 ppublish 519368 PMC1597301

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1979 British medical journal