Latest & greatest articles for corticosteroids

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Top results for corticosteroids

1. Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? (SRS Therapy)

Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? (SRS Therapy) TAKE-HOME MESSAGE For adult patients with severe community-acquired pneumonia, corticosteroids reduce morbidity and mortality. For pediatric patients and adults with nonsevere community-acquired pneumonia, corticosteroids appear to reduce morbidity, but not mortality. Are Corticosteroids Bene?cial in the Treatment of Community-Acquired Pneumonia? EBEM Commentators Thomas Seagraves, MD Michael Gottlieb (...) , MD Department of Emergency Medicine Rush University Medical Center Chicago, IL Results Comparison of corticosteroids with control for community-acquired pneumonia. Outcome No. of Studies (No. of Participants) Relative Risk (95% CI) I 2 ,% Mortality (adults with severe CAP) 9 (995) 0.58 (0.40–0.84) 12 Mortality (adults with nonsevere CAP) 4 (868) 0.95 (0.45–2.00) 0 Early clinical failure (adults with severe CAP) 5 (419) 0.32 (0.15–0.70) 74 Early clinical failure (adults with nonsevere CAP) 2 (905

2018 Annals of Emergency Medicine Systematic Review Snapshots

2. Corticosteroids

the Cochrane Central Register of Controlled Trials (CENTRAL) which contains the Cochrane ARI Group's Specialised Register, MEDLINE (Ovid), Embase (Elsevier), CINAHL (EBSCO), Web of Science (Thomson Reuters), and LILACS (BIREME) for published studies 2018 8. Corticosteroids - inhaled Corticosteroids - inhaled - NICE CKS Clinical Knowledge Summaries Share Corticosteroids - inhaled - Summary Corticosteroids are synthetic analogues of hormones produced by the adrenal cortex. Inhaled corticosteroids (...) of one day earlier. Reduced need for artificial breathing support was the main benefit for people with non-severe pneumonia. The review showed that using corticosteroids increased levels of blood sugar. This and other potential adverse events were not well 2018 12. Corticosteroids - oral Corticosteroids - oral - NICE CKS Clinical Knowledge Summaries Share Corticosteroids - oral - Summary Corticosteroids are synthetic analogues of hormones produced by the adrenal cortex. Corticosteroids are either

2018 Trip Latest and Greatest

3. Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? Full Text available with Trip Pro

Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 1, Pages e1–e3 Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? x Thomas Seagraves , MD (EBEM Commentator) , x Michael Gottlieb , MD (EBEM Commentator (...) ) Department of Emergency Medicine, Rush University Medical Center, Chicago, IL DOI: | Publication History Published online: June 21, 2018 Expand all Collapse all Article Outline Take-Home Message For adult patients with severe community-acquired pneumonia, corticosteroids reduce morbidity and mortality. For pediatric patients and adults with nonsevere community-acquired pneumonia, corticosteroids appear to reduce morbidity, but not mortality. Methods Data Sources The authors searched the Cochrane Acute

2019 Annals of Emergency Medicine Systematic Review Snapshots

4. Treating tennis elbow (lateral epicondylalgia) with corticosteroid injections are beneficial in the short term but harmful in the long term

Treating tennis elbow (lateral epicondylalgia) with corticosteroid injections are beneficial in the short term but harmful in the long term 1 sbu – swedish council on health technology assessment What is tennis elbow? Tendon pain is referred to as tendinopathy when the pain is associated with a tendon, or enthesopathy when the pain is associated with the areas where liga- ments or tendons are attached to the bone. Tendons and their associated tissues can become painful and swollen in response (...) with local injec- tions of the anti-inflammatory agent corticosteroid. Treatment in Sweden Tennis elbow occurs in 0.3–1.1 percent of the Swedish population [1], meaning that between 29,000 and 105,000 Swedish people suffer from tennis elbow each year [2]. Tennis elbow most commonly effects people between the ages of 40 and 60. It is unclear to what extent corticosteroid injections are used to treat tennis elbow in Sweden, however direct communication with several health clinics revealed that the method

2014 Swedish Council on Technology Assessement

5. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy)

is a potentially deadly con- dition. Primary treatments include sourcecontrol,antimicrobials,and resuscitation with hemodynamic support (intravenous?uids and va- sopressors).Inaddition,thereexist several accepted indications for corticosteroid therapy in patients with sepsis including immunosup- pression and adrenal insuf?- ciency. 8-11 One of the most common steroid regimens used is hydrocortisone at less than 400 Results of included trials. Study Intervention Mean OR for Shock Reversal (95% CI) Mean (...) Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy) TAKE-HOME MESSAGE No studied corticosteroid regimen is superior to placebo or any other regimen in patient-centered outcomes including mortality; however, hydrocortisone infusion improves shock reversal compared with placebo or methylprednisolone. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? EBEM Commentators Brit Long, MD Michael D. April, MD, DPhil

2018 Annals of Emergency Medicine Systematic Review Snapshots

6. Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma

Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma Comparative Effectiveness Review Number 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma e Comparative Effectiveness Review Number 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 (...) Questions (KQs) 1c and 2a-c. These KQs were related to the combined use of inhaled corticosteroids and long-acting beta agonists as controller and quick relief therapy and to the use of long-acting muscarinic antagonists as add-on therapy to inhaled corticosteroids. The original search was conducted in August 2016 using the earliest date for each database. This update was made on November 28, 2017. No new studies met inclusion criteria. iii Key Messages Purpose of Review To assess the efficacy

2018 Effective Health Care Program (AHRQ)

7. Antenatal Corticosteroid Therapy for Fetal Maturation

from repeated courses (especially in the reduction and severity of respiratory distress), there also are animal and human data that suggest deleterious effects on the fetus regarding cerebral myelination, lung growth, and function of the hypothalamic–pituitary–adrenal axis. Follow-up of children at 2 years of age who were exposed to repeat courses of antenatal corticosteroids showed no significant difference in physical or neurocognitive measures in two studies ( , ), and the same outcome was found (...) in younger children in a third study ( ). Although not statistically significant, the relative risk of cerebral palsy in infants exposed to serial courses of antenatal corticosteroids (RR, 5.7; 95% confidence interval, 0.7–46.7; P =.12) in one study is of concern and warrants further study (39). Maternal effects include increased risk of infection and suppression of the hypothalamic–pituitary–adrenal axis ( , ). Regularly scheduled repeat courses or serial courses (more than two) are not currently

2017 American College of Obstetricians and Gynecologists

8. Do Corticosteroids Benefit Patients With Sore Throat?

Do Corticosteroids Benefit Patients With Sore Throat? Systematic Review Snapshot TAKE-HOME MESSAGE The use of corticosteroids decreases pain and time to symptom resolution in patients with sore throat, especially among those with severe exudative pharyngitis. Do Corticosteroids Bene?t Patients With Sore Throat? EBEM Commentators Julie L. Welch, MD Dylan D. Cooper, MD Department of Emergency Medicine Indiana University School of Medicine Indianapolis, IN Results The literature search identi?ed (...) - ferenceinpatientoutcomesreported. The only possible subgroup compari- son was route of administration, Corticosteroids versus placebo in patients with pharyngitis. Corticosteroid vs Placebo Outcome (95% CI) NNT (95% CI) Number of Studies (Patients) Resolution of pain at 24 h RR¼3.2 (2.0 to 5.1) 3.7 (2.8 to 5.9) 4 (286) Resolution of pain at 48 h RR¼1.7 (1.3 to 2.1) 3.3 (2.4 to 5.6) 3 (209) Time to pain relief MD¼–6.3 h (–9.3 to –3.4) n/a 6 (609) Time to resolution of pain MD¼–14.4 h (–24.0 to –3.9) n/a 5 (500) Recurrence

2013 Annals of Emergency Medicine Systematic Review Snapshots

9. Epicondylitis (tennis elbow) and corticosteroids: less success than physiotherapy

Epicondylitis (tennis elbow) and corticosteroids: less success than physiotherapy Prescrire IN ENGLISH - Spotlight ''Epicondylitis (tennis elbow) and corticosteroids: less success than physiotherapy'', 1 June 2015 {1} {1} {1} | | > > > Epicondylitis (tennis elbow) and corticosteroids: less success than physiotherapy Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |    (...) |  Spotlight Epicondylitis (tennis elbow) and corticosteroids: less success than physiotherapy A local corticosteroid injection gives short-term relief, but increases the risk of recurrence, in contrast to physiotherapy. Patients suffering from epicondylitis, or "tennis elbow", generally experience pain around the outside of the elbow. The pain is generally moderate and is triggered by certain movements, but it can become intense and continual, restricting activity and reducing grip strength

2015 Prescrire

10. Systemic corticosteroids for acute otitis media in children. Full Text available with Trip Pro

Systemic corticosteroids for acute otitis media in children. Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days. There is insufficient evidence for benefits of other treatment options, including systemic corticosteroids. However, systemic corticosteroids are potent anti-inflammatory drugs, and so (...) theoretically could be effective, either alone or as an addition to antibiotics.To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) which contains the Cochrane ARI Group's Specialised Register, MEDLINE (Ovid), Embase (Elsevier), CINAHL (EBSCO), Web of Science (Thomson Reuters), and LILACS (BIREME) for published studies, and ClinicalTrials.gov and the World Health

2018 Cochrane

12. Allergic Rhinitis - Guidelines for Prescribing Intranasal Corticosteroids

that INCS are not effective for hormonal rhinitis in pregnancy (nasal congestion without any signs of upper respiratory infection or known allergic cause). If the patient has previously diagnosed allergic rhinitis, treatment with antihistamines and/or intranasal corticosteroids is considered safe. Lactation: Use of nasal corticosteroids while breastfeeding is considered acceptable. Children : Mometasone or fluticasone recommended because systemic absorption is minimal and there is no evidence of growth (...) Allergic Rhinitis - Guidelines for Prescribing Intranasal Corticosteroids Allergic Rhinitis - Guidelines for Prescribing Intranasal Corticosteroids - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Allergic Rhinitis - Guidelines for Prescribing Intranasal Corticosteroids An inflammatory disorder of the nose which occurs when the membranes lining the nose become sensitized to allergens. Mediated by immunoglobulin E (IgE

2017 medSask

13. Comparison Between Corticosteroid and Lidocaine Injection in the Treatment of Tennis Elbow: A Randomized, Double-Blinded, Controlled Trial. (Abstract)

Comparison Between Corticosteroid and Lidocaine Injection in the Treatment of Tennis Elbow: A Randomized, Double-Blinded, Controlled Trial. The aim of the study was to compare the effects of corticosteroid injection with lidocaine injection in treating tennis elbow.It is a prospective, double-blinded, randomized controlled trial. Patients with tennis elbow for more than 1 mo were recruited from a hospital-based rehabilitation outpatient clinic. A total of 70 patients were recruited, and 61 (...) patients completed the study. Patients received an injection of either 10 mg (1 ml) of triamcinolone (corticosteroid group, n = 30) or 1 ml of 1% lidocaine (lidocaine group, n = 31). All of the outcome measures were evaluated before the intervention and at 2 wks and 2 mos after treatment.No significant group differences were observed between the corticosteroid and lidocaine groups regarding Patient-Rated Tennis Elbow Evaluation, Disability of the Arm, Shoulder, and Hand, visual analog scale for pain

2019 American journal of physical medicine & rehabilitation Controlled trial quality: predicted high

14. Tiotropium add-on to inhaled corticosteroids versus addition of long-acting β<sub>2</sub>-agonists for adults with asthma. Full Text available with Trip Pro

Tiotropium add-on to inhaled corticosteroids versus addition of long-acting β2-agonists for adults with asthma. Additional management options, and better use of current options, are needed to help support a large proportion of patients with asthma whose symptoms remain uncontrolled on inhaled corticosteroids (ICS). Here, we aim to review the safety and efficacy of adding tiotropium to ICS compared with adding a long-acting β2-agonist (LABA) for adults whose asthma is not well

2018 Respiratory medicine

15. Do Corticosteroids Provide Benefit to Patients With Community-Acquired Pneumonia?

Do Corticosteroids Provide Benefit to Patients With Community-Acquired Pneumonia? TAKE-HOME MESSAGE For adult patients with community-acquired pneumonia requiring hospitalization, datasuggestthatcorticosteroid therapy mayreduce mortality, needformechanical ventilation, and hospital length of stay. Do Corticosteroids Provide Bene?t to Patients With Community-Acquired Pneumonia? EBEM Commentators Michael Gottlieb, MD John Bailitz, MD Department of Emergency Medicine Cook County Hospital Chicago (...) as an intravenous bolus followed by an infusion for 7 to 10 days. Five studies enrolling 70% of the total sample had an overall low risk of bias. Of the remaining studies, 6 had incom- plete allocation concealment, 4 had inadequate blinding, 1 had incomplete follow-up, and 1 was halted early after statistical signi- ?cance was attained during a planned interim analysis. Overall, systemic corticosteroids demonstrated decreased need for mechanical ventilation, decreased progression to acute respiratory distress

2016 Annals of Emergency Medicine Systematic Review Snapshots

16. Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes

and adrenal suppression. Intended Users Maternity care providers including midwives, family physicians, and obstetricians. Target Population Pregnant women. Evidence Medline, PubMed, Embase, and the Cochrane Library were searched from inception to September 2017. Medical Subject Heading (MeSH) terms and key words related to pregnancy, prematurity, corticosteroids, and perinatal and neonatal mortality and morbidity were used. Statements from professional organizations including that of the National (...) Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 40, Issue 9, Pages 1219–1239 No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes x Amanda Skoll , MD * Vancouver, BC x Amélie Boutin , PhD * Québec City, QC x Emmanuel Bujold , MD, MSc Québec City, QC x Jason

2018 Society of Obstetricians and Gynaecologists of Canada

17. Interventions to prevent and treat corticosteroid-induced osteoporosis and prevent osteoporotic fractures in Duchenne muscular dystrophy. Full Text available with Trip Pro

Interventions to prevent and treat corticosteroid-induced osteoporosis and prevent osteoporotic fractures in Duchenne muscular dystrophy. Corticosteroid treatment is considered the 'gold standard' for Duchenne muscular dystrophy (DMD); however, it is also known to induce osteoporosis and thus increase the risk of vertebral fragility fractures. Good practice in the care of those with DMD requires prevention of these adverse effects. Treatments to increase bone mineral density include (...) bisphosphonates and vitamin D and calcium supplements, and in adolescents with pubertal delay, testosterone. Bone health management is an important part of lifelong care for patients with DMD.To assess the effects of interventions to prevent or treat osteoporosis in children and adults with DMD taking long-term corticosteroids; to assess the effects of these interventions on the frequency of vertebral fragility fractures and long-bone fractures, and on quality of life; and to assess adverse events.On 12

2017 Cochrane

18. Do corticosteroid injections improve carpal tunnel syndrome symptoms?

Do corticosteroid injections improve carpal tunnel syndrome symptoms? Do corticosteroid injections improve carpal tunnel syndrome symptoms? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do corticosteroid injections improve carpal tunnel syndrome symptoms? View/ Open Date 2016-02 Format Metadata Abstract Q: Do (...) corticosteroid injections improve carpal tunnel syndrome symptoms? Evidence-based answer: Yes. injected corticosteroids reduce symptoms of carpal tunnel syndrome (CTS) more effectively than placebo or systemic steroids, but no better than anti-inflammatory medication and splinting, from one to 12 weeks after therapy (strength of recommendation [SOR]: A, meta-analysis of randomized controlled trials [RCTs] and consistent RCT). A 40-mg injection of methylprednisolone reduces symptoms as effectively as an 80-mg

2016 Clinical Inquiries

19. Comparison between montelukast and tiotropium as add-on therapy to inhaled corticosteroids plus a long-acting β<sub>2</sub>-agonist in for patients with asthma. (Abstract)

Comparison between montelukast and tiotropium as add-on therapy to inhaled corticosteroids plus a long-acting β2-agonist in for patients with asthma. Asthma often remains uncontrolled despite treatment with inhaled corticosteroids (ICS) alone or with ICS plus a long-acting β2-agonist (LABA). The recommended alternative is the addition of either montelukast or tiotropium. The aim of this study was to compare the effects of montelukast and tiotropium on airway inflammation

2018 Journal of Asthma Controlled trial quality: uncertain

20. The effect of impactful papers on clinical practice in the US: Corticosteroid injection for patients with lateral epicondylitis. Full Text available with Trip Pro

The effect of impactful papers on clinical practice in the US: Corticosteroid injection for patients with lateral epicondylitis. Following publication of high-level evidence demonstrating that it is not an effective treatment for lateral epicondylitis, a reduction in the corticosteroid injection rate would be expected. The authors aimed to clarify current clinical practice pattern for lateral epicondylitis and identify factors that influence the introduction of evidence into clinical (...) practice.In this administrative claims analysis, the authors used 2009 to 2015 Truven MarketScan data to extract claims for corticosteroid injection, physical therapy, platelet-rich plasma injection, and surgery for lateral epicondylitis. The authors performed multivariable analysis using a generalized estimating equation model to identify the variables that potentially affect the odds of receiving a given treatment.Among 711,726 claims, the authors found that the odds of receiving a corticosteroid

2018 Plastic and reconstructive surgery