Latest & greatest articles for corticosteroids

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on corticosteroids or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on corticosteroids and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for corticosteroids

41. Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis

Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis 29475879 2018 02 24 1468-2052 2018 Feb 23 Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis. fetalneonatal-2017-313759 10.1136/archdischild-2017-313759 To determine the comparative efficacy and safety of corticosteroids in the (...) prevention of bronchopulmonary dysplasia (BPD) in preterm infants. We systematically searched PubMed, EMBASE and the Cochrane Library. Two reviewers independently selected randomised controlled trials (RCTs) of postnatal corticosteroids in preterm infants. A Bayesian network meta-analysis and subgroup analyses were performed. We included 47 RCTs with 6747 participants. The use of dexamethasone at either high dose or low dose decreased the risk of BPD (OR 0.29, 95% credible interval (CrI) 0.14 to 0.52

EvidenceUpdates2018

42. Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis?

Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis? 29881814 2018 11 14 2471-254X 2 6 2018 Jun Hepatology communications Hepatol Commun Can we reliably predict response to corticosteroid treatment in severe alcoholic hepatitis? 625-627 10.1002/hep4.1191 Chokshi Shilpa S Chief Scientific Officer Institute of Hepatology Foundation for Liver Research London United Kingdom. eng Editorial 2018 04 27 United States Hepatol Commun 101695860 2471-254X 2018 03 29

Hepatology communications2018 Full Text: Link to full Text with Trip Pro

43. Corticosteroid injections provide only short term relief for rotator cuff disorders

Corticosteroid injections provide only short term relief for rotator cuff disorders NIHR DC | Signal - Corticosteroid injections provide only short term relief for rotator cuff disorders Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Corticosteroid injections provide only short term relief for rotator cuff disorders Published on 5 October 2016 A corticosteroid steroid injection into the shoulder provides some short-term pain relief for adults with rotator cuff disorders (...) . This review compared injection of corticosteroids (‘steroids’) with injection of local anaesthetic or placebo. The average improvement in pain relief at two months was calculated as moderate using standardised techniques. The effect wore off by three months. Given the temporary benefits, it may be worth considering other treatments including physiotherapy alongside a steroid injection. Information given by an injecting physiotherapist, for example, regarding the expected duration of pain relief could also

NIHR Dissemination Centre2018

44. Corticosteroids improve recovery rates after Bell’s palsy

Corticosteroids improve recovery rates after Bell’s palsy NIHR DC | Signal - Corticosteroids improve recovery rates after Bell’s palsy Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Corticosteroids improve recovery rates after Bell’s palsy Published on 29 November 2016 Taking a corticosteroid within 72 hours of Bell’s palsy first appearing reduces the number of people with incomplete facial recovery after six months. Bell’s palsy is a sudden onset of weakness or paralysis (...) of the muscles on one side of the face. Most people recover completely within nine months, often with no treatment, but about three in 10 people are left with some weakness or unwanted facial movements. This Cochrane review found that ten people needed to be treated with corticosteroid, compared to placebo tablets, to avoid one incomplete recovery. It also showed that side effects were uncommon and mild. Corticosteroids are often already prescribed to treat Bell’s palsy in practice. This review confirms

NIHR Dissemination Centre2018

45. Moisturisers improve eczema symptoms and lessen the need for corticosteroids

Moisturisers improve eczema symptoms and lessen the need for corticosteroids NIHR DC | Signal - Moisturisers improve eczema symptoms and lessen the need for corticosteroids Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Moisturisers improve eczema symptoms and lessen the need for corticosteroids Published on 27 June 2017 Moisturisers help reduce eczema symptoms compared to no treatment, but to a minor extent. They do lengthen the time between each flare, and reduce the number (...) of flares. Importantly they reduce the amount of corticosteroid creams required. Moisturisers seem well tolerated, though there is little data on patient satisfaction. This Cochrane review of 77 trials does not provide information on which moisturiser might be preferred for different parts of the body or different disease severity. Nevertheless, since moisturisers reduce flares and form part of combined treatment with other active treatments, it makes sense to encourage their continued use. Given

NIHR Dissemination Centre2018

46. A dose of corticosteroids benefit most women anticipating a preterm delivery

A dose of corticosteroids benefit most women anticipating a preterm delivery NIHR DC | Signal - A dose of corticosteroids benefit most women anticipating a preterm delivery Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal A dose of corticosteroids benefit most women anticipating a preterm delivery Published on 16 May 2017 Giving corticosteroids to most women who are anticipating labour before completing 37 weeks of pregnancy helps reduce immediate health problems in the baby (...) compared with placebo or no intervention. Deaths around the time of birth were reduced by 28% and babies were a third (34%) less likely to develop respiratory distress syndrome. A corticosteroid dose is already used for women who go into labour or if waters break before 37 weeks or where delivery is planned for other reasons. The drug accelerates the development of the baby’s lungs and reduces breathing difficulties at birth. This recommendation followed decades of research. This review supports

NIHR Dissemination Centre2018

47. Antenatal corticosteroids reduce breathing problems in late preterm babies

Antenatal corticosteroids reduce breathing problems in late preterm babies NIHR DC | Signal - Antenatal corticosteroids reduce breathing problems in late preterm babies Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Antenatal corticosteroids reduce breathing problems in late preterm babies Published on 21 February 2017 Giving corticosteroids to women at risk of preterm birth at 34 weeks of pregnancy or later reduced the risk of severe breathing problems in the baby after (...) of low blood sugar in the new-born, which would need monitoring. The risks and benefits need to be considered before further recommendations can be made extending the use of antenatal corticosteroids to this late preterm age. This includes exploring the long-term effects and consequences for specific groups of women such as those with diabetes or pregnant with more than one baby. Why was this study needed? In the UK, about one baby in every 13 is born prematurely, before 37 weeks of pregnancy. Preterm new-borns

NIHR Dissemination Centre2018

48. Corticosteroids given early reduce risk of heart problems in children with Kawasaki disease

Corticosteroids given early reduce risk of heart problems in children with Kawasaki disease NIHR DC | Signal - Corticosteroids given early reduce risk of heart problems in children with Kawasaki disease Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Corticosteroids given early reduce risk of heart problems in children with Kawasaki disease Published on 14 February 2017 Early treatment with corticosteroids on top of standard therapy reduces the risk of serious heart problems (...) of the evidence found that adding corticosteroids early to standard treatment within five days of onset of symptoms reduced the risk of serious abnormalities in the heart arteries by more than two thirds. Corticosteroids were not effective when used as rescue treatment after standard treatment had failed. Increasing awareness of the presenting symptoms of children with Kawasaki disease should ensure children are referred early for treatment. Specialist clinicians may want to consider adding corticosteroids to

NIHR Dissemination Centre2018

49. Saline irrigation and corticosteroid spray are effective first choice treatments for chronic sinusitis

Saline irrigation and corticosteroid spray are effective first choice treatments for chronic sinusitis NIHR DC | Signal - Saline irrigation and corticosteroid spray are effective first choice treatments for chronic sinusitis Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Saline irrigation and corticosteroid spray are effective first choice treatments for chronic sinusitis Published on 22 December 2015 The authors of this systematic review found that high-volume saline (...) irrigation and corticosteroid nasal sprays were effective at reducing symptoms of sinusitis. They recommend a combination of these two therapies as the first line treatment of choice, in accordance with guidelines from the Royal College of Surgeons and ENT UK. In addition they found that, in those with nasal polyps, corticosteroids sprays reduced the polyp size, and during acute exacerbations a two to three week course of oral corticosteroids, doxycycline or a leukotriene antagonist was the most

NIHR Dissemination Centre2018

50. Corticosteroids could help reduce deaths due to blood poisoning

Corticosteroids could help reduce deaths due to blood poisoning NIHR DC | Signal - Corticosteroids could help reduce deaths due to blood poisoning Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal Corticosteroids could help reduce deaths due to blood poisoning Published on 23 March 2016 Treatment with low dose corticosteroids given over three or more days reduces the death rate from blood poisoning by 13%, saving about 43 lives per 1000 treated at one month. Blood sugar (...) and sodium levels rose slightly but there was no increased risk of gastrointestinal bleeding or additional infection. Current international guidance from 2012 only recommends using corticosteroids as an add-on therapy for people with blood poisoning whose circulation has not been restored by adequate fluid replacement and vasopressors. This review lends some weight to the case for using corticosteroids more widely for sepsis, but is not definitive. This uncertainty is due to inconsistency in results

NIHR Dissemination Centre2018

51. New evidence available on corticosteroids added to antibiotics in severe pneumonia

New evidence available on corticosteroids added to antibiotics in severe pneumonia NIHR DC | Signal - New evidence available on corticosteroids added to antibiotics in severe pneumonia Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal New evidence available on corticosteroids added to antibiotics in severe pneumonia Published on 9 November 2015 For adults admitted to hospital with severe pneumonia, this review found that adding corticosteroids to the usual antibiotic treatment (...) may be beneficial. The evidence was less supportive of using corticosteroids in people with less severe pneumonia. Results showed modest benefits in allowing patients to reach a clinically stable recovery and leave hospital an average of one day earlier. Reduced need for artificial breathing support was the main benefit for people with non-severe pneumonia. The review showed that using corticosteroids increased levels of blood sugar. This and other potential adverse events were not well

NIHR Dissemination Centre2018

52. Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis

Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis 30071930 2018 11 14 2147-9720 5 3 2018 Sep European journal of rheumatology Eur J Rheumatol Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis. 160-164 10.5152/eurjrheum.2018.17148 Adverse changes in body composition, specifically decreased muscle mass (MM (...) ) and increased fat mass, characterize rheumatoid arthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA following a single intramuscular (IM) corticosteroid (CS) injection to treat a disease flare. The aim of the current study is to determine whether this apparent iatrogenic effect of IM CS is typical, i.e., does this routine, recommended

European journal of rheumatology2018 Full Text: Link to full Text with Trip Pro

53. Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma

Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma Comparative Effectiveness Review Number 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma e Comparative Effectiveness Review Number 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 (...) Questions (KQs) 1c and 2a-c. These KQs were related to the combined use of inhaled corticosteroids and long-acting beta agonists as controller and quick relief therapy and to the use of long-acting muscarinic antagonists as add-on therapy to inhaled corticosteroids. The original search was conducted in August 2016 using the earliest date for each database. This update was made on November 28, 2017. No new studies met inclusion criteria. iii Key Messages Purpose of Review To assess the efficacy

Effective Health Care Program (AHRQ)2018

54. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease.

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. BACKGROUND: Current guidelines recommend that patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) should be treated with systemic corticosteroid for seven to 14 days. Intermittent systemic corticosteroid use is cumulatively associated with adverse effects such as osteoporosis, hyperglycaemia and muscle weakness. Shorter treatment could reduce adverse effects (...) . OBJECTIVES: To compare the efficacy of short-duration (seven or fewer days) and conventional longer-duration (longer than seven days) systemic corticosteroid treatment of adults with acute exacerbations of COPD. SEARCH METHODS: Searches were carried out using the Cochrane Airways Group Specialised Register of Trials, MEDLINE and CENTRAL (Cochrane Central Register of Controlled Trials) and ongoing trials registers up to March 2017. SELECTION CRITERIA: Randomised controlled trials comparing different

Cochrane2018

55. Systemic corticosteroids for acute otitis media in children.

Systemic corticosteroids for acute otitis media in children. BACKGROUND: Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days. There is insufficient evidence for benefits of other treatment options, including systemic corticosteroids. However, systemic corticosteroids are potent anti-inflammatory drugs, and so (...) theoretically could be effective, either alone or as an addition to antibiotics. OBJECTIVES: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) which contains the Cochrane ARI Group's Specialised Register, MEDLINE (Ovid), Embase (Elsevier), CINAHL (EBSCO), Web of Science (Thomson Reuters), and LILACS (BIREME) for published studies

Cochrane2018

56. Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid

Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid 29357330 2018 01 22 2150-1149 21 1 2018 Jan Pain physician Pain Physician Ultrasound-Guided Genicular Nerve Block for Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid. 41-52 Recently, several studies suggested that radiofrequency (RF) ablation (...) of the genicular nerves is a safe and effective therapeutic procedure for intractable pain associated with chronic knee osteoarthritis (OA). Diagnostic genicular nerve block (GNB) with local anesthetic has been generally conducted before making decisions regarding RF ablation. Although GNB has been recently performed together with corticosteroid, the analgesic effects of corticosteroids for treating chronic pain remain controversial. The current study aims to assess the effects of combining corticosteroids and

EvidenceUpdates2018

57. Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture

Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture 28716642 2018 02 06 1931-3543 153 2 2018 Feb Chest Chest Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture. 321-328 S0012-3692(17)31243-6 10.1016/j.chest.2017.07.002 It is uncertain whether long-term use of inhaled corticosteroids (ICSs), widely used to treat COPD, increases the risk of fracture, particularly in women, in view of the postmenopausal risks. We assessed whether long-term ICS use (...) for Clinical Epidemiology, Jewish General Hospital - Lady Davis Research Institute, Montreal, QC, Canada. Ernst Pierre P Centre for Clinical Epidemiology, Jewish General Hospital - Lady Davis Research Institute, Montreal, QC, Canada. Suissa Samy S Centre for Clinical Epidemiology, Jewish General Hospital - Lady Davis Research Institute, Montreal, QC, Canada. Electronic address: samy.suissa@mcgill.ca. eng Journal Article 2017 07 14 United States Chest 0231335 0012-3692 COPD fracture inhaled corticosteroids

EvidenceUpdates2018

58. Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial

Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial 29370788 2018 02 13 1471-2474 19 1 2018 01 25 BMC musculoskeletal disorders BMC Musculoskelet Disord Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized (...) clinical function between single-dose rESWT and local corticosteroid injection (LCsI) over the mid-term (24 weeks). Twenty-five patients with mild to moderately severe CTS were randomized to receive either single-dose rESWT (n = 13) or LCsI (n = 12). Primary outcomes were evaluated using the Boston self-assessment questionnaire (BQ), while secondary outcomes used the Visual analogue scale (VAS) and electrodiagnostic parameters. Evaluations at baseline and at 1, 4, 12 and 24 weeks after treatment were

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

59. Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis

Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis Changes in Natural Killer Cells and Exhausted Memory Regulatory T Cells With Corticosteroid Therapy in Acute Autoimmune Hepatitis Hannah C. Jeffery, 1 Manjit K. Braitch, 1 Chris Bagnall, 2 James Hodson, 3 Louisa E. Jeffery, 1 Rebecca E. Wawman, 1,4 Lin Lee Wong, 5 Jane Birtwistle, 6 Helen Bartlett, 1 Ansgar W. Lohse, 7 Gideon M. Hirsch?eld, 1,8 Jessica Dyson, 5 David (...) Jones, 5 Stefan G. Hubscher, 1,9 Paul Klenerman, 10 David H. Adams , 1,8 and Ye H. Oo 1,8 Autoimmune hepatitis (AIH) is an immune-mediated liver disease currently treated by immunosuppressive medications with signi?cant side effects. Thus, novel mechanistic treatments are greatly needed. We performed prospective deep immunophenotyping of blood immune cells in patients with acute AIH before and after corticosteroid therapy. Blood samples from 26 patients with acute AIH (United Kingdom-AIH Consortium

Hepatology communications2018 Full Text: Link to full Text with Trip Pro